2024
Bone Pain and Survival Among Patients With Metastatic, Hormone-Sensitive Prostate Cancer
Gebrael G, Jo Y, Swami U, Plets M, Chehade C, Narang A, Gupta S, Myint Z, Sayegh N, Tangen C, Hussain M, Dorff T, Lara P, Lerner S, Thompson I, Agarwal N. Bone Pain and Survival Among Patients With Metastatic, Hormone-Sensitive Prostate Cancer. JAMA Network Open 2024, 7: e2419966. PMID: 38980676, PMCID: PMC11234233, DOI: 10.1001/jamanetworkopen.2024.19966.Peer-Reviewed Original ResearchConceptsProgression-free survivalAndrogen deprivation therapyProstate-specific antigenHormone-sensitive prostate cancerBone painOverall survivalPost hoc secondary analysisProstate cancerSurvival outcomesPain statusAssociated with shorter progression-free survivalClinical trialsPresence of bone painProstate-specific antigen levelAssociated with worse overall survivalCastration-resistant prostate cancerShorter progression-free survivalIntention-to-treat populationSecondary analysisZubrod performance statusHigh-volume diseaseCompare survival outcomesCox proportional hazards regression modelsSecondary end pointsProportional hazards regression modelsRacial disparities in the management and outcomes of primary osseous neoplasms of the spine: a SEER analysis
Elsamadicy A, Sayeed S, Sherman J, Hengartner A, Pennington Z, Hersh A, Lo S, Shin J, Mendel E, Sciubba D. Racial disparities in the management and outcomes of primary osseous neoplasms of the spine: a SEER analysis. Journal Of Neuro-Oncology 2024, 166: 293-301. PMID: 38225469, DOI: 10.1007/s11060-023-04557-3.Peer-Reviewed Original ResearchMeSH KeywordsBone NeoplasmsChondrosarcomaChordomaHumansOsteosarcomaRetrospective StudiesSarcoma, EwingSEER ProgramSpineConceptsRacial disparitiesTumor characteristicsEwing sarcomaWhite patientsOsseous neoplasmsAssociated with tumor characteristicsImpact of racial disparitiesNon-Hispanic whitesAssociated with reduced survivalPrimary osseous neoplasmsUtilization of chemotherapyProportion of black patientsFive-year survivalOutcomes of patientsProportion of blacksNon-white patientsCancer RegistryHispanic cohortMedian survivalRare tumorHispanic patientsStudy patientsTumor typesEnd ResultsRace patients
2023
Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas
Kummar S, Shen L, Hong D, McDermott R, Keedy V, Casanova M, Demetri G, Dowlati A, Melcón S, Lassen U, Leyvraz S, Liu T, Moreno V, Patel J, Patil T, Mallick A, Sousa N, Tahara M, Ziegler D, Norenberg R, Arvis P, Brega N, Drilon A, Tan D. Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas. Cancer 2023, 129: 3772-3782. PMID: 37769113, PMCID: PMC11265530, DOI: 10.1002/cncr.35036.Peer-Reviewed Original ResearchConceptsTropomyosin receptor kinaseNTRK gene fusionsAdult patientsFusion sarcomaAdverse eventsData cutoffGrade 3 treatment-emergent adverse eventsTropomyosin receptor kinase fusion cancerCohort of adult patientsClinical management of adult patientsExtended survival benefitSafety of larotrectinibManagement of adult patientsGastrointestinal stromal tumorsSoft tissue sarcomasTreatment of patientsFirst-in-classGene fusionsInvestigator-assessedNTRK genesReceptor kinaseStromal tumorsSurvival benefitPediatric patientsSolid tumorsSecond Primary Malignancies of the Bones and Joints: More Common than Expected in Osteosarcoma Patients
Freedman I, Dowd H, Dhodapkar M, Halperin S, Grauer J. Second Primary Malignancies of the Bones and Joints: More Common than Expected in Osteosarcoma Patients. JAAOS Global Research And Reviews 2023, 7: e22.00275. PMID: 36695170, PMCID: PMC9875998, DOI: 10.5435/jaaosglobal-d-22-00275.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBone NeoplasmsChildHumansIncidenceNeoplasms, Second PrimaryOsteosarcomaSEER ProgramYoung AdultConceptsSecond primary malignanciesStandardized incidence ratiosOsteosarcoma survivorsPrimary malignancyCommon second primary malignancyNational Cancer Institute's SurveillanceEnd Results 18 databaseCommon primary bone tumorPrimary bone tumorsPopulation-level dataIncidence ratiosOverall incidenceOsteosarcoma patientsPatient populationExcess riskBone tumorsAnatomic locationLong-term eventsOsteosarcoma casesPatientsYoung adultsTumorsSoft tissueMalignancyOsteosarcomaUpdate of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone
Wang A, Maloney E, Al-Dasuqi K, Irshaid L, Ahmed A, Haims A, Porrino J. Update of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone. Skeletal Radiology 2023, 52: 1443-1463. PMID: 36656343, DOI: 10.1007/s00256-023-04286-8.Peer-Reviewed Original ResearchConceptsUndifferentiated small round cell sarcomaSmall round cell sarcomasBone tumorsRound cell sarcomasPediatric populationCell sarcomaMesenchymal tumorsHematopoietic neoplasmsWorld Health Organization classificationGiant cell-rich tumorsPediatric bone tumorsOsteogenic tumorsOrganization classificationVascular tumorsNotochordal tumorsTumorsGenetic sequencing techniquesChondrogenic tumorsCertain lesionsSoft tissueBoneSarcomaNeoplasmsSeparate manuscriptDetailed updateOptimization of Radium-223 Treatment of Castration-resistant Prostate Cancer Based on the Burden of Skeletal Metastasis and Clinical Parameters
Shariftabrizi A, Kothari S, George S, Attwood K, Levine E, Lamonica D. Optimization of Radium-223 Treatment of Castration-resistant Prostate Cancer Based on the Burden of Skeletal Metastasis and Clinical Parameters. The Oncologist 2023, 28: 246-251. PMID: 36651837, PMCID: PMC10020806, DOI: 10.1093/oncolo/oyac245.Peer-Reviewed Original ResearchMeSH KeywordsBone and BonesBone NeoplasmsHumansMaleProstatic Neoplasms, Castration-ResistantRadiumRetrospective StudiesConceptsBaseline BSIBone scan indexMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerProstate cancerOverall survivalSkeletal metastasesRa-223 therapyRa-223 treatmentRadium-223 treatmentTreatment-associated reductionChemotherapy-naïve patientsMedian overall survivalAbsolute neutrophil countRadium-223 dichlorideHigh serum PSANovel treatment modalitiesAlkaline phosphatase levelsChemotherapy-naïveTreatment tolerabilityNeutrophil countSerum PSABone scanLaboratory parametersPatient selection
2022
Update of pediatric bone tumors—notochordal tumors, chondrogenic tumors, and vascular tumors of the bone
Lee H, Wang A, Cheng R, Moran J, Al-Dasuqi K, Irshaid L, Maloney E, Porrino J. Update of pediatric bone tumors—notochordal tumors, chondrogenic tumors, and vascular tumors of the bone. Skeletal Radiology 2022, 52: 1101-1117. PMID: 36369290, DOI: 10.1007/s00256-022-04235-x.Peer-Reviewed Original ResearchMeSH KeywordsBone NeoplasmsChildDiagnostic ImagingHumansNeoplasms, Connective TissuePrognosisWorld Health OrganizationUpdate of pediatric bone tumors: osteogenic tumors and osteoclastic giant cell-rich tumors
Al-Dasuqi K, Cheng R, Moran J, Irshaid L, Maloney E, Porrino J. Update of pediatric bone tumors: osteogenic tumors and osteoclastic giant cell-rich tumors. Skeletal Radiology 2022, 52: 671-685. PMID: 36326880, DOI: 10.1007/s00256-022-04221-3.Peer-Reviewed Original ResearchMeSH KeywordsBone NeoplasmsChildGiant Cell TumorsGiant CellsHumansPrognosisWorld Health OrganizationChondrosarcoma patient characteristics, management, and outcomes based on over 5,000 cases from the National Cancer Database (NCDB)
Ottesen TD, Shultz BN, Munger AM, Amick M, Toombs CS, Friedaender GE, Grauer JN. Chondrosarcoma patient characteristics, management, and outcomes based on over 5,000 cases from the National Cancer Database (NCDB). PLOS ONE 2022, 17: e0268215. PMID: 35901087, PMCID: PMC9333210, DOI: 10.1371/journal.pone.0268215.Peer-Reviewed Original ResearchMeSH KeywordsBone NeoplasmsChondrosarcomaDatabases, FactualFemaleHumansKaplan-Meier EstimateMaleTreatment OutcomeConceptsNational Cancer DatabaseLong-term survivalMultivariate Cox analysisDistant metastasisSurgical treatmentChondrosarcoma patientsCox analysisCancer DatabaseLong-term survival dataKaplan-Meier survival curvesKaplan-Meier survival analysisPrimary osseous tumorsMainstay of treatmentExtent of diseasePoor prognostic factorPrimary tumor siteAge categoriesLikelihood of deathAxial involvementPatient characteristicsWorse survivalPrognostic factorsSurgical excisionMale sexOsseous tumorsTreatment at high-volume facilities is associated with improved overall survival for patients with cutaneous B-cell lymphoma
Cheraghlou S, Ugwu N, Girardi M. Treatment at high-volume facilities is associated with improved overall survival for patients with cutaneous B-cell lymphoma. Journal Of The American Academy Of Dermatology 2022, 88: 203-205. PMID: 35476920, DOI: 10.1016/j.jaad.2022.04.032.Peer-Reviewed Original ResearchCharacteristics, Management, and Outcomes of Patients With Osteosarcoma: An Analysis of Outcomes From the National Cancer Database
Ottesen TD, Shultz BN, Munger AM, Sibindi C, Yurter A, Varthi AG, Grauer JN. Characteristics, Management, and Outcomes of Patients With Osteosarcoma: An Analysis of Outcomes From the National Cancer Database. JAAOS Global Research And Reviews 2022, 6: e22.00009. PMID: 35192571, PMCID: PMC8865506, DOI: 10.5435/jaaosglobal-d-22-00009.Peer-Reviewed Original ResearchConceptsLikelihood of deathDistant metastasisKaplan-Meier survival curvesNational Cancer DatabaseOutcomes of patientsPoor prognostic signMultivariate Cox analysisMeier survival curvesAnalysis of outcomesPatient characteristicsCox analysisPrognostic signSurgical excisionMale sexPatient survivalPatient numbersCancer DatabasePatient variablesTumor managementPrimary siteTumor typesSurvival curvesTreatment dataOsteosarcomaPatientsRuptured Bony Metastasis in Renal Cell Carcinoma
Gier C, Sankey C. Ruptured Bony Metastasis in Renal Cell Carcinoma. Journal Of General Internal Medicine 2022, 37: 1547-1548. PMID: 35102479, PMCID: PMC9086094, DOI: 10.1007/s11606-021-07366-4.Peer-Reviewed Case Reports and Technical NotesPatient-reported neurocognitive function in adult survivors of childhood and adolescent osteosarcoma and Ewing sarcoma
Kadan-Lottick NS, Zheng DJ, Wang M, Bishop MW, Srivastava DK, Ross WL, Rodwin RL, Ness KK, Gibson TM, Spunt SL, Okcu MF, Leisenring WM, Robison LL, Armstrong GT, Krull KR. Patient-reported neurocognitive function in adult survivors of childhood and adolescent osteosarcoma and Ewing sarcoma. Journal Of Cancer Survivorship 2022, 17: 1238-1250. PMID: 35059962, PMCID: PMC9300774, DOI: 10.1007/s11764-021-01154-z.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone NeoplasmsCancer SurvivorsHumansNeoplasmsOsteosarcomaSarcoma, EwingSurvivorsConceptsChronic health conditionsLong-term neurocognitive outcomesNeurocognitive outcomesNeurocognitive difficultiesChildhood osteosarcomaHealth conditionsChildhood Cancer Survivor Study Neurocognitive QuestionnaireAdult survivorsModified Poisson regressionPotential risk factorsOsteosarcoma survivorsSarcoma survivorsNeurocognitive QuestionnaireRisk factorsHigh prevalenceEwing's sarcomaPatient reportsNeurological conditionsRespiratory conditionsTreatment exposureNeurocognitive functionPoisson regressionOsteosarcomaDiagnostic groupsComorbid impairmentsEvolution of Surgical Management of Metastatic Disease of the Pelvis.
Benevenia J, Guinand LA, Ippolito J, Neilson JC, Fabbri N, Lee FY, Yang R, Kurland AM. Evolution of Surgical Management of Metastatic Disease of the Pelvis. Instructional Course Lectures 2022, 71: 185-201. PMID: 35254782.Peer-Reviewed Original ResearchConceptsSurgical managementSignificant pain reliefMetastatic bone diseaseRestoration of ambulationStandardized modalityPain reliefSevere painMetastatic diseasePostoperative periodSurgical treatmentMinimal complicationsSuccessful treatmentSurgical methodsSurgical reconstructionBone diseasePelvic lesionsInterventional methodsPatientsFrail stateMultidisciplinary approachDiseaseWound healingComplicationsLesionsLimited life span
2021
ASO Author Reflections: Apocrine Breast Cancer: More Questions than Answers
Saridakis A, Berger ER, Greenup R, Golshan M, Lannin DR. ASO Author Reflections: Apocrine Breast Cancer: More Questions than Answers. Annals Of Surgical Oncology 2021, 29: 581-582. PMID: 34743280, DOI: 10.1245/s10434-021-10649-z.Peer-Reviewed Original ResearchApocrine Breast Cancer: Unique Features of a Predominantly Triple-Negative Breast Cancer
Saridakis A, Berger ER, Harigopal M, Park T, Horowitz N, Le Blanc J, Zanieski G, Chagpar A, Greenup R, Golshan M, Lannin DR. Apocrine Breast Cancer: Unique Features of a Predominantly Triple-Negative Breast Cancer. Annals Of Surgical Oncology 2021, 28: 5610-5616. PMID: 34426884, DOI: 10.1245/s10434-021-10518-9.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBone NeoplasmsCarcinoma, Ductal, BreastFemaleHumansRetrospective StudiesTriple Negative Breast NeoplasmsConceptsBreast cancer-specific survivalCancer-specific survivalHigh-grade tumorsMolecular subtypesApocrine carcinomaBreast cancerBetter survivalHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerRare breast cancerEnd Results (SEER) databaseGrowth factor receptor 2Triple-negative patientsTriple-negative cancersLow-grade tumorsFactor receptor 2Life table methodApocrine tumorsLuminal patientsWorse survivalClinicopathologic featuresResults databaseAggressive featuresReceptor 2Fenestrated pedicle screws for thoracolumbar instrumentation in patients with poor bone quality: Case series and systematic review of the literature
Ehresman J, Pennington Z, Elsamadicy AA, Hersh A, Lubelski D, Lehner K, Cottrill E, Schilling A, Lakomkin N, Ahmed AK, Lo SF, Sciubba DM. Fenestrated pedicle screws for thoracolumbar instrumentation in patients with poor bone quality: Case series and systematic review of the literature. Clinical Neurology And Neurosurgery 2021, 206: 106675. PMID: 34020324, DOI: 10.1016/j.clineuro.2021.106675.Peer-Reviewed Original ResearchConceptsPulmonary cement embolismFenestrated pedicle screwsCement leakageBone qualityCement embolismInstrumented fusionHardware looseningOsteoporotic fracturesPedicle screwsSystematic reviewSymptomatic pulmonary cement embolismNon-augmented patientsSingle-surgeon seriesDegenerative spine diseaseHigh-quality evidencePoor bone qualityEndpoints of interestLow reported ratesPathologic fractureCase seriesSpine metastasesFenestrated screwsSpine diseasePRISMA guidelinesPatientsAblation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases.
Toombs C, Conway D, Munger AM, Alder KD, Latich I, Lee FY. Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases. Instructional Course Lectures 2021, 70: 503-514. PMID: 33438931.Peer-Reviewed Original ResearchMeSH KeywordsBone CementsBone NeoplasmsCementoplastyFracture Fixation, InternalHumansOsteolysisTreatment OutcomeConceptsInternal fixationLocal cancer controlBalloon osteoplastySurgical stabilizationCancer controlConventional open surgical proceduresLocal cancer progressionProgressive bone destructionFirst-line treatmentPercutaneous treatment optionsAmbulatory surgery settingProgressive bone lossSurgical reconstructive proceduresEarly clinical resultsImage-guided ablationNew effective therapiesOpen surgical proceduresInvasive surgical interventionOptimal internal fixationOsteolytic metastatic diseasePolymethyl methacrylate cementUncontrolled painMetastatic diseaseBone destructionOsteolytic metastases
2020
Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease
Collins D, Sundar R, Constantinidou A, Dolling D, Yap T, Popat S, O’Brien M, Banerji U, de Bono J, Lopez J, Tunariu N, Minchom A. Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease. BMC Cancer 2020, 20: 1210. PMID: 33298007, PMCID: PMC7724793, DOI: 10.1186/s12885-020-07662-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBone NeoplasmsBrain NeoplasmsClinical Trials, Phase I as TopicCombined Modality TherapyDiagnostic ImagingFemaleHumansKaplan-Meier EstimateLiver NeoplasmsLung NeoplasmsMaleMesothelioma, MalignantMiddle AgedPeritoneal NeoplasmsPleural NeoplasmsProportional Hazards ModelsRetrospective StudiesConceptsDistant metastasisPeritoneal metastasisMPM patientsTreatment paradigmCohort of MPM patientsFrequency of distant metastasesIncidence of bone metastasesPresence of distant metastasesPattern of metastatic spreadDistant metastatic diseaseDistant metastatic disseminationBackgroundMalignant pleural mesotheliomaPresence of symptomsIncidence of boneMetastatic diseaseMetastatic sitesBone metastasesOverall survivalMetastatic spreadContralateral lungPrognostic implicationsMetastatic disseminationRadiological investigationsRetrospective studyPleural mesotheliomaBone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.
Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43: e498-e502. PMID: 32882054, DOI: 10.3928/01477447-20200827-05.Peer-Reviewed Original ResearchConceptsRadionuclide bone scanBone scanMRI scansPositive findingsNegative findingsMagnetic resonance imaging (MRI) scansBone scan findingsProgression of lesionsResonance imaging scansDiagnosis of enchondromaAcademic medical centerBivariate logistic regressionAssociation of boneScan findingsAggressive featuresRadiographic findingsEndosteal scallopingBenign enchondromaImaging scansMedical recordsMedical CenterMalignant lesionsCartilaginous lesionsEnchondromaPatients
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