2025
Quantifying associations between socio-spatial factors and cognitive development in the ABCD cohort
Osayande N, Marotta J, Aggarwal S, Kopal J, Holmes A, Yip S, Bzdok D. Quantifying associations between socio-spatial factors and cognitive development in the ABCD cohort. Nature Computational Science 2025, 5: 221-233. PMID: 40114020, DOI: 10.1038/s43588-025-00774-0.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive Development StudyCognitive developmentUS Census dataCognitive Development StudyBayesian multilevel regressionPost-stratificationSocio-spatial factorsSociodemographic disparitiesSocioeconomic statusABCD cohortSociodemographic variablesBayesian multilevel modelsQuantify associationsInter-individual differencesMultilevel regressionPublic healthMultilevel modelsCensus dataInterpretation of model predictionsDemographic groupsDevelopment studiesHolistic explanationHomogeneous representationModeling frameworkMounting demandATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Slusher A, Santoro N, Vash-Margita A, Galderisi A, Hu P, Tokoglu F, Li Z, Tarabra E, Strober J, Vatner D, Shulman G, Caprio S. ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis. Journal Of Clinical Investigation 2025, 135: e184740. PMID: 40091831, PMCID: PMC11910223, DOI: 10.1172/jci184740.Peer-Reviewed Original ResearchConceptsHyperinsulinemic-euglycemic clampSubcutaneous adipose tissueInsulin resistanceAdipose triglyceride lipaseInsulin infusionOral glucose tolerance testAbdominal fat distributionGlucose tolerance testMeasuring abdominal fat distributionLower liver fatActivating adipose triglyceride lipaseMetabolic disease riskLiver fat contentEctopic lipid storageFUNDINGThis workAdipose tissue lipolysisInhibition of adipose tissue lipolysisSubcutaneous adipose tissue samplesFat distributionTolerance testInsulin exposureLiver fatInfusionGlycerol turnoverAdipose tissueIdentifying the Financial Toxicity Experiences of Childhood Cancer Survivors Through Partnership With a Community Organization Serving Rural and Minoritized Families
Benedict C, Bloomer K, Billman E, Smith M, Boynton H, Schapira L, Smith S. Identifying the Financial Toxicity Experiences of Childhood Cancer Survivors Through Partnership With a Community Organization Serving Rural and Minoritized Families. Psycho-Oncology 2025, 34: e70120. PMID: 40097346, DOI: 10.1002/pon.70120.Peer-Reviewed Original ResearchConceptsAYA survivors of childhood cancerSurvivors of childhood cancerChildhood cancerAYA survivorsFinancial toxicityAdolescent/young adultPerspectives of staff membersNon-English language preferenceStaff membersCancer support organizationsThematic analysis approachCommunity-based organizationsRural regionsParental employmentIndirect medical costsNeeds assessment studySemi-structured interviewsMedical visitsVulnerable populationsLanguage preferenceInsurance coverageMedical costsQualitative dataRural areasMinoritized familiesThe Effect of a Brief Medical Huddle on Patient and Family Experience During Rounds.
Osborn R, Boolchandani H, Bennett A, Beagan R, Yankova L, Butala N, Collette H. The Effect of a Brief Medical Huddle on Patient and Family Experience During Rounds. Hospital Pediatrics 2025, 15: 318-324. PMID: 40068809, DOI: 10.1542/hpeds.2024-007998.Peer-Reviewed Original ResearchConceptsPatient- and family-centered roundsPre-intervention periodPostintervention periodFamily experiencesFamily satisfactionFamily-centered rounds encounterFamily-centered roundsGeneral inpatient settingQuasi-experimental designPrimary outcome measureRounding encountersLikert scale surveyInpatient settingPostinterventionRound timeMean scoreOutcome measuresPrimary outcomeTeam membersParental interestHuddlingScale surveyHospitalized childrenDoctorsSatisfactionPerinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)
Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, DOI: 10.1186/s12940-025-01159-6.Peer-Reviewed Original ResearchConceptsHispanic childrenSarcoma riskControls frequency-matched to casesFrequency-matched to casesBirth yearPopulation-based case-control studyOdds ratioPM2.5 exposureConfidence intervalsAir pollution exposureCalifornia birth cohortNon-Hispanic childrenAmbient PM2.5 exposureFine particle air pollutionCase-control studyAmbient fine particulate matterHigher PM2.5 levelsMaternal residenceCancer riskMaternal educationPotential disparitiesBirth cohortHispanic ethnicityElevated oddsLinkage studiesSystemic Therapies for Pediatric Alopecia Areata
Kalil L, Welch D, Heath C, Craiglow B. Systemic Therapies for Pediatric Alopecia Areata. Pediatric Dermatology 2025, 42: 36-42. PMID: 40044621, DOI: 10.1111/pde.15822.Peer-Reviewed Original ResearchConceptsAlopecia areataSystemic therapyPediatric alopecia areataAutoimmune hair loss disorderJanus kinase inhibitorsHair loss disorderComorbid atopyOral minoxidilLong-term useSystemic corticosteroidsTopical therapySystemic treatmentPediatric AACase reportAdjunctive treatmentMild diseaseKinase inhibitorsImmunomodulatory medicinesTherapyExtensive involvementAdverse effectsNarrative reviewAreataPatientsTreatmentGlobal, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021
Collaborators G, Kerr J, Patton G, Cini K, Abate Y, Abbas N, Al Magied A, ElHafeez S, Abd-Elsalam S, Abdollahi A, Abdoun M, Abdulah D, Abdulkader R, Abdullahi A, Abeywickrama H, Abie A, Abiodun O, Abohashem S, Abtahi D, Abualruz H, Abubakar B, Abu-Gharbieh E, Abukhadijah H, Abu-Rmeileh N, Aburuz S, Abu-Zaid A, Adams L, Adane M, Addo I, Adedokun K, Adegoke N, Adesola R, Adetunji J, Adeyeoluwa T, Adiga U, Adnani Q, Afify A, Afolabi A, Afzal M, Afzal S, Agampodi S, Aghamiri S, Sobrinho C, Agyemang-Duah W, Ahinkorah B, Ahlstrom A, Ahmad A, Ahmad D, Ahmad F, Ahmad M, Ahmad N, Ahmad S, Ahmed A, Ahmed H, Ahmed L, Ahmed M, Ahmed M, Ahmed S, Ajami M, Akkaif M, Akrami A, Al Hamad H, Al Hasan S, Al Ta'ani Z, Al Thaher Y, Alalwan T, Al-Aly Z, Alam K, Al-amer R, Alansari A, Al-Ashwal F, Albashtawy M, Alemayehu B, Algammal A, Alhabib K, Alhuwail D, Ali A, Ali E, Ali M, Ali M, Ali R, Ali W, Alif M, Alimohamadi Y, Al-Jabi S, Aljofan M, Aljunid S, Alkhatib A, Almahmeed W, Al-Marwani S, Alomari M, Alqahtani S, Alqarni A, Alrawashdeh A, Alrimawi I, Alrousan S, Alshahrani N, Altaany Z, Altaf A, Alvi F, Alvis-Guzman N, Al-Wardat M, Al-Worafi Y, Aly H, Aly S, Alzoubi K, Mohammadi M, Amera T, Amiri S, Amu H, Amugsi D, Amusa G, Ananda R, Ancuceanu R, Ansari M, Ansari S, Anuoluwa B, Anuoluwa I, Anvari S, Anwar S, Anyasodor A, Arab J, Arabloo J, Arafat M, Aravkin A, Areda D, Aregawi B, Arifin H, Armocida B, Ärnlöv J, Arooj M, Arora A, Artamonov A, Artanti K, Arumugam A, Asghari-Jafarabadi M, Ashraf T, Asiamah-Asare B, Astell-Burt T, Athari S, Atorkey, Atreya A, Aumoldaeva Z, Awoke M, Awotidebe A, Aychiluhm S, Azimi A, Aziz S, Aziz S, Azzam A, Azzolino D, Babashahi M, Babu G, Badran A, Bagheri N, Bai R, Baig A, Bakkannavar S, Balakrishnan S, Baltatu O, Bam K, Banik R, Barati S, Bardhan M, Barqawi H, Barquera S, Barrow A, Barua L, Bastan M, Basu S, Bayat R, Bayih M, Bayleyegn N, Beeraka N, Behera P, Ramirez D, Bello U, Belo L, Bennett D, Bergami M, Berhe K, Berihun A, Bhadoria A, Bhala N, Bharadwaj R, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhat A, Bhattacharjee P, Bhatti G, Bhatti J, Bilgin C, Bisignano C, Biswas B, Peroni B, Bjertness E, Bjørge T, Boloor A, Boppana S, Bosoka S, Bouaoud S, Boyko E, Braithwaite D, Brazo-Sayavera J, Brenner H, Bryazka D, Bugiardini R, Bui L, Bustanji Y, Butt N, Butt Z, Barsbay M, Calina D, Cámera L, Campos L, Cao S, Capodici A, Carletti C, Carvalho A, Carvalho M, Cattafesta M, Cattaruzza M, Cegolon L, Cembranel F, Cerin E, Cernigliaro A, Chadwick J, Chakraborty C, Chandrasekar E, Chang J, Chattu V, Chaudhary A, Chaurasia A, Chen A, Chen H, Chew N, Chi G, Chimoriya R, Ching P, Chitheer A, Choi D, Chong B, Chong C, Chopra H, Chopra S, Chou H, Choudhari S, Chung S, Chung S, Chutiyami M, Cogen R, Columbus A, Conrad N, Criqui M, Cruz-Martins N, da Silva A, Dadras O, Dai X, Dalakoti M, D'Amico E, Dandona L, Dandona R, D'Anna L, Danpanichkul P, Darcho S, Soltani R, Dash N, Davletov K, Dehghan A, Denova-Gutiérrez E, Molla M, Dergaa I, Desale A, Devanbu V, Devegowda D, Dhali A, Dhungel B, Diaz D, Dinu M, Chi T, do Prado C, Dodangeh M, Doegah P, Dohare S, Dokova K, Doku P, Dolatkhah N, D'Oria M, Dorostkar F, Doshi O, Doshi R, Dowou R, Du M, Dumith S, Dumuid D, Duncan B, Dutta S, Ebrahimi A, Edvardsson K, Sedeh A, Ekholuenetale M, Arab R, Bayoumy I, Eladl M, El-Ashker S, Elbarazi I, Elgendy I, Elhadi M, El-Metwally A, Elmonem M, Elnaem M, Elsheikh R, Eltaha C, Emeto T, Eslami M, Fabin N, Fadavian H, Fagbamigbe A, Fakhradiyev I, Faraji S, Farinha C, Faris M, Faris P, Kouhanjani M, Farooque U, Farrokhpour H, Fasusi S, Fazeli P, Fazylov T, Feizkhah A, Fekadu G, Feng X, Fernandez-Jimenez R, Ferreira N, Foigt N, Folayan M, Fomenkov A, Foroumadi R, Rodrigues C, Foschi M, Francis K, Franklin R, Gába A, Gadanya M, Gaidhane A, Galali Y, Gallus S, Ganesan B, Gangachannaiah S, Gebregergis M, Gebrehiwot M, Getacher L, Getie M, Ghadirian F, Ghazy R, Gil A, Gill T, Gillum R, Girmay A, Golechha M, Goleij P, Goulart A, Grada A, Grivna M, Grover A, Guan Z, Guarducci G, Gubari M, Guha A, Gulati S, Gunawardane D, Guo Z, Gupta B, Gupta R, Gupta R, Gupta V, Gutiérrez-Murillo R, Guzman-Esquivel J, Hadi N, Hadian Z, Hamdy N, Hamidi S, Hanif A, Hanifi N, Hankey G, Haq A, Haro J, Hasan F, Hashempour R, Hashempur M, Hasnain S, Hassan A, Hassan N, Hassanipour S, Rad A, Havmoeller R, Hay S, Hebert J, Hezam K, Hiraike Y, Hoang M, Holla R, Hossain A, Hosseinzadeh H, Hostiuc M, Hostiuc S, Htay Z, Hu M, Hu Y, Humayun A, Hundie T, Husseiny M, Hussien F, Huynh H, Hwang B, Ibrahim R, Ibrayeva A, Ikeda N, Ilesanmi O, Ilic I, Ilic M, Inbaraj L, Inok A, Iqbal K, Islam S, Islam F, Islam R, Islam M, Ismail N, Iso H, Isola G, Ituka M, Iwagami M, Iwu-Jaja C, Iyasu A, Jacob L, Jaffar S, Jahrami H, Jain A, Jain R, Jairoun A, Jakovljevic M, Javaid S, Jayapal S, Jayaram S, Jebasingh F, Jee S, Jema A, Jeswani B, Jonas J, Joseph N, Joshua C, Jozwiak J, Jürisson M, Kaambwa B, Kabir A, Kadashetti V, Kakkar A, Kalra S, Kanaan S, Kankam S, Kanmanthareddy A, Kanmodi K, Kantar R, Kar D, Karajizadeh M, Karakasis P, Behnagh A, Karimzadhagh S, Kassebaum N, Kauppila J, Kayode G, Kedir S, Kehagias D, Keshwani A, Kesse-Guyot E, Keykhaei M, Khajuria H, Khalili P, Khalilian A, Khalis M, Khan A, Khan M, Khan A, Khan M, Khan M, Khan M, Khan N, Khanal V, Khanmohammadi S, Khatatbeh M, Kheirkhah M, Khidri F, Khokhar M, Khosla A, Khosravi S, Khosrowjerdi M, Khusun H, Kim G, Kim J, Kim J, Kim M, Kim Y, Kimokoti R, Kisa A, Kishore L, Shivakumar K, Kokkorakis M, Kompani F, Korzh O, Kostev K, Laxminarayana S, Kretchy I, Kua C, Defo B, Kuddus M, Kulimbet M, Kulkarni V, Kumar G, Kumar V, Kundu S, Kunutsor S, Kurmi O, Kurniasari M, Kusuma D, Kytö V, La Vecchia C, Lacey B, Lahariya C, Lai D, Landires I, Larijani B, Lassi Z, Le H, Le N, Lee H, Lee M, Lee P, Lee S, Lee W, Li A, Li M, Li W, Li Y, Lim S, Lin J, Lin Q, Lindholm D, Lindstedt P, Liu J, Lo J, López-Gil J, Lorkowski S, Lucchetti G, Lugo A, Lutambi A, Feei Z, Gómez J, Maghbouli N, Mahalleh M, Mahmood N, Majeed A, Makris K, Rad E, Malekzadeh R, Malhotra K, Malik A, Malik I, Malta D, Mamun A, Manu E, Marateb H, Marino M, Marjani A, Martinez-Piedra R, Martorell M, März W, Marzouk S, Masrouri S, Mathangasinghe Y, Matozinhos F, Matthias T, Mattiello R, Maugeri A, Mazidi M, McPhail S, Mechili E, Salas M, Mehmood A, Mehrabani-Zeinabad K, Meto T, Meles H, Mendoza W, Menezes R, Mengistie E, Meo A, Mestrovic T, Mettananda C, Mettananda S, Miao H, Miller T, Ming W, Mirrakhimov E, Misganaw A, Mitiku H, Mittal M, Mohamed J, Mohamed M, Mohamed N, Mohammad T, Mohammad-Alizadeh-Charandabi S, Mohammadian-Hafshejani A, Mohammadzadeh I, Mohammed S, Mokdad A, Monasta L, Mondello S, Moni M, Namin S, Ghalibaf A, Moradi Y, Morrison S, Motappa R, Mubarik S, Mulita F, Mullany E, Munkhsaikhan Y, Murillo-Zamora E, Murray C, Musa S, Mustafa G, Muthu S, Mwita J, Myung W, Nafiu A, Nagel G, Naik G, Naik H, Nambi G, Nangia V, Nargus S, Nascimento G, Nassar M, Nauman J, Naureen Z, Navaratna S, Nawsherwan, Nayak B, Nazri-Panjaki A, Negahdary M, Negoi I, Negoi R, Nematollahi S, Nepal S, Netsere H, Ng M, Ngunjiri J, Nguyen D, Nguyen P, Phuong The Nguyen, Niazi R, Nieddu L, Niknam M, Nikolouzakis T, Nikoobar A, Nkeck J, Nomura S, Noor S, Noreen M, Noubiap J, Nouri M, Nri-Ezedi C, Nugen F, Nuñez-Samudio V, Nur A, Nyande F, Nzoputam C, Oancea B, O'Connell E, Odetokun I, Ofakunrin A, Oguta J, Oh I, Okati-Aliabad H, Okeke S, Okekunle A, Okonji O, Olagunju A, Olalusi O, Olasehinde T, Oliveira A, Oliveira G, Oluwafemi Y, Omar H, Bali A, Omer N, Ong S, Ordak M, Ortiz A, Osborne A, Osman W, Otoiu A, Oumer A, Ouyahia A, Owolabi M, Owusu I, Oyebola K, Oyelade T, A M, Padron-Monedero A, Padubidri J, Palicz T, Panda S, Panda-Jonas S, Pandey A, Pandi-Perumal S, Pant S, Pardhan S, Parekh U, Parija P, Parikh R, Park E, Passera R, Patel J, Patoulias D, Paudel S, Peprah, Pereira M, Perico N, Perna S, Petcu I, Petermann-Rocha F, Pham H, Pham T, Pirouzpanah S, Polibin R, Popovic D, Potani I, Pourghazi F, Pourshams A, Pradhan J, Pradhan P, Prasad M, Prashant A, Prates E, Puvvula J, Qattea I, Qiao Y, Radhakrishnan V, Radojˇić M, Raggi C, Rahman F, Rahman M, Rahman M, Rahman M, Rahman M, Rahmanian M, Rahmanian V, Rahmati M, Kumar R, Raimondo I, Raj J, Rajput P, Ramadan M, Ramasamy C, Ramasamy S, Ramazanu S, Rana K, Ranabhat C, Rao M, Rao S, Rashedi S, Rashidi M, Rasouli-Saravani A, Rathish D, Rauniyar S, Rautalin I, Rawaf D, Rawaf S, Redwan E, Rege S, Rehman A, Reis-Mendes A, Remuzzi G, Rezaei N, Rezaeian M, Rhee T, Rocha-Gomes J, da Silva T, Rodriguez J, Roever L, Rohloff P, Romadlon D, Rony M, Roshandel G, Rout H, Roy N, Rwegerera G, Saad A, Saber-Ayad M, Sabzmakan L, Sadarangani K, Saddik B, Sadeghi M, Saeed U, Sagoe D, Sharif-Askari F, Sahebkar A, Sahoo S, Sajadi S, Sajid M, Salami A, Salaroli L, Saleem S, Saleh M, Salem M, Salihu D, Salimi S, Samy A, Santric-Milicevic M, Sarkar T, Sarmadi M, Sarode G, Sarode S, Sassano M, Saulam J, Sawhney M, Saxena S, Saya G, Schinckus C, Schmidt M, Schuermans A, Selvaraj S, Sendekie A, Sengupta P, Senol Y, Senthilkumaran S, Sepanlou S, Sethi Y, Seylani A, Shafie M, Shah S, Shahid S, Shahwan M, Shamim M, Shams-Beyranvand M, Shamsutdinova A, Shanawaz M, Shannawaz M, Sharath M, Sharifan A, Sharma M, Sharma U, Sharma V, Sheida F, Shenoy R, Shetty P, Shiferaw D, Shin M, Lapari M, Shiri R, Shittu A, Shool S, Shorofi S, Shrestha G, Shrestha R, Shuval K, Si Y, Sibuyi N, Siddig E, Siervo M, Silva D, Silva L, Singh A, Singh B, Singh H, Singh J, Singh K, Singh L, Singh M, Singh P, Singh S, Skryabina A, Smith A, Smith G, Soliman S, Soraneh S, Spartalis M, Srichawla B, Stanikzai M, Starodubova A, Straif K, Stubbs P, Subramaniyan V, Odidi M, Sulkowski A, Meo A, Sun Z, Sunny S, Sunuwar D, Swain C, Szarpak L, Y S, Tabarés-Seisdedos R, Tabatabaei S, Malazy O, Tabatabaeizadeh S, Tabatabai S, Tabche C, Tabish M, Taiba J, Tampa M, Tamuzi J, Tan K, Tanwar M, Tariq S, Tat N, Temsah M, Temsah R, Teramoto M, Terefa D, Tewari J, Thangaraju P, Thapar R, Thavamani A, Thirunavukkarasu S, Thomas J, Tiruneh S, Tiruye T, Titova M, Tiwari K, Tomo S, Tonelli M, Touvier M, Tovani-Palone M, Trabelsi K, Tran N, Tran T, Duc N, Trico D, Truyen T, Tsegay G, Tumurkhuu M, Tye S, Udoakang A, Ullah A, Ullah S, Ullah S, Umair M, Umar L, Umar U, Unim B, Upadhya D, Upadhyay E, Usman J, Ustunsoz D, Vaezghasemi M, Vaithinathan A, Van den Eynde J, Varghese J, Vasankari T, Vaziri S, Vellingiri B, Venketasubramanian N, Verma M, Verras G, Villalobos-Daniel V, Vladimirov S, Vlassov V, Vollset S, Vukovic R, Wahiduzzaman M, Wang C, Wang S, Wang X, Wang Y, Weerakoon K, Wei F, Wicaksana A, Wickramasinghe D, Wickramasinghe N, Willeit P, Wojewodzic M, Xia Q, Xiao G, Xie W, Xu S, Xu X, Yahya G, Yamagishi K, Yano Y, Yao H, Yarahmadi A, Yaribeygi H, Ye P, Yesuf S, Yin D, Yon D, Yonemoto N, Yu C, Yuan C, Yuce D, Yunusa I, Zamagni G, Zastrozhin M, Zeariya M, Zhang C, Zhang H, Zhang J, Zhang L, Zhang X, Zhang Z, Zhao H, Zheng D, Zhong A, Zhong C, Zhou J, Zhu B, Zhumagaliuly A, Zielińska M, Zitoun O, Zoghi G, Zou Z, Zyoud S, Gakidou E, Sawyer S, Azzopardi P. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. The Lancet 2025, 405: 785-812. PMID: 40049185, PMCID: PMC11920006, DOI: 10.1016/s0140-6736(25)00397-6.Peer-Reviewed Original ResearchConceptsHigh-income North AmericaSouthern sub-Saharan AfricaExcess body massObesity prevalenceAged 5Non-communicable diseases in adulthoodGlobal burdenGlobal Burden of Disease StudyBurden of Disease StudyGlobal Burden of DiseaseSub-Saharan AfricaCentral Latin AmericaNational prevalence of childrenRisk Factors StudySpatiotemporal Gaussian process regression modelingBurden of diseaseMales aged 5Prevalence of childrenConsequences of obesityOverweight prevalenceAdolescent overweightAge-standardisedBody massIndividuals aged 5Females aged 5Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees
Mulligan C, Quinn E, Hamadmad D, Dutton C, Nevell L, Binder A, Panter-Brick C, Dajani R. Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees. Scientific Reports 2025, 15: 5945. PMID: 40016245, PMCID: PMC11868390, DOI: 10.1038/s41598-025-89818-z.Peer-Reviewed Original ResearchConceptsSyrian refugeesExposure to violenceWar-related violenceExposed to violenceExposure to warAdult health outcomesViolenceIntergenerational exposureSurvey dataRefugeesHealth outcomesEpigenome-wide association studiesTrauma effectsInfluence infantsImpact future generationsEpigenetic age accelerationFuture generationsMothersAssociated with germlineMaternal traumaFamilyAssociation studiesPregnant mothersWarDNA methylationSingle cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma
Thompson D, Wabara Y, Duran S, Reichenbach A, Chen L, Collado K, Yon C, Greally DMed J, Rastogi D. Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma. Scientific Reports 2025, 15: 6844. PMID: 40000680, PMCID: PMC11861978, DOI: 10.1038/s41598-025-88423-4.Peer-Reviewed Original ResearchConceptsCD4+ T cellsT cell subtypesT cellsSteroid resistanceTh1 inflammationObese asthmaTh1 responseCentral memory T cellsObese asthma phenotypeEffector T cellsMemory T cellsObesity-related asthmaCD4+ T cell subtypesPediatric obesity-related asthmaT helper 1Healthy-weight controlsPulmonary function deficitsCD4Th1Asthma phenotypesGlucocorticoid receptorSingle-cell transcriptomicsFunctional deficitsInflammationSteroidsGlobal, regional, and national burden of suicide, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Collaborators G, Weaver N, Bertolacci G, Rosenblad E, Ghoba S, Cunningham M, Ikuta K, Moberg M, Mougin V, Han C, Wool E, Abate Y, Adewuyi H, Adnani Q, Adzigbli L, Afolabi A, Agampodi S, Ahinkorah B, Ahmad A, Ahmad D, Ahmad S, Ahmed A, Ahmed H, Al Hamad H, Al-Ajlouni Y, Al-amer R, Albashtawy M, Aldhaleei W, Ali S, Ali W, Alomari M, Alsabri M, Alvis-Guzman N, Al-Worafi Y, Amindarolzarbi A, Amiri S, Andrei T, Anvari S, Arabloo J, Areda D, Artamonov A, Ashraf T, Athari S, Atout M, Azzam A, Badiye A, Baghcheghi N, Bahramian S, Banach M, Barker-Collo S, Bärnighausen T, Barrow A, Bashiri A, Bashiru H, Bastan M, Batra K, Batra R, Bayati M, Benjet C, Benzian H, Bertuccio P, Bhagavathula A, Bhattacharjee P, Bills C, Boppana S, Borges G, Borhany H, Bustanji Y, dos Santos F, Castelpietra G, Caye A, Cenderadewi M, Chandika R, Chandrasekar E, Charalampous P, Chen Y, Chimoriya R, Chopra H, Choudhari S, Chu D, Chukwu I, Chutiyami M, Cowden R, Dachew B, Dadras O, Dai X, Dalal K, Dandona L, Dandona R, Darcho S, Soltani R, Dávila-Cervantes C, de la Torre-Luque A, Debopadhaya S, Degenhardt L, Delgado-Enciso I, Dervišević E, Diaz M, Dongarwar D, Doshi O, Dsouza H, Dumith S, Duraisamy S, Eboreime E, Efendi F, Ekholuenetale M, Arab R, Elhadi M, ELNahas G, Eltaha C, Haque S, Eskandarieh S, Fahim A, Faro A, Fatehizadeh A, Fazeli P, Feizkhah A, Fekadu G, Ferreira N, Fischer F, Franklin R, Fridayani N, Gajdács M, Gandhi A, Ganesan B, Gebregergis M, Gebrehiwot M, Gebremeskel T, Getie M, Ghadimi D, Ghailan K, Ghashghaee A, Gholamrezanezhad A, Goleij P, Grada A, Grivna M, Guan S, Gulati S, Gupta S, Gutiérrez R, Gutiérrez-Murillo R, Hamilton E, Hanifi N, Hasan I, Tabatabaei M, Hay S, Heidari M, Hemmati M, Hoan N, Hosseinzadeh M, Hostiuc S, Huang J, Huynh H, Ibitoye S, Ilesanmi O, Ilic I, Ilic M, Immurana M, Inok A, Iwu C, Jahrami H, Jaka S, Yengejeh R, Ji Z, Jin S, Joseph N, Joshua C, Jozwiak J, Kabir Z, Kadashetti V, Kanmodi K, Kantar R, Kapoor N, Karaye I, Karmakar S, Kaur H, Kerr J, Khajuria H, Khan A, Khatab K, Kheirallah K, Kim K, Kim M, Shivakumar S, Kolahi A, Koohestani H, Krishna V, Kugbey N, Kulimbet M, Kumar G, Kumar M, Kundu S, Kytö V, Landires I, Le N, Lee D, Lee W, Lee Y, Lim S, Lin J, Liu R, López-Gil J, Lucchetti G, Feei Z, Maled V, Malhotra K, Malik A, Marconi A, Martinez-Piedra R, Marzo R, Mathangasinghe Y, Maulik P, Meles H, Menezes R, Meretoja T, Mestrovic T, Michalek I, Miller T, Mirza M, Misganaw A, Mittal C, Mohamed A, Mohamed N, Mohammadian-Hafshejani A, Mokdad A, Molinaro S, Monasta L, Ghalibaf A, Morrison S, Motappa R, Mughal F, Mulita F, Munkhsaikhan Y, Murray C, Muthu S, Myung W, Nafei A, Naghavi P, Naik G, Naik G, Natto Z, Naveed M, Navid S, Nayak B, Nazri-Panjaki A, Netsere H, Neupane S, Nguyen H, Nguyen N, Nguyen P, Phuong The Nguyen, Nguyen V, Nikoobar A, Noguer I, Nomura S, Nri-Ezedi C, Nuñez-Samudio V, Nzoputam O, Oancea B, Oduro M, Oh I, Okeke S, Oluwafemi Y, Ong S, Ordak M, Orpana H, Ortiz-Prado E, Osuagwu U, Padron-Monedero A, Padubidri J, Palma-Alvarez R, Pandey A, Pandey A, Pantazopoulos I, Park S, Park S, Pashaei A, Patel J, Pawar S, Peprah, Peres M, Petcu I, Philip A, Phillips M, Piracha Z, Pradhan J, Prates E, Pribadi D, Puvvula J, Qattea I, Qian G, Radhakrishnan V, Raghav P, Rahimibarghani S, Rahimi-Movaghar A, Rahimi-Movaghar V, Rahman M, Rahman M, Rahman M, Rahmanian M, Rajpoot P, Ramadan M, Ramasamy S, Rani S, Rao M, Rao S, Rashidi M, Rastogi P, Rathish D, Rawaf D, Reifels L, Rezaeian M, Rhee T, Rickard J, Roever L, Rony M, Chandan S, Saddik B, Sadeghian F, Saeb M, Saeed U, Moghaddam S, Safari M, Sagoe D, Sharif-Askari N, Sahoo P, Sahoo S, Salamati P, Salihu D, Salimi S, Salum G, Sameen S, Samy A, Santric-Milicevic M, Sarkar C, Sarode G, Sarode S, Sathian B, Schumacher A, Šekerija M, Semreen M, Sepanlou S, Shafie M, Shahid S, Shaikh A, Shaikh M, Sharifan A, Rad J, Sharma A, Sharma V, Sheikhi R, Shetty M, Shetty P, Shetty P, Shivarov V, Shool S, Singh P, Singh P, Singh S, Socea B, Stein D, Stein M, Sun J, Swain C, Szarpak L, Y S, Tabatabaei S, Tabche C, Tareke M, Temsah M, Thum C, Tiruye T, Tovani-Palone M, Tran N, Tran T, Duc N, Tromans S, Truyen T, Tsegay G, Tumurkhuu M, Vahdati S, Vaithinathan A, Valdez P, Vasankari T, Veroux M, Verras G, Vinayak M, Vos T, Walde M, Wang Y, Ward J, Wickramasinghe N, Wojewodzic M, Yesodharan R, Yiğit A, Yin D, Yip P, Yon D, Yonemoto N, Yu C, Zare I, Zeariya M, Zhang H, Zhong C, Zhu B, Zhumagaliuly A, Naghavi M. Global, regional, and national burden of suicide, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Public Health 2025, 10: e189-e202. PMID: 39986290, PMCID: PMC11876099, DOI: 10.1016/s2468-2667(25)00006-4.Peer-Reviewed Original ResearchConceptsAge-standardised mortality ratesBurden of suicideRates of suicideIncidence of suicide attemptsGlobal burdenHighest age-standardised rateGlobal Burden of Disease StudyBurden of Disease StudyGlobal Burden of DiseaseSouthern sub-Saharan AfricaMortality rateAge-standardised ratesSub-Saharan AfricaPublic health frameworkRisk Factors StudyReduce suicide mortalityBurden of diseasePopulation mortality ratesMortality surveillanceCentral sub-Saharan AfricaVerbal autopsySuicide attemptsSuicide burdenVital registrationHealth frameworkUnderstanding the development of a functional brain circuit: reward processing as an illustration
Opendak M, Meyer H, Callaghan B, Abramson L, John S, Bath K, Lee F, Tottenham N, Sullivan R. Understanding the development of a functional brain circuit: reward processing as an illustration. Translational Psychiatry 2025, 15: 53. PMID: 39962048, PMCID: PMC11832941, DOI: 10.1038/s41398-025-03280-z.Peer-Reviewed Original ResearchConceptsReward processingReward systemAberrant reward processingNeural reward circuitsAdult circuit functionEnvironmental demands changePromote adaptive behaviorFunctional brain circuitsBrain network functionDevelopmental research questionsReward circuitReward behaviorPsychiatric disordersBrain circuitsAdaptive behaviorRewardCircuit functionDevelopmental transitionsImpact infantsDevelopmental processesDisordersStimuliBrainBehaviorChildhoodImpact of maternal institutionalization on children’s language development: A multidisciplinary study
Zhukova M, Chinn L, Cheek C, Sukmanova A, Kustova T, Grigorenko E. Impact of maternal institutionalization on children’s language development: A multidisciplinary study. Journal Of Experimental Child Psychology 2025, 253: 106197. PMID: 39938244, DOI: 10.1016/j.jecp.2025.106197.Peer-Reviewed Original ResearchConceptsHistory of institutionalizationEvent-related potentialsLanguage developmentEvent-related potential measuresEffects of institutional rearingChildren's language abilitiesChildren's language developmentMother-child dyadsP400 responseAccuracy childrenLanguage deficitsNative Russian speakersFewer wordsInstitutional rearingNeural measuresLanguage abilityLanguage scoresNeural responsesConversational turnsLanguage violationsChildren of mothersImpoverished environmentBiological familiesRussian speakersFemale offspringAdverse childhood experiences, anger, and violence among justice-involved youth: A network analysis
Li N, Shelton M, Grigorenko E. Adverse childhood experiences, anger, and violence among justice-involved youth: A network analysis. Child Abuse & Neglect 2025, 161: 107301. PMID: 39929035, DOI: 10.1016/j.chiabu.2025.107301.Peer-Reviewed Original ResearchConceptsViolent offendersAdverse childhood experiencesLikelihood of violent offendingPhysical abuseJuvenile justice systemJuvenile probation departmentChildhood experiencesPhysical neglectCriminogenic needsJustice systemProbation departmentsOffendersImpact of angerEmotional abuseJIYParental separation/divorceAbuseEarly adverse experiencesUnited StatesAngerYouthEvidence-based interventionsNeglectEnvironmental risksAdverse experiencesPhoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018
Sanchez-Pinto L, Daniels L, Atreya M, Faustino E, Farris R, Geva A, Khemani R, Rogerson C, Shah S, Weiss S, Bennett T. Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018. Pediatric Critical Care Medicine 2025, 26: e155-e165. PMID: 39982153, PMCID: PMC11792981, DOI: 10.1097/pcc.0000000000003675.Peer-Reviewed Original ResearchConceptsInternational Pediatric Sepsis Consensus ConferenceInternational Pediatric Sepsis Consensus Conference criteriaPhoenix criteriaCritically ill childrenSepsis criteriaPICU admissionCohort of critically ill childrenOrgan dysfunction scoreIll childrenMulticenter cohort studyHigher risk of mortalityMortality of patientsAge groupsIn-hospital mortalityRisk of mortalitySeverity of illnessDiscrimination of mortalityBloodstream infectionsSuspected infectionMulticenter cohortSeptic shockSepsis scoreDysfunction scorePatient subgroupsRetrospective analysisDifferential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks
Qureshi A, Nielsen J, Sepulcre J. Differential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks. Cerebral Cortex 2025, 35: bhae474. PMID: 40007052, PMCID: PMC11859958, DOI: 10.1093/cercor/bhae474.Peer-Reviewed Original ResearchConceptsInferior parietal lobuleSuperior temporal gyrusLarge-scale networksDeletion carriersHeteromodal association areasDifferential linksHypo-connectivitySocial impairmentTemporal gyrusParietal lobulePosterior insulaAssociated with greater communicationAberrant connectivityAssociation areasCingulate sulcusBehavioral changesGlobal coherenceEntangled connectionsSulcusGreater communicationInsulaCingulateGyrusCopy number variationsImpairmentDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokinesAssociations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study
Bailey M, Fairchild G, Hammerton G, Bauer A, Carpena M, Murray J, Santos I, Barros A, Tovo-Rodrigues L, Danese A, Halligan S, Matijasevich A. Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study. The Lancet Global Health 2025, 13: e309-e318. PMID: 39890231, DOI: 10.1016/s2214-109x(24)00452-2.Peer-Reviewed Original ResearchConceptsLow-income and-middle-income countriesPopulation attributable fractionPelotas Birth CohortAdolescent psychiatric disordersAnxiety disordersPsychiatric disordersTrauma exposureCumulative traumaBirth cohortLongitudinal associationsChildhood traumaMood disordersComputed population attributable fractionsTrauma loadPopulation-based birth cohort studyMental disordersRisk of mental disordersAnd Middle-Income CountriesExposure to childhood traumaPrevalence of trauma exposureAssociated with increased oddsAssociated with mental disordersBirth cohort studyIncreased exposure to traumaBurden of traumaEvaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh
Khanam F, Rickett N, Ahmmed F, Islam M, Mbae C, Im J, Aziz A, Ongadi B, Chowdhury F, Khan A, Akter A, Firoj M, Rahman S, Haile K, Park S, Mwebia M, Mwangi M, Ngugi B, Behute M, Kering K, Agampodi S, Kanungo S, Liu X, Pollard A, Zaman K, Kim D, Kariuki S, Qadri F, Clemens J. Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh. BMC Infectious Diseases 2025, 25: 149. PMID: 39891051, PMCID: PMC11786536, DOI: 10.1186/s12879-025-10548-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, BacterialBangladeshChildChild, PreschoolCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GIncidenceInfantMaleMiddle AgedPolysaccharides, BacterialSalmonella typhiSeroepidemiologic StudiesTyphoid FeverTyphoid-Paratyphoid VaccinesYoung AdultConceptsAnti-Vi antibodiesTyphoid feverReceiver operating characteristicTyphoid riskIncidence of typhoid feverCulture-confirmed typhoid feverAntibody titersResultsThe ROC analysisCox proportional hazards modelsRisk of typhoidTyphoid infectionEnzyme-linked immunosorbent assayProportional hazards modelMethodsWe analyzed dataPresence of antibodiesTyphoidCohort studyTyphoid vaccineROC analysisAntibody levelsCrude analysisIncreased seroprevalenceFeverHazards modelNatural immunityMonitoring molecular markers associated with antimalarial drug resistance in south-east Senegal from 2021 to 2023
Wade A, Sene S, Caspar E, Diallo F, Platon L, Thiebaut L, Pouye M, Ba A, Thiam L, Fall M, Sadio B, Desamours I, Guerra N, Hagadorn K, Amambua-Ngwa A, Bei A, Vigan-Womas I, Ménard D, Mbengue A. Monitoring molecular markers associated with antimalarial drug resistance in south-east Senegal from 2021 to 2023. Journal Of Antimicrobial Chemotherapy 2025, 80: 828-839. PMID: 39846779, PMCID: PMC11879165, DOI: 10.1093/jac/dkaf006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntimalarialsArtemisininsChildChild, PreschoolDrug CombinationsDrug ResistanceFemaleHumansMalaria, FalciparumMaleMembrane Transport ProteinsMiddle AgedMultidrug Resistance-Associated ProteinsMutationPlasmodium falciparumProtozoan ProteinsPyrimethamineSenegalSulfadoxineTetrahydrofolate DehydrogenaseYoung AdultConceptsArtemisinin-based combination therapyMolecular markers associated with antimalarial drug resistanceArtemisinin-based combination therapy efficacyP. falciparum infectionSulfadoxine-pyrimethamine resistanceAntimalarial drug resistanceInvestigated gene polymorphismsCQ-RResistance in vitroVenous blood samplesClinical outcome studiesI356TK76TPfcrt mutationsChloroquine resistanceAntimalarial resistancePfmdr-1CQ useMalaria eliminationCombination therapyResistance surveillanceGene polymorphismsPlasmodium falciparumDrug resistanceAmplicon deep sequencingMeasurement of Blood Pressure in Children and Adolescents Outside the Office for the Diagnosis of Hypertension
Nugent J. Measurement of Blood Pressure in Children and Adolescents Outside the Office for the Diagnosis of Hypertension. Current Cardiology Reports 2025, 27: 27. PMID: 39826056, DOI: 10.1007/s11886-024-02178-4.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringBlood pressure monitoringHome blood pressure monitoringDiagnosis of hypertensionBlood pressurePressure monitoringUsefulness of ambulatory blood pressure monitoringOffice blood pressureOut-of-office blood pressure measurementsTarget organ damageNovel care pathwayHome blood pressureMeasurement of blood pressureBlood pressure measurementsOrgan damageHypertensionHypertension statusSubspecialty settingsCare pathwaysDiagnosis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply