2025
Screening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer
Huang S, Westvold S, Soulos P, Fan J, Winer E, Zhan H, Lustberg M, Lewin J, Robinson T, Dinan M. Screening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer. JAMA Network Open 2025, 8: e255322. PMID: 40232715, DOI: 10.1001/jamanetworkopen.2025.5322.Peer-Reviewed Original ResearchConceptsBreast cancer-specific mortalityBreast cancer mortalityBreast cancer diagnosisCancer-specific mortalityCancer mortalityCancer diagnosisScreening mammographyHazard of breast cancer-specific deathFee-for-service Medicare Parts AAssociated with reduced breast cancer mortalityLower breast cancer mortalityHazard of breast cancer-specific mortalityBreast cancerImprove breast cancer outcomesScreen-detected breast cancerCohort studyBreast cancer-specific deathStudy of older womenBreast cancer outcomesFee-for-serviceDetection of breast cancerMedicare Part ALater-stage diseaseCox proportional hazards modelsAssociated with early stagesEnsemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images PRESENT SHD
Dhingra L, Aminorroaya A, Sangha V, Pedroso A, Shankar S, Coppi A, Foppa M, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images PRESENT SHD. Journal Of The American College Of Cardiology 2025, 85: 1302-1313. PMID: 40139886, DOI: 10.1016/j.jacc.2025.01.030.Peer-Reviewed Original ResearchConceptsStructural heart diseaseYale-New Haven HospitalTransthoracic echocardiogramRisk stratificationHeart failureLeft-sided valvular diseaseSevere left ventricular hypertrophyLeft ventricular ejection fractionReceiver-operating characteristic curveVentricular ejection fractionLeft ventricular hypertrophyHeart disease screeningELSA-BrasilEnsemble deep learning algorithmRisk of deathConvolutional neural network modelEjection fractionEnsemble deep learning approachVentricular hypertrophyDeep learning algorithmsNew Haven HospitalDeep learning approachValvular diseaseNeural network modelClinical cohortUsing Radiology as a Screening Tool to Identify Intimate Partner Violence
Lenehan P, Tang A, Watane G, Gujrathi R, Park H, Gosangi B, Thomas R, Franco F, Patel K, Warsofsky I, Rosner B, Khurana B. Using Radiology as a Screening Tool to Identify Intimate Partner Violence. Journal Of The American College Of Radiology 2025, 22: 395-404. PMID: 40044319, PMCID: PMC11887577, DOI: 10.1016/j.jacr.2025.01.003.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratiosEmergency departmentRetrospective case-control studyImaging utilization patternsEvident injuriesCox proportional hazards regressionRace-matched controlsCase-control studyTime-to-event analysisProportional hazards regressionImaging utilizationIncidence rate ratiosCumulative incidenceAnatomical sitesScreening mammogramsHazards regressionOdds ratioImaging studiesIntimate partner violencePatientsInjury patternsLogistic regressionInjuryOrgan systemsPoisson regressionLung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement.
Henderson L, Kim R, Tanner N, Tsai E, Begnaud A, Dako F, Gieske M, Kallianos K, Richman I, Sakoda L, Schwartz R, Yeboah J, Fong K, Lam S, Lee P, Pasquinelli M, Smith R, Triplette M, Tanoue L, Rivera M. Lung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 436-451. PMID: 39928329, PMCID: PMC11936151, DOI: 10.1164/rccm.202501-0011st.Peer-Reviewed Original ResearchConceptsLow-dose computed tomographyManagement of incidental findingsLung cancer screeningCancer screeningThree-round modified Delphi processReporting of incidental findingsClinically significant IFsPrioritized questionsDelphi processIncidental findingClinicians' effortsMultidisciplinary panelPatient anxietyResearch questionsPotential harmLDCT examinationsCoronary artery calcificationIncreased awarenessSignificant IFsExcess costsHarmPotential benefitsArtery calcificationKnowledge gapsComputed tomographyEvaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems
Aminorroaya A, Dhingra L, Oikonomou E, Khera R. Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems. Circulation Genomic And Precision Medicine 2025, 18: e004632. PMID: 39846171, PMCID: PMC11835527, DOI: 10.1161/circgen.124.004632.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemHealth systemVanderbilt University Medical CenterHealth system electronic health recordUniversity Medical CenterCoronary Artery Risk DevelopmentMulti-Ethnic Study of AtherosclerosisElectronic health recordsMedical CenterUS health systemHealth system patientsAssociated with significantly higher oddsMulti-Ethnic StudyUS-based cohortStudy of AtherosclerosisSignificantly higher oddsHealth recordsUK BiobankAtherosclerosis RiskRisk DevelopmentHigher oddsElevated Lp(aUniversal screeningSystem patientsStudy cohort
2024
Generalizing from qualitative data: a case example using critical realist thematic analysis and mechanism mapping to evaluate a community health worker-led screening program in India
Broderick K, Vaidyanathan A, Ponticiello M, Hooda M, Kulkarni V, Chalem A, Chebrolu P, Onawale A, Baumann A, Mathad J, Sundararajan R. Generalizing from qualitative data: a case example using critical realist thematic analysis and mechanism mapping to evaluate a community health worker-led screening program in India. Implementation Science 2024, 19: 81. PMID: 39719615, PMCID: PMC11667965, DOI: 10.1186/s13012-024-01407-2.Peer-Reviewed Original ResearchConceptsThematic analysisQualitative dataGoal of implementation scienceHealth system interventionsPurposively sampled participantsThematic analysis approachEvidence-based practiceThematic analysis methodPopulation of womenScreening uptakeScreening interventionsMethodsQualitative interviewsManagement of GDMIntervention developmentImplementation scienceHealth programsOral glucose tolerance testTraditional risk factorsEvidence-based managementImprove uptakeInterview transcriptsScreening programIntervention successSystem interventionsTreatment of GDMImpact of active case finding for tuberculosis with mass chest X-ray screening in Glasgow, Scotland, 1950–1963: An epidemiological analysis of historical data
MacPherson P, Stagg H, Schwalb A, Henderson H, Taylor A, Burke R, Rickman H, Miller C, Houben R, Dodd P, Corbett E. Impact of active case finding for tuberculosis with mass chest X-ray screening in Glasgow, Scotland, 1950–1963: An epidemiological analysis of historical data. PLOS Medicine 2024, 21: e1004448. PMID: 39499677, PMCID: PMC11537369, DOI: 10.1371/journal.pmed.1004448.Peer-Reviewed Original ResearchConceptsCase notification rateActive case findingCase notificationChest X-ray screeningHighest tuberculosis burden countriesInterrupted time series analysisSynthesis of evidenceMultilevel regression modelsPublic health recordsScreening interventionsTuberculosis burden countriesX-ray screeningPost-interventionHealth recordsHigh-burden countriesPre-interventionScreening programmeAnnual rate of declineCase findingContemporaneous interventionsNotification ratesScreening toolBurden countriesBCG vaccination programmeCity wardsScreening, brief intervention, and referral to treatment for pain management for veterans separating from military service: study protocol of a hybrid type 2 study testing implementation facilitation versus training-as-usual
Sellinger J, Rosen M, Lazar C, Gilstad-Hayden K, Dziura J, Li F, Mattocks K, Weede A, Sullivan-Tibbs M, Rose L, Vassallo G, Manhapra A, Turner A, Vogt D, Woodward E, Hartmann C, Haskell S, Mohammad A, Martino S. Screening, brief intervention, and referral to treatment for pain management for veterans separating from military service: study protocol of a hybrid type 2 study testing implementation facilitation versus training-as-usual. Pain Medicine 2024, 25: s99-s106. PMID: 39514877, DOI: 10.1093/pm/pnae062.Peer-Reviewed Original ResearchConceptsTraining-as-usualImplementation facilitatorsReferral to treatmentCase managementBrief interventionHybrid type 2 effectiveness-implementation trialPain managementImplementation strategiesPrimary implementation outcomeSubstance misuseProportion of participantsPain careUsefulness of screeningVeteran engagementVA sitesImplementation outcomesPragmatic trialPain serviceVeteran participantsCase management systemPain intensityDischarged veteransStudy enrollmentVeteransChronic painCost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study
Su J, Yeo Y, Jeetoo M, Morojele N, Francis J, Shenoi S, Braithwaite R. Cost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study. BMC Medicine 2024, 22: 481. PMID: 39428460, PMCID: PMC11492560, DOI: 10.1186/s12916-024-03674-8.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyBackgroundAlcohol use disorderTreating alcohol useCompared to baselineLong-acting PrEPDepressive disorderTreat AUDUse disorderMDDMDD screeningAlcohol usePHQ-9Quality-adjusted life yearsAUDCost-effectiveness of screeningSub-Saharan African settingDisordersImpact of screeningIntervention costsHIV infectionHIV transmissionHIV reductionInterventionHIV outcomesHIV epidemicUSPSTF Colorectal Cancer Screening Recommendation and Uptake for Individuals Aged 45 to 49 Years
Siddique S, Wang R, Yasin F, Gaddy J, Zhang L, Gross C, Ma X. USPSTF Colorectal Cancer Screening Recommendation and Uptake for Individuals Aged 45 to 49 Years. JAMA Network Open 2024, 7: e2436358. PMID: 39361285, PMCID: PMC11450516, DOI: 10.1001/jamanetworkopen.2024.36358.Peer-Reviewed Original ResearchConceptsUS Preventive Services Task ForceUS Preventive Services Task Force recommendationsColorectal cancer screening uptakeAverage-risk individualsScreening uptakeHigher socioeconomic statusSocioeconomic statusScreening recommendationsColorectal cancerColorectal cancer screening recommendationsPreventive Services Task ForceCohort studyCancer screening recommendationsScreening uptake ratesInterrupted time series analysisLow socioeconomic statusPrivate insurance beneficiariesScreening ratesSocioeconomic disparitiesRetrospective cohort studyMain OutcomesPotential disparitiesEvaluate changesClaims dataAbsolute changePositive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic
Firestein M, Manessis A, Warmingham J, Xu R, Hu Y, Finkel M, Kyle M, Hussain M, Ahmed I, Lavallée A, Solis A, Chaves V, Rodriguez C, Goldman S, Muhle R, Lee S, Austin J, Silver W, O’Reilly K, Bain J, Penn A, Veenstra-VanderWeele J, Stockwell M, Fifer W, Marsh R, Monk C, Shuffrey L, Dumitriu D. Positive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2435005. PMID: 39312236, PMCID: PMC11420691, DOI: 10.1001/jamanetworkopen.2024.35005.Peer-Reviewed Original ResearchConceptsElectronic health recordsCOVID-19 Mother Baby OutcomesM-CHAT-RScreening ratesPandemic exposureMaternal SARS-CoV-2 infectionCohort studyColumbia University Irving Medical CenterMaternal SARS-CoV-2 statusLogistic regression modelsPrenatal exposureSARS-CoV-2 infectionHealth recordsProspective longitudinal studyModified checklistMain OutcomesClinical careBaby outcomeSARS-CoV-2 statusNew York CityPrimary outcomeScreen-positiveMedical CenterPrimary analysisGroup of childrenCost-effectiveness and health impact of screening and treatment of Mycobacterium tuberculosis infection among formerly incarcerated individuals in Brazil: a Markov modelling study
van Lieshout Titan A, Klaassen F, Pelissari D, de Barros Silva J, Alves K, Alves L, Sanchez M, Bartholomay P, Johansen F, Croda J, Andrews J, Castro M, Cohen T, Vuik C, Menzies N. Cost-effectiveness and health impact of screening and treatment of Mycobacterium tuberculosis infection among formerly incarcerated individuals in Brazil: a Markov modelling study. The Lancet Global Health 2024, 12: e1446-e1455. PMID: 39151980, PMCID: PMC11339731, DOI: 10.1016/s2214-109x(24)00221-3.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsTuberculosis preventive treatmentTuberculosis deathsHealth impactsImpact of screeningIntervention cost-effectivenessInfection screeningCost-effectiveNational Institutes of HealthHealth outcomesHealth gainsInstitutes of HealthQuantify health effectsTuberculosis casesCost-effectiveness ratioTreatment of Mycobacterium tuberculosis infectionPotential health impactsLife yearsGreater health benefitsTuberculosis preventionTarget populationMonths of isoniazidMarkov modelling studiesHealth statesHealthImpact of COVID-19 on recorded blood pressure screening and hypertension management in England: an analysis of monthly changes in the quality and outcomes framework indicators in OpenSAFELY
Wiedemann M, Speed V, Cunningham C, Higgins R, Curtis H, Andrews C, Fisher L, Hopcroft L, Rentsch C, Mahalingasivam V, Tomlinson L, Morton C, Samuel M, Green A, Wood C, Brown A, Massey J, Walters C, Smith R, Inglesby P, Evans D, Maude S, Dillingham I, Walker A, Morley J, Mehrkar A, Bacon S, Bates C, Cockburn J, Parry J, Hester F, McManus R, Goldacre B, MacKenna B. Impact of COVID-19 on recorded blood pressure screening and hypertension management in England: an analysis of monthly changes in the quality and outcomes framework indicators in OpenSAFELY. Open Heart 2024, 11: e002732. PMID: 39214534, PMCID: PMC11664366, DOI: 10.1136/openhrt-2024-002732.Peer-Reviewed Original ResearchConceptsBlood pressure screeningPressure screeningPercentage of patientsHypertension prevalenceHypertension managementPopulation-based cohort studyRecord of hypertensionCardiovascular disease managementClinical subgroupsQOF indicatorsScreening ratesPrimary careGeneral practiceHome statusNHS patientsOlder peopleBlood pressure measurementsCare schemesCohort studyDisease managementImpact of COVID-19COVID-19Framework indicatorsNational qualityNHSImplementation and Impact of Intimate Partner Violence Screening Expansion in the Veterans Health Administration: Protocol for a Mixed Methods Evaluation
Portnoy G, Relyea M, Dichter M, Iverson K, Presseau C, Brandt C, Skanderson M, Bruce L, Martino S. Implementation and Impact of Intimate Partner Violence Screening Expansion in the Veterans Health Administration: Protocol for a Mixed Methods Evaluation. JMIR Research Protocols 2024, 13: e59918. PMID: 39194059, PMCID: PMC11391160, DOI: 10.2196/59918.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationImpact of screeningINTERNATIONAL REGISTERED REPORT IDENTIFIERHealth care systemIntimate partner violenceIPV screeningQualitative interviewsCare systemHealth AdministrationConsolidated Framework for Implementation ResearchVeterans Health Administration facilitiesElectronic health record dataIntimate partner violence screeningMixed methods evaluationHealth record dataNational health care systemLongitudinal observational designPotential implementation barriersSignificant public health problemMen's health careClinical practice implicationsPatient populationMethod evaluationRE-AIMPublic health problemCosts of HIV testing services in sub-Saharan Africa: a systematic literature review
Ahmed N, Ong J, McGee K, d’Elbée M, Johnson C, Cambiano V, Hatzold K, Corbett E, Terris-Prestholt F, Maheswaran H. Costs of HIV testing services in sub-Saharan Africa: a systematic literature review. BMC Infectious Diseases 2024, 22: 980. PMID: 39192180, PMCID: PMC11348535, DOI: 10.1186/s12879-024-09770-7.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaFemaleHealth Care CostsHIV InfectionsHIV TestingHumansMaleMass ScreeningSelf-TestingConceptsHIV testing servicesHome-basedSub-Saharan AfricaTesting servicesGeneral populationHIV testing modalitiesHIV self-testingSystematic literature reviewSub-SaharanHIV-positive personsResultsSixty-five studiesTesting modalitiesHIV testingHealth facilitiesSelf-testingElectronic databasesLiterature reviewIncremental cost estimatesMale partnersIncremental costPrimary testHIVCost estimatesCampaign-styleServicesEvolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop.
Greenbaum C, Nepom G, Wood-Heickman L, Wherrett D, DiMeglio L, Herold K, Krischer J. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop. Diabetes 2024, 73: 1780-1790. PMID: 39167668, PMCID: PMC11493760, DOI: 10.2337/dbi24-0020.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, Monoclonal, HumanizedDiabetes Mellitus, Type 1HumansMass ScreeningUnited StatesConceptsType 1 diabetesClinical trialsType 1 Diabetes TrialNetEtiology of type 1 diabetesImmune Tolerance NetworkFood and Drug AdministrationU.S. Food and Drug AdministrationNational Institute of DiabetesDigestive and Kidney DiseasesMultiple immune pathwaysDisease-modifying therapiesMechanism of actionTherapeutic responsePrognostic markerKidney diseaseDrug AdministrationTrialNetClinical diagnosisImmune pathwaysDiabetesTeplizumabRegulatory approvalClinical carePathophysiologyDiseaseNational rollout of a medication safety dashboard to improve testing for latent infections among biologic and targeted synthetic disease‐modifying agent users within the Veterans Health Administration
Schmajuk G, Ware A, Li J, Tarasovsky G, Shiboski S, Barton J, Miller K, Mitchell H, Dana J, Reiter K, Wahl E, Rozenberg‐Ben‐Dror K, Hauser R, Whooley M. National rollout of a medication safety dashboard to improve testing for latent infections among biologic and targeted synthetic disease‐modifying agent users within the Veterans Health Administration. Health Services Research 2024, 60: e14363. PMID: 39056425, PMCID: PMC11782092, DOI: 10.1111/1475-6773.14363.Peer-Reviewed Original ResearchConceptsVeterans Affairs Healthcare SystemVA facilitiesVeterans Health AdministrationAudit log dataInterrupted time seriesPost-deploymentFrequency of sessionsWeeks post-deploymentFacility levelNational rolloutEHR dataHealth AdministrationHealthcare personnelHealthcare systemUnited States Veterans Affairs healthcare systemPercentage of patientsScreening dataEHRDashboard deploymentFacility personnelStudy periodSessionsScreeningUnited StatesFacilitiesConnecticut Implements a Team-Based Approach to Cardiovascular Disease Prevention Using Community Health Workers and Mobile Medical Devices
Griffin A, Ogazi C, Vozzolo C, Davis K, Baker R. Connecticut Implements a Team-Based Approach to Cardiovascular Disease Prevention Using Community Health Workers and Mobile Medical Devices. Journal Of Public Health Management And Practice 2024, 30: s124-s126. PMID: 39041747, DOI: 10.1097/phh.0000000000001939.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesCommunity Health WorkersConnecticutFemaleHumansMass ScreeningMiddle AgedConceptsCommunity health workersRisk reduction counselingHealth workersReduction counselingCervical cancer screening servicesSocial determinants of healthCancer screening servicesDeterminants of healthCardiovascular disease risk assessmentService access barriersHealth Action PlanTeam-based approachDeliver breastHealth coachingScreening servicesHealthcare accessCommunity settingsDisease risk assessmentOutreach sessionsAccess barriersClinical servicesPrevention programsConduct outreachTeam-basedScreening assessmentIs yearly interferon gamma release assay latent tuberculosis infection screening warranted among patients with rheumatological diseases on disease-modifying drugs in non-endemic settings?
Palacios C, Chowdhary V, Hao R, Danve A, Malinis M. Is yearly interferon gamma release assay latent tuberculosis infection screening warranted among patients with rheumatological diseases on disease-modifying drugs in non-endemic settings? PLOS ONE 2024, 19: e0306337. PMID: 38959249, PMCID: PMC11221665, DOI: 10.1371/journal.pone.0306337.Peer-Reviewed Original ResearchConceptsInterferon-gamma release assayDisease-modifying antirheumatic drugsInterferon-gamma release assay testLatent tuberculosis infectionNon-endemic settingsRheumatologic diseasesRisk factorsPositive interferon-gamma release assayLatent tuberculosis infection screeningLatent tuberculosis infection diagnosisPositive IGRA testMonths of rifampinLow-risk patientsRetrospective chart reviewTNF-alpha inhibitorsTB risk factorsTargeted LTBI screeningOutpatient rheumatology clinicDisease-modifying drugsIGRA testPatient demographicsAdult patientsChart reviewAntirheumatic drugsNon-endemic areasScreening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure
Mezzacappa C, Kim N, Vutien P, Kaplan D, Ioannou G, Taddei T. Screening for Hepatocellular Carcinoma and Survival in Patients With Cirrhosis After Hepatitis C Virus Cure. JAMA Network Open 2024, 7: e2420963. PMID: 38985470, PMCID: PMC11238019, DOI: 10.1001/jamanetworkopen.2024.20963.Peer-Reviewed Original ResearchConceptsHepatitis C virus cureHepatitis C virusAssociated with improved overall survivalHepatocellular carcinoma diagnosisEarly-stage hepatocellular carcinomaImproved overall survivalOverall survivalHepatocellular carcinomaFollow-upHCC screeningCurative treatmentCumulative incidence of hepatocellular carcinomaDirect-acting antiviral (DAA) therapyCohort studyVeterans Affairs health care systemIncidence of hepatocellular carcinomaRisk of hepatocellular carcinomaCohort study of personsHepatitis C virus cirrhosisDiagnosis of hepatocellular carcinomaLikelihood of curative treatmentYears of follow-upHealth care systemHepatocellular carcinoma screeningHCV-related cirrhosis
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