2024
Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions
Banou L, Sarrafpour S, Teng C, Liu J. Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions. The Yale Journal Of Biology And Medicine 2024, 97: 491-503. PMID: 39703610, PMCID: PMC11650918, DOI: 10.59249/hwid7537.Peer-Reviewed Original ResearchConceptsAdeno-associated virusOcular gene therapyGene therapyFood and Drug AdministrationViral vectorsImmune responsePotential application of gene therapyClinical trialsApproval of voretigene neparvovecViral vector-based therapyApplication of gene therapyImproved delivery techniquesVector-based therapyImmune-privileged statusInduce immune responsesReduced immune responseVoretigene neparvovecContralateral eyeRetinal dystrophyImmune privilegeOcular diseasesDeliver genesEye diseaseTherapeutic efficacyTherapyArtificial intelligence in ophthalmology
Khossravi A, Chen Q, Adelman R. Artificial intelligence in ophthalmology. Current Opinion In Ophthalmology 2024, 36: 35-38. PMID: 39607311, DOI: 10.1097/icu.0000000000001111.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceDiagnostic Techniques, OphthalmologicalEye DiseasesHumansOphthalmologyConceptsTreatment of diabetic retinopathyImprove accuracy of diagnosisProgression of diseasePersonalized treatment plansCorneal infectionVisual outcomeIntraocular pressureMacular degenerationDiabetic retinopathyAccuracy of diagnosisFollow-upTreatment planningOcular imagingPersonalization of medicinePredictive of progression of diseasePatient outcomesDiagnosisEnhance patient outcomesIncorporation of genomicsTreatmentHome monitoringOutcomesCornealGlaucomaEctasiaDisorders with Ophthalmic and Thoracic Involvement.
Gosangi B, Lang P, Johnson M, Zukerman R, Tu L, Traube L, Bader A, Rubinowitz A. Disorders with Ophthalmic and Thoracic Involvement. RadioGraphics 2024, 44: e230132. PMID: 38870047, DOI: 10.1148/rg.230132.Peer-Reviewed Original ResearchConceptsClinical manifestationsExamination of family membersEhlers-Danlos syndromeAffecting patient outcomesAcute sarcoidosisOphthalmologic examinationThoracic symptomsDry eyeThoracic involvementOphthalmological symptomsOphthalmologic manifestationsEye symptomsMarfan syndromeSjogren's syndromeImaging findingsRadiological studiesLung diseasePatient outcomesEhlers-DanlosFamily membersMultimodal imagingSystem conditionsSyndromeThoracicSarcoidosis
2023
Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy
Spadaro J, Chow R, Sinard J, Watsky K, Habib L. Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: e78-e81. PMID: 36852835, DOI: 10.1097/iop.0000000000002338.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaLow-dose radiation therapyPeriorbital edemaRadiation therapyChronic Lymphocytic Leukemia PresentingBilateral periorbital edemaLeukemia cutisOcular involvementOcular manifestationsPrompt diagnosisBlood dyscrasiasCase reportNeoplastic lymphocytesLymphocytic leukemiaTissue infiltrationTherapeutic interventionsEdemaPatientsTherapyLeukemiaInfiltrationEcchymosisPresentingDyscrasiasLymphocytesOcular complications of plasma cell dyscrasias
Singh R, Singhal S, Sinha S, Cho J, Nguyen A, Dhingra L, Kaur S, Sharma V, Agarwal A. Ocular complications of plasma cell dyscrasias. European Journal Of Ophthalmology 2023, 33: 1786-1800. PMID: 36760117, PMCID: PMC10472748, DOI: 10.1177/11206721231155974.Peer-Reviewed Original ResearchConceptsPlasma cell dyscrasiaMonoclonal gammopathyMultiple myelomaMalignant plasma cellsEfficacious treatment strategiesSearch of PubMedOcular presentationOcular complicationsTreating ophthalmologistClinical suspicionAsymptomatic patientsOphthalmological signsWaldenstrom's macroglobulinemiaSystemic findingsOphthalmologic disordersPre-malignantUnderlying diseasePosterior segmentPlasma cellsSkin changesTreatment strategiesOver-secretionEarly diagnosisCochrane DatabaseSystemic amyloidosis
2022
Recurrent Periorbital Edema Associated With Retained Foreign Body After Filler Injection
Shoji M, Maeng M, Khzam R, Dubovy S, Johnson T. Recurrent Periorbital Edema Associated With Retained Foreign Body After Filler Injection. Ophthalmic Plastic And Reconstructive Surgery 2022, 39: e30-e33. PMID: 36700871, DOI: 10.1097/iop.0000000000002274.Peer-Reviewed Original ResearchMeSH KeywordsAdultCellulitisCosmetic TechniquesDermal FillersEdemaEye DiseasesFaceForeign BodiesHumansInflammationMaleConceptsForeign bodyFiller injectionMetallic foreign bodyRight upper cheekBilateral periorbital swellingPeriorbital swellingPeriorbital edemaVision lossSurgical explorationLower eyelidGranulomatous inflammationTender nodulesFacial fillersUpper cheekAesthetic proceduresInflammatory reactionSoft tissueComplicationsEdemaIron depositionInjectionInjection techniqueRacial, Ethnic, and Socioeconomic Disparities Drive Appointment No-Show in Patients with Chronic Eye Disease
Greig EC, Gonzalez-Colaso R, Nwanyanwu K. Racial, Ethnic, and Socioeconomic Disparities Drive Appointment No-Show in Patients with Chronic Eye Disease. Journal Of Racial And Ethnic Health Disparities 2022, 10: 1790-1797. PMID: 35864353, PMCID: PMC10392104, DOI: 10.1007/s40615-022-01363-x.Peer-Reviewed Original ResearchConceptsChronic eye diseaseEye diseaseRetrospective case-control studyAge-related macular degenerationVision-threatening complicationsRelevant medical historyCase-control studyDiagnosis of glaucomaYears of ageChronic eye conditionsAppointments of patientsLogistic regression modelsAcademic ophthalmology practicePatient characteristicsMedicaid insuranceMedicare insuranceUnique patientsResultsA totalBlack raceMedical historyDiabetic retinopathyDisease progressionMacular degenerationOphthalmology practiceHispanic ethnicity
2021
An evidence-based approach to nontraumatic ocular complaints in children.
Iqbal A, Langhan ML, Rotruck J, Soma G. An evidence-based approach to nontraumatic ocular complaints in children. Pediatric Emergency Medicine Practice 2021, 18: 1-28. PMID: 33476507.Peer-Reviewed Original Research
2020
Ophthalmic Emergency Department Visits: Factors Associated With Loss to Follow-up
Chen EM, Ahluwalia A, Parikh R, Nwanyanwu K. Ophthalmic Emergency Department Visits: Factors Associated With Loss to Follow-up. American Journal Of Ophthalmology 2020, 222: 126-136. PMID: 32882220, PMCID: PMC8328190, DOI: 10.1016/j.ajo.2020.08.038.Peer-Reviewed Original ResearchConceptsED revisitsED visitsOphthalmic careOphthalmic conditionsSingle-institution retrospective cohort studyED revisit ratesIndex ED visitRetrospective cohort studyEmergency department dischargeQuarter of patientsMain outcome measuresTertiary health systemIndex visitCohort studyED presentationsPatients LTFUMultivariable analysisVisual acuityPrimary diagnosisMedical recordsRisk factorsLTFUOutcome measuresPrior historyPatientsOn-Label and Off-Label Clinical Studies of FDA–Approved Ophthalmic Therapeutics
Gopal AD, Wallach JD, Shah SA, Regillo C, Ross JS. On-Label and Off-Label Clinical Studies of FDA–Approved Ophthalmic Therapeutics. Ophthalmology 2020, 128: 332-334. PMID: 32682839, PMCID: PMC9900733, DOI: 10.1016/j.ophtha.2020.07.028.Peer-Reviewed Original ResearchOphthalmic Medication Expenditures and Out-of-Pocket Spending An Analysis of United States Prescriptions from 2007 through 2016
Chen EM, Kombo N, Teng CC, Mruthyunjaya P, Nwanyanwu K, Parikh R. Ophthalmic Medication Expenditures and Out-of-Pocket Spending An Analysis of United States Prescriptions from 2007 through 2016. Ophthalmology 2020, 127: 1292-1302. PMID: 32359935, PMCID: PMC7508869, DOI: 10.1016/j.ophtha.2020.04.037.Peer-Reviewed Original ResearchConceptsOphthalmic medicationsMedication expendituresOOP expenditureLongitudinal cohort studyOverall drug expendituresUnited States populationPrescription drug spendingGlaucoma medicationsCohort studyMedication useDry eyePrescription usePrescription expendituresPrescription medicationsOOP expensesMedicationsCopayment assistancePocket expenditureOOP spendingDrug expendituresPocket spendingDrug spendingIndirect costsMEPS participantsLinear regression
2019
Idiopathic Epiretinal Membrane and Vitreomacular Traction Preferred Practice Pattern®
Flaxel CJ, Adelman RA, Bailey ST, Fawzi A, Lim JI, Vemulakonda GA, Ying GS. Idiopathic Epiretinal Membrane and Vitreomacular Traction Preferred Practice Pattern®. Ophthalmology 2019, 127: p145-p183. PMID: 31757497, DOI: 10.1016/j.ophtha.2019.09.022.Peer-Reviewed Original ResearchOphthalmic Immune-Related Adverse Events of Immunotherapy: A Single-Site Case Series
Kim J, Materin MA, Sznol M, Kluger H, Weiss S, Chow J, Stoessel K, Kombo N, Del Priore L, Pointdujour-Lim R. Ophthalmic Immune-Related Adverse Events of Immunotherapy: A Single-Site Case Series. Ophthalmology 2019, 126: 1058-1062. PMID: 30735682, PMCID: PMC6933747, DOI: 10.1016/j.ophtha.2019.01.031.Peer-Reviewed Original Research
2018
Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement
Yan H, Ma X, Sun W, Mendez S, Stryker S, Starr‐Baier S, Delliturri G, Zhu D, Nath R, Chen Z, Roberts K, MacDonald CA, Liu W. Monte Carlo dosimetry modeling of focused kV x‐ray radiotherapy of eye diseases with potential nanoparticle dose enhancement. Medical Physics 2018, 45: 4720-4733. PMID: 30133705, DOI: 10.1002/mp.13144.Peer-Reviewed Original ResearchConceptsX-ray beamMC simulation programEye plaque treatmentCentral axis depth doseMC simulationsDose distributionBeam focusingEye Physics plaquesPhantom irradiationDose enhancementEnergy spectrumDepth doseLens modelingDosimetry modelingPhotoelectric absorptionKV rangeKV X-ray beamsBeamEBT3 filmSimulation programEnergy regimeModelingX-ray techniquesHalf maximumMore flexibilityPhenotypes of organ involvement in sarcoidosis
Schupp J, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho L, Gaede K, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane M, O'Beirne S, Donnelly S, Haraldsdottir S, Jorundsdottir K, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. European Respiratory Journal 2018, 51: 1700991. PMID: 29371378, DOI: 10.1183/13993003.00991-2017.Peer-Reviewed Original ResearchConceptsOrgan involvementIntrathoracic lymph node involvementAbdominal organ involvementLymph node involvementEuropean multicentre studySystemic granulomatous diseaseNew clinical phenotypeHitherto unknown etiologyAcute onsetExtrapulmonary involvementNode involvementSkin involvementFemale patientsMulticentre studyDisease involvementUnknown etiologyCaucasian patientsGranulomatous diseaseHomogenous cohortSarcoidosisPatientsClinical phenotypeStudy centersStandardised protocolDisease phenotype
2016
Epidemiology of Eye-Related Emergency Department Visits
Channa R, Zafar SN, Canner JK, Haring RS, Schneider EB, Friedman DS. Epidemiology of Eye-Related Emergency Department Visits. JAMA Ophthalmology 2016, 134: 312. PMID: 26821577, DOI: 10.1001/jamaophthalmol.2015.5778.Peer-Reviewed Original ResearchConceptsNationwide Emergency Department SampleED visitsEmergency departmentIncidence rateUS Nationwide Emergency Department SampleAge groupsPopulation-based incidence ratesEmergency Department SampleInflation-adjusted chargesHighest income quartileDifferent age groupsEmergent visitsCorneal abrasionOlder patientsEye injuriesSubconjunctival hemorrhageNonemergent conditionsOcular problemsOcular conditionsNonemergent visitsExternal eyeEye problemsForeign bodyMAIN OUTCOMEIndependent factors
2014
Targeted agents: management of dermatologic toxicities.
Burtness B. Targeted agents: management of dermatologic toxicities. Journal Of The National Comprehensive Cancer Network 2014, 12: 793-6. PMID: 24853219, DOI: 10.6004/jnccn.2014.0192.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptor inhibitorsGrowth factor receptor inhibitorsDermatologic side effectsQuality of lifeDermatologic toxicitiesCutaneous complicationsSkin complicationsTherapeutic mainstayReceptor inhibitorsCommon culpritsToxicity profileMTOR inhibitorsSide effectsCosmetic issuesAnticancer treatmentPotential infectionComplicationsTreatmentInhibitorsTherapyAgentsCancerInfectionMainstayBRAF
2013
Translational models of ocular disease
Zeiss CJ. Translational models of ocular disease. Veterinary Ophthalmology 2013, 16: 15-33. PMID: 23750503, DOI: 10.1111/vop.12065.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, DomesticAnimals, LaboratoryEye DiseasesHumansTranslational Research, BiomedicalConceptsLarge animal modelIntraocular neoplasiaStromal diseaseOcular diseasesAnimal modelsRetinal dystrophyTherapeutic potentialTranslational modelClinical veterinary medicineLaboratory animalsDomestic animalsDiseaseHuman medicineAnimalsVeterinary medicineMechanistic discoveriesGenetic contributionHumansMedicineUveitis
2011
Imaging findings in encephalocraniocutaneous lipomatosis
Svoronos A, Hirsch LJ, Khandji AG. Imaging findings in encephalocraniocutaneous lipomatosis. Neurology 2011, 77: 694. PMID: 21844526, DOI: 10.1212/wnl.0b013e3182299fa9.Peer-Reviewed Original ResearchTransplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice
Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice. PLOS ONE 2011, 6: e18992. PMID: 21559507, PMCID: PMC3084746, DOI: 10.1371/journal.pone.0018992.Peer-Reviewed Original ResearchConceptsRetinal functionNormal retinal physiologyOuter nuclear layerRetinal precursorsC-MycRetinal degenerative diseasesRetinal outer nuclear layerDelivery of neurotransmittersRetinal degenerative (rd) miceRetinal transplantationSubretinal transplantationNuclear layerAdult miceDsRed miceTransplantationRetinal structureRetinal physiologyPhotoreceptor markersDegenerative diseasesMiceRetroviral inductionFunctional anatomyPhotoreceptor precursorsPhotoreceptor cellsFibroblast-derived iPSCs
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