2025
Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis
Kyriakoulis I, Tzoumas A, Kyriakoulis K, Kardoutsos I, Ntoumaziou A, Nagraj S, Kokkinidis D, Palaiodimos L. Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis. Future Cardiology 2025, 21: 113-121. PMID: 39882735, PMCID: PMC11812418, DOI: 10.1080/14796678.2025.2457898.Peer-Reviewed Original ResearchConceptsSystemic embolic eventsInfective endocarditisEmbolic eventsHeart failureAssociated with increased risk of short-term mortalityRisk of short-term mortalityAssociated with increased riskLikelihood of poor prognosisRisk of complicationsOne-year mortalityStudy of patientsShort-term mortalityHeart valvesClinical suspicionSurgical managementPoor prognosisEndocarditisVirulent microorganismsPatientsInclusion criteriaIdentified studiesMortalityPrognosisSystematic searchHeart
2024
3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study
Zahr F, Ramlawi B, Reardon M, Deeb G, Yakubov S, Song H, Kleiman N, Chetcuti S, Gada H, Mumtaz M, Leung S, Merhi W, Rovin J, DeFrain M, Muppala M, Kauten J, Rajagopal V, Huang J, Ito S, Forrest J. 3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study. JACC Cardiovascular Interventions 2024, 17: 1667-1675. PMID: 39048253, DOI: 10.1016/j.jcin.2024.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseBioprosthesisFemaleHeart Valve DiseasesHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesProsthesis DesignRecovery of FunctionRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementRates of all-cause mortalityAll-cause mortalityAortic stenosisThoracic Surgeons Predicted Risk of Mortality scoreThoracic Surgeons Predicted RiskSevere paravalvular aortic regurgitationBicuspid aortic valve anatomyRisk of Mortality scoreEchocardiographic core laboratoryLow-surgical risk patientsAortic valve anatomyKaplan-Meier ratesLow surgical riskClinical events committeeAortic valve replacementSevere aortic stenosisParavalvular aortic regurgitationPermanent pacemaker implantationBicuspid aortic stenosisFavorable hemodynamic performanceEvaluated 3 yearsAttempted implantEchocardiographic outcomesAortic regurgitationMitral Annular Calcification and Valve Dysfunction: Insights and Future Directions
Dal-Bianco J, Levine R, Hung J. Mitral Annular Calcification and Valve Dysfunction: Insights and Future Directions. Journal Of The American Society Of Echocardiography 2024, 37: 756-758. PMID: 38871339, DOI: 10.1016/j.echo.2024.06.002.Peer-Reviewed Original ResearchChallenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community
Aikawa E, Blaser M, Singh S, Levine R, Yacoub M. Challenges and Opportunities in Valvular Heart Disease: From Molecular Mechanisms to the Community. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 763-767. PMID: 38536897, PMCID: PMC10977651, DOI: 10.1161/atvbaha.123.319563.Peer-Reviewed Original ResearchLymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Lupieri A, Passos L, Levine R, Nizet V, Aikawa E. Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 822-825. PMID: 38357818, PMCID: PMC10978236, DOI: 10.1161/atvbaha.124.320708.Peer-Reviewed Original ResearchAssessment of valve regurgitation severity via contrastive learning and multi-view video integration
Kim S, Ren H, Charton J, Hu J, Gonzalez C, Khambhati J, Cheng J, DeFrancesco J, Waheed A, Marciniak S, Moura F, Cardoso R, Lima B, McKinney S, Picard M, Li X, Li Q. Assessment of valve regurgitation severity via contrastive learning and multi-view video integration. Physics In Medicine And Biology 2024, 69: 045020. PMID: 38271727, DOI: 10.1088/1361-6560/ad22a4.Peer-Reviewed Original ResearchConceptsRepresentation learningContrastive learningMulti-view video processingState-of-the-art methodsContrastive learning frameworkState-of-the-artIn-house datasetVideo processingContrastive networkEmbedding spaceImage inputLearning frameworkVideo integrationIntricate taskLoss termMulti-modal clinical dataLearningRepresentationLabor-intensiveAccuracyEfficient methodVideo seriesEmbeddingDatasetNetworkGuidelines for the Evaluation of Prosthetic Valve Function With Cardiovascular Imaging: A Report From the American Society of Echocardiography Developed in Collaboration With the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography
Zoghbi W, Jone P, Chamsi-Pasha M, Chen T, Collins K, Desai M, Grayburn P, Groves D, Hahn R, Little S, Kruse E, Sanborn D, Shah S, Sugeng L, Swaminathan M, Thaden J, Thavendiranathan P, Tsang W, Weir-McCall J, Gill E. Guidelines for the Evaluation of Prosthetic Valve Function With Cardiovascular Imaging: A Report From the American Society of Echocardiography Developed in Collaboration With the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography. Journal Of The American Society Of Echocardiography 2024, 37: 2-63. PMID: 38182282, DOI: 10.1016/j.echo.2023.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultEchocardiographyHeartHeart Valve DiseasesHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyProstheses and ImplantsConceptsProsthetic valve functionEvaluation of prosthetic valve functionCardiac magnetic resonanceValve repairComputed tomographyValve functionTransesophageal echocardiographyValve replacementAmerican Society of Echocardiography guidelinesThree-dimensional transesophageal echocardiographyAmerican Society of EchocardiographySociety of Cardiovascular Computed TomographyCardiac computed tomographyPercutaneous valve repairCardiovascular magnetic resonanceCardiovascular computed tomographyValvular heart diseaseCardiac valvular diseaseFirst-line methodAmerican SocietyEchocardiography guidelinesTricuspid regurgitationTransthoracic approachEchocardiographic techniquesValvular disease
2023
Clinical Profile and Outcomes of Rheumatic Heart Disease Patients Undergoing Surgical Valve Procedures in Uganda
Rwebembera J, Chang A, Kitooleko S, Kaudha G, de Loizaga S, Nalule M, Ahabwe K, Zhang W, Okello E, Sinha P, Mwambu T, Sable C, Beaton A, Longenecker C. Clinical Profile and Outcomes of Rheumatic Heart Disease Patients Undergoing Surgical Valve Procedures in Uganda. Global Heart 2023, 18: 62. PMID: 38028964, PMCID: PMC10655755, DOI: 10.5334/gh.1260.Peer-Reviewed Original ResearchConceptsRheumatic heart diseaseAcute rheumatic feverComplication of acute rheumatic feverHeart diseaseValve surgery proceduresPost-operative survivalCohort of patientsProportion of patientsOutcome of operated patientsRetrospective cohort studyFifteen-year survivalValvular heart diseaseChronic valvular heart diseaseLong-term complicationsMortality of patientsValve surgeryValve repairValvular operationsValve proceduresPublic health problemRe-operationValve replacementSurgical managementUgandan patientsValvular interventionsQuantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients
Kwan J, Arbune A, Henry M, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader A, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre L. Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. PLOS ONE 2023, 18: e0286364. PMID: 37252927, PMCID: PMC10228774, DOI: 10.1371/journal.pone.0286364.Peer-Reviewed Original ResearchConceptsBreast cancer patientsSystolic heart failureCardiovascular outcomesCancer patientsHeart failureValvular diseaseStrain abnormalitiesLeft ventricular ejection fraction reductionCancer treatment-related cardiotoxicityCardiovascular magnetic resonance findingsVentricular ejection fraction reductionYale-New Haven HospitalEjection fraction reductionTreatment-related cardiotoxicityAdverse cardiovascular outcomesClinical risk factorsNormal LV functionGlobal longitudinal strainIschemic heart diseaseMagnetic resonance findingsRisk regression modelsNew Haven HospitalSubclinical cardiotoxicityDiastolic dysfunctionStatin useThe use of transesophageal echocardiography to predict surgical complexity scoring system for degenerative mitral valve repair
Bhatt H, Lisann‐Goldman L, Baron E, Salter B, Lin H, Itagaki S, Anyanwu A, Adams D, Fischer G, El‐Eshmawi A. The use of transesophageal echocardiography to predict surgical complexity scoring system for degenerative mitral valve repair. Echocardiography 2023, 40: 562-567. PMID: 37212377, DOI: 10.1111/echo.15597.Peer-Reviewed Original ResearchConceptsSurgical scoreMV repairMitral valveDegenerative mitral valve repairMcNemar testSurgical complexity scoreSurgical MV repairMitral valve repairHigh-volume centersSevere mitral valveExamination of patientsCommissural prolapseComplex scoring systemsValve repairTEE examinationTransesophageal echocardiographyPreoperative stratificationSurgical repairVolume centersCardiac anesthesiologistsProlapsePosteromedial commissureGold standardScoring systemImaging modalities
2022
Variability in surveillance practice for patients with diagnosis of bicuspid aortic valve syndrome
Kahler-Quesada A, Vallabhajosyula I, Yousef S, Mori M, Amabile A, Assi R, Geirsson A, Vallabhajosyula P. Variability in surveillance practice for patients with diagnosis of bicuspid aortic valve syndrome. Scientific Reports 2022, 12: 22009. PMID: 36539583, PMCID: PMC9768129, DOI: 10.1038/s41598-022-25571-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortaAortic ValveBicuspid Aortic Valve DiseaseEchocardiographyFemaleHeart Valve DiseasesHumansMaleMiddle AgedRetrospective StudiesSyndromeConceptsBicuspid aortic valveTertiary care centerAortic valveCare centerCardiovascular specialistsBicuspid aortic valve syndromeAortic pathologySurveillance imagingDisease progressionPatientsBivariate analysisEchocardiogramGuide interventionDiagnosisHigher proportionValveSurveillance practicesUrgent needGuidelinesValvulopathySpecialistsSurgeryValvularSyndromeFollowNatural history of bicuspid aortic valves and ascending aortic aneurysms: Aortic center experience
Bellaire CP, Tharakan SM, Roy J, Puskas JD, Di Luozzo G. Natural history of bicuspid aortic valves and ascending aortic aneurysms: Aortic center experience. Journal Of Cardiac Surgery 2022, 37: 2326-2335. PMID: 35535018, DOI: 10.1111/jocs.16597.Peer-Reviewed Original ResearchMeSH KeywordsAortaAortic AneurysmAortic ValveBicuspid Aortic Valve DiseaseHeart Valve DiseasesHumansConceptsBicuspid aortic valveAdverse event ratesTAV patientsEntire cohortAortic aneurysmAortic valveComputerized tomographyLow adverse event ratesOverall adverse event rateNatural historyEvent ratesTricuspid aortic valve patientsValve typeRoutine computerized tomographyMore CT scansAortic valve patientsCoronary artery diseaseMean aneurysm sizeAneurysm growth rateAortic valve typeSimilar natural historyAortic eventsConservative managementSmoking historyUnmatched cohortGlobal and regional burden and quality of care of non-rheumatic valvular heart diseases: a systematic analysis of Global Burden of Disease 1990–2017
Nejad M, Ahmadi N, Mohammadi E, Shabani M, Sherafati A, Aryannejad A, Rezaei N, Ghanbari A, Yoosefi M, Aminorroaya A, Shabani M, Rezaei N, Salavati T, Larijani B, Naderimagham S, Farzadfar F. Global and regional burden and quality of care of non-rheumatic valvular heart diseases: a systematic analysis of Global Burden of Disease 1990–2017. International Journal For Quality In Health Care 2022, 34: mzac026. PMID: 35434737, DOI: 10.1093/intqhc/mzac026.Peer-Reviewed Original ResearchConceptsQuality of care indexGlobal Burden of DiseaseNon-rheumatic valvular heart diseaseQuality of careSociodemographic indexBurden of diseaseQuality of care index scoreLow SDI quintileWHO world regionsSociodemographic index countriesHeart diseaseHealthcare qualityHealthcare accessCare indexEastern Mediterranean RegionHealthcare systemRegional burdenGlobal burdenWestern Pacific RegionValvular heart diseaseHealthcareAge groupsQuintilePrimary measureCare
2021
A change of heart: new roles for cilia in cardiac development and disease
Djenoune L, Berg K, Brueckner M, Yuan S. A change of heart: new roles for cilia in cardiac development and disease. Nature Reviews Cardiology 2021, 19: 211-227. PMID: 34862511, PMCID: PMC10161238, DOI: 10.1038/s41569-021-00635-z.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseHeart diseaseCardiac valve disordersAortic valve diseaseMitral valve prolapseCardiac developmentValve diseaseValve prolapseMyocardial fibrosisValve disordersCardiac abnormalitiesPresence of ciliaCardiac fibroblastsCilia functionContractile forceDiseaseFunction contributesLines of evidenceDefective primary ciliaPotential roleHeart regenerationBroader roleHeartDisordersLatest findingsCharacteristics, interventions and outcomes of patients with valvular heart disease hospitalised in China: a cross-sectional study
Huang X, Dhruva SS, Yuan X, Bai X, Lu Y, Yan X, Liu J, Li W, Hu D, Ji R, Gao M, Miao F, Li J, Ge J, Krumholz HM, Li J. Characteristics, interventions and outcomes of patients with valvular heart disease hospitalised in China: a cross-sectional study. BMJ Open 2021, 11: e052946. PMID: 34732492, PMCID: PMC8572400, DOI: 10.1136/bmjopen-2021-052946.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesEchocardiographyHeart Valve DiseasesHumansMaleMitral Valve InsufficiencyTricuspid Valve InsufficiencyConceptsSevere valvular heart diseaseValvular heart diseaseHigh operative riskRheumatic originValve interventionHospital outcomesOperative riskCommon etiologyPrimary diagnosisHeart diseaseSeverity of VHDTypes of VHDCommon valvular heart diseaseMultivariable logistic regression analysisDegenerative valvular heart diseaseOutcomes of patientsCross-sectional studyLogistic regression analysisTwo-stage random sampling designClinical characteristicsFrequent etiologyPredominant etiologyTricuspid regurgitationAdult patientsPatient characteristics2020 ACC/AHA guideline for the management of patients with valvular heart disease A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Members W, Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O'Gara PT, Rigolin VH, Sundt TM, Thompson A, Toly C, Members A, O'Gara PT, Beckman JA, Levine GN, Al-Khatib SM, Armbruster A, Birtcher KK, Ciggaroa J, Deswal A, Dixon DL, Fleisher LA, de las Fuentes L, Goldberger Z, Gorenek B, Haynes N, Hernandez A, Hlatky M, Joglar J, Jones W, Marine J, Mark D, Palaniappan L, Piano M, Spatz E, Tamis-Holland J, Wijeysundera D, Woo Y. 2020 ACC/AHA guideline for the management of patients with valvular heart disease A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal Of Thoracic And Cardiovascular Surgery 2021, 162: e183-e353. PMID: 33972115, DOI: 10.1016/j.jtcvs.2021.04.002.Peer-Reviewed Original ResearchCavitron ultrasonic surgical aspirator for mitral annular decalcification.
Weininger G, Green J, Mori M, Geirsson A. Cavitron ultrasonic surgical aspirator for mitral annular decalcification. Multimedia Manual Of Cardio-Thoracic Surgery 2021, 2021 PMID: 33691046, DOI: 10.1510/mmcts.2021.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedCalcinosisCardiac Surgical ProceduresFemaleHeart Valve DiseasesHumansMitral ValvePostoperative PeriodTreatment OutcomeUltrasonic Surgical ProceduresConceptsMitral annular calcificationCavitron Ultrasonic Surgical AspiratorUltrasonic surgical aspiratorAnnular calcificationSurgical aspiratorAnnular decalcificationMitral annulusSevere mitral annular calcificationMitral valve surgeryProper surgical techniqueProper techniqueValve surgerySurgical complicationsSevere calcificationHigh morbidityPostoperative imagingPatient presentationSurgical techniqueCalcificationPatientsAspiratorDecalcificationMorbidityComplicationsSurgeryA Case Report on Papillary Muscle Rupture Following Mitral Valve Replacement in the Setting of Previously Undiagnosed Amyloidosis.
Choudhury N, Munoz Acuna R, Chaudhary O, Chu L, VanderLaan P, Mahmood F, Sharkey A. A Case Report on Papillary Muscle Rupture Following Mitral Valve Replacement in the Setting of Previously Undiagnosed Amyloidosis. A&A Practice 2021, 15: e01415. PMID: 33684090, DOI: 10.1213/xaa.0000000000001415.Peer-Reviewed Original ResearchMeSH KeywordsAmyloidosisHeart Valve DiseasesHumansMitral ValveMitral Valve InsufficiencyPapillary MusclesConceptsCoronary artery diseaseAbsence of CADMitral valve replacement surgeryMitral valve replacementValve replacement surgeryLight chain subtypesCardiac involvementValve replacementArtery diseaseCardiopulmonary bypassAmyloid depositionCase reportReplacement surgeryCardiac amyloidosisSubvalvular apparatusPapillary musclesSubsequent pathologyAmyloidosisPatientsIschemiaSurgeryBypassTherapyMortalitySubtypes
2020
Essential information on surgical heart valve characteristics for optimal valve prosthesis selection: Expert consensus document from the European Association for Cardio-Thoracic Surgery (EACTS)–The Society of Thoracic Surgeons (STS)–American Association for Thoracic Surgery (AATS) Valve Labelling Task Force
Durko AP, Pibarot P, Atluri P, Bapat V, Cameron D, Casselman FPA, Chen EP, Dahle G, Elefteriades JA, Lancellotti P, Prager RL, Rosenhek R, Speir A, Stijnen M, Tasca G, Yoganathan A, Walther T, De Paulis R, Force E, De Paulis R, Atluri P, Bapat V, Cameron D, Casselman F, Chen E, Dahle G, Durko A, Elefteriades J, Prager R, Speir A, Tasca G, Lancellotti P, Pibarot P, Rosenhek R, de Hart J, Stijnen M, Yoganathan A, Ibrahim N, Laschinger J, Wu C, Di Rienzo G, McLaren A, Randall H, Becker L, Capps S, Duncan B, Green C, Hay J, Head S, Ieropoli O, Jacob A, Kappetein A, Manasse E, Marquez S, Northrup W, Ryan T, Smith W. Essential information on surgical heart valve characteristics for optimal valve prosthesis selection: Expert consensus document from the European Association for Cardio-Thoracic Surgery (EACTS)–The Society of Thoracic Surgeons (STS)–American Association for Thoracic Surgery (AATS) Valve Labelling Task Force. Journal Of Thoracic And Cardiovascular Surgery 2020, 161: 545-558. PMID: 33070936, DOI: 10.1016/j.jtcvs.2020.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveBioprosthesisHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHeart ValvesHemodynamicsHumansConceptsSurgical heart valvesThe Role of Novel Transcatheter Procedures in Patients With Congenital Heart Disease
Joffe D, Sheu R, Keeshan B, Burbano-Vera N. The Role of Novel Transcatheter Procedures in Patients With Congenital Heart Disease. Journal Of Cardiothoracic And Vascular Anesthesia 2020, 35: 2180-2193. PMID: 32758406, DOI: 10.1053/j.jvca.2020.07.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCardiac CatheterizationHeart Defects, CongenitalHeart Valve DiseasesHeart Valve Prosthesis ImplantationHumans
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