2025
Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
Qiu Y, Jacobs D, Messer K, Salmon D, Wellington C, Stukas S, Revta C, Brewer J, Léger G, Askew B, Donahue L, Kaplita S, Coric V, Qureshi I, Feldman H. Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease. Alzheimer's Research & Therapy 2025, 17: 97. PMID: 40317057, PMCID: PMC12046789, DOI: 10.1186/s13195-025-01745-3.Peer-Reviewed Original ResearchConceptsMild to moderate ADADAS-cog11CDR-SBBaseline plasma NfLAlzheimer's diseasePlasma biomarkersMild-to-moderate Alzheimer's diseasePrognostic valueClinical trialsBaseline NfLPlasma NfLPlacebo-controlled trialCortical volumeConcentrations of plasma biomarkersMethodsPost hoc analysisDesign of clinical trialsClinical outcome dataIncreased ventricular volumeTrial participantsVolumetric MRIBaseline concentrationsEarly disease stagesClinical trial designTrial entry criteriaAD trialsMedicare Parity and Outpatient Mental Health Service Use and Costs Among Beneficiaries With Depression
Tetlow S, Phillips V, Hockenberry J. Medicare Parity and Outpatient Mental Health Service Use and Costs Among Beneficiaries With Depression. JAMA Network Open 2025, 8: e258491. PMID: 40314953, PMCID: PMC12048850, DOI: 10.1001/jamanetworkopen.2025.8491.Peer-Reviewed Original ResearchConceptsMental health service useOutpatient mental health service useHealth service useOut-of-pocket expenditureMental health servicesOutpatient mental health servicesService useMedicare beneficiariesHealth servicesDepression screeningUS Preventive Services Task Force recommendationsAccessibility of mental health servicesMedical Expenditure Panel Survey Household ComponentInterrupted time series designOutpatient mental healthMental health careCost-sharingMental health conditionsEconomic evaluationProportion of beneficiariesTask Force recommendationsBarriers to treatmentNationally representative sampleTime series designOlder with depressionRadiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study
Justet A, Jackson L, Bardon M, Lerouge D, Césaire M, Loiseau C, Bergot E, Christy F, Thariat J. Radiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study. Cancer/Radiothérapie 2025, 29: 104622. PMID: 40311519, DOI: 10.1016/j.canrad.2025.104622.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseNon-small cell lung cancerProgression-free survivalCell lung cancerOverall survivalLung diseaseCase-control studyLung cancerCentral reviewOligometastatic non-small cell lung cancerMedian progression-free survivalCase-control study of patientsPrevalence of interstitial lung diseaseConsecutive lung cancer patientsIntensity-modulated radiotherapyStereotactic body radiotherapyMedian overall survivalThree-dimensional radiotherapyScore of fibrosisPrognosis of patientsGround-glass patternInterstitial pulmonary fibrosisStudy of patientsLung cancer patientsCancer treatment characteristicsClinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Zhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, DOI: 10.1186/s12879-025-10900-y.Peer-Reviewed Original ResearchConceptsDisseminated intravascular coagulationOutcomes of disseminated intravascular coagulationPresence of disseminated intravascular coagulationNon-DIC groupIndependent risk factorIntravascular coagulationClinical characteristicsRisk factorsDisseminated intravascular coagulation groupThrombocytopenia syndromeMultivariate logistic regression analysisAssociated with high mortalityIn-hospital mortality of patientsCumulative survival rateZhongnan Hospital of Wuhan UniversityMortality of patientsIn-hospital mortalitySevere feverLogistic regression analysisConsecutive patientsFerritin levelsD-dimerViral loadClinical dataCystatin CScreening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer
Huang S, Westvold S, Soulos P, Fan J, Winer E, Zhan H, Lustberg M, Lewin J, Robinson T, Dinan M. Screening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer. JAMA Network Open 2025, 8: e255322. PMID: 40232715, DOI: 10.1001/jamanetworkopen.2025.5322.Peer-Reviewed Original ResearchConceptsBreast cancer-specific mortalityBreast cancer mortalityBreast cancer diagnosisCancer-specific mortalityCancer mortalityCancer diagnosisScreening mammographyHazard of breast cancer-specific deathFee-for-service Medicare Parts AAssociated with reduced breast cancer mortalityLower breast cancer mortalityHazard of breast cancer-specific mortalityBreast cancerImprove breast cancer outcomesScreen-detected breast cancerCohort studyBreast cancer-specific deathStudy of older womenBreast cancer outcomesFee-for-serviceDetection of breast cancerMedicare Part ALater-stage diseaseCox proportional hazards modelsAssociated with early stagesHealth System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers
Reuben D, Gill T, Stevens A, Williamson J, Volpi E, Lichtenstein M, Jennings L, Galloway R, Summapund J, Araujo K, Bass D, Weitzman L, Tan Z, Evertson L, Yang M, Currie K, Green A, Godoy S, Abraham S, Reese J, Samper-Ternent R, Hirst R, Borek P, Charpentier P, Meng C, Dziura J, Xu Y, Skokos E, He Z, Aiudi S, Peduzzi P, Greene E, Serrano K, Unger E, Arruda L, Bautista L, Callahan C, Maslow K, Ling S, Bonner A, Pace D, Cherry D, Kremer I, Nicholson B, Stephens C, Hendler R, Carnie M, Shelton A, Mignosa B, Funaro B, Eisenmann K, Lu C, Chattopadhyay S, Rhoades D, Lakomski A, Maher D, McCurry D, Williamson S, Moyer S, Robertson L, Tilles A, Battle L, Walker W, Levine S, Knight G, Eaton A, Rose T, Weston E, Orr B, Lang S, Rinaldi S, Shore J, Garboczi L, Phoenix K, Mitchell M, Levan L, Layza M, Musgrave D, Silverman J, Martin A, Nienstedt J, Handoo R, Woolard N, Burcombe D, Hutchens C, Sanghi S, Ocloo A, Essiet S, Shah M, Bartosh H, Banda J, Birchfield T, Roznos T, Collins B, Parker D, Matlock M, Drew L, Jones T, Hill B, Walker J, Wills J, Andrews M, Kroloff S, Brown G, Franz C, Perez G, Castillo E, Flores C, Raji M, Martinez E, Skinkis P, Williams A, Minello S, Sherrod J, Odejimi A, Lockhart M, McDonald A, Gibson D, Tobias N, Spetter K, Finney G, Ladd I, Weaver K, Nicoletto P, Smith D, DeLucca R, Delmar N, Dopko J, Patel M, Berry P, Zimmerman K, Fasciana J, Hendricks L, Freedman K, Gudonis S, Drutarovsky H, Gurzynski A, Shillabeer M, Shipsky K, Cannon C, Rahm A, Sharf L, Kearney K, Liu J, Keeler E, Ruder T. Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers. JAMA 2025, 333: 950-961. PMID: 39878968, PMCID: PMC11780506, DOI: 10.1001/jama.2024.25056.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCaregiversCommunity Health ServicesDementiaFemaleHumansIndependent LivingMaleMiddle AgedConceptsCommunity-based careModified Caregiver Strain IndexHealth system-basedCaregiver Strain IndexCaregiver self-efficacyUsual careDementia careHealth systemCommunity-basedNPI-QPrimary outcomeApproaches to dementia careCommunity-based dementia careCommunity-based care interventionsSelf-efficacyDementia care programDementia care specialistsSecondary outcomesStrain indexSystem-based careCommunity-dwelling personsNeuropsychiatric Inventory QuestionnairePatient behavioral symptomsNPI-Q scoresCaregiver outcomesNovel indices of state- and county-level social disadvantage in older Americans and disparities in mortality
Wang Y, Zang E, Davis-Plourde K, Gill T, Becher R. Novel indices of state- and county-level social disadvantage in older Americans and disparities in mortality. Health & Place 2025, 92: 103438. PMID: 40058245, DOI: 10.1016/j.healthplace.2025.103438.Peer-Reviewed Original ResearchConceptsIncreased mortality riskContextual disadvantageOlder personsOlder AmericansCommunity-living older personsSocial disadvantageMortality riskIndices of social disadvantageReduce health disparitiesPopulation of older AmericansCounty-levelPublic health policiesNon-disadvantaged groupsMortality disparitiesHealth disparitiesHealth policyMortality existUnited StatesDisadvantaged countiesNegative binomial modelGeriatric populationComposite indexDisparitiesDisadvantaged statesMultidimensional factorsVoxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrainCerebral HemorrhageCohort StudiesFemaleHematomaHumansMaleMiddle AgedTomography, X-Ray ComputedConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageMediators of Racial Inequities in Non‐Small Cell Lung Cancer Care
Hamid S, Lee D, Herrin J, Yu J, Pollack C, Dean L, Gaddy J, Oladele C, Feder S, Canavan M, Nunez-Smith M, Soulos P, Gross C. Mediators of Racial Inequities in Non‐Small Cell Lung Cancer Care. Cancer Medicine 2025, 14: e70757. PMID: 40052387, DOI: 10.1002/cam4.70757.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancer carePhase of careSocioeconomic statusNon-small cell lung cancerIndividual-level socioeconomic statusNeighborhood-level socioeconomic statusMedicare-Medicaid dual eligibilityWhite patientsHealth care accessLung cancer careNon-Hispanic blacksIndirect effects of mediatorsDiagnosis stageStage-appropriate treatmentTwo-year survivalCancer careCare accessEffects of raceOptimal careDual eligiblesCareStructural racismRacial inequalityBlack patientsInadequate evaluationEosinophilic esophagitis manifesting as intractable hiccups in an elderly patient: a case report
Jalloul S, Salem J, Karam K, Chamoun C, Chaptini L. Eosinophilic esophagitis manifesting as intractable hiccups in an elderly patient: a case report. Journal Of Medical Case Reports 2025, 19: 99. PMID: 40045389, PMCID: PMC11884032, DOI: 10.1186/s13256-025-05044-1.Peer-Reviewed Original ResearchConceptsDiagnosis of eosinophilic esophagitisEosinophilic esophagitisEosinophil infiltrationSymptoms related to esophageal dysfunctionComputed tomography of the chestSymptoms of eosinophilic esophagitisElevated peripheral eosinophil countPeripheral eosinophil countEsophagitis treatmentRefractory hiccupsBackgroundEosinophilic esophagitisConclusionThis caseEsophageal dysfunctionCase reportWeUpper endoscopyFood impactionIntermittent dysphagiaCase reportEndoscopic findingsDistal esophagusElderly patientsEosinophil countEsophageal mucosaComputed tomographyIntractable hiccupsPolygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
D'Aoust T, Clocchiatti‐Tuozzo S, Rivier C, Mishra A, Hachiya T, Grenier‐Boley B, Soumaré A, Duperron M, Le Grand Q, Bouteloup V, Proust‐Lima C, Samieri C, Neuffer J, Sargurupremraj M, Chêne G, Helmer C, Thibault M, Amouyel P, Lambert J, Kamatani Y, Jacqmin‐Gadda H, Tregouët D, Inouye M, Dufouil C, Falcone G, Debette S. Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification. Alzheimer's & Dementia 2025, 21: e70014. PMID: 40042447, PMCID: PMC11881617, DOI: 10.1002/alz.70014.Peer-Reviewed Original ResearchConceptsOlder community-dwelling peopleCommunity-dwelling peopleDementia risk stratificationVascular contribution to dementiaAssociated with dementia riskGenetic riskDementia clinical trialsApo E4Polygenic risk scoresGenetic risk groupsHigh-risk individualsDementia riskImprove risk predictionEast Asian ancestryAD-PRSPopulation-basedPolygenic scoresRisk stratificationMemory-clinic patientsPrevention programsClinical risk factorsDementiaClinical participantsRisk scoreAlzheimer's diseaseBurden and care time for dementia caregivers in the LIVE@Home.Path trial
Berge L, Angeles R, Gedde M, Fæø S, Mannseth J, Vislapuu M, Puaschitz N, Hillestad E, Aarsland D, Achterberg W, Allore H, Ballard C, Li F, Selbæk G, Vahia I, Husebo B. Burden and care time for dementia caregivers in the LIVE@Home.Path trial. Alzheimer's & Dementia 2025, 21: e14622. PMID: 40042468, PMCID: PMC11881633, DOI: 10.1002/alz.14622.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overCaregiver BurdenCaregiversDementiaFemaleHumansMaleMiddle AgedConceptsRelative Stress ScaleInformal care timeCaregiver burdenLiving interventionsCare timeIntervention periodStepped wedge randomized controlled trialVolunteer supportHome-dwelling peopleStepped-wedge trialPersonal activitiesDementia caregiversRandomized controlled trialsIntention-to-treatStress ScaleMunicipal coordinatorCaregiversPersonal supportRandomized dyadsDementiaControlled trialsPrimary outcomeControl periodInterventionPositive changesEarly Release - Mycobacterium nebraskense Isolated from Patients in Connecticut and Oregon, USA - Volume 31, Number 3—March 2025 - Emerging Infectious Diseases journal - CDC
Metersky M, Losier A, Fraulino D, Warnock T, Varley C, Le A, Winthrop K, McArdle J, Shakir S, Khare R. Early Release - Mycobacterium nebraskense Isolated from Patients in Connecticut and Oregon, USA - Volume 31, Number 3—March 2025 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2025, 31: 507-515. PMID: 40023800, PMCID: PMC11878316, DOI: 10.3201/eid3103.240608.Peer-Reviewed Original ResearchConceptsNontuberculous mycobacterial pulmonary diseaseMycobacterial pulmonary diseaseAmerican Thoracic Society/Infectious Diseases Society of America criteriaAntimicrobial drug susceptibility testingPulmonary diseaseDrug susceptibility testingRefractory to treatmentClinically significant causeClarithromycin susceptibilitySusceptibility testingConnecticut patientsRespiratory secretionsPatientsNo symptomsOptimum treatmentSignificant causeInfectionHuman casesDiseaseTreatmentCDCClarithromycinCasesClinicM. nebraskenseSafety and Antitumor Activity of a Novel aCD25 Treg Depleter RG6292 as a Single Agent and in Combination with Atezolizumab in Patients with Solid Tumors
Gambardella V, Ong M, Rodriguez-Ruiz M, Machiels J, Sanmamed M, Galvao V, Spreafico A, Renouf D, Luen S, Galot R, de Spéville B, Calvo E, Naing A, Curdt S, Kolben T, Rossmann E, Tanos T, Smart K, Amann M, Xie Y, Xu L, Alcaide E, Städler N, Justies N, Boetsch C, Karanikas V, Schnetzler G, Rohrberg K. Safety and Antitumor Activity of a Novel aCD25 Treg Depleter RG6292 as a Single Agent and in Combination with Atezolizumab in Patients with Solid Tumors. Cancer Research Communications 2025, 5: 422-432. PMID: 39983024, PMCID: PMC11891644, DOI: 10.1158/2767-9764.crc-24-0638.Peer-Reviewed Original ResearchConceptsRecommended phase II dosePhase II doseMaximum tolerated dosePhase I studyTreg depletionSolid tumorsII doseTolerated doseResistance to cancer immunotherapyRegulatory T-cell depletionImmunosuppressive regulatory T cellsEffector T cell functionAdvanced solid tumorsT-cell depletionRegulatory T cellsAnti-CD25 antibodyFrequent adverse eventsT cell functionDose-dependent depletionIL-2 signalingAtezolizumab combinationDeplete TregsTreg reductionDose escalationPeripheral TregsElevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection
Dylla L, Reisz J, Poisson S, Herson P, Sansing L, Monte A. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108268. PMID: 40015349, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108268.Peer-Reviewed Original ResearchConceptsPost-stroke infectionsAssociated with increased oddsTryptophan metabolitesHistory of diabetes mellitusEnd stage renal diseaseNIH Stroke Scale scoreConcentrations of kynurenineAcute ischemic stroke patientsMultivariate logistic regressionStage renal diseaseStroke Scale scoreCirculating kynurenineIschemic stroke onsetIschemic stroke patientsKynurenine concentrationsConcentrations of tryptophanEmergency department admissionsKynurenic acidDiabetes mellitusMortality of ischemic strokeRenal diseaseTryptophan metabolismOdds ratioQuinolinic acidImmune responseDeep learning to quantify the pace of brain aging in relation to neurocognitive changes
Yin C, Imms P, Chowdhury N, Chaudhari N, Ping H, Wang H, Bogdan P, Irimia A, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Landau S, Rivera-Mindt M, Okonkwo O, Shaw L, Lee E, Toga A, Beckett L, Harvey D, Green R, Saykin A, Nho K, Perrin R, Tosun D, Sachdev P, Green R, Drake E, Montine T, Conti C, Weiner M, Nosheny R, Truran Sacrey D, Fockler J, Miller M, Conti C, Kwang W, Jin C, Diaz A, Ashford M, Flenniken D, Kormos A, Petersen R, Aisen P, Rafii M, Raman R, Jimenez G, Donohue M, Salazar J, Fidell A, Boatwright V, Robison J, Zimmerman C, Cabrera Y, Walter S, Clanton T, Shaffer E, Webb C, Hergesheimer L, Smith S, Ogwang S, Adegoke O, Mahboubi P, Pizzola J, Jenkins C, Beckett L, Harvey D, Donohue M, Saito N, Diaz A, Hussen K, Okonkwo O, Rivera-Mindt M, Amaza H, Thao M, Parkins S, Ayo O, Glittenberg M, Hoang I, Germano K, Strong J, Weisensel T, Magana F, Thomas L, Guzman V, Ajayi A, Di Benedetto J, Talavera S, Jack C, Felmlee J, Fox N, Thompson P, DeCarli C, Forghanian-Arani A, Borowski B, Reyes C, Hedberg C, Ward C, Schwarz C, Reyes D, Gunter J, Moore-Weiss J, Kantarci K, Matoush L, Senjem M, Vemuri P, Reid R, Malone I, Thomopoulos S, Nir T, Jahanshad N, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Rossi Chen S, Choe M, Crawford K, Yushkevich P, Das S, Jagust W, Landau S, Koeppe R, Rabinovici G, Villemagne V, LoPresti B, Perrin R, Morris J, Franklin E, Bernhardt H, Cairns N, Taylor-Reinwald L, Shaw L, Lee E, Lee V, Korecka M, Brylska M, Wan Y, Trojanowki J, Toga A, Crawford K, Neu S, Saykin A, Nho K, Foroud T, Jo T, Risacher S, Craft H, Apostolova L, Nudelman K, Faber K, Potter Z, Lacy K, Kaddurah-Daouk R, Shen L, Karlawish J, Erickson C, Grill J, Largent E, Harkins K, Weiner M, Thal L, Kachaturian Z, Frank R, Snyder P, Buckholtz N, Hsiao J, Ryan L, Molchan S, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Perrin R, Ryan L, Silverberg N, Silbert L, Kaye J, White S, Pierce A, Thomas A, Clay T, Schwartz D, Devereux G, Taylor J, Ryan J, Nguyen M, DeCapo M, Shang Y, Schneider L, Munoz C, Ferman D, Conant C, Martin K, Oleary K, Pawluczyk S, Trejo E, Dagerman K, Teodoro L, Becerra M, Fairooz M, Garrison S, Boudreau J, Avila Y, Brewer J, Jacobson A, Gama A, Kim C, Little E, Frascino J, Ferng N, Trujillo S, Heidebrink J, Koeppe R, MacDonald S, Malyarenko D, Ziolkowski J, O’Connor J, Robert N, Lowe S, Rogers V, Petersen R, Hackenmiller B, Boeve B, Albers C, Kreuger C, Jones D, Knopman D, Botha H, Magnuson J, Graff-Radford J, Crawley K, Schumacher M, McKinzie S, Smith S, Helland T, Lowe V, Ramanan V, Pavlik V, Faircloth J, Bishop J, Nath J, Chaudhary M, Kataki M, Yu M, Pacini N, Barker R, Brooks R, Aggarwal R, Honig L, Stern Y, Mintz A, Cordona J, Hernandez M, Long J, Arnold A, Groves A, Middleton A, Vogler B, McCurry C, Mayo C, Raji C, Amtashar F, Klemp H, Elmore H, Ruszkiewicz J, Kusuran J, Stewart J, Horenkamp J, Greeson J, Wever K, Vo K, Larkin K, Rao L, Schoolcraft L, Gallagher L, Paczynski M, McMillan M, Holt M, Gagliano N, Henson R, LaBarge R, Swarm R, Munie S, Cepeda S, Winterton S, Hegedus S, Wilson T, Harte T, Bonacorsi Z, Geldmacher D, Watkins A, Barger B, Smelser B, Bates C, Stover C, McKinley E, Ikner G, Hendrix H, Cooper H, Mahaffey J, Booth Robbins L, Brown Ashley L, Natelson-Love M, Carter P, Solomon V, Grossman H, Groome A, Ardolino A, Kaplan A, Sheppard F, Burgos-Rivera G, Garcia-Camilo G, Lim J, Neugroschl J, Jackson K, Evans K, Soleimani L, Sano M, Ghesani N, Binder S, Apuango X, Sood A, Troutman A, Blanchard K, Richards A, Nelson G, Hendrickson K, Yurko E, Plenge J, Rufo V, Shah R, Duara R, Lynch B, Chirinos C, Dittrich C, Campbell D, Mejia D, Perez G, Colvee H, Gonzalez J, Gondrez J, Knaack J, Acevedo M, Cereijo M, Greig-Custo M, Villar M, Wishnia M, Detling S, Barker W, Albert M, Moghekar A, Rodzon B, Demsky C, Pontone G, Pekar J, Farrington L, Pomper M, Johnson N, Alo T, Sadowski M, Ulysse A, Masurkar A, Marti B, Mossa D, Geesey E, Petrocca E, Schulze E, Wong J, Boonsiri J, Kenowsky S, Martinez T, Briglall V, Doraiswamy P, Nwosu A, Adhikari A, Hellegers C, Petrella J, James O, Wong T, Hawk T, Vaishnavi S, McCoubrey H, Nasrallah I, Rovere R, Maneval J, Robinson E, Rivera F, Uffelman J, Combs M, O’Donnell P, Manning S, King R, Nieto A, Glueck A, Mandal A, Swain A, Gamble B, Meacham B, Forenback D, Ross D, Cheatham E, Hartman E, Cornell G, Harp J, Ashe L, Goins L, Watts L, Yazell M, Mandal P, Buckler R, Vincent S, Rudd T, Lopez O, Malia A, Chiado C, Zik C, Ruszkiewicz J, Savage K, Fenice L, Oakley M, Tacey P, Berman S, Bowser S, Hegedus S, Saganis X, Porsteinsson A, Mathewson A, Widman A, Holvey B, Clark E, Morales E, Young I, Ruszkiewicz J, Hopkins K, Martin K, Kowalski N, Hunt R, Calzavara R, Kurvach R, D’Ambrosio S, Thai G, Vides B, Lieb B, McAdams-Ortiz C, Toso C, Mares I, Moorlach K, Liu L, Corona M, Nguyen M, Tallakson M, McDonnell M, Rangel M, Basheer N, Place P, Romero R, Tam S, Nguyen T, Thomas A, Frolov A, Khera A, Browning A, Kelley B, Dawson C, Mathews D, Most E, Phillips E, Nguyen L, Nunez M, Miller M, Jones M, Martinez N, Logan R, McColl R, Pham S, Fox T, Moore T, Levey A, Brown A, Kippels A, Ellison A, Lyons C, Hales C, Parry C, Williams C, McCorkle E, Harris G, Rose H, Jooma I, Al-Amin J, Lah J, Webster J, Swiniarski J, Chapman L, Donnelly L, Mariotti L, Locke M, Vaughn P, Penn R, Carpentier S, Yeboah S, Basadre S, Malakauskas S, Lyron S, Villinger T, Burney T, Burns J, Abusalim A, Dahlgren A, Montero A, Arthur A, Dooly H, Kreszyn K, Berner K, Gillen L, Scanlan M, Madison M, Mathis N, Switzer P, Townley R, Fikru S, Sullivan S, Wright E, Beigi M, Daley A, Ko A, Luong B, Nyborg G, Morales J, Durbin K, Garcia L, Parand L, Macias L, Monserratt L, Farchi M, Wu P, Hernandez R, Rodriguez T, Graff-Radford N, Marolt A, Thomas A, Aloszka D, Moncayo E, Westerhold E, Day G, Chrestensen K, Imhansiemhonehi M, McKinzie S, Stephens S, Grant S, Brosch J, Perkins A, Saunders A, Kovac D, Polson H, Mwaura I, Mejia K, Britt K, King K, Nichols K, Lawrence K, Rankin L, Farlow M, Wiesenauer P, Bryant R, Herring S, Lynch S, Wilson S, Day T, Korst W, van Dyck C, Mecca A, Miller A, Brennan A, Khan A, Ruan A, Gunnoud C, Mendonca C, Raynes-Goldfinger D, Salardini E, Hidalgo E, Cooper E, Singh E, Murphy E, May J, Stanhope J, Lam J, Waszak J, Nelsen K, Sacaza K, Hasbani M, Donahue M, Chen M, Barcelos N, Eigenberger P, Bonomi R, O’Dell R, Jefferson S, Khasnavis S, Smilowitz S, DeStefano S, Good S, Camarro T, Clayton V, Cavrel Y, Lu Y, Chertkow H, Bergman H, Hosein C, Black S, Kapadia A, Bhan A, Lam B, Scott C, Gabriel G, Bray J, Zotovic L, Gutierrez M, Masellis M, Farshadi M, Gui M, Mitchell M, Taylor R, Endre R, Taghi-Zada Z, Hsiung R, English C, Kim E, Yau E, Tong H, Barlow L, Jennings L, Assaly M, Nunes P, Marian T, Kertesz A, Rogers J, Trost D, Wint D, Bernick C, Munic D, Grant I, Korkoyah A, Raja A, Lapins A, Ryan C, Pejic J, Basham K, Lukose L, Haddad L, Quinlan L, 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Steinberg E, Denis R, Killiany R, Singh S, Lenio S, Qiu W, Devis Y, Obisesan T, Stone A, Ordor D, Udodong I, Okonkwo I, Khan J, Turner J, Hughes K, Kadiri O, Duffy C, Moss A, Stapleton K, Toth M, Sanders M, Ayres M, Hamski M, Fatica P, Ogrocki P, Ash S, Pot S, Chen D, Soto A, Tanase C, Bissig D, Vanya H, Russell H, Patel H, Zhang H, Wallace K, Ayers K, Gallegos M, Forloines M, Sinn M, Kahulugan Q, Isip R, Calderon S, Hamm T, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Tariot P, Fleisher A, Reeder S, Capote H, Emborsky A, Mattle A, Ajtai B, Wagner B, Myers B, Slazyk D, Fragale D, Fransen E, Macnamara H, Falletta J, Hirtreiter J, Mechtler L, King M, Asbach M, Rainka M, Zawislak R, Wisniewski S, O’Malley S, Jimenez-Knight T, Peehler T, Aladeen T, Bates V, Wenner V, Elmalik W, Scharre D, Ramamurthy A, Bouchachi S, Kataki M, Tarawneh R, Kelley B, Celmins D, Leader A, Figueroa C, Bauerle H, Patterson K, Reposa M, Presto S, Ahmed T, Stewart W, Pearlson G, Blank K, 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Deep learning to quantify the pace of brain aging in relation to neurocognitive changes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2413442122. PMID: 39993207, PMCID: PMC11912385, DOI: 10.1073/pnas.2413442122.Peer-Reviewed Original ResearchConceptsCN adultsBrain agingNeuroanatomical agingLongitudinal modelAdverse cognitive changesChronological ageAlzheimer's diseaseNeurocognitive agingCognitive changesNeurocognitive changesCognitive functionNeurocognitive statusAssociated with changesAge trendsLongitudinal MRIAdultsBrainQuantify DNA methylationAD risk assessmentBlood-brain barrierExamining multimorbidity contributors to dementia over time
Klee M, Markwardt S, Elman M, Han L, Leist A, Allore H, Quiñones A. Examining multimorbidity contributors to dementia over time. Alzheimer's & Dementia 2025, 21: e14589. PMID: 39988573, PMCID: PMC11847647, DOI: 10.1002/alz.14589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDementiaFemaleHumansIncidenceLongitudinal StudiesMaleMedicareMultimorbidityRisk FactorsUnited StatesConceptsAverage attributable fractionDementia incidenceDementia riskAttributable fractionChronic conditionsAssociated with increased risk of dementiaHealth and Retirement Study participantsMedicare fee-for-service beneficiariesAcute myocardial infarctionFee-for-service beneficiariesRetirement Study participantsRisk of dementiaPatterns of comorbiditiesAssociated with increased riskDementia casesMyocardial infarctionClaims algorithmIncident casesADRDStudy participantsIschemic heart diseaseDementiaConfidence intervalsMultimorbidityHeart diseasePalliative Care Initiated in the Emergency Department
Grudzen C, Siman N, Cuthel A, Adeyemi O, Yamarik R, Goldfeld K, Abella B, Bellolio F, Bourenane S, Brody A, Cameron-Comasco L, Chodosh J, Cooper J, Deutsch A, Elie M, Elsayem A, Fernandez R, Fleischer-Black J, Gang M, Genes N, Goett R, Heaton H, Hill J, Horwitz L, Isaacs E, Jubanyik K, Lamba S, Lawrence K, Lin M, Loprinzi-Brauer C, Madsen T, Miller J, Modrek A, Otero R, Ouchi K, Richardson C, Richardson L, Ryan M, Schoenfeld E, Shaw M, Shreves A, Southerland L, Tan A, Uspal J, Venkat A, Walker L, Wittman I, Zimny E. Palliative Care Initiated in the Emergency Department. JAMA 2025, 333: 599-608. PMID: 39813042, PMCID: PMC11836764, DOI: 10.1001/jama.2024.23696.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDecision Support Systems, ClinicalEmergency Service, HospitalFemaleHospitalizationHumansMalePalliative CareConceptsInitiate palliative careLife-limiting illnessHealth care usePalliative carePostintervention periodPreintervention periodMulticomponent interventionCare useEmergency departmentOlder adultsHospital admissionRates of hospice useShort-term mortalitySecondary outcomesRate of hospital admissionsED clinical staffHome health useClinical decision supportNursing home patientsSimulation-based workshopGagne comorbidity scoreRate of admissionRisk of short-term mortalityHospice useIllness communicationPathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening
Sato Y, Torii S, Kawai K, Yahagi K, Kutyna M, Kawakami R, Konishi T, Vozenilek A, Jinnouchi H, Sakamoto A, Mori H, Cornelissen A, Mori M, Tanaka T, Sekimoto T, Kutys R, Ghosh S, Forrest J, Reardon M, Romero M, Kolodgie F, Virmani R, Finn A. Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening. Circulation Cardiovascular Interventions 2025, 18: e014523. PMID: 39965045, PMCID: PMC11827688, DOI: 10.1161/circinterventions.124.014523.Peer-Reviewed Original ResearchConceptsHypoattenuated leaflet thickeningLeaflet thickeningHistological findingsClinical trialsEvaluate histological findingsAortic valve proceduresSelf-expanding transcatheter aortic valvesAortic bioprosthetic valvesAortic valve leafletsInfective endocarditisValve proceduresTranscatheter aortic valveValve thrombosisAortic bioprosthesesSurgical explantationInflammation scoreAortic valveAcute thrombusImplant durationOrganized thrombusBioprosthetic valvesDay groupLeaflet thrombosisThrombusValve leafletsPrognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports
Shin E, Choi J, Hung T, Poon C, Riaz N, Yu Y, Kang J. Prognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports. JCO Clinical Cancer Informatics 2025, 9: e2400177. PMID: 39965177, DOI: 10.1200/cci-24-00177.Peer-Reviewed Original ResearchConceptsProgression-free survivalCancer-specific survivalOropharyngeal cancerHPV testingPathology reportsTreatment de-escalationCurative radiation therapyHPV+ oropharyngeal cancerPrimary end pointMinority of patientsPositive predictive valueStandard-of-careCancer-related deathsIn situ hybridizationStatistically significant differenceP16 statusP16-negativeHPV statusRadiation therapyInferior prognosisOverall survivalConsecutive patientsAcademic cancer centerDiscordant tumorsTreatment deintensification
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