2025
Relating Solute–Membrane Electrostatic Interactions to Solute Permeability in Reverse Osmosis Membranes
Cao T, Wang L, Pataroque K, Wang R, Elimelech M. Relating Solute–Membrane Electrostatic Interactions to Solute Permeability in Reverse Osmosis Membranes. Environmental Science And Technology 2025, 59: 5819-5828. PMID: 40070342, DOI: 10.1021/acs.est.4c13212.Peer-Reviewed Original ResearchMeSH KeywordsCelluloseHydrogen-Ion ConcentrationMembranes, ArtificialNylonsOsmosisPermeabilityStatic ElectricityWater PurificationConceptsRO membranesCellulose triacetateSalt rejectionPA membraneReverse osmosisElectrostatic interactionsSolution pHReverse osmosis membranesDonnan potentialSolute transportSolute permeabilityNeutral moleculesOsmosis membranesCellulose triacetate membraneHigher solution pHSalt permeabilityMembrane-solution interfaceWater desalinationCo ionsSolute-membrane interactionsMembrane charge densityAcidic conditionsCharge densityNeutral solute transportDonnan effectReduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchSorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Khan M, Walsh J, Kurdi S, Mishra S, Mihailović J, Coman D, Hyder F. Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study. NMR In Biomedicine 2025, 38: e5319. PMID: 39764672, DOI: 10.1002/nbm.5319.Peer-Reviewed Original ResearchConceptsU87 tumorsSorafenib-treated tumorsUpregulated aerobic glycolysisSodium-potassium pumpInterstitial spaceTumor microenvironmentIntracellular NaTumor growthSpectroscopic imaging studiesTumor invasionGlioblastoma modelSodium levelsTumorGlioblastoma therapyImaging studiesPlaceboSorafenibMetabolic changesImmune functionCancer hallmarksAerobic glycolysisProliferative stateMeasure treatment effectsIonic changesProliferation rate
2024
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation
Chen Y, Shi R, Xiang Y, Fan L, Tang H, He G, Zhou M, Feng X, Tan J, Huang P, Ye X, Zhao K, Fu W, Li L, Bian X, Chen H, Wang F, Wang T, Zhang C, Zhou B, Chen W, Liang T, Lv J, Kang X, Shi Y, Kim E, Qin Y, Hettinghouse A, Wang K, Zhao X, Yang M, Tang Y, Piao H, Guo L, Liu C, Miao H, Tang K. Malate initiates a proton-sensing pathway essential for pH regulation of inflammation. Signal Transduction And Targeted Therapy 2024, 9: 367. PMID: 39737965, PMCID: PMC11683149, DOI: 10.1038/s41392-024-02076-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansHydrogen-Ion ConcentrationInflammationMacrophagesMalatesMiceProtonsRAW 264.7 CellsReceptors, G-Protein-CoupledSignal TransductionConceptsL-malateInflammatory responseCytosolic pHBind BiPTCA intermediatesSensing pathwaysRegulation of inflammatory responsesBiological informationAnti-inflammatory metabolitesAnti-inflammatory proteinPro-inflammatory macrophagesRegulation of inflammationSignaling modalitiesPhysiological adaptationsAnti-inflammatory effectsIRF2BP2BiPPH regulationCarboxylate metaboliteChemical languageIn vivoIn vitroMacrophagesPathwayPH reductionTRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization
Gualdani R, Barbeau S, Yuan J, Jacobs D, Gailly P, Dib-Hajj S, Waxman S. TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406186121. PMID: 39226353, PMCID: PMC11406256, DOI: 10.1073/pnas.2406186121.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBradykininCapsaicinCorneaHEK293 CellsHumansHydrogen-Ion ConcentrationMutationNeuralgiaPhotorefractive KeratectomyRatsTRPV Cation ChannelsConceptsLaser-assisted in situ keratomileusisPhotorefractive keratectomyOcular Surface Disease Index scoreCapsaicin-induced desensitizationPhotorefractive keratectomy enhancementDisease Index scorePhysiological membrane potentialsCorneal neuralgiaTRPV1 variantsCorneal painRefractive surgeryRefractive errorCapsaicin desensitizationPersistent painBradykinin sensitivityNerve injuryM mutationPatch clampChannel activitySurgical techniqueLeftward shiftInflammatory mediatorsM-channelPainIndex scorePoint-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples
Schinkel E, Nelson E, Kim J, Perrin M, Dyer R, Elango R, Bode L, Dallas D, Lueangsakulthai J, Briere C, Taylor S. Point-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples. Journal Of Perinatology 2024, 44: 1575-1583. PMID: 38760580, PMCID: PMC11518986, DOI: 10.1038/s41372-024-01988-2.Peer-Reviewed Original ResearchMeSH KeywordsCell SurvivalFemaleHumansHydrogen-Ion ConcentrationInfant, NewbornInfant, PrematureMilk, HumanOsmolar ConcentrationOsmosisPoint-of-Care SystemsConceptsMilk concentrationsOsmotic concentrationHM samplesFresh HMHuman milk concentrationsMilk samplesHM componentsHuman milk samplesEnzyme activityHuman milkOptimal growthPassive osmosisFeeding parametersPost-concentrationCell viabilityTotal cell viabilityPHOsmolalityWater removalMilkConcentrationRemoval of waterMacronutrientsRemoval
2023
Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia
Nirmal G, Liao C, Lin Z, Alshetaili A, Hwang E, Yang S, Fang J. Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia. Drug Delivery 2023, 30: 2245169. PMID: 37585684, PMCID: PMC10416745, DOI: 10.1080/10717544.2023.2245169.Peer-Reviewed Original Research
2022
Tools for analyzing protonation states and for tracing proton transfer pathways with examples from the Rb. sphaeroides photosynthetic reaction centers
Wei R, Khaniya U, Mao J, Liu J, Batista V, Gunner M. Tools for analyzing protonation states and for tracing proton transfer pathways with examples from the Rb. sphaeroides photosynthetic reaction centers. Photosynthesis Research 2022, 156: 101-112. PMID: 36307598, DOI: 10.1007/s11120-022-00973-0.Peer-Reviewed Original ResearchMeSH KeywordsElectron TransportHydrogen-Ion ConcentrationPhotosynthesisPhotosynthetic Reaction Center Complex ProteinsProtonsRhodobacter sphaeroidesConceptsProtonation stateMolecular dynamicsProton affinityReaction centersSide chainsElectron transfer reactionsProton transfer pathwayHydroxy side chainsBacterial reaction centersProton-transfer networkPhotosynthetic reaction centersChains of waterGrotthuss mechanismTransfer reactionsActive siteTransfer pathwayQB siteProton bindingProtein conformationTransmembrane electrochemical gradientEvaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum
Rodriguez L, Morley‐Fletcher A, Winter H, Timothy B. Evaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 450-454. PMID: 35830732, DOI: 10.1097/mpg.0000000000003561.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderAutistic DisorderChildEsophageal pH MonitoringFemaleGastroesophageal RefluxHumansHydrogen-Ion ConcentrationMaleNitrilesRetrospective StudiesConceptsGastroesophageal reflux diseaseSymptom correlationBravo wirelessReflux diseaseEvaluation of GERDMedian reflux indexNon-ASD childrenSignificant side effectsASD childrenNormal esophageal mucosaAutism spectrum disorderSelf-injurious behaviorChest painReflux indexGER episodesGER symptomsMale predominanceAbnormal studiesPatient populationEsophageal mucosaSupine positionLarge cohortSide effectsBehavioral symptomsStudy durationPotassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation
Wang N, Zhou L, Shao C, Wang X, Zhang N, Ma J, Hu H, Wang Y, Qiu M, Shen Y. Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation. Glia 2022, 70: 2093-2107. PMID: 35775976, DOI: 10.1002/glia.24240.Peer-Reviewed Original ResearchMeSH KeywordsHumansHydrogen-Ion ConcentrationNeurogenesisOligodendrocyte Precursor CellsOligodendrogliaPotassiumPotassium Channels, Inwardly RectifyingConceptsOL precursor cellsIntracellular pHImpaired OL maturationProgressive neurological declineLoss-of-function mutationsIntracellular pH regulationSeSAME/EAST syndromeNeurological declineDemyelinating diseaseLineage cellsOPC developmentPrecursor cellsOL maturationOligodendrocyte differentiationOligodendrocytesOL developmentDown-regulationDifferentiationPH regulationCellsExpressionKCNJ10Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects
Laine L, Sharma P, Mulford DJ, Hunt B, Leifke E, Smith N, Howden CW. Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects. The American Journal Of Gastroenterology 2022, 117: 1158-1161. PMID: 35294415, DOI: 10.14309/ajg.0000000000001735.Peer-Reviewed Original ResearchMeSH KeywordsAdultHumansHydrogen-Ion ConcentrationLansoprazolePotassiumProton Pump InhibitorsPyrrolesSulfonamides
2021
High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents
Mihailovic JM, Huang Y, Walsh JJ, Khan MH, Mishra SK, Samuels S, Hyder F, Coman D. High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents. NMR In Biomedicine 2021, 35: e4658. PMID: 34837412, DOI: 10.1002/nbm.4658.Peer-Reviewed Original ResearchFunctional cell death, corneoptosis, requires temporally controlled intracellular acidification
Moore JL, Greco V. Functional cell death, corneoptosis, requires temporally controlled intracellular acidification. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2106633118. PMID: 33986147, PMCID: PMC8179175, DOI: 10.1073/pnas.2106633118.Peer-Reviewed Original ResearchCell DeathHydrogen-Ion ConcentrationPepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells
Doukas PG, Vageli DP, Sasaki CT, Judson BL. Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells. International Journal Of Molecular Sciences 2021, 22: 4275. PMID: 33924087, PMCID: PMC8074291, DOI: 10.3390/ijms22084275.Peer-Reviewed Original ResearchConceptsRelated-signaling pathwaysOncogenic pathwaysLaryngopharyngeal reflux diseaseEpidermal growth factor receptorSpecific oncogenic pathwaysDownstream oncogenic pathwaysGrowth factor receptorHypopharyngeal cellsReflux diseaseRisk factorsTherapeutic approachesIntermittent exposureTumorigenic effectsPronounced activationOncogenic factorSignificant upregulationFactor receptorSTAT3 activationAcidic pepsinEGFR activationCell viabilityPromotes ActivationActivationPrimary cellsCellsGlucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH
Wang M, An Y, Gao L, Dong S, Zhou X, Feng Y, Wang P, Dimopoulos G, Tang H, Wang J. Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH. Cell Reports 2021, 35: 108992. PMID: 33882310, PMCID: PMC8116483, DOI: 10.1016/j.celrep.2021.108992.Peer-Reviewed Original ResearchConceptsPlasmodium infectionGlucose metabolismMalaria parasitesCommensal bacteriumMosquito midgutPlasmodium berghei infectionGut commensal bacteriumBerghei infectionMosquito-microbiota interactionsDietary glucoseInfectionMetabolome changesVector competencePlasmodium gametogenesisVector competencyGlucoseImportant determinantPlasmodiumProliferationMetabolismMosquitoesParasitesAsaia bogorensisTargeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides
Dharmaratne NU, Kaplan AR, Glazer PM. Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides. Cells 2021, 10: 541. PMID: 33806273, PMCID: PMC8000199, DOI: 10.3390/cells10030541.Peer-Reviewed Original ResearchConceptsNucleic acid analoguesPH-sensitive peptideLow insertion peptideAcidic tumor microenvironmentPoor bioavailabilityInsertion peptideFluorescent dyeHigh toxicitySelective deliveryAcid analoguesSmall molecule inhibitorsNanoparticlesCancer therapeuticsMolecule inhibitorsDyePeptidesReview articleAcidityPHLIPPromising toolBioavailabilityAnaloguesDeliveryHypoxic tumor microenvironmentNear-Infrared Ratiometric Two-Photon Probe for pH Measurement in Human Stomach Cancer Tissue
Juvekar V, Lim C, Lee D, Song D, Noh C, Kang H, Shin S, Kim H. Near-Infrared Ratiometric Two-Photon Probe for pH Measurement in Human Stomach Cancer Tissue. ACS Applied Bio Materials 2021, 4: 2135-2141. PMID: 35014342, DOI: 10.1021/acsabm.0c01546.Peer-Reviewed Original ResearchMeSH KeywordsBiocompatible MaterialsCell Line, TumorFluorescent DyesHumansHydrogen-Ion ConcentrationMaterials TestingMolecular StructureParticle SizePhotonsStomach Neoplasms
2020
A high‐throughput imaging platform to characterize extracellular pH in organotypic three‐dimensional in vitro models of liver cancer
Savic LJ, Schobert IT, Hamm CA, Adam LC, Hyder F, Coman D. A high‐throughput imaging platform to characterize extracellular pH in organotypic three‐dimensional in vitro models of liver cancer. NMR In Biomedicine 2020, 34: e4465. PMID: 33354836, DOI: 10.1002/nbm.4465.Peer-Reviewed Original ResearchConceptsLiver cancer modelLiver cancerHepatocellular carcinomaCancer modelNon-tumorous hepatocytesUnpaired t-testCell linesDose-dependent mannerHepatocyte cell lineTreatment responseTherapy resistanceMagnetic resonance spectroscopicT MR scannerPersonalized treatmentTumor metabolismCancerTumor pHMR resultsT-testCarcinomaViability assaysExtracellular pHMR scannerANOVA testTreatmentIdarubicin-Loaded ONCOZENE Drug-Eluting Bead Chemoembolization in a Rabbit Liver Tumor Model: Investigating Safety, Therapeutic Efficacy, and Effects on Tumor Microenvironment
Borde T, Gaupp F, Geschwind JF, Savic LJ, Miszczuk M, Rexha I, Adam L, Walsh JJ, Huber S, Duncan JS, Peters DC, Sinusas A, Schlachter T, Gebauer B, Hyder F, Coman D, van Breugel JMM, Chapiro J. Idarubicin-Loaded ONCOZENE Drug-Eluting Bead Chemoembolization in a Rabbit Liver Tumor Model: Investigating Safety, Therapeutic Efficacy, and Effects on Tumor Microenvironment. Journal Of Vascular And Interventional Radiology 2020, 31: 1706-1716.e1. PMID: 32684417, PMCID: PMC7541537, DOI: 10.1016/j.jvir.2020.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibiotics, AntineoplasticBiosensing TechniquesCell Line, TumorCell ProliferationChemoembolization, TherapeuticDiffusion Magnetic Resonance ImagingHydrogen-Ion ConcentrationIdarubicinLiver Neoplasms, ExperimentalMaleMicrospheresMultidetector Computed TomographyParticle SizeRabbitsTumor MicroenvironmentConceptsMultiparametric magnetic resonanceRabbit liver tumor modelDiffusion-weighted imagingLiver tumor modelDEE chemoembolizationDrug-eluting embolic transarterial chemoembolizationTumor microenvironmentTumor modelMale New Zealand white rabbitsTumor acidosisNew Zealand white rabbitsVX2 liver tumorsZealand white rabbitsLaboratory parametersTransarterial chemoembolizationBead chemoembolizationMultiparametric MRDCE MR imagingLiver enzymesPostprocedural increaseIntratumoral hypoxiaLiver tumorsEntire lesionTherapeutic mechanismChemoembolizationIdentification of a Na+‑Binding Site near the Oxygen-Evolving Complex of Spinach Photosystem II
Wang J, Perez-Cruet JM, Huang HL, Reiss K, Gisriel CJ, Banerjee G, Kaur D, Ghosh I, Dziarski A, Gunner MR, Batista VS, Brudvig GW. Identification of a Na+‑Binding Site near the Oxygen-Evolving Complex of Spinach Photosystem II. Biochemistry 2020, 59: 2823-2831. PMID: 32650633, DOI: 10.1021/acs.biochem.0c00303.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesDensity Functional TheoryHydrogen-Ion ConcentrationLigandsModels, MolecularOxygenPhotosystem II Protein ComplexSodiumSpinacia oleraceaStatic ElectricityConceptsOxygen-evolving complexSpinach photosystem IIRedox-active Mn ionPhotosystem IIOxygen evolution activityQuantum mechanical calculationsOxomanganese clusterHydroxide anionCommon counterionCryo-electron microscopy mapMechanical calculationsAmino acid residuesMn ionsIonsElectrostatic simulationsMicroscopy mapsAcid residuesComplexesDeprotonationAnionsCounterionsNaChlorideSitesCl
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