2025
Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial
Patel R, Kumskova M, Kodali H, Budnik I, Kuznetsov V, Jain A, Jha A, Thedens D, Dhanesha N, Sutariya B, Nagarkatti K, Lamb J, Kamat P, Shi Y, Avery B, Imai T, Jin X, Chauhan A, Boisserand L, Khan M, Dhandapani K, Sanganahalli B, Sansing L, Hess D, Koehler R, McCullough L, Aronowski J, Ayata C, Diniz M, Lyden P, Planas A, Chamorro A, Chauhan A, Leira E, Investigators O. Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial. Stroke 2025, 56: 965-973. PMID: 40091742, PMCID: PMC11932773, DOI: 10.1161/strokeaha.124.048748.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsComorbidityFemaleHumansInfarction, Middle Cerebral ArteryIschemic StrokeMaleNeuroprotective AgentsRatsSex FactorsStrokeUric AcidConceptsUA-treated animalsPrimary functional outcomeFunctional outcomesMiddle cerebral artery filament occlusionModified intention-to-treat populationIntention-to-treat populationUric acidHuman clinical trialsImprove functional outcomesStudy drugIntravenous salineEffects of UARelevant to patientsClinical trialsPrimary outcomeSaline controlsSecondary outcomesPreclinical trialsDay 2Survival rateDay 7Filament occlusionGroups of animalsComorbiditiesDiverse comorbidities
2024
Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Imai T, Jin X, Locascio J, Boisserand L, Herman A, Chauhan A, Lamb J, Nagarkatti K, Diniz M, Kumskova M, Dhanesha N, Kamat P, Khan M, Dhandapani K, Patel R, Sutariya B, Shi Y, van Leyen K, Kimberly W, Hess D, Aronowski J, Leira E, Koehler R, Chauhan A, Sansing L, Lyden P, Ayata C. Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial. Circulation Research 2024, 135: 575-592. PMID: 39034919, PMCID: PMC11428171, DOI: 10.1161/circresaha.123.324139.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalFemaleInfarction, Middle Cerebral ArteryIschemic StrokeMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLProspective StudiesStrokeConceptsMiddle cerebral artery occlusionFilament middle cerebral artery occlusionHigh-fat dietProcedural variablesHigh-fatOlder ageStroke outcomeBlood flow monitoringCerebral blood flow monitoringPredictors of outcomeBody weightProspective designInfluence stroke outcomeAssociated with smaller infarctsCerebral artery occlusionExperimental focal cerebral ischemiaFocal cerebral ischemiaLonger anesthesia durationExperimental stroke modelsBlood flow dropAcute stroke interventionExperimental stroke outcomesMulticenter prospective designProcedural predictorsPreclinical studiesTenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection
Albers G, Jumaa M, Purdon B, Zaidi S, Streib C, Shuaib A, Sangha N, Kim M, Froehler M, Schwartz N, Clark W, Kircher C, Yang M, Massaro L, Lu X, Rippon G, Broderick J, Butcher K, Lansberg M, Liebeskind D, Nouh A, Schwamm L, Campbell B. Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection. New England Journal Of Medicine 2024, 390: 701-711. PMID: 38329148, DOI: 10.1056/nejmoa2310392.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSymptomatic intracranial hemorrhageInternal carotid arteryMiddle cerebral arteryRankin ScalePlacebo groupTenecteplase groupIntracranial hemorrhageIncidence of symptomatic intracranial hemorrhageCerebral arteryIncidence of symptomatic intracerebral hemorrhageCarotid arteryPlacebo-controlled trialSymptomatic intracerebral hemorrhageEvidence of occlusionSafety populationDouble-blindPerfusion-imagingMedian timeClinical outcomesIntracerebral hemorrhagePlaceboPerfusion imagingPrimary outcomeOdds ratioAbsence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice
Ge Y, Yang J, Chen J, Dai M, Dou X, Yao S, Yao C, Lin Y. Absence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice. CNS Neuroscience & Therapeutics 2024, 30: e14551. PMID: 38421089, PMCID: PMC10850801, DOI: 10.1111/cns.14551.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBromodeoxyuridineCognitionInfarction, Middle Cerebral ArteryIschemic StrokeKi-67 AntigenMiceMicrogliaNestinPyroptosisStrokeConceptsMorris water mazeNovel object recognition testObject recognition testCX3CR1<sup>-/-</sup> micePost-stroke cognitive impairmentRecognition testCX3CR1 receptorCognitive behavioral performanceWater mazeBehavioral performanceCognitive dysfunctionDouble-positive cellsCognitive functionSource of morbidityCognitive impairmentPositron emission tomographyEnhanced neurogenesisCognitive function recoveryCX3CR1 knockoutExpression of GSDMDMicroglial pyroptosisChronic phaseInfarct volumeCX3CR1Hippocampus
2023
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDeuteriumFluorodeoxyglucose F18GlucoseInfarction, Middle Cerebral ArteryIschemic StrokeMiceMice, Inbred C57BLPilot ProjectsPositron-Emission TomographyStrokeConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline valuesEmbracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Locascio J, Sansing L, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig J, Bosetti F, Lyden P, Ayata C, Bosetti F, Koenig J, Lyden P, Lamb J, Nagarkatti K, Hess D, Kamat P, Khan M, Dhandapani K, Arbab A, Siddiqui S, Smith C, Nisar M, Leira E, Chauhan A, Dhanesha N, Patel R, Kumskova M, Thedens D, Wang K, Ayata C, Morais A, Imai T, Qin T, Jin X, Erdogan T, Yu L, Mandeville J, Kimberly W, Whittier J, Lo E, Arai K, Van Leyen K, Sansing L, Hyder F, Mihailovic J, Sanganahalli B, Diaz-Perez S, Velazquez S, Beatty H, Johnson C, Herman A, Boisserand L, Immakavar E, Koehler R, Dawson T, Dawson V, Shi Y, Avery B, Lannon S, Bibic A, Akhter K, Karuppagounder S, Aronowski J, McCullough L, Obertas L, Goh A, Huang S, Chauhan A. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke 2023, 54: 620-631. PMID: 36601951, PMCID: PMC9870939, DOI: 10.1161/strokeaha.122.040638.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebrovascular CirculationDisease Models, AnimalInfarction, Middle Cerebral ArteryIschemic Attack, TransientMiceMulticenter Studies as TopicResearch DesignStrokeConceptsTotal anesthesia durationAnesthesia durationIndependent predictorsMultivariable analysisClinical trialsTransient focal cerebral ischemiaFocal cerebral ischemiaCerebral blood flowLaser Doppler flowCentralized randomizationModified intentionTreat populationExperimental strokeCerebral ischemiaDoppler flowRodent modelsMCAOBlood flowNetwork trialFlow dropPreclinical trialsMouse cohortsStudy designTrialsTrial onset
2022
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results
Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A, Siddiqui S, Sheth K, Matouk C, Cruz C, Zhou J, Dawson V, Dawson T, Liang J, van Zijl P, Zeiler S, Taylor Kimberly W, Erdogan T, Yu L, Mandeville J, Whittier J. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke 2022, 53: 1802-1812. PMID: 35354299, PMCID: PMC9038686, DOI: 10.1161/strokeaha.121.038047.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsBrainBrain IschemiaFeasibility StudiesHumansInfarction, Middle Cerebral ArteryMaleMiceStrokeConceptsPreclinical assessmentStroke treatmentCandidate treatmentMiddle cerebral artery occlusion (MCAO) surgeryClinical stroke trialsSuccessful stroke treatmentInclusion/exclusion criteriaStroke clinical trialsClinical trial designYoung male animalsComorbid diseasesOcclusion surgeryCerebral ischemiaNeurological disabilityComorbid conditionsStroke trialsProtocol adherenceBlinded assessmentSuch therapyClinical trialsClinical studiesExclusion criteriaTrial designAged animalsOutcome assessment
2021
Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia
Kiyose R, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Magota H, Oka S, Ukai R, Takemura M, Yokoyama T, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia. World Neurosurgery 2021, 149: e160-e169. PMID: 33618048, DOI: 10.1016/j.wneu.2021.02.056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral RevascularizationCerebrovascular CirculationInfarction, Middle Cerebral ArteryInfusions, IntravenousMaleMesenchymal Stem Cell TransplantationMicrovesselsRatsRats, Sprague-DawleyConceptsRegional cerebral blood flowInfused mesenchymal stem cellsReperfusion therapyPermanent MCAOIntravenous infusionMesenchymal stem cellsTherapeutic efficacyTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelArterial spin labeling magnetic resonance imagingArtery occlusion modelStandard therapeutic strategyTransient MCAO modelCerebral blood flowBehavioral functionsNon-favorable outcomeRat model systemStem cellsMCAO groupStroke inductionAcute strokeCerebral ischemiaNeurologic functionInfusion groupMCAO modelImpaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis
Yaghi S, de Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis. Journal Of Neuroimaging 2021, 31: 475-479. PMID: 33565162, PMCID: PMC8119309, DOI: 10.1111/jon.12839.Peer-Reviewed Original ResearchConceptsTransient ischemic attackMCA stenosisPerfusion delayPerfusion imagingSymptomatic middle cerebral artery stenosisMiddle cerebral artery stenosisSymptomatic MCA stenosisComprehensive stroke centerSymptomatic intracranial stenosisCerebral artery stenosisContinuous variablesHospital stayIschemic attackIschemic strokeStenosis patientsStroke centersSymptom onsetConsecutive patientsArtery stenosisIntracranial stenosisProspective studyRetrospective studyPredicts LengthInclusion criteriaMismatch volumeEffect of Methylene Blue on White Matter Injury after Ischemic Stroke
Cheng Q, Chen X, Ma J, Jiang X, Chen J, Zhang M, Wu Y, Zhang W, Chen C. Effect of Methylene Blue on White Matter Injury after Ischemic Stroke. Oxidative Medicine And Cellular Longevity 2021, 2021: 6632411. PMID: 33603949, PMCID: PMC7872771, DOI: 10.1155/2021/6632411.Peer-Reviewed Original ResearchConceptsWhite matter injuryMiddle cerebral artery occlusionCerebral artery occlusionInfarct volumeIschemic strokeArtery occlusionBehavioral deficitsFDA-grandfathered drugWhite matter protectionBrain white matter injuryAdministration of MBGarcia neurological scoresTherapeutic time windowEffect of methylene bluePhotothrombotic middle cerebral artery occlusionPotential therapeutic effectsFoot-fault testNeurological deficitsMyelin basic proteinIntraperitoneal administrationNeurological scoreAnimal modelsTherapeutic effectMB administrationTTC staining
2020
Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study
de Havenon A, Narata AP, Amelot A, Saver JL, Bozorgchami H, Mattle HP, Ribo M, Andersson T, Zaidat OO, investigators A. Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study. Journal Of NeuroInterventional Surgery 2020, 13: 779-783. PMID: 33219148, PMCID: PMC8134506, DOI: 10.1136/neurintsurg-2020-016427.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEndovascular ProceduresHumansInfarction, Middle Cerebral ArteryMiddle Cerebral ArteryStrokeThrombectomyTreatment OutcomeConceptsMiddle cerebral artery occlusionM2 occlusionsCerebral artery occlusionM1 occlusionEndovascular thrombectomyAdverse eventsBetter outcomesArtery occlusionIschemic strokeReperfusion ratesM2-segment middle cerebral artery occlusionM2 middle cerebral artery occlusionsScale scoreHealth Stroke Scale scoreBaseline National InstitutesStroke Scale scoreAcute ischemic strokeMajor adverse eventsRankin Scale scorePaucity of dataLogistic regression modelsII trialSuccessful reperfusionII studyPrespecified analysisPost-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone
Atif F, Yousuf S, Espinosa-Garcia C, Harris W, Stein D. Post-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone. Neuropharmacology 2020, 181: 108327. PMID: 32950558, DOI: 10.1016/j.neuropharm.2020.108327.Peer-Reviewed Original ResearchConceptsPeripheral immune dysfunctionVitamin D hormoneTransient middle cerebral artery occlusion/reperfusionImmune dysfunctionSystemic inflammationInfarct volumeSubsets of immune cellsNeuronal inflammationMeasure infarct volumePost-stroke infectionsInjection of lipopolysaccharideIn-hospital infectionStandard of careFlow cytometric analysisMiddle cerebral artery occlusion/reperfusionCleaved caspase-3Combination therapyInflammation groupImmune cellsAdult ratsIncreased morbidityD hormoneBrain post-strokeImmunomodulatory effectsCombined treatmentEffects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke
Al-Dasuqi K, Payabvash S, Torres-Flores GA, Strander SM, Nguyen CK, Peshwe KU, Kodali S, Silverman A, Malhotra A, Johnson MH, Matouk CC, Schindler JL, Sansing LH, Falcone GJ, Sheth KN, Petersen NH. Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke. Stroke 2020, 51: e193-e202. PMID: 32781941, PMCID: PMC7484023, DOI: 10.1161/strokeaha.120.029892.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArterial Occlusive DiseasesCerebral InfarctionCohort StudiesCollateral CirculationComputed Tomography AngiographyEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryLinear ModelsMagnetic Resonance AngiographyMaleMiddle AgedReperfusionRetrospective StudiesStrokeThrombectomyTreatment OutcomeWhite MatterConceptsLarge vessel occlusion strokeFinal infarct volumeCollateral statusPoor collateral statusFavorable outcomeInfarct distributionInfarct volumeReperfusion successIndependent predictorsOcclusion strokeInternal capsuleAnterior circulation large vessel occlusion ischemic strokeLarge vessel occlusion ischemic strokeDeep white matter tractsBaseline collateral statusBorder-zone infarctionEarly favorable outcomeEarly functional outcomesRankin Scale scoreCohort of patientsDegree of reperfusionLarge vessel occlusionComputed tomography angiographyDeep white matterMagnetic resonance imagingMemantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia
Gu S, Sonkar V, Katare P, Kumar R, Kruger W, Arning E, Bottiglieri T, Lentz S, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. Journal Of The American Heart Association 2020, 9: e013368. PMID: 32067580, PMCID: PMC7070222, DOI: 10.1161/jaha.119.013368.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierCell DeathCells, CulturedCystathionine beta-SynthaseDisease Models, AnimalDisease ProgressionExcitatory Amino Acid AntagonistsHomocysteineHomocystinuriaHyperhomocysteinemiaInfarction, Middle Cerebral ArteryMemantineMice, KnockoutNeuronsNeuroprotective AgentsReceptors, N-Methyl-D-AspartateSeverity of Illness IndexConceptsN-methyl-D-aspartatePlasma total homocysteineBlood-brain barrier disruptionTotal homocysteineBrain barrier disruptionIschemic strokeN-methyl-D-aspartate receptor antagonismBarrier disruptionCerebrovascular injuryN-methyl-D-aspartate receptor antagonistExpression of NR2B subunitN-methyl-D-aspartate receptor subunitsExpression of N-methyl-D-aspartate receptor subunitsN-methyl-D-aspartate receptor antagonist memantineCystathionine beta-synthaseEffects of memantineCerebral infarct sizeTargeted treatment strategiesAcute ischemic strokeBlood-brain barrierReceptor antagonismNR2B subunitReceptor antagonistSevere elevationHomocysteine levelsDepletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke
Harris NM, Roy-O'Reilly M, Ritzel RM, Holmes A, Sansing LH, O'Keefe LM, McCullough LD, Chauhan A. Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke. Experimental Neurology 2020, 326: 113202. PMID: 31954116, PMCID: PMC7059209, DOI: 10.1016/j.expneurol.2020.113202.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsBehavior, AnimalBrain ChemistryBrain IschemiaCD4-Positive T-LymphocytesChemokinesCytokinesFemaleInfarction, Middle Cerebral ArteryInflammationMaleMiceMice, Inbred C57BLStrokeTreatment OutcomeConceptsIP-10 levelsMiddle cerebral artery occlusionCD4 T cellsT cellsIschemic strokeStroke patientsIsotype controlBrain-infiltrating T cellsCD4 T-cell depletionCerebral artery occlusionT-cell depletionAged mouse modelAged male micePro-inflammatory factorsT cell dysfunctionPro-inflammatory cytokinesAnti-CD4 antibodiesAged stroke patientsIgG isotype controlCD4 treatmentDepletion antibodyArtery occlusionExperimental strokeStroke onsetSham surgery
2019
Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans
Payabvash S, Falcone GJ, Sze GK, Jain A, Beslow LA, Petersen NH, Sheth KN, Kimberly WT. Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans. Journal Of Stroke And Cerebrovascular Diseases 2019, 29: 104488. PMID: 31787498, PMCID: PMC8820410, DOI: 10.1016/j.jstrokecerebrovasdis.2019.104488.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAgedAnterior Cerebral ArteryCerebrovascular CirculationCerebrumClinical Trials as TopicClinical Trials, Phase II as TopicDiffusion Magnetic Resonance ImagingDisability EvaluationExtremitiesFemaleGlyburideHumansHypoglycemic AgentsInfarction, Anterior Cerebral ArteryInfarction, Middle Cerebral ArteryMaleMiddle AgedMiddle Cerebral ArteryPatient AdmissionPredictive Value of TestsRecovery of FunctionRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsLarge hemispheric infarctionInfarct volumeIndependent predictorsInfarct lesionsHemispheric infarctionHealth Stroke Scale total scorePost-stroke day 3Anterior cerebral artery territoryTotal scoreLeft MCA infarctLeg motor functionNIHSS total scoreHours of onsetOnly independent predictorPoor functional outcomeBorder zoneScale total scoreAnterior extensionMultivariate regression analysisVoxel-wise analysisLHI patientsAdmission NIHSSArtery territoryGlibenclamide treatmentMCA infarctNeuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues—Liraglutide and Semaglutide
Basalay M, Davidson S, Yellon D. Neuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues—Liraglutide and Semaglutide. Cardiovascular Drugs And Therapy 2019, 33: 661-667. PMID: 31721014, PMCID: PMC6994526, DOI: 10.1007/s10557-019-06915-8.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Middle cerebral artery occlusionReduced infarct sizeImproved neuroscoreInfarct sizeReperfusion therapyAcute ischaemic damageAntagonist exendin(9-39Functional neuroprotective effectsNeuroprotective treatment strategiesGlucagon-like peptide-1 analoguesIschaemia-reperfusion injuryDose-dependent mannerCerebral artery occlusionEffects of liraglutideAcute ischaemic strokeIschaemic stroke patientsNeuroprotective effects of liraglutideExendin(9-39Dose-dependentlyGLP-1RsIschaemia-reperfusionTreatment strategiesSemaglutideArtery occlusionNeurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats
Sun H, Li A, Hou T, Tao X, Chen M, Wu C, Chen S, Zhu L, Liao H. Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats. Brain Behavior And Immunity 2019, 82: 354-371. PMID: 31513876, DOI: 10.1016/j.bbi.2019.09.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCell DifferentiationCell ProliferationExercise TestHippocampusInfarction, Middle Cerebral ArteryMaleNeural Stem CellsNeurogenesisNeuronsPhysical Conditioning, AnimalPhysical ExertionRatsRats, Sprague-DawleyReceptors, ImmunologicRecovery of FunctionSignal TransductionStrokeStroke RehabilitationConceptsCD200/CD200RCognitive functional recoveryTransient middle cerebral artery occlusionFunctional recoveryTreadmill exercisePost-stroke functional recoveryMiddle cerebral artery occlusionExercise-induced neurogenesisPre-existing neuronsCerebral artery occlusionNeurotrophic factor expressionLong-term disabilityPromotion of neurogenesisNeural stem/progenitor cell proliferationCommon treatment strategyTNF-α expressionPotential therapeutic targetAugmentation of neurogenesisStem/progenitor cell proliferationPotential molecular mechanismsProgenitor cell proliferationArtery occlusionIpsilateral hippocampusCD200R expressionSubgranular zone
2018
Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction
Nagahama H, Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Namioka T, Namioka A, Oka S, Onodera R, Suzuki J, Sasaki Y, Kocsis JD, Honmou O. Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction. Brain Research 2018, 1695: 37-44. PMID: 29802840, DOI: 10.1016/j.brainres.2018.05.033.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus CallosumDiffusion Tensor ImagingDisease Models, AnimalInfarction, Middle Cerebral ArteryInfusions, IntravenousMesenchymal Stem Cell TransplantationMesenchymal Stem CellsRatsRats, Sprague-DawleyStrokeConceptsInterhemispheric cortical connectionsCorpus callosumIntravenous infusionMesenchymal stem cellsDiffusion tensor imagingMotor cortexFunctional improvementCortical connectionsAdeno-associated virusRat middle cerebral artery occlusion stroke modelMiddle cerebral artery occlusion stroke modelContralateral motor cortexBlood-brain barrierMotor cortex connectivityVehicle-infused groupMRI diffusion tensor imagingPotential therapeutic mechanismNeuroanatomical tracing techniquesStem cellsCerebral infarctionInflammatory infiltrationAnatomical restorationCerebral strokeFunctional recoveryNeurotrophic factorTime From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke
Tsai JP, Mlynash M, Christensen S, Kemp S, Kim S, Mishra NK, Federau C, Nogueira RG, Jovin TG, Devlin TG, Akhtar N, Yavagal DR, Bammer R, Straka M, Zaharchuk G, Marks MP, Albers GW, Lansberg MG. Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke. Stroke 2018, 49: 952-957. PMID: 29581341, PMCID: PMC5875452, DOI: 10.1161/strokeaha.117.018858.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAngiography, Digital SubtractionCerebral AngiographyCohort StudiesEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedPerfusion ImagingPrognosisRecovery of FunctionReperfusionStrokeThrombectomyTime-to-TreatmentTomography, X-Ray ComputedTreatment OutcomeConceptsTarget mismatch profileReperfusion timeFunctional independenceMismatch profileInfarct growthCTP scansLarger final infarct volumeTarget mismatch patientsAcute ischemic strokeCohort of patientsFinal infarct volumeTarget mismatchSuccessful endovascular reperfusionMismatch patientsEndovascular reperfusionInfarct volumeRadiological outcomesSuccessful reperfusionAcute strokeIschemic strokeRadiographic outcomesEndovascular therapyBaseline imagingMalignant profileTomographic perfusion
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