2025
Early Release - Mycobacterium nebraskense Isolated from Patients in Connecticut and Oregon, USA - Volume 31, Number 3—March 2025 - Emerging Infectious Diseases journal - CDC
Metersky M, Losier A, Fraulino D, Warnock T, Varley C, Le A, Winthrop K, McArdle J, Shakir S, Khare R. Early Release - Mycobacterium nebraskense Isolated from Patients in Connecticut and Oregon, USA - Volume 31, Number 3—March 2025 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2025, 31: 507-515. PMID: 40023800, PMCID: PMC11878316, DOI: 10.3201/eid3103.240608.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Bacterial AgentsConnecticutFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium Infections, NontuberculousNontuberculous MycobacteriaOregonConceptsNontuberculous mycobacterial pulmonary diseaseMycobacterial pulmonary diseaseAmerican Thoracic Society/Infectious Diseases Society of America criteriaAntimicrobial drug susceptibility testingPulmonary diseaseDrug susceptibility testingRefractory to treatmentClinically significant causeClarithromycin susceptibilitySusceptibility testingConnecticut patientsRespiratory secretionsPatientsNo symptomsOptimum treatmentSignificant causeInfectionHuman casesDiseaseTreatmentCDCClarithromycinCasesClinicM. nebraskense
2024
Durlobactam in combination with β-lactams to combat Mycobacterium abscessus
Shin E, Dousa K, Taracila M, Bethel C, Nantongo M, Nguyen D, Akusobi C, Kurz S, Plummer M, Daley C, Holland S, Rubin E, Bulitta J, Boom W, Kreiswirth B, Bonomo R. Durlobactam in combination with β-lactams to combat Mycobacterium abscessus. Antimicrobial Agents And Chemotherapy 2024, 69: e01174-24. PMID: 39714147, PMCID: PMC11823594, DOI: 10.1128/aac.01174-24.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsDrug SynergismImipenemMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium Infections, NontuberculousPhylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC
Cudahy P, Liu P, Warren J, Sobkowiak B, Yang C, Ioerger T, Wu C, Lu P, Wang J, Chang H, Huang H, Cohen T, Lin H. Phylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan - Volume 30, Number 8—August 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1562-1570. PMID: 39043390, PMCID: PMC11286038, DOI: 10.3201/eid3008.240021.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overFemaleHumansLung DiseasesMaleMiddle AgedMycobacterium Infections, NontuberculousMycobacterium kansasiiPhylogenyPhylogeographyRetrospective StudiesRisk FactorsTaiwanWhole Genome SequencingConceptsM. kansasii lung diseaseM. kansasii pulmonary diseasePulmonary diseaseM. kansasii isolatesSputum mycobacterial cultureWhole-genome sequencingEvaluate risk factorsPhylogeographic analysisAge of participantsGenetic relatednessEnvironmental acquisitionLung diseaseMycobacterial cultureOdds ratioRisk factorsM. kansasiiPatientsDiseasePlantsEnvironmental transmissionIsolatesPark plantingsCDCRiskImmunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Cinco I, Napier E, Rhoades N, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I. Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection. MBio 2024, 15: e00829-24. PMID: 38771046, PMCID: PMC11237422, DOI: 10.1128/mbio.00829-24.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsFemaleLungMacaca mulattaMaleMicrobiotaMycobacterium Infections, NontuberculousTomography, X-Ray ComputedTranscriptomeConceptsNTM pulmonary diseaseIncreased disease severityNontuberculous mycobacteriaDisease severityBacterial DNAAged animalsAntigen-specific T cellsPulmonary diseaseAssociated with increased disease severityDysregulated macrophage responsePersistence of bacterial DNALack of animal modelsRhesus macaquesSingle-cell RNA sequencingNontuberculous mycobacterial infectionsImmune cell infiltrationRhesus macaque modelBacterial loadAged rhesus macaquesTesting novel therapeuticsRight caudal lobeLower respiratory microbiomeYears of ageMAH infectionMicrobial communitiesSynergistic effects of sulopenem in combination with cefuroxime or durlobactam against Mycobacterium abscessus
Dousa K, Shin E, Kurz S, Plummer M, Nantongo M, Bethel C, Taracila M, Nguyen D, Kreiswith B, Daley C, Remy K, Holland S, Bonomo R. Synergistic effects of sulopenem in combination with cefuroxime or durlobactam against Mycobacterium abscessus. MBio 2024, 15: e00609-24. PMID: 38742824, PMCID: PMC11237399, DOI: 10.1128/mbio.00609-24.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial Agentsbeta-Lactamase InhibitorsCefuroximeDrug SynergismHumansMicrobial Sensitivity TestsMolecular Docking SimulationMycobacterium abscessusMycobacterium Infections, NontuberculousProhibitinsConceptsD,D-carboxypeptidaseMinimum inhibitory concentrationB-lactamPenicillin-binding-proteinCell wall synthesisL,D-transpeptidasesResistance to common antibioticsLowest minimum inhibitory concentrationWall synthesisCystic fibrosisD-carboxypeptidaseMass spectrometry analysisB-lactamaseThioester bondRate of treatment failureCell-based assaysMultiple antibioticsB-lactam ringsCommon antibioticsD-transpeptidasesB-lactamase inhibitorsCysteine residuesTime-kill studiesStructural lung diseaseMultidrug-resistant tuberculosisHistologic Features of Mycobacterial Spindle Cell Pseudotumors
Szczepanski J, Lieberman J, Lamps L, Gonzalez R, Xue Y, Zhang X, Yilmaz O, Hart J, Krausz T, Mantilla J, McHugh J, Westerhoff M. Histologic Features of Mycobacterial Spindle Cell Pseudotumors. The American Journal Of Surgical Pathology 2024, 48: 890-900. PMID: 38726848, DOI: 10.1097/pas.0000000000002234.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsyDiagnosis, DifferentialFemaleHumansImmunocompromised HostMaleMiddle AgedMycobacterium Infections, NontuberculousPredictive Value of TestsYoung AdultConceptsMycobacterial spindle cell pseudotumorSpindle cell pseudotumorImmunocompromised patientsFoamy histiocytesLymph nodesNeutrophilic inflammationNeutrophilic microabscessesEvaluated lymph nodesComposition of inflammatory infiltratesSpindle cell neoplasmSecondary to infectionNon-tuberculous mycobacteriaArchitectural growth patternAcid-fast stainingMultinucleated giant cellsPeripheral granulomaSurgical therapyCell neoplasmsStromal changesHistological factorsSpindle cellsLymphocytic inflammationMicrobiological findingsClinical historyInflammatory infiltrate
2023
Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease
Siegel S, Griffith D, Philley J, Brown-Elliott B, Brunton A, Sullivan P, Fuss C, Strnad L, Wallace R, Winthrop K. Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease. CHEST Journal 2023, 164: 846-859. PMID: 37419144, PMCID: PMC10645596, DOI: 10.1016/j.chest.2023.05.036.Peer-Reviewed Original ResearchMeSH KeywordsAmikacinAnti-Bacterial AgentsAzithromycinClofazimineCystic FibrosisDrug Resistance, BacterialFemaleHumansLeprostatic AgentsLiposomesMacrolidesMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium abscessusMycobacterium Infections, NontuberculousConceptsAmikacin liposome inhalation suspensionAmikacin resistanceCulture conversionInhalation suspensionMycobacterium abscessus lung diseasePresence of macrolide resistanceEnd pointsMicrobiological end pointsMonthly sputum culturesSputum culture conversionTreatment-refractory diseaseOpen-label protocolSecondary end pointsOpen-label trialCohort of patientsCavitary diseaseSputum culturePretreatment isolatesM abscessusOpen-labelOral antimicrobialsParenteral antibioticsCompanion therapyMacrolide resistanceMultidrug therapy
2022
Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease
Blanc PD, Balmes JR, Redlich C. Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease. CHEST Journal 2022, 162: e106-e107. PMID: 35940661, DOI: 10.1016/j.chest.2022.03.049.Commentaries, Editorials and LettersHumansLungLung DiseasesMycobacterium Infections, NontuberculousNontuberculous MycobacteriaOccupational Exposure
2021
Outcomes of Resectional Thoracic Surgery for the Treatment of Pulmonary Nontuberculous Mycobacterial Disease in 105 Patients in the United States
Ku J, Siegel S, Philley J, Schipper P, Thanawala R, Hendrick M, Sigler C, Strnad L, McShane P, Griffith D, Tieu B, Caccitolo J, Fuss C, Le A, Winthrop K. Outcomes of Resectional Thoracic Surgery for the Treatment of Pulmonary Nontuberculous Mycobacterial Disease in 105 Patients in the United States. CHEST Journal 2021, 161: 365-369. PMID: 34390707, DOI: 10.1016/j.chest.2021.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overFemaleHumansLung DiseasesMaleMiddle AgedMycobacterium Infections, NontuberculousThoracic Surgical ProceduresUnited States“One-Two Punch”: Synergistic ß-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes
Nguyen D, Dousa K, Kurz S, Brown S, Drusano G, Holland S, Kreiswirth B, Boom W, Daley C, Bonomo R. “One-Two Punch”: Synergistic ß-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes. Clinical Infectious Diseases 2021, 73: 1532-1536. PMID: 34113990, PMCID: PMC8677594, DOI: 10.1093/cid/ciab535.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsDrug SynergismHumansLactamsMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium Infections, NontuberculousPeptidoglycanConceptsPeptidoglycan synthesis enzymesMinimum inhibitory concentration of clinical isolatesB-lactamCombination of imipenemSynthesis enzymesSynergistic in vitroClinical isolatesMinimum inhibitory concentrationMycobacterium abscessusClinical trialsMycobacterial infectionAbscessusEnzymeCeftarolineImipenem
2020
Mycobacterium marinum: nodular hand lesions after a fishing expedition
Tuan J, Spichler-Moffarah A, Ogbuagu O. Mycobacterium marinum: nodular hand lesions after a fishing expedition. BMJ Case Reports 2020, 13: e238835. PMID: 33318281, PMCID: PMC7737068, DOI: 10.1136/bcr-2020-238835.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAnti-Bacterial AgentsFinger InjuriesHumansLeisure ActivitiesMaleMiddle AgedMycobacterium Infections, NontuberculousMycobacterium marinumRadiographySkin Diseases, BacterialSoft Tissue InfectionsTreatment OutcomeConceptsSoft tissue infectionsDeep space infectionsTissue infectionsSpace infectionAcid-fast bacilliTreatment of skinNon-tuberculous mycobacteriaTerms of treatmentDisseminated diseaseOptimal regimenHand lesionsMedical managementExtremity lesionsCombination therapyInfectionLesionsAddition of rifampicinFurther dataSkinTreatmentMycobacteriaOsteomyelitisRegimenPatientsSurgerySummary for Clinicians: 2020 Clinical Practice Guideline Summary for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease.
Kurz S, Zha B, Herman D, Holt M, Daley C, Ruminjo J, Thomson C. Summary for Clinicians: 2020 Clinical Practice Guideline Summary for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease. Annals Of The American Thoracic Society 2020, 17: 1033-1039. PMID: 32870060, DOI: 10.1513/annalsats.202003-222cme.Peer-Reviewed Original ResearchMeSH KeywordsHumansLung DiseasesMycobacterium Infections, NontuberculousSocieties, MedicalUnited StatesNontuberculous mycobacterial infections in left ventricular assist device patients
Radcliffe C, Doilicho N, Grant M. Nontuberculous mycobacterial infections in left ventricular assist device patients. Journal Of Cardiac Surgery 2020, 35: 1138-1141. PMID: 32253770, DOI: 10.1111/jocs.14530.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAgedAnti-Bacterial AgentsAzithromycinCiprofloxacinDevice RemovalFatal OutcomeHeart FailureHeart-Assist DevicesHumansMaleMeropenemMycobacterium fortuitumMycobacterium Infections, NontuberculousProsthesis-Related InfectionsConceptsNontuberculous mycobacterial infectionNTM infectionMycobacterial infectionLeft ventricular assist device patientsVentricular assist device patientsRefractory heart failureContinuous-flow LVADVentricular assist deviceLVAD infectionGram-negative enteric bacteriaLVAD patientsDevice patientsHeart failureDriveline infectionDevice exchangeMost infectionsClinical challengeNegative culturesAssist deviceSystematic reviewInfectionDevice placementMycobacterium fortuitumStaphylococcal sppPatientsTime to Expand the Picture of Mycobacterial Lipids: Spotlight on Nontuberculous Mycobacteria
Kurz S, Rivas-Santiago B. Time to Expand the Picture of Mycobacterial Lipids: Spotlight on Nontuberculous Mycobacteria. American Journal Of Respiratory Cell And Molecular Biology 2020, 62: 275-276. PMID: 31580721, PMCID: PMC7055696, DOI: 10.1165/rcmb.2019-0324ed.Peer-Reviewed Original Research
2019
Evaluating differences in tuberculosis and nontuberculous mycobacterial lung disease in Florida
Klann E, Beal S, Tremblay E. Evaluating differences in tuberculosis and nontuberculous mycobacterial lung disease in Florida. American Journal Of Infection Control 2019, 47: 1324-1328. PMID: 31204093, DOI: 10.1016/j.ajic.2019.04.171.Peer-Reviewed Original ResearchConceptsNontuberculous mycobacteriaIsolation precautionsLung diseasePositive acid-fast bacilli stainsNontuberculous mycobacterial lung diseasePre-existing lung diseaseLogistic regressionAirborne isolation precautionsMycobacterial lung diseasePulmonary nontuberculous mycobacteriaAcid-fast bacilli stainPositive respiratory culturesTobacco smoke exposureIncidence of HIVUnpaired Student's t-testHistory of incarcerationPreliminary positive resultsElectronic medical record systemStudent's t-testMedical record systemClinical presentationSmoke exposureRadiographic findingsRespiratory culturesMedical history
2018
Financial Implications of Atypical Mycobacterial Infections After Cosmetic Tourism
Lee J, Morrison K, Maeng M, Ascherman J, Rohde C. Financial Implications of Atypical Mycobacterial Infections After Cosmetic Tourism. Annals Of Plastic Surgery 2018, 81: 269-273. PMID: 30028752, DOI: 10.1097/sap.0000000000001563.Peer-Reviewed Original ResearchMeSH KeywordsAdultColombiaCosmetic TechniquesCost SavingsCost-Benefit AnalysisDominican RepublicFemaleHealth Care CostsHumansMedical TourismMiddle AgedMycobacterium Infections, NontuberculousNew York CityRetrospective StudiesRiskSurgical Wound InfectionConceptsCosmetic tourismAtypical mycobacterial infectionMycobacterial infectionFinancial riskTourismHospital billing informationClinical courseManagement of mycobacterial infectionsFinancial benefitsClinical course of patientsReturn to work timeIncidence of mycobacterial infectionsCourse of patientsFinancial implicationsSurgical site infectionColumbia University Medical CenterCosts associated with complicationsPlastic Surgery DivisionUniversity Medical CenterPotential costsEconomic impactRetrospective reviewClinical chartsSite infectionPatient demographics
2017
Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria
Matsuyama M, Martins A, Shallom S, Kamenyeva O, Kashyap A, Sampaio E, Kabat J, Olivier K, Zelazny A, Tsang J, Holland S. Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria. American Journal Of Respiratory Cell And Molecular Biology 2017, 58: 241-252. PMID: 28915071, PMCID: PMC5806000, DOI: 10.1165/rcmb.2017-0218oc.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBacterial AdhesionCell MovementCells, CulturedCholesterolEpithelial CellsFemaleGene Expression ProfilingHumansInterleukin-17InterleukinsLungMaleMiddle AgedMycobacterium Infections, NontuberculousNontuberculous MycobacteriaRespiratory MucosaConceptsCholesterol biosynthesisUpregulation of genesRespiratory epitheliumGene expression signaturesCiliary genesTranscriptional responseRNA sequencingEpithelial cell infectionResponse genesInflammatory response genesHost responseCytokine/chemokine productionRespiratory epithelial cell culturesEpithelial cell culturesPulmonary nontuberculous mycobacteria (NTM) diseaseExpression signaturesMajor host responsesCytokines/chemokinesGenesRespiratory epithelial cellsCiliary functionNontuberculous mycobacteria diseaseCell infectionMultiplicity of infectionBiosynthesisMisidentification of Mycobacterium paraense as Mycobacterium avium Complex by Accuprobe
Poonawala H, Piscitelli VE, Ladutko L, Campbell S. Misidentification of Mycobacterium paraense as Mycobacterium avium Complex by Accuprobe. Journal Of Clinical Microbiology 2017, 55: 2283-2284. PMID: 28468858, PMCID: PMC5483933, DOI: 10.1128/jcm.00663-17.Peer-Reviewed Original ResearchDNA ProbesFalse Positive ReactionsHigh-Throughput Nucleotide SequencingHumansMolecular Diagnostic TechniquesMycobacteriumMycobacterium aviumMycobacterium avium ComplexMycobacterium avium-intracellulare InfectionMycobacterium Infections, NontuberculousSensitivity and SpecificitySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationUnited StatesMycobacterium goodii endocarditis following mitral valve ring annuloplasty
Parikh RB, Grant M. Mycobacterium goodii endocarditis following mitral valve ring annuloplasty. Annals Of Clinical Microbiology And Antimicrobials 2017, 16: 14. PMID: 28327156, PMCID: PMC5361780, DOI: 10.1186/s12941-017-0190-4.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAgedAnti-Bacterial AgentsCluster AnalysisDNA, BacterialDNA, RibosomalEchocardiography, TransesophagealEndocarditis, BacterialHeartHumansMaleMitral Valve AnnuloplastyMycobacteriumMycobacterium Infections, NontuberculousPhylogenyRadiography, ThoracicReplantationRNA, Ribosomal, 16SSequence Analysis, DNATomography, X-Ray ComputedTreatment OutcomeConceptsMitral valve ring annuloplastyInfrequent human pathogenMitral valve replacementCombination of ciprofloxacinTrimethoprim/sulfamethoxazoleDrug susceptibility testingValve replacementCase presentationWeProsthetic infectionSuccessful treatmentDifferential diagnosisRing annuloplastyMicrobiologic laboratorySusceptibility testingEndocarditisPositive rodsInfectionDiagnosisHuman pathogensGene sequencingRDNA gene sequencingAnnuloplastyPatientsMolecular techniquesInjuryMycobacterium genavense‐induced spindle cell pseudotumor in a pediatric hematopoietic stem cell transplant recipient: Case report and review of the literature
Coelho R, Hanna R, Flagg A, Stempak LM, Ondrejka S, Procop GW, Harrington S, Zembillas A, Kusick K, Gonzalez BE. Mycobacterium genavense‐induced spindle cell pseudotumor in a pediatric hematopoietic stem cell transplant recipient: Case report and review of the literature. Transplant Infectious Disease 2017, 19 PMID: 28039955, DOI: 10.1111/tid.12656.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAbdomenAdolescentAlemtuzumabAntibiotic ProphylaxisAntibiotics, AntitubercularAntibodies, Monoclonal, HumanizedBone Marrow TransplantationBronchoalveolar Lavage FluidCyclosporineDiabetes Mellitus, Type 1DiarrheaGenetic Diseases, X-LinkedGraft RejectionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistiocytesHumansImmune System DiseasesImmunosuppressive AgentsLymph NodesMaleMelphalanMycobacterium Infections, NontuberculousMycophenolic AcidNontuberculous MycobacteriaPhotopheresisPolymerase Chain ReactionTransplantation ConditioningVidarabine
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