2023
Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease
Siegel S, Griffith D, Philley J, Brown-Elliott B, Brunton A, Sullivan P, Fuss C, Strnad L, Wallace R, Winthrop K. Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease. CHEST Journal 2023, 164: 846-859. PMID: 37419144, PMCID: PMC10645596, DOI: 10.1016/j.chest.2023.05.036.Peer-Reviewed Original ResearchConceptsAmikacin liposome inhalation suspensionAmikacin resistanceCulture conversionInhalation suspensionMycobacterium abscessus lung diseasePresence of macrolide resistanceEnd pointsMicrobiological end pointsMonthly sputum culturesSputum culture conversionTreatment-refractory diseaseOpen-label protocolSecondary end pointsOpen-label trialCohort of patientsCavitary diseaseSputum culturePretreatment isolatesM abscessusOpen-labelOral antimicrobialsParenteral antibioticsCompanion therapyMacrolide resistanceMultidrug therapy
2022
High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa
Dabbousi A, Osman M, Dabboussi F, Hamze M. High rates of macrolide and fluoroquinolone resistance in human campylobacteriosis in the Middle East and North Africa. Future Microbiology 2022, 17: 957-967. PMID: 35796073, DOI: 10.2217/fmb-2021-0302.Peer-Reviewed Original ResearchConceptsHuman campylobacteriosisRoutine stool cultureBacterial gastrointestinal infectionsClinical laboratoriesIncidence of campylobacteriosisPaucity of dataMain causative agentStool culturesGastrointestinal infectionsDiarrheal patientsMicrobiological diagnosisClinical importanceFluoroquinolone resistanceInfection prevalenceAntimicrobial resistanceZoonotic diseaseCausative agentCampylobacteriosisHigh rateAlarming ratePatientsCritical needEpidemiologyInfectionPrevalenceA global snapshot on the prevalent macrolide-resistant emm types of Group A Streptococcus worldwide, their phenotypes and their resistance marker genotypes during the last two decades: A systematic review
Rafei R, Al Iaali R, Osman M, Dabboussi F, Hamze M. A global snapshot on the prevalent macrolide-resistant emm types of Group A Streptococcus worldwide, their phenotypes and their resistance marker genotypes during the last two decades: A systematic review. Infection Genetics And Evolution 2022, 99: 105258. PMID: 35219865, DOI: 10.1016/j.meegid.2022.105258.Peer-Reviewed Original ResearchConceptsEmm typesMacrolide resistance phenotypeEmm clustersMacrolide resistanceSystematic reviewPeculiar epidemiological featuresPresent systematic reviewEmm pattern AGroup A StreptococcusResistance phenotypeClinical presentationMiddle-income countriesEpidemiological featuresHigh-income countriesExclusion criteriaMacrolide susceptibilityA StreptococcusEpidemiological surveillanceSustained surveillancePattern EPattern AIncome countriesPhenotypeSurveillanceEpidemiological dynamicsLow doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies
Martelli F, Hernandes N, Zuo Z, Wang J, Wong C, Karagas N, Roessner U, Rupasinghe T, Robin C, Venkatachalam K, Perry T, Batterham P, Bellen H. Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies. ELife 2022, 11: e73812. PMID: 35191376, PMCID: PMC8863376, DOI: 10.7554/elife.73812.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesBeneficial insectsBeneficial insect speciesElevated reactive oxygen speciesInsect speciesInsect pestsMitochondrial stressMitochondrial defectsAdult virgin femalesLysosomal defectsGlobal declineAntioxidant N-acetylcysteine amidePopulation sizeSpinosad toxicityMode of actionLipid storageMetabolic tissuesVirgin femalesInsecticide applicationsLysosomal dysfunctionInsectsSevere neurodegenerationSynthetic insecticidesOxygen speciesAlpha 6
2021
Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity
Zhang H, Zou J, Yan X, Chen J, Cao X, Wu J, Liu Y, Wang T. Marine-Derived Macrolides 1990–2020: An Overview of Chemical and Biological Diversity. Marine Drugs 2021, 19: 180. PMID: 33806230, PMCID: PMC8066444, DOI: 10.3390/md19040180.Peer-Reviewed Original Research
2020
Efficient Preparation of Bafilomycin A1 from Marine Streptomyces lohii Fermentation Using Three-Phase Extraction and High-Speed Counter-Current Chromatography
Yuan Y, He X, Wang T, Zhang X, Li Z, Xu X, Zhang W, Yan X, Li S, He S. Efficient Preparation of Bafilomycin A1 from Marine Streptomyces lohii Fermentation Using Three-Phase Extraction and High-Speed Counter-Current Chromatography. Marine Drugs 2020, 18: 332. PMID: 32630403, PMCID: PMC7345786, DOI: 10.3390/md18060332.Peer-Reviewed Original ResearchDistribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region
Rafei R, Hawli M, Osman M, Dabboussi F, Hamze M. Distribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa region. Journal Of Global Antimicrobial Resistance 2020, 22: 334-348. PMID: 32084609, DOI: 10.1016/j.jgar.2020.02.005.Peer-Reviewed Original ResearchMeSH KeywordsAfrica, NorthernAnti-Bacterial AgentsDrug Resistance, BacterialGenotypeHumansMacrolidesMiddle EastConceptsInvasive GAS infectionsGAS infectionVaccine candidatesProtein-based vaccine candidatesEpidemiology of groupMacrolide resistance determinantsMacrolide resistance profilesGAS prevalencePharyngitis patientsDisease burdenEmm typesGAS isolatesHealthy carriersSystematic surveillanceResistance profilesErythromycin resistancePotential coverageBurdenResistance determinantsInfectionStreptococciCoverage rateEmm28Emm4Emm89
2019
Five-year safety and performance data of a novel third-generation novolimus-eluting bioresorbable scaffold in single de novo lesions.
Verheye S, Costa R, Schofer J, Ormiston J, Maeng M, Dudek D, Skurk C, Botelho R, Costa J, Chamié D, Abizaid A, Boersma E, Abizaid A. Five-year safety and performance data of a novel third-generation novolimus-eluting bioresorbable scaffold in single de novo lesions. EuroIntervention 2019, 15: 685-687. PMID: 30530403, DOI: 10.4244/eij-d-18-00292.Peer-Reviewed Original Research
2018
Tunability of Biodegradable Poly(amine-co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications
Kauffman AC, Piotrowski-Daspit AS, Nakazawa KH, Jiang Y, Datye A, Saltzman WM. Tunability of Biodegradable Poly(amine-co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications. Biomacromolecules 2018, 19: 3861-3873. PMID: 30110158, PMCID: PMC6510397, DOI: 10.1021/acs.biomac.8b00997.Peer-Reviewed Original ResearchConceptsNucleic acid deliveryAcid deliveryLow charge density polymersBiomedical applicationsGene therapyEnzyme-Catalyzed PolymerizationEfficient delivery vehiclesCatalyzed polymerizationEfficient transfectionTerpolymer compositionUnique tunabilityPolymersViral vectorsDelivery vehiclesVivo applicationsPolycationic vectorsLow toxicityNucleic acidsCellular barriersTunabilitySpecific cell typesDNA plasmidsPolymerizationTerpolymerApplicationsSerial intravascular ultrasound evaluation of the DESolve™ novolimus‐eluting bioresorbable coronary scaffold system
Barreira G, Costa J, Costa R, Staico R, Chamie D, Slhessarenko J, Tanajura L, Abizaid A, Sousa A, Abizaid A. Serial intravascular ultrasound evaluation of the DESolve™ novolimus‐eluting bioresorbable coronary scaffold system. Catheterization And Cardiovascular Interventions 2018, 92: e368-e374. PMID: 29521477, DOI: 10.1002/ccd.27591.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedCardiovascular AgentsCoated Materials, BiocompatibleCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleHumansMacrolidesMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesTime FactorsTreatment OutcomeUltrasonography, InterventionalConceptsBioresorbable coronary scaffoldsSafety of coronary angioplastySuppression of neointimal proliferationAdverse cardiac eventsTime pointsLate lumen lossNon-randomized studiesPercutaneous coronary interventionDevice dimensionsIntravascular ultrasound evaluationScaffold systemConsecutive patientsCoronary scaffoldsPrimary endpointSingle-centerCardiac eventsAngiographic successUltrasound evaluationFollow-upLumen lossCoronary interventionSerial evaluationNeointimal proliferationScaffold areaCoronary angioplasty
2017
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
Scholl UI, Abriola L, Zhang C, Reimer EN, Plummer M, Kazmierczak BI, Zhang J, Hoyer D, Merkel JS, Wang W, Lifton RP. Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma. Journal Of Clinical Investigation 2017, 127: 2739-2750. PMID: 28604387, PMCID: PMC5490757, DOI: 10.1172/jci91733.Peer-Reviewed Original ResearchConceptsAldosterone-producing adenomaAldosterone productionAdrenocortical cancer cell lineKCNJ5 potassium channelPotassium channel KCNJ5Motilin receptor agonistSteroid hormone aldosteroneMillions of casesAPA diagnosisCancer cell linesSevere hypertensionAdrenal glandReceptor agonistBenign tumorsHormone aldosteroneCalcium influxInvasive proceduresKCNJ5 mutationsAdrenocortical cellsNoninvasive diagnosisPotassium channelsMembrane depolarizationDiagnosisCell proliferationCell linesMolecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon
Ashkar S, Osman M, Rafei R, Mallat H, Achkar M, Dabboussi F, Hamze M. Molecular detection of genes responsible for macrolide resistance among Streptococcus pneumoniae isolated in North Lebanon. Journal Of Infection And Public Health 2017, 10: 745-748. PMID: 28215918, DOI: 10.1016/j.jiph.2016.11.014.Peer-Reviewed Original ResearchConceptsMacrolide resistance genotypesS. pneumoniaeMacrolide resistanceStreptococcus pneumoniaeS. pneumoniae isolatesUse of macrolidesS. pneumoniae strainsNorth LebanonResistance genotypesCMLSB phenotypePolymerase chain reactionPneumoniae isolatesPneumoniae strainsClinical isolatesPneumoniaeChain reactionEfflux pumpsPhenotypic diagnosisCommon resistance genesMolecular detection
2016
Effect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease
Pettigrew MM, Tsuji BT, Gent JF, Kong Y, Holden PN, Sethi S, Murphy TF. Effect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Antimicrobial Agents And Chemotherapy 2016, 60: 4151-4158. PMID: 27139476, PMCID: PMC4914697, DOI: 10.1128/aac.00301-16.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseH. influenzae isolatesH. influenzaePulmonary diseaseFluoroquinolone administrationInfluenzae isolatesDevelopment of resistanceHaemophilus influenzaeEradication of carriageEffects of macrolidesQuinolone resistance-determining regionsMICs of antibioticsEffects of fluoroquinolonesResistance-determining regionMacrolide administrationCOPD patientsEffects of antibioticsAzithromycin MICsAntibiotic useSusceptibility breakpointsAntibiotic susceptibilityMacrolide susceptibilityInfluenzaeAdministrationSerial Multimodality Imaging and 2-Year Clinical Outcomes of the Novel DESolve Novolimus-Eluting Bioresorbable Coronary Scaffold System for the Treatment of Single De Novo Coronary Lesions
Abizaid A, Costa R, Schofer J, Ormiston J, Maeng M, Witzenbichler B, Botelho R, Costa J, Chamié D, Abizaid A, Castro J, Morrison L, Toyloy S, Bhat V, Yan J, Verheye S. Serial Multimodality Imaging and 2-Year Clinical Outcomes of the Novel DESolve Novolimus-Eluting Bioresorbable Coronary Scaffold System for the Treatment of Single De Novo Coronary Lesions. JACC Cardiovascular Interventions 2016, 9: 565-574. PMID: 27013155, DOI: 10.1016/j.jcin.2015.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedBrazilCardiovascular AgentsCoated Materials, BiocompatibleCoronary AngiographyCoronary Artery DiseaseCoronary VesselsEuropeFemaleHumansHyperplasiaMacrolidesMaleMiddle AgedNeointimaNew ZealandPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesTime FactorsTomography, Optical CoherenceTreatment OutcomeUltrasonography, InterventionalConceptsClinical outcomesFollow-upLumen lossTreatment of de novo coronary lesionsOptical coherence tomography analysisMajor adverse cardiac eventsAdverse cardiac event ratesComposite of cardiac deathCardiac event rateAngiographic follow-upDevice success rateAdverse cardiac eventsInhibition of neointimal hyperplasiaTarget vessel myocardial infarctionOptical coherence tomographyTarget lesion revascularizationDrug-eluting metal stentsRisk of future adverse eventsIntravascular ultrasound analysisScaffold dimensionsBioresorbable coronary scaffoldsPrimary endpointSafety endpointsCardiac eventsPost-procedure
2015
Site-Selective Reactions with Peptide-Based Catalysts
Giuliano MW, Miller SJ. Site-Selective Reactions with Peptide-Based Catalysts. 2015, 372: 157-201. PMID: 26307403, DOI: 10.1007/128_2015_653.Peer-Reviewed Original ResearchMeSH KeywordsCatalysisErythromycinGlycopeptidesMacrolidesOxidation-ReductionPeptidesPhosphorylationPyrones
2014
Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes
Wei M, Li Z, Yang Z. Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes. Molecular And Cellular Biochemistry 2014, 394: 261-273. PMID: 24957786, DOI: 10.1007/s11010-014-2102-7.Peer-Reviewed Original Research
2012
Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport
Du Z, Wan L, Yan Q, Weinbaum S, Weinstein A, Wang T. Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport. American Journal Of Physiology. Renal Physiology 2012, 303: f1507-f1516. PMID: 22952281, PMCID: PMC3532483, DOI: 10.1152/ajprenal.00277.2012.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsBicarbonatesBiological TransportEnzyme InhibitorsFemaleHemostasisIn Vitro TechniquesKidney GlomerulusKidney TubulesLosartanMacrolidesMiceMice, KnockoutModels, AnimalProton-Translocating ATPasesReceptor, Angiotensin, Type 1SodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsNa(+)-H(+) exchanger 3Mouse tubulesImpact of angiotensin IIH-ATPaseMicroperfused in vitroAT(2) receptorsAT(1A) receptorFlow-mediated changesH-ATPase activityParacellular Cl(-Receptor availabilityAngiotensin IIAT(1ARegulate Na(+Increased Na(+Local angiotensinBasolateral transportJ(HCO3Mouse kidneyNet fluidInhibitor bafilomycinProtein levelsMiceReceptorsTubulesRegulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport
Du Z, Yan Q, Wan L, Weinbaum S, Weinstein A, Wang T. Regulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport. American Journal Of Physiology. Renal Physiology 2012, 303: f386-f395. PMID: 22552936, PMCID: PMC3433864, DOI: 10.1152/ajprenal.00531.2011.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAlgorithmsAnimalsBenzazepinesBicarbonatesBiological Transport, ActiveChloridesCyclic AMP-Dependent Protein KinasesDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsFemaleIsoquinolinesKidney GlomerulusKidney TubulesKidney Tubules, ProximalMacrolidesMiceMicrovilliProton-Translocating ATPasesReceptors, Dopamine D1SodiumSulfonamidesSulpirideConceptsNa/H exchanger 3Impact of dopamineNa(+) transportNa-K-ATPase activityResponse to volume expansionProximal tubules in vitroCl(-) reabsorptionPKA-mediated mechanismMicroperfused in vitroEffects of exogenous dopamineMouse proximal tubuleNa-K-ATPaseProximal tubule reabsorptionStimulation of Cl(-PKA inhibitor H89Luminal flowH-ATPase activityTubules in vitroLuminal flow rateNHE3 activityDA1 receptorsNa/H exchangeTubule reabsorptionProximal tubulesInhibitor H89
2011
Angiotensin II Stimulates H+-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts
Wagner CA, Mohebbi N, Uhlig U, Giebisch GH, Breton S, Brown D, Geibel JP. Angiotensin II Stimulates H+-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts. Cellular Physiology And Biochemistry 2011, 28: 513-520. PMID: 22116365, PMCID: PMC3709473, DOI: 10.1159/000335112.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAnion Transport ProteinsBicarbonatesCell MembraneChloridesColchicineHydrogen-Ion ConcentrationImmunohistochemistryKidney CortexKidney Tubules, CollectingMacrolidesMaleMiceMice, Inbred C57BLReceptors, AngiotensinSaralasinSodiumSulfate TransportersVacuolar Proton-Translocating ATPasesConceptsCNT/CCDAngiotensin IICortical collecting ductsBicarbonate secretionChloride absorptionCollecting ductsType 1 angiotensin II receptorAngiotensin II stimulatesAngiotensin II receptorsAcid-base statusConnecting tubuleATPase activityII receptorsSpecific subtypesNephron segmentsIndependent intracellularAcid extrusionType BSecretionTubulesDuct systemDuctPendrinPresent studyCellsVacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell
Kopic S, Wagner ME, Griessenauer C, Socrates T, Ritter M, Geibel JP. Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Pflügers Archiv - European Journal Of Physiology 2011, 463: 419-427. PMID: 22146938, DOI: 10.1007/s00424-011-1060-0.Peer-Reviewed Original ResearchConceptsV-ATPase activityV-ATPaseAcid secretionParietal cellsRat parietal cellsProton pump inhibitor therapyCertain specialized cellsK-ATPaseProton transportVacuolar-type H-ATPaseK-ATPase inhibitionSecretion pathwayTrafficking mechanismsSpecialized cellsMicrotubule networkActive acidificationInhibitor therapyIntracellular organellesK-ATPase activityRat gastric glandsConcanamycin APharmacological inhibitionAcid loadIntracellular alkalinizationAcid breakthrough
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