2025
Multiple sclerosis diagnosis and its differential diagnosis in patients presenting with type four ‘mirror pattern’ CSF oligoclonal bands
Marastoni D, Sicchieri M, Pizzini F, Scartezzini A, Virla F, Turano E, Anni D, Bertolazzo M, Ziccardi S, Camera V, Tamanti A, Marini M, Lippi G, Bonetti B, Solomon A, Calabrese M. Multiple sclerosis diagnosis and its differential diagnosis in patients presenting with type four ‘mirror pattern’ CSF oligoclonal bands. Journal Of Neurology 2025, 272: 207. PMID: 39954124, PMCID: PMC11829897, DOI: 10.1007/s00415-025-12947-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiagnosis, DifferentialFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisOligoclonal BandsYoung AdultConceptsCentral nervous systemCSF oligoclonal bandsOligoclonal bandsDiagnosis of MSAlternative diagnosesCerebrospinal fluidDemyelinating eventCentral nervous system demyelinating eventMultiple sclerosisInitial central nervous systemOligoclonal banding patternsRadiological follow-upDiagnostic work-upFrequent alternative diagnosesGroup of patientsMethodsSeventy-six patientsCentral nervous system disordersConclusionThe diagnosisMultiple sclerosis diagnosisClinical attacksMRI lesionsParaclinical examinationsDifferential diagnosisFollow-upWork-upMisoprostol administration mimicking a febrile transfusion reaction
Yurtsever N, Snyder E. Misoprostol administration mimicking a febrile transfusion reaction. Transfusion 2025, 65: 643-646. PMID: 39907501, DOI: 10.1111/trf.18150.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiagnosis, DifferentialErythrocyte TransfusionFemaleFeverHumansMisoprostolOxytocicsPregnancyTransfusion ReactionConceptsFebrile nonhemolytic transfusion reactionsTransfusion reactionsBlood culturesSynthetic prostaglandin E1 analogueThermogenic effectAdministration of misoprostolProstaglandin E1 analogueRed cell transfusionTransfusion medicineFebrile transfusion reactionsNonhemolytic transfusion reactionsG1P0 femaleMisoprostol administrationCell transfusionE1 analogueChart reviewSerological workupCase reportDifferential diagnosisEnhance patient satisfactionMisoprostolTransfusionUterotonic propertiesSerological findingsSide effects
2024
Artificial intelligence-based CT-free quantitative thyroid SPECT for thyrotoxicosis: study protocol of a multicentre, prospective, non-inferiority study
Oh D, Ryoo H, Chung H, Cho S, Kwon K, Kim J, So Y, Moon J, Ahn S, Lee W. Artificial intelligence-based CT-free quantitative thyroid SPECT for thyrotoxicosis: study protocol of a multicentre, prospective, non-inferiority study. BMJ Open 2024, 14: e089552. PMID: 39401965, PMCID: PMC11475049, DOI: 10.1136/bmjopen-2024-089552.Peer-Reviewed Original ResearchMeSH KeywordsAdultArtificial IntelligenceDiagnosis, DifferentialEquivalence Trials as TopicFemaleGraves DiseaseHumansMaleMulticenter Studies as TopicProspective StudiesRepublic of KoreaSingle Photon Emission Computed Tomography Computed TomographySingle-Blind MethodThyroid GlandThyroiditisThyrotoxicosisTomography, Emission-Computed, Single-PhotonConceptsGraves' diseaseDestructive thyroiditisDifferential diagnosisDifferential diagnosis of Graves' diseaseDifferential diagnosis of thyrotoxicosisDiagnosis of Graves' diseaseKonkuk University Medical CenterSingle-photon emission CT/CTSeoul National University Bundang HospitalTc-99m pertechnetateDiagnosis of thyrotoxicosisChonnam National University HospitalHistory of hyperthyroidismAttenuation correctionStudy protocolNational University HospitalNon-inferiority studyUniversity Medical CenterClinical Research Information ServiceInstitutional review boardPrimary endpointThyrotoxicosis patientsSecondary endpointsTechnetium thyroid uptakeThyroid uptakeDifferential diagnosis of suspected multiple sclerosis: global health considerations
Correale J, Solomon A, Cohen J, Banwell B, Gracia F, Gyang T, de Bedoya F, Harnegie M, Hemmer B, Jacob A, Kim H, Marrie R, Mateen F, Newsome S, Pandit L, Prayoonwiwat N, Sahraian M, Sato D, Saylor D, Shi F, Siva A, Tan K, Viswanathan S, Wattjes M, Weinshenker B, Yamout B, Fujihara K. Differential diagnosis of suspected multiple sclerosis: global health considerations. The Lancet Neurology 2024, 23: 1035-1049. PMID: 39304243, DOI: 10.1016/s1474-4422(24)00256-4.Peer-Reviewed Original ResearchConceptsWestern EuropeLatin AmericaEastern EuropeMiddle EastSoutheast AsiaNorth AmericaLatinEuropeHealth considerationsDifferential diagnosis of multiple sclerosisAfricaAmericaPacific regionAsiaDiagnosis of multiple sclerosisDifferential diagnosisCollaborative effortsComprehensive approachMultiple sclerosisEastMedical careDifferential diagnosis of suspected multiple sclerosis: considerations in people from minority ethnic and racial backgrounds in North America, northern Europe, and Australasia
Amezcua L, Rotstein D, Shirani A, Ciccarelli O, Ontaneda D, Magyari M, Rivera V, Kimbrough D, Dobson R, Taylor B, Williams M, Marrie R, Banwell B, Hemmer B, Newsome S, Cohen J, Solomon A, Royal W. Differential diagnosis of suspected multiple sclerosis: considerations in people from minority ethnic and racial backgrounds in North America, northern Europe, and Australasia. The Lancet Neurology 2024, 23: 1050-1062. PMID: 39304244, DOI: 10.1016/s1474-4422(24)00288-6.Peer-Reviewed Original ResearchMeSH KeywordsAustralasiaDiagnosis, DifferentialEthnic and Racial MinoritiesEthnicityEuropeHumansMultiple SclerosisNorth AmericaConceptsSocial determinants of healthDeterminants of healthRacial backgroundSocial determinantsDiagnosis of multiple sclerosisClinical characteristics of peopleCharacteristics of peopleWhite peopleMultiple sclerosisDifferential diagnosisPrevalence of multiple sclerosisSocial challengesMinorityChanging demographicsDifferential diagnosis of multiple sclerosisWhite populationNorthern EuropePeopleEuropeResidual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas
Bitar R, Langdon J, Kaur M, Crandall I, McNamara R, Revzin M. Residual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas. Ultrasound Quarterly 2024, 40: e00694. PMID: 39466239, DOI: 10.1097/ruq.0000000000000694.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedContrast MediaDiagnosis, DifferentialEchocardiographyFemaleGasesHumansImage EnhancementMaleMiddle AgedPortal VeinUltrasonographyConceptsUltrasound enhancing agentsPortal venous gasBowel ischemiaAbdominal ultrasoundVenous gasEchogenic fociContrast-enhanced echocardiographyEvaluation of cardiac functionPortal venous systemSeries of casesSonographic detectionCardiac functionDifferential diagnosisPortal veinVenous systemObservational studyLiver parenchymaPortal triadsVascular patencyBowelIschemiaEchocardiographyLiverUltrasoundThe Grief Debate, the DSM, and Clinical Practice
Phillips J. The Grief Debate, the DSM, and Clinical Practice. Journal Of Psychiatric Practice 2024, 30: 292-296. PMID: 39058529, DOI: 10.1097/pra.0000000000000792.Peer-Reviewed Original ResearchMeSH KeywordsBereavementDepressive Disorder, MajorDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersGriefHumansConceptsProlonged grief disorderGrief disorderDSM-IIIDepressive symptomsStatistical manual of mental disordersManual of mental disordersPerson-centered approachInventory of symptomsBereavement exclusionDSM-IVDSM-5Statistical manualUncomplicated bereavementMental disordersTreatment programsDepressionDisordersDSMGriefSymptomsBereavementIndividualsTemporal limitsInventoryClinical challengeDisorders with Ophthalmic and Thoracic Involvement.
Gosangi B, Lang P, Johnson M, Zukerman R, Tu L, Traube L, Bader A, Rubinowitz A. Disorders with Ophthalmic and Thoracic Involvement. RadioGraphics 2024, 44: e230132. PMID: 38870047, DOI: 10.1148/rg.230132.Peer-Reviewed Original ResearchConceptsClinical manifestationsExamination of family membersEhlers-Danlos syndromeAffecting patient outcomesAcute sarcoidosisOphthalmologic examinationThoracic symptomsDry eyeThoracic involvementOphthalmological symptomsOphthalmologic manifestationsEye symptomsMarfan syndromeSjogren's syndromeImaging findingsRadiological studiesLung diseasePatient outcomesEhlers-DanlosFamily membersMultimodal imagingSystem conditionsSyndromeThoracicSarcoidosisConventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis.
Jiménez-Serrano S, Páez-Carpio A, Doménech-Ximenos B, Cornellas L, Sánchez M, Revzin M, Vollmer I. Conventional and Contrast-enhanced US of the Lung: From Performance to Diagnosis. RadioGraphics 2024, 44: e230171. PMID: 38935548, DOI: 10.1148/rg.230171.Peer-Reviewed Original ResearchMeSH KeywordsContrast MediaDiagnosis, DifferentialHumansImage EnhancementImage-Guided BiopsyLungLung DiseasesUltrasonographyConceptsPeripheral lung diseaseContrast-enhanced USDiagnosis of peripheral lung diseasePercutaneous biopsyLung USEnhancement patternLung diseaseImage-guided percutaneous biopsyAccurate differential diagnosisDiagnostic chest imagingLung biopsySubpleural lesionsConventional USDifferential diagnosisPathological findingsPulmonary physiologyChest imagingArterial supplyBiopsyLungDiagnostic testsDiagnosisSoft tissueDiseaseImaging timeHistologic Features of Mycobacterial Spindle Cell Pseudotumors
Szczepanski J, Lieberman J, Lamps L, Gonzalez R, Xue Y, Zhang X, Yilmaz O, Hart J, Krausz T, Mantilla J, McHugh J, Westerhoff M. Histologic Features of Mycobacterial Spindle Cell Pseudotumors. The American Journal Of Surgical Pathology 2024, 48: 890-900. PMID: 38726848, DOI: 10.1097/pas.0000000000002234.Peer-Reviewed Original ResearchConceptsMycobacterial spindle cell pseudotumorSpindle cell pseudotumorImmunocompromised patientsFoamy histiocytesLymph nodesNeutrophilic inflammationNeutrophilic microabscessesEvaluated lymph nodesComposition of inflammatory infiltratesSpindle cell neoplasmSecondary to infectionNon-tuberculous mycobacteriaArchitectural growth patternAcid-fast stainingMultinucleated giant cellsPeripheral granulomaSurgical therapyCell neoplasmsStromal changesHistological factorsSpindle cellsLymphocytic inflammationMicrobiological findingsClinical historyInflammatory infiltrateBRAF Mutated and Morphologically Spitzoid Tumors, a Subgroup of Melanocytic Neoplasms Difficult to Distinguish From True Spitz Neoplasms
Gerami P, Chen A, Sharma N, Patel P, Hagstrom M, Kancherla P, Geraminejad T, Olivares S, Biswas A, Bosenberg M, Busam K, de La Fouchardière A, Duncan L, Elder D, Ko J, Landman G, Lazar A, Lowe L, Massi D, Mihic-Probst D, Parker D, Scolyer R, Shea C, Zembowicz A, Yun S, Blokx W, Barnhill R. BRAF Mutated and Morphologically Spitzoid Tumors, a Subgroup of Melanocytic Neoplasms Difficult to Distinguish From True Spitz Neoplasms. The American Journal Of Surgical Pathology 2024, 48: 538-545. PMID: 38525831, DOI: 10.1097/pas.0000000000002194.Peer-Reviewed Original ResearchMeSH KeywordsDiagnosis, DifferentialHumansMelanomaNevusNevus, Epithelioid and Spindle CellProto-Oncogene Proteins B-rafSkin NeoplasmsHepatorenal Syndrome Type 1: Diagnosis and Treatment
Belcher J. Hepatorenal Syndrome Type 1: Diagnosis and Treatment. Advances In Kidney Disease And Health 2024, 31: 100-110. PMID: 38649214, DOI: 10.1053/j.akdh.2023.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiomarkersDiagnosis, DifferentialHepatorenal SyndromeHumansLipocalin-2LypressinTerlipressinVasoconstrictor AgentsConceptsAcute kidney injuryHepatorenal syndromeKidney injuryFunctional acute kidney injuryUrinary biomarkers of kidney injuryAssociated with significant morbidityFractional excretion of sodiumNeutrophil gelatinase-associated lipocalinDiagnostic criteriaBiomarkers of kidney injuryMultiple urinary biomarkersOptimal dosing strategiesExcretion of sodiumPoint-of-care ultrasoundAccurate differential diagnosisAnalog of vasopressinSets of diagnostic criteriaAdvanced cirrhosisAlbumin administrationSignificant morbidityVolume resuscitationTherapeutic optionsDosing strategiesFractional excretionDifferential diagnosisMan With Dyspnea
Boivin Z, Cannata D, She T. Man With Dyspnea. Annals Of Emergency Medicine 2024, 83: 166-167. PMID: 38245230, DOI: 10.1016/j.annemergmed.2023.08.480.Peer-Reviewed Original ResearchPitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review
Turner N, Ko C, McNiff J, Galan A. Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review. American Journal Of Dermatopathology 2024, 46: 21-30. PMID: 37982498, DOI: 10.1097/dad.0000000000002584.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NeoplasmDiagnosis, DifferentialDysplastic Nevus SyndromeFemaleHumansImmunohistochemistryMaleMelanocytesMelanomaSkin NeoplasmsTranscription FactorsConceptsConventional malignant melanomaMalignant melanomaPRAME immunohistochemistryBorderline lesionsNonmelanocytic lesionsDysplastic neviAmerican Joint CommitteePathological tumor stageMalignant melanocytic proliferationsBanal melanocytic nevusUlceration statusInstitution experienceBreslow depthMean ageTumor stageClinicopathologic correlationConsecutive casesMale genderAtypical fibroxanthomaSevere atypiaJoint CommitteeLarge seriesAmbiguous melanocytic lesionsMelanocytic proliferationMalignant counterparts
2023
A 56-Year-Old Man With Progressive Subacute Hypoxemia
Steinberg A, Zeba F, Rassias A, Mota P. A 56-Year-Old Man With Progressive Subacute Hypoxemia. CHEST Journal 2023, 164: e169-e172. PMID: 38070964, DOI: 10.1016/j.chest.2023.06.042.Peer-Reviewed Original ResearchFocal nodular hyperplasia–like nodules arising in the setting of hepatic vascular disorders with portosystemic shunting show β-catenin activation
Umetsu S, Joseph N, Cho S, Morotti R, Deshpande V, Jain D, Kakar S. Focal nodular hyperplasia–like nodules arising in the setting of hepatic vascular disorders with portosystemic shunting show β-catenin activation. Human Pathology 2023, 142: 20-26. PMID: 37806391, DOI: 10.1016/j.humpath.2023.09.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver Cellbeta CateninCarcinoma, HepatocellularDiagnosis, DifferentialFocal Nodular HyperplasiaHumansLiver NeoplasmsVascular DiseasesConceptsHepatic vascular disordersFocal nodular hyperplasiaFNH-like nodulesHepatocellular adenomaVascular disordersHepatocellular carcinomaΒ-catenin activationPortosystemic shuntRegenerative nodulesFocal nodular hyperplasia-like nodulesPost-Fontan procedureGlutamine synthetase stainingAbernethy malformationLiver resectionPortosystemic shuntingHistologic featuresMalignant neoplasmsNodular lesionsVascular diseaseDuctular reactionNodular hyperplasiaNodular architectureHepatocellular nodulesBenign lesionsFibrous septaSolitary Fibrous Tumor of the Pancreas
Yavas A, Tan J, Ozkan H, Yilmaz F, Reid M, Bagci P, Shi J, Shia J, Adsay V, Klimstra D, Basturk O. Solitary Fibrous Tumor of the Pancreas. The American Journal Of Surgical Pathology 2023, 47: 1230-1242. PMID: 37573546, PMCID: PMC10592360, DOI: 10.1097/pas.0000000000002108.Peer-Reviewed Original ResearchConceptsPancreatic solitary fibrous tumorSolitary fibrous tumorNuclear STAT6 expressionFibrous tumorTumor cellsDifferential diagnosis of mesenchymal neoplasmsSTAT6 expressionAtypical spindle cell tumorDiagnosis of mesenchymal neoplasmsLow-grade stromal tumorsMetastatic renal cell carcinomaSpindle tumor cellsFree of diseaseLow-grade sarcomaSpindle cell tumorsRenal cell carcinomaNAB2-STAT6 fusionFollow-up dataStromal tumorsHypervascular massNeuroendocrine tumorsCell carcinomaMesenchymal neoplasmsCell tumorsCystic areasApplying a validated scoring rubric to pre-clerkship medical students’ standardized patient notes: a pilot study
Gallagher B, Green M, Talwalkar J. Applying a validated scoring rubric to pre-clerkship medical students’ standardized patient notes: a pilot study. BMC Medical Education 2023, 23: 504. PMID: 37438775, PMCID: PMC10339528, DOI: 10.1186/s12909-023-04424-9.Peer-Reviewed Original ResearchPremenarchal lichen sclerosus: a multicentre examination of the novel diagnostic tool, the SWIFT model
Lawson A, Wininger M, Wang M, Steger M, Peccerillo K, Vash-Margita A. Premenarchal lichen sclerosus: a multicentre examination of the novel diagnostic tool, the SWIFT model. British Journal Of Dermatology 2023, 189: 353-354. PMID: 37235769, DOI: 10.1093/bjd/ljad180.Peer-Reviewed Original ResearchPRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ
Roy S, Panse G, McNiff J. PRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ. Journal Of Cutaneous Pathology 2023, 50: 450-454. PMID: 36789669, DOI: 10.1111/cup.14407.Peer-Reviewed Original Research
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