2025
Gender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries
Balkan E, Babbs G, Meyers D, Kelly P, Yee K, Pletta D, Shireman T, Alpert A, Baker K, Hughto J. Gender-Affirming Surgery for Transgender and Gender Diverse Medicare Beneficiaries. JAMA Network Open 2025, 8: e258072. PMID: 40310645, PMCID: PMC12046427, DOI: 10.1001/jamanetworkopen.2025.8072.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCross-Sectional StudiesFemaleHumansMaleMedicareMiddle AgedTransgender PersonsUnited StatesConceptsGender-affirming surgeryTransgender individualsRates of chronic conditionsTransgenderBeneficiaries' useProportion of residentsRegional differencesDual statusBeneficiariesChronic conditionsDiverse beneficiariesBeneficiary characteristicsMedicare beneficiariesGenderCross-sectional studyMedicare entitlementGender-affirming surgical proceduresPropensity score matchingNational Medicare dataMedicare programMedicaidProportion of Medicare beneficiariesSouthSurgical proceduresDescriptive analysisMedicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic
Havlik J, Ghomi R, An N, Budhiraja P, Arzubi E. Medicaid Costs and Outcomes for Patients Treated in an Outpatient Telepsychiatry Clinic. JAMA Network Open 2025, 8: e258558. PMID: 40323598, DOI: 10.1001/jamanetworkopen.2025.8558.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareCross-Sectional StudiesFemaleHealth Care CostsHospitalizationHumansMaleMedicaidMental DisordersMiddle AgedTelemedicineUnited StatesConceptsTelepsychiatry clinicRate of admissionCross-sectional studyMedicaid costsEmergency departmentClinical servicesMedicaid patientsHospitalization ratesTelepsychiatry patientsEvidence of cost savingsReduce hospital admissionsInpatient hospitalization ratesClinic patientsAnnual hospitalization rateOutcomes associated with useTelepsychiatry carePropensity-matched controlsTimely carePsychiatric careMain OutcomesCare costsPMPM costsHospital readmissionInpatient hospitalizationTelepsychiatryConversion Therapy Exposure and Elevated Cardiovascular Disease Risk
Gibb J, Schrock J, Smith M, D’Aquila R, McDade T, Mustanski B. Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk. JAMA Network Open 2025, 8: e258745. PMID: 40327341, DOI: 10.1001/jamanetworkopen.2025.8745.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCardiovascular DiseasesChicagoCohort StudiesCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansMaleSexual and Gender MinoritiesYoung AdultConceptsHigh blood pressureSystolic blood pressureDiastolic blood pressureSelf-reported high blood pressureCohort studyCardiovascular health dataCardiovascular health indicatorsSelf-reported hypertensionSGM health disparitiesMental health impactsCardiovascular health consequencesCardiovascular disease riskBlood pressureElevated diastolic blood pressureHealth disparitiesCare approachElevated systolic blood pressureHealth indicatorsMain OutcomesIncreased DBPBehavioral covariatesHealth dataSGM individualsDisease riskHealth consequencesSocioecological factors linked to co-occurring early childhood sleep health disparities and developmental outcomes: protocol for the sleep in preschoolers cross-sectional study
Uwah E, Cicalese O, Davis B, Neelapu M, Steinberg G, Handa A, Johnson T, Mindell J, Njoroge W, Stefanovski D, Tapia I, Waller R, Williamson A. Socioecological factors linked to co-occurring early childhood sleep health disparities and developmental outcomes: protocol for the sleep in preschoolers cross-sectional study. BMJ Open 2025, 15: e100956. PMID: 40118487, PMCID: PMC11931971, DOI: 10.1136/bmjopen-2025-100956.Peer-Reviewed Original ResearchConceptsInsufficient sleepRacial disparitiesSleep health disparitiesSocioecological factorsBlack/African American childrenSleep deficiencyCross-sectional observational studySocial-emotional functioningAdverse health outcomesFactors associated with variationSleep-disordered breathingCross-sectional studyPeer-reviewed publicationsShort sleep durationHealth disparitiesQualitative themesHealth outcomesSleep disparitiesComprehensive interventionThematic analysisJoint displaysYear old childrenQualitative interviewsChildren's Hospital of PhiladelphiaGroups of BlackLipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoringSerum anti-mullerian hormone levels and age among Samoan women
O’Brien G, Lambert-Messerlian G, Hawley N, Fidow U, Naseri T, Reupena M, Kershaw E, Azar M, Pangburn M, McGarvey S. Serum anti-mullerian hormone levels and age among Samoan women. Reproductive Biology And Endocrinology 2025, 23: 45. PMID: 40108611, PMCID: PMC11921511, DOI: 10.1186/s12958-025-01379-y.Peer-Reviewed Original ResearchConceptsPCOS prevalencePolycystic ovary syndromeSerum anti-Mullerian hormoneAnti-Mullerian hormoneAnti-Mullerian hormone levelsSamoan womenAssociation of anti-Mullerian hormoneContraceptive useBody mass indexSerum anti-mullerian hormone levelsEthnic minority populationsHormonal contraceptive useAMH levelsAssociated with ageFree androgen indexMinority populationsSex hormone binding globulinReproductive healthAssociated with body mass indexSerum total testosteroneAndrogen indexPrevalence of obesityRelated declineTobacco useAdult womenNotch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice
Gaspar R, Macêdo A, Nakandakari S, Muñoz V, Abud G, Vieira R, de Sousa Neto I, Pavan I, da Silva L, Simabuco F, da Silva A, Salgado W, Marchini J, Nonino C, Cintra D, Ropelle E, Pajvani U, de Freitas E, Pauli J. Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice. Liver International 2025, 45: e70068. PMID: 40078075, DOI: 10.1111/liv.70068.Peer-Reviewed Original ResearchConceptsNotch1 signalingAerobic exerciseRegulation of hepatic glucoseObese miceImpact of aerobic exerciseEffects of Notch1 signalingAerobic exercise trainingMTORC1 pathway activationNotch1 pathwayObese individualsTissue of obese miceCross-sectional studyNotch1 mRNA levelsMitochondrial respirationExercise trainingLivers of obese individualsTreadmill runningGluconeogenic enzymesHepG2 cell lineLipid accumulationTraining groupHepatic glucoseHepatic metabolismNotch1 proteinPathway activationEvaluating community knowledge of tuberculosis preventive therapy in rural South Africa
Foppiano Palacios C, Moll A, Shrestha R, Kompala T, Davis J, Charalambous S, Chimoyi L, Chihota V, Andrews L, Shenoi S. Evaluating community knowledge of tuberculosis preventive therapy in rural South Africa. BMC Public Health 2025, 25: 918. PMID: 40055618, DOI: 10.1186/s12889-025-21719-2.Peer-Reviewed Original ResearchConceptsKnowledge of TBTB knowledgeExploratory factor analysisCommunity membersPublic health educationRural South AfricaCross-sectional studyPreventive therapyTuberculosis preventive therapyMultivariate linear regressionLinear regressionHealth educationChi-square testMedian scoreCounseling effortsCommunity eventsDescriptive statisticsEvaluate knowledgeTesting initiativesCultural beliefsTB incidenceCommunity knowledgeKwaZulu NatalSouth AfricaFactor analysisBrain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsAdaptation and validation of perceived HIV and TB stigma scales among persons with TB.
Ponticiello M, Nanziri L, Hennein R, Ochom E, Gupta A, Turimumahoro P, White M, Armstrong-Hough M, Katamba A, Davis J. Adaptation and validation of perceived HIV and TB stigma scales among persons with TB. The International Journal Of Tuberculosis And Lung Disease 2025, 29: 127-134. PMID: 40052658, DOI: 10.5588/ijtld.24.0497.Peer-Reviewed Original ResearchConceptsPerceived social supportSocial supportTB stigma scaleConvergent validityCommunity health workersAssess convergent validityEvaluate internal validityTB-affected householdsExperiences of personsCross-sectional studyInternal validityMultidisciplinary research teamMeasure stigmaOne-factor solutionTB stigmaStigma ScaleHIV ScaleHIV stigmaEvidence of convergent validityHealth workersFactor analysisExploratory factor analysisCognitive interviewsPsychometric propertiesMarginal model fitWorkplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies
Duah E, Ephraim R, Kotam G, Kumordzi S, Amoah S, Addy N, Kwashie S, Rahamani A. Workplace bullying among medical laboratory professionals in Ghana: insights from self-reported experiences, challenges to mitigation structures, and coping strategies. BMC Health Services Research 2025, 25: 310. PMID: 40001166, PMCID: PMC11853304, DOI: 10.1186/s12913-025-12458-6.Peer-Reviewed Original ResearchConceptsMedical laboratory professionalsLaboratory professionalsPatient careConfidence intervalsCross-sectional surveyRevised Negative Acts QuestionnaireSelf-reported experiencesBackgroundWorkplace bullyingNegative Acts QuestionnaireConclusionThe high prevalenceWorkplace bullyingHealthcare professionalsUrban counterpartsBachelor's degree holdersDegree holdersHigher oddsNAQ-RCoping strategiesOdds ratioRural professionalsActs QuestionnaireLogistic regressionDemographic informationProfessionalsWorkplace characteristicsDeep learning to quantify the pace of brain aging in relation to neurocognitive changes
Yin C, Imms P, Chowdhury N, Chaudhari N, Ping H, Wang H, Bogdan P, Irimia A, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Landau S, Rivera-Mindt M, Okonkwo O, Shaw L, Lee E, Toga A, Beckett L, Harvey D, Green R, Saykin A, Nho K, Perrin R, Tosun D, Sachdev P, Green R, Drake E, Montine T, Conti C, Weiner M, Nosheny R, Truran Sacrey D, Fockler J, Miller M, Conti C, Kwang W, Jin C, Diaz A, Ashford M, Flenniken D, Kormos A, Petersen R, Aisen P, Rafii M, Raman R, Jimenez G, Donohue M, Salazar J, Fidell A, Boatwright V, Robison J, Zimmerman C, Cabrera Y, Walter S, Clanton T, Shaffer E, Webb C, Hergesheimer L, Smith S, Ogwang S, Adegoke O, Mahboubi P, Pizzola J, Jenkins C, Beckett L, Harvey D, Donohue M, Saito N, Diaz A, Hussen K, Okonkwo O, Rivera-Mindt M, Amaza H, Thao M, Parkins S, Ayo O, Glittenberg M, Hoang I, Germano K, Strong J, Weisensel T, Magana F, Thomas L, Guzman V, Ajayi A, Di Benedetto J, Talavera S, Jack C, Felmlee J, Fox N, Thompson P, DeCarli C, Forghanian-Arani A, Borowski B, Reyes C, Hedberg C, Ward C, Schwarz C, Reyes D, Gunter J, Moore-Weiss J, Kantarci K, Matoush L, Senjem M, Vemuri P, Reid R, Malone I, Thomopoulos S, Nir T, Jahanshad N, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Rossi Chen S, Choe M, Crawford K, Yushkevich P, Das S, Jagust W, Landau S, Koeppe R, Rabinovici G, Villemagne V, LoPresti B, Perrin R, Morris J, Franklin E, Bernhardt H, Cairns N, Taylor-Reinwald L, Shaw L, Lee E, Lee V, Korecka M, Brylska M, Wan Y, Trojanowki J, Toga A, Crawford K, Neu S, Saykin A, Nho K, Foroud T, Jo T, Risacher S, Craft H, Apostolova L, Nudelman K, Faber K, Potter Z, Lacy K, Kaddurah-Daouk R, Shen L, Karlawish J, Erickson C, Grill J, Largent E, Harkins K, Weiner M, Thal L, Kachaturian Z, Frank R, Snyder P, Buckholtz N, Hsiao J, Ryan L, Molchan S, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Perrin R, Ryan L, Silverberg N, Silbert L, Kaye J, White S, Pierce A, Thomas A, Clay T, Schwartz D, Devereux G, Taylor J, Ryan J, Nguyen M, DeCapo M, Shang Y, Schneider L, Munoz C, Ferman D, Conant C, Martin K, Oleary K, Pawluczyk S, Trejo E, Dagerman K, Teodoro L, Becerra M, Fairooz M, Garrison S, Boudreau J, Avila Y, Brewer J, Jacobson A, Gama A, Kim C, Little E, Frascino J, Ferng N, Trujillo S, Heidebrink J, Koeppe R, MacDonald S, Malyarenko D, Ziolkowski J, O’Connor J, Robert N, Lowe S, Rogers V, Petersen R, Hackenmiller B, Boeve B, Albers C, Kreuger C, Jones D, Knopman D, Botha H, Magnuson J, Graff-Radford J, Crawley K, Schumacher M, McKinzie S, Smith S, Helland T, Lowe V, Ramanan V, Pavlik V, Faircloth J, Bishop J, Nath J, Chaudhary M, Kataki M, Yu M, Pacini N, Barker R, Brooks R, Aggarwal R, Honig L, Stern Y, Mintz A, Cordona J, Hernandez M, Long J, Arnold A, Groves A, Middleton A, Vogler B, McCurry C, Mayo C, Raji C, Amtashar F, Klemp H, Elmore H, Ruszkiewicz J, Kusuran J, Stewart J, Horenkamp J, Greeson J, Wever K, Vo K, Larkin K, Rao L, Schoolcraft L, Gallagher L, Paczynski M, McMillan M, Holt M, Gagliano N, Henson R, LaBarge R, Swarm R, Munie S, Cepeda S, Winterton S, Hegedus S, Wilson T, Harte T, Bonacorsi Z, Geldmacher D, Watkins A, Barger B, Smelser B, Bates C, Stover C, McKinley E, Ikner G, Hendrix H, Cooper H, Mahaffey J, Booth Robbins L, Brown Ashley L, Natelson-Love M, Carter P, Solomon V, Grossman H, Groome A, Ardolino A, Kaplan A, Sheppard F, Burgos-Rivera G, Garcia-Camilo G, Lim J, Neugroschl J, Jackson K, Evans K, Soleimani L, Sano M, Ghesani N, Binder S, Apuango X, Sood A, Troutman A, Blanchard K, Richards A, Nelson G, Hendrickson K, Yurko E, Plenge J, Rufo V, Shah R, Duara R, Lynch B, Chirinos C, Dittrich C, Campbell D, Mejia D, Perez G, Colvee H, Gonzalez J, Gondrez J, Knaack J, Acevedo M, Cereijo M, Greig-Custo M, Villar M, Wishnia M, Detling S, Barker W, Albert M, Moghekar A, Rodzon B, Demsky C, Pontone G, Pekar J, Farrington L, Pomper M, Johnson N, Alo T, Sadowski M, Ulysse A, Masurkar A, Marti B, Mossa D, Geesey E, Petrocca E, Schulze E, Wong J, Boonsiri J, Kenowsky S, Martinez T, Briglall V, Doraiswamy P, Nwosu A, Adhikari A, Hellegers C, Petrella J, James O, Wong T, Hawk T, Vaishnavi S, McCoubrey H, Nasrallah I, Rovere R, Maneval J, Robinson E, Rivera F, Uffelman J, Combs M, O’Donnell P, Manning S, King R, Nieto A, Glueck A, Mandal A, Swain A, Gamble B, Meacham B, Forenback D, Ross D, Cheatham E, Hartman E, Cornell G, Harp J, Ashe L, Goins L, Watts L, Yazell M, Mandal P, Buckler R, Vincent S, Rudd T, Lopez O, Malia A, Chiado C, Zik C, Ruszkiewicz J, Savage K, Fenice L, Oakley M, Tacey P, Berman S, Bowser S, Hegedus S, Saganis X, Porsteinsson A, Mathewson A, Widman A, Holvey B, Clark E, Morales E, Young I, Ruszkiewicz J, Hopkins K, Martin K, Kowalski N, Hunt R, Calzavara R, Kurvach R, D’Ambrosio S, Thai G, Vides B, Lieb B, McAdams-Ortiz C, Toso C, Mares I, Moorlach K, Liu L, Corona M, Nguyen M, Tallakson M, McDonnell M, Rangel M, Basheer N, Place P, Romero R, Tam S, Nguyen T, Thomas A, Frolov A, Khera A, Browning A, Kelley B, Dawson C, Mathews D, Most E, Phillips E, Nguyen L, Nunez M, Miller M, Jones M, Martinez N, Logan R, McColl R, Pham S, Fox T, Moore T, Levey A, Brown A, Kippels A, Ellison A, Lyons C, Hales C, Parry C, Williams C, McCorkle E, Harris G, Rose H, Jooma I, Al-Amin J, Lah J, Webster J, Swiniarski J, Chapman L, Donnelly L, Mariotti L, Locke M, Vaughn P, Penn R, Carpentier S, Yeboah S, Basadre S, Malakauskas S, Lyron S, Villinger T, Burney T, Burns J, Abusalim A, Dahlgren A, Montero A, Arthur A, Dooly H, Kreszyn K, Berner K, Gillen L, Scanlan M, Madison M, Mathis N, Switzer P, Townley R, Fikru S, Sullivan S, Wright E, Beigi M, Daley A, Ko A, Luong B, Nyborg G, Morales J, Durbin K, Garcia L, Parand L, Macias L, Monserratt L, Farchi M, Wu P, Hernandez R, Rodriguez T, Graff-Radford N, Marolt A, Thomas A, Aloszka D, Moncayo E, Westerhold E, Day G, Chrestensen K, Imhansiemhonehi M, McKinzie S, Stephens S, Grant S, Brosch J, Perkins A, Saunders A, Kovac D, Polson H, Mwaura I, Mejia K, Britt K, King K, Nichols K, Lawrence K, Rankin L, Farlow M, Wiesenauer P, Bryant R, Herring S, Lynch S, Wilson S, Day T, Korst W, van Dyck C, Mecca A, Miller A, Brennan A, Khan A, Ruan A, Gunnoud C, Mendonca C, Raynes-Goldfinger D, Salardini E, Hidalgo E, Cooper E, Singh E, Murphy E, May J, Stanhope J, Lam J, Waszak J, Nelsen K, Sacaza K, Hasbani M, Donahue M, Chen M, Barcelos N, Eigenberger P, Bonomi R, O’Dell R, Jefferson S, Khasnavis S, Smilowitz S, DeStefano S, Good S, Camarro T, Clayton V, Cavrel Y, Lu Y, Chertkow H, Bergman H, Hosein C, Black S, Kapadia A, Bhan A, Lam B, Scott C, Gabriel G, Bray J, Zotovic L, Gutierrez M, Masellis M, Farshadi M, Gui M, Mitchell M, Taylor R, Endre R, Taghi-Zada Z, Hsiung R, English C, Kim E, Yau E, Tong H, Barlow L, Jennings L, Assaly M, Nunes P, Marian T, Kertesz A, Rogers J, Trost D, Wint D, Bernick C, Munic D, Grant I, Korkoyah A, Raja A, Lapins A, Ryan C, Pejic J, Basham K, Lukose L, Haddad L, Quinlan L, Houghtaling N, Sadowsky C, Martinez W, Villena T, Reynolds B, Forero A, Ward C, Brennan E, Figueroa E, Esposito G, Mallory J, Johnson K, Turner K, Seidenberg K, McCann K, Bassett M, Chadwick M, Turner R, Bean R, Sharma S, Marshall G, Haviari A, Pietras A, Wallace B, Munro C, Rivera-Delpin G, Hustead H, Levesque I, Ramirez J, Nolan K, Glennon K, Palou M, Erkkinen M, DaSilva N, Friedman P, Silver R, Salazar R, Polleys R, McGinnis S, Gale S, Hall T, Luu T, Chao S, Lin E, Coleman J, Epperson K, Vasanawala M, Atri A, Rangel A, Evans B, Monarrez C, Cline C, Liebsack C, Bandy D, Goldfarb D, Intorcia D, Olgin J, Clark K, King K, York K, Reade M, Callan M, Glass M, Johnson M, Gutierrez M, Goddard M, Trncic N, Choudhury P, Reyes P, Lowery S, Hall S, Olgin S, de Santiago S, Alosco M, Ton A, Jimenez A, Ellison A, Tran A, Anderson B, Carter D, Veronelli D, Lenio S, Steinberg E, Mez J, Weller J, Johns J, Mez J, Harkins J, Puleio A, Hoti I, Mwicigi J, Puleio A, Alosco M, Schultz O, Lauture M, Steinberg E, Denis R, Killiany R, Singh S, Lenio S, Qiu W, Devis Y, Obisesan T, Stone A, Ordor D, Udodong I, Okonkwo I, Khan J, Turner J, Hughes K, Kadiri O, Duffy C, Moss A, Stapleton K, Toth M, Sanders M, Ayres M, Hamski M, Fatica P, Ogrocki P, Ash S, Pot S, Chen D, Soto A, Tanase C, Bissig D, Vanya H, Russell H, Patel H, Zhang H, Wallace K, Ayers K, Gallegos M, Forloines M, Sinn M, Kahulugan Q, Isip R, Calderon S, Hamm T, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Tariot P, Fleisher A, Reeder S, Capote H, Emborsky A, Mattle A, Ajtai B, Wagner B, Myers B, Slazyk D, Fragale D, Fransen E, Macnamara H, Falletta J, Hirtreiter J, Mechtler L, King M, Asbach M, Rainka M, Zawislak R, Wisniewski S, O’Malley S, Jimenez-Knight T, Peehler T, Aladeen T, Bates V, Wenner V, Elmalik W, Scharre D, Ramamurthy A, Bouchachi S, Kataki M, Tarawneh R, Kelley B, Celmins D, Leader A, Figueroa C, Bauerle H, Patterson K, Reposa M, Presto S, Ahmed T, Stewart W, Pearlson G, Blank K, Anderson K, Santulli R, Schwartz E, Williamson J, Jessup A, Williams A, Duncan C, O’Connell A, Gagnon K, Zamora E, Bateman J, Crawford F, Thompson D, Walker E, Rowell J, White M, Ledford P, Bohlman S, Henkle S, Bottoms J, Moretz L, Hoover B, Shannon M, Rogers S, Baker W, Harrison W, Wu C, DeMarco A, Stipanovich A, Arcuri D, Clark J, Davis J, Doyon K, Amoyaw M, Acosta M, Bailey R, Warren S, Fogerty T, Sanborn V, Riddle M, Salloway S, Malloy P, Correia S, Windon C, Blackburn M, Rosen H, Miller B, Smith A, Mba I, Echevarria J, Janavs J, Roglaski E, Yong M, Devine R, Okhravi H, Rivera E, Kalowsky T, Smith C, Rosario C, Masdeu J, Le R, Gurung M, Sabbagh M, Garcia A, Ellis Slaughter M, Elayan N, Acothley S, Pomara N, Hernando R, Pomara V, Reichert C, Brawman-Mintzer O, Acree A, Williams A, Long C, Long R, Newhouse P, Hill S, Boegel A, Seshadri S, Saklad A, Jones F, Hu W, Sotelo V, Gonazalez Rojas Y, Mintzer J, Flynn Longmire C, Spicer K. Deep learning to quantify the pace of brain aging in relation to neurocognitive changes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2413442122. PMID: 39993207, PMCID: PMC11912385, DOI: 10.1073/pnas.2413442122.Peer-Reviewed Original ResearchConceptsCN adultsBrain agingNeuroanatomical agingLongitudinal modelAdverse cognitive changesChronological ageAlzheimer's diseaseNeurocognitive agingCognitive changesNeurocognitive changesCognitive functionNeurocognitive statusAssociated with changesAge trendsLongitudinal MRIAdultsBrainQuantify DNA methylationAD risk assessmentBlood-brain barrierInternational perspectives on physician knowledge, attitudes, and practices related to medical cannabis
Syed S, Singh J, Elkholy H, Palavra I, Tomicevic M, Eric A, da Costa M, Guloksuz S, Radhakrishnan R. International perspectives on physician knowledge, attitudes, and practices related to medical cannabis. Frontiers In Public Health 2025, 13: 1463871. PMID: 40051509, PMCID: PMC11882600, DOI: 10.3389/fpubh.2025.1463871.Peer-Reviewed Original ResearchConceptsPhysicians' knowledgeStrength of evidenceMedical cannabisCross-sectional survey of physiciansSurvey of physiciansCross-sectional surveyYears of clinical experienceNegative health outcomesCannabis useClinical experienceRefractory chronic neuropathic painClinical decision-makingHealth outcomesPhysicians' attitudesPhysicians' willingnessChronic neuropathic painMedical use of cannabisRisk of psychosisDaily cannabis useMedication useDescriptive statisticsRisk of addictionMedical indicationsUse of cannabisPhysiciansMotives for pornography use and women's sexual wellbeing: Insights from a 42-country study.
Gewirtz-Meydan A, Feder H, Nagy L, Koós M, Kraus S, Demetrovics Z, Potenza M, Ballester-Arnal R, Batthyány D, Bergeron S, Billieux J, Briken P, Burkauskas J, Cárdenas-López G, Carvalho J, Castro-Calvo J, Chen L, Ciocca G, Corazza O, Csako R, Fernandez D, Fernandez E, Fujiwara H, Fuss J, Gabrhelík R, Gjoneska B, Gola M, Grubbs J, Hashim H, Islam M, Ismail M, Jiménez-Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee C, Lee S, Lewczuk K, Lin C, Lochner C, López-Alvarado S, Lukavská K, Mayta-Tristán P, Miller D, Orosová O, Orosz G, _ _, Ponce F, Quintana G, Quintero Garzola G, Ramos-Diaz J, Rigaud K, Rousseau A, De Tubino Scanavino M, Schulmeyer M, Sharan P, Shibata M, Shoib S, Sigre-Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Strizek J, Štulhofer A, Ünsal B, Vaillancourt-Morel M, Van Hout M, Bőthe B. Motives for pornography use and women's sexual wellbeing: Insights from a 42-country study. Journal Of Behavioral Addictions 2025, 14: 114-130. PMID: 39945771, DOI: 10.1556/2006.2024.00040.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCross-Sectional StudiesEroticaFemaleHumansLibidoMiddle AgedMotivationPersonal SatisfactionSexual BehaviorYoung AdultConceptsPornography useSexual wellbeingWomen's motivationsSexual desireLack of sexual satisfactionSexual satisfactionSexual function problemsSelf-report survey designGrowing body of researchPornography use motivationsWomen's sexual wellbeingBody of researchPornographyHigher sexual desireSexual curiosityWellbeingMeasures of sexual functionMultifaceted natureParticipant ageWomenGrowing bodySurvey designLongitudinal designDesireParticipantsRisk Factors and Hospitalizations Associated with Pediatric Adenovirus and Rotavirus Infections in Northern Lebanon
Khalife S, Osman M, Moubayed S, Kassem I, Safadi D. Risk Factors and Hospitalizations Associated with Pediatric Adenovirus and Rotavirus Infections in Northern Lebanon. Medicina 2025, 61: 296. PMID: 40005411, PMCID: PMC11857655, DOI: 10.3390/medicina61020296.Peer-Reviewed Original ResearchConceptsAcute gastroenteritisRotavirus infectionRisk factorsSusceptibility to rotavirus infectionAssociated with breastfeedingBurden of rotavirusInfection rateLevel of maternal educationCross-sectional studyClinical dataRotavirus vaccinePediatric departmentFrequent viral agentsPediatric morbidityStool samplesLow infection rateTargeted public health interventionsChromatographic immunoassayNorth LebanonViral agentsInfectionProtective effectAdenovirusMaternal educationRotavirusAssociation of workforce participation with depression among US older adults: results from NHANES 2005–2018
Sun Z, Wang Y, Chen X, Qian D. Association of workforce participation with depression among US older adults: results from NHANES 2005–2018. BMC Geriatrics 2025, 25: 77. PMID: 39905307, PMCID: PMC11792604, DOI: 10.1186/s12877-025-05712-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesDepressionEmploymentFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesConceptsNational Health and Nutrition Examination SurveyUS older adultsPHQ-9 scoresOlder adultsDepression riskLogistic regression modelsWorkforce participationPatient Health Questionnaire-9 itemsWork statusHealth and Nutrition Examination SurveyAnalysis of subgroupsRegular daytimeMethodsThis cross-sectional studyNutrition Examination SurveyPrevalence of depressionDecrease depression riskPotential reverse causationRegression modelsCross-sectional studyNon-linear associationInstrumental variablesPHQ-9Propensity score matchingExamination SurveyReverse causationPatient-reported strategies for prevention and treatment of chemotherapy-induced peripheral neuropathy
Hertz D, Tanay M, Tofthagen C, Rossi E, Bernasconi D, Sheffield K, Carlson M, Nekhlyudov L, Grech L, Von Ah D, Mayo S, Ruddy K, Chan A, Alberti P, Lustberg M. Patient-reported strategies for prevention and treatment of chemotherapy-induced peripheral neuropathy. Supportive Care In Cancer 2025, 33: 142. PMID: 39899120, DOI: 10.1007/s00520-025-09190-6.Peer-Reviewed Original ResearchConceptsSelf-reported peripheral neuropathyCross-sectional online surveyGuideline-recommended strategyEvidence of effectivenessNon-prescribed medicationTreating CIPNPurposeChemotherapy-induced peripheral neuropathyChemotherapy-induced peripheral neuropathyPeripheral neuropathyClinical teamStrategies patientsPrescription medicationsNeurotoxic chemotherapy treatmentMultinational AssociationDescriptive statisticsPrescribed medicationsSurvey participantsPrevention strategiesGuideline-recommendedTreatment of chemotherapy-induced peripheral neuropathyOnline surveyCIPNDebilitating toxicityImprove treatment outcomesMedicationThe Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students
Kersh L, Serrato P, Anderson C, Raguveer V, Peck C, Ally S, Gondi I, Subhedar S, Rollins A, Hauser B, Jayaram A, Hill S, Wariso B, Rehman S, Alliance G, Clune J. The Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students. Journal Of Surgical Education 2025, 82: 103441. PMID: 39894006, DOI: 10.1016/j.jsurg.2025.103441.Peer-Reviewed Original ResearchConceptsMedical school experienceGlobal surgeryMedical studentsMedical schoolsSurgical mission tripsCross-sectional survey studyAssociated with lower oddsMission tripsAssociated with increased oddsMedical school curriculumGlobal health researchU.S. medical studentsCareer planningSurgery researchGlobal surgery educationResponding medical studentsMultivariate regression modelHealth researchSurgery opportunitiesLower oddsSchool experiencesSurgeryOddsSurgery educationMedical institutionsAssociations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study
Bailey M, Fairchild G, Hammerton G, Bauer A, Carpena M, Murray J, Santos I, Barros A, Tovo-Rodrigues L, Danese A, Halligan S, Matijasevich A. Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study. The Lancet Global Health 2025, 13: e309-e318. PMID: 39890231, DOI: 10.1016/s2214-109x(24)00452-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdverse Childhood ExperiencesBirth CohortBrazilChildCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMental DisordersConceptsLow-income and-middle-income countriesPopulation attributable fractionPelotas Birth CohortAdolescent psychiatric disordersAnxiety disordersPsychiatric disordersTrauma exposureCumulative traumaBirth cohortLongitudinal associationsChildhood traumaMood disordersComputed population attributable fractionsTrauma loadPopulation-based birth cohort studyMental disordersRisk of mental disordersAnd Middle-Income CountriesExposure to childhood traumaPrevalence of trauma exposureAssociated with increased oddsAssociated with mental disordersBirth cohort studyIncreased exposure to traumaBurden of traumaEvidence for alpha-synuclein aggregation in older individuals with hyposmia: a cross-sectional study
Marek K, Russell D, Concha-Marambio L, Choi S, Jennings D, Brumm M, Coffey C, Brown E, Seibyl J, Stern M, Soto C, Siderowf A. Evidence for alpha-synuclein aggregation in older individuals with hyposmia: a cross-sectional study. EBioMedicine 2025, 112: 105567. PMID: 39893720, PMCID: PMC11835612, DOI: 10.1016/j.ebiom.2025.105567.Peer-Reviewed Original ResearchConceptsDementia with Lewy bodiesCross-sectional studyCognitive symptomsParkinson Associated Risk Syndrome StudyPrevention StudyYear follow-upOlder individualsDopamine transporter imagingHigh riskSyndrome studiesParticipantsParkinson's diseaseHyposmic individualsFollow-upSynuclein pathologySymptomsHyposmicsDepartment of DefenseU.S. Department of DefenseIndividualsRiskLewy bodiesClinical parkinsonismMichael J. Fox FoundationDementia
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