2024
Phenotypic spectrum of inclusion body myositis.
Roy B, Dimachkie M, Naddaf E. Phenotypic spectrum of inclusion body myositis. Clinical And Experimental Rheumatology 2024, 42: 445-453. PMID: 38436356, DOI: 10.55563/clinexprheumatol/fhrx3q.Peer-Reviewed Original ResearchMeSH KeywordsDeglutition DisordersHumansMuscle WeaknessMyositisMyositis, Inclusion BodyQuality of LifeConceptsInclusion body myositisAtypical presentationInitiation of disease-modifying therapyDeep finger flexorsQuality of lifeLoss of hand functionBenefits of early diagnosisInclusion body myositis patientsYears of disease onsetDebilitating muscle diseaseTime to diagnosisFoot dropAsymptomatic hyper-CKemiaFinger flexorsQuadriceps muscleImpaired ambulationHand functionDisease-modifying therapiesGeneral populationFacial diplegiaAxial weaknessClinical spectrumIsolated dysphagiaProximal weaknessHyper-CKemia
2023
Leg MRI as a Complementary Diagnostic Tool in the Assessment of Foot Drop
Torabi T, Zubair A, Nowak R, Tseng B, Haims A, Roy B. Leg MRI as a Complementary Diagnostic Tool in the Assessment of Foot Drop. Journal Of Clinical Neuromuscular Disease 2023, 25: 57-58. PMID: 37611274, DOI: 10.1097/cnd.0000000000000433.Peer-Reviewed Original ResearchUncovering the Relationship Between Statins and Muscle Problems in the ELSA-Brasil MSK Cohort
Pedroso A, Barreto S, Telles R, Machado L, Haueisen Sander Diniz M, Duncan B, Figueiredo R. Uncovering the Relationship Between Statins and Muscle Problems in the ELSA-Brasil MSK Cohort. Cardiovascular Drugs And Therapy 2023, 38: 1409-1414. PMID: 37261675, DOI: 10.1007/s10557-023-07476-7.Peer-Reviewed Original ResearchConceptsFive-times-sit-to-standStatin useMSK cohortMuscle problemsELSA-BrasilMuscle painHandgrip testFive-times-sit-to-stand testDuration of statin treatmentSecondary analysisMultivariate logistic regression analysisBrazilian civil servantsLogistic regression analysisNo significant associationSelf-reported symptomsCross-sectional data analysisStatin treatmentEfficacy-effectiveness gapMuscle strengthHandgrip strengthHighest quintileMuscle groupsMuscle weaknessStatinsPain
2021
Diagnosis of Guillain-Barré Syndrome After Total Hip Arthroplasty: A Case Report.
Tesoriero P, Feng JE, Anoushiravani AA, Kiprovski K, Marwin S, Wiznia D. Diagnosis of Guillain-Barré Syndrome After Total Hip Arthroplasty: A Case Report. JBJS Case Connector 2021, 11 PMID: 34038913, DOI: 10.2106/jbjs.cc.20.00848.Peer-Reviewed Case Reports and Technical NotesConceptsTotal hip arthroplastyCase reportHip arthroplastyGuillain-Barré syndrome variantsAcute periprosthetic infectionLower extremity weaknessSingle-stage revisionGuillain-Barré syndromeElectrodiagnostic studiesExtremity weaknessIntravenous immunoglobulinClinical suspicionSurgical debridementPostsurgical complicationsPeriprosthetic infectionNeuromuscular deficitsDisease progressionSyndrome variantLiner exchangeArthroplastyReportDebridementPainComplicationsAmbulationMyotonic Muscular Dystrophy Type 2 in CT, USA: A Single-Center Experience With 50 Patients.
Roy B, Wu Q, Whitaker C, Felice K. Myotonic Muscular Dystrophy Type 2 in CT, USA: A Single-Center Experience With 50 Patients. Journal Of Clinical Neuromuscular Disease 2021, 22: 135-146. PMID: 33595997, DOI: 10.1097/cnd.0000000000000340.Peer-Reviewed Original ResearchConceptsClinicopathological findingsSymptom onsetNonischemic dilated cardiomyopathySingle-center experienceProximal lower extremityType 2Medical Research Council scoreAutosomal dominant disorderMuscle pathological changesAge of symptom onsetMyotonic dystrophy type 2Cardiac transplantationPain symptomsDilated cardiomyopathySingle-centerClinical myotoniaCardiac abnormalitiesDominant disorderLimb weaknessCNBP geneMuscular dystrophyPatientsMyotonic dischargesLower extremitiesPathological changes
2020
Acute flaccid myelitis: cause, diagnosis, and management
Murphy O, Messacar K, Benson L, Bove R, Carpenter J, Crawford T, Dean J, DeBiasi R, Desai J, Elrick M, Farias-Moeller R, Gombolay G, Greenberg B, Harmelink M, Hong S, Hopkins S, Oleszek J, Otten C, Sadowsky C, Schreiner T, Thakur K, Van Haren K, Carballo C, Chong P, Fall A, Gowda V, Helfferich J, Kira R, Lim M, Lopez E, Wells E, Yeh E, Pardo C, group A, Salazar-Camelo A, Mithal D, Wilson-Murphy M, Bauer A, Watkins C, Abzug M, Dominguez S, Press C, Yang M, Ahsan N, Ramos-Platt L, Tiongson E, Seruya M, Tilton A, Katz E, Kirschen M, Shah A, Ulloa E, Yum S, Mondok L, Blaufuss M, Rosenfeld A, Vargas W, Zucker J, Yeshokumar A, Navis A, Chao K, Hagen K, Melicosta M, Porter C, Tunney M, Scheuermann R, Duggal P, Pekosz A, Bayliss A, Moore M, Belzberg A, Bembea M, O'Brien C, Riggs R, Nance J, Milstone A, Rice J, Garcia-Dominguez M, Flanagan E, Tillema J, Bosques G, Bhatia S, Gordon-Lipkin E, Deike D, Revivo G, Zlotolow D, deFiebre G, Lazerow P, Lotze T, Bitnun A, Davidge K, Vajsar J, Moore A, Konersman C, Nash K, Strober J, Gupta N, Chiu C, Sweeney M, Jackson W, Simon D, Thakkar K, Cheng J, Luce J, Das S, Vogt M, Vu N, Gofshteyn J, Makhani N, Patel P. Acute flaccid myelitis: cause, diagnosis, and management. The Lancet 2020, 397: 334-346. PMID: 33357469, PMCID: PMC7909727, DOI: 10.1016/s0140-6736(20)32723-9.Peer-Reviewed Original ResearchConceptsAcute flaccid myelitisNon-polio enterovirus infectionMajor public health challengeAcute neurological illnessCerebrospinal fluid characteristicsPolio-like illnessSubstantial residual disabilityProfound muscle weaknessLong-term outcomesTargeted therapeutic approachesPublic health challengeLong-term rehabilitationResidual disabilityAcute phaseClinical featuresClinical presentationEnterovirus infectionImmunological featuresMuscle weaknessNeurological illnessTherapeutic approachesHost-virus interactionsPathogen factorsHealth challengesDiagnosisAtypical case of Miller-Fisher syndrome presenting with severe dysphagia and weight loss
Patel K, Nussbaum E, Sico J, Merchant N. Atypical case of Miller-Fisher syndrome presenting with severe dysphagia and weight loss. BMJ Case Reports 2020, 13: e234316. PMID: 32467120, PMCID: PMC7259814, DOI: 10.1136/bcr-2020-234316.Peer-Reviewed Case Reports and Technical NotesConceptsMiller Fisher syndromeAtypical casesLower extremity muscle weaknessWeight lossExtremity muscle weaknessFormal swallow evaluationThorough neurological examinationResolution of symptomsAlbuminocytological dissociationIntravenous immunoglobulinPresenting symptomProgressive dysphagiaSevere dysphagiaSwallow evaluationSymptom onsetExtraocular movementsNeurological examinationMuscle weaknessPhysical examinationAntibody titresDysphagiaCerebrospinal fluidGait stabilityPatientsSyndrome
2019
Clinical Reasoning: Progressive proximal weakness in a 56-year-old man with bone pain
Torabi T, Huttner A, Nowak RJ, Roy B. Clinical Reasoning: Progressive proximal weakness in a 56-year-old man with bone pain. Neurology 2019, 93: 939-944. PMID: 31740511, DOI: 10.1212/wnl.0000000000008535.Peer-Reviewed Original ResearchDiagnosis, DifferentialElectromyographyFrontotemporal DementiaHumansLambert-Eaton Myasthenic SyndromeMaleMiddle AgedMuscle WeaknessMuscular Dystrophies, Limb-GirdleMyositisMyositis, Inclusion BodyOsteitis DeformansPainPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingValosin Containing ProteinAtypical presentation of necrotising autoimmune myopathy
Ajiboye O, Manesh M, Asmi N, Mba B. Atypical presentation of necrotising autoimmune myopathy. BMJ Case Reports 2019, 12: e229119. PMID: 31142488, PMCID: PMC6557363, DOI: 10.1136/bcr-2018-229119.Peer-Reviewed Original ResearchConceptsProximal muscle weaknessAutoimmune myopathyStatin useAtypical presentationMuscle weaknessSymmetrical proximal muscle weaknessElevated creatine kinase levelsNecrotising autoimmune myopathySevere oropharyngeal dysphagiaCreatine kinase levelsCase of statinsSevere quadriparesisInitial presentationOropharyngeal dysphagiaHistological findingsMyocyte necrosisRemote historyRapid progressionAutoimmune antibodiesIrritable myopathyKinase levelsHigh indexRare diseaseRemarkable inflammationPresentation patterns
2018
Isolated Upper Limb Weakness From Ischemic Stroke: Mechanisms and Outcome
Topcuoglu M, Rocha E, Siddiqui A, Mills B, Silva G, Schwamm L, Lamuraglia G, Singhal A. Isolated Upper Limb Weakness From Ischemic Stroke: Mechanisms and Outcome. Journal Of Stroke And Cerebrovascular Diseases 2018, 27: 2712-2719. PMID: 30033098, DOI: 10.1016/j.jstrokecerebrovasdis.2018.05.050.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCarotid StenosisCerebral AngiographyComputed Tomography AngiographyDiffusion Magnetic Resonance ImagingDisability EvaluationEmbolismFemaleHeart DiseasesHumansMagnetic Resonance AngiographyMaleMiddle AgedMotor ActivityMotor CortexMuscle StrengthMuscle WeaknessMuscle, SkeletalPlaque, AtheroscleroticPrognosisRecovery of FunctionRetrospective StudiesRisk FactorsRupture, SpontaneousStrokeUpper ExtremityConceptsCarotid artery stenosisArtery stenosisCarotid stenosisSubcortical white matter infarctsClinical imaging featuresUpper extremity weaknessDiffusion-weighted magnetic resonance imagingUpper limb weaknessRecurrent stroke riskWhite matter infarctsMagnetic resonance imagingCardioembolic mechanismRecurrent strokeBrainstem infarctsExtremity weaknessMultiple infarctsIschemic strokeLimb weaknessStroke riskMotor stripStroke evaluationMean agePlaque ulcerationStroke mechanismInfarctsDifferential aging‐related changes in neurophysiology and gene expression in IB4‐positive and IB4‐negative nociceptive neurons
Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib‐Hajj S, Waxman SG, Stevens EB, Randall AD. Differential aging‐related changes in neurophysiology and gene expression in IB4‐positive and IB4‐negative nociceptive neurons. Aging Cell 2018, 17: e12795. PMID: 29943484, PMCID: PMC6052481, DOI: 10.1111/acel.12795.Peer-Reviewed Original ResearchConceptsIB4-negative neuronsIB4-positive neuronsIsolectin B4Age-dependent changesTTX-resistant sodium currentsProperties of nociceptorsDorsal root gangliaCurrent-clamp experimentsAging-related changesMiddle-aged rodentsHigh input resistancePain prevalenceNociceptive neuronsPain treatmentNociceptor excitabilityMembrane potentialPain sensitivityRoot gangliaCultured neuronsNeurons pointsRepetitive firingSodium currentWindow currentNociceptorsNeuronsManagement of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine
Thilen SR, Ng IC, Cain KC, Treggiari MM, Bhananker SM. Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine. British Journal Of Anaesthesia 2018, 121: 367-377. PMID: 30032875, DOI: 10.1016/j.bja.2018.03.029.Peer-Reviewed Original ResearchConceptsPostoperative residual neuromuscular blockResidual neuromuscular blockNeuromuscular blockTracheal extubationNeostigmine reversalRocuronium neuromuscular blockIdeal body weightConfidence intervalsNeostigmine administrationRocuronium administrationSecondary endpointsAppropriate dosingAbdominal surgeryFemale sexDose reductionExtubationBody weightControl groupPatientsIncidenceSurgical requirementsSignificant differencesNeostigmineAdministrationSubjective monitoring
2017
Case 34-2017
Lyons JL, Schaefer PW, Cho TA, Azar MM. Case 34-2017. New England Journal Of Medicine 2017, 377: 1878-1886. PMID: 29117489, DOI: 10.1056/nejmcpc1707557.Peer-Reviewed Case Reports and Technical NotesA Strong Diagnosis of Weakness
Sudo M, Wada Y, Narita I, Mba B, Houchens N. A Strong Diagnosis of Weakness. Journal Of Hospital Medicine 2017, 12: 989-993. PMID: 29236098, DOI: 10.12788/jhm.2858.Peer-Reviewed Original ResearchCase 26-2017
Letourneau AR, Price MC, Azar MM. Case 26-2017. New England Journal Of Medicine 2017, 377: 770-778. PMID: 28834480, DOI: 10.1056/nejmcpc1616402.Peer-Reviewed Case Reports and Technical NotesClinical Reasoning
Roy B, Chahin N. Clinical Reasoning. Neurology 2017, 88: e96-e100. PMID: 28289174, DOI: 10.1212/wnl.0000000000003718.Peer-Reviewed Original Research
2016
Hypophosphatemia promotes lower rates of muscle ATP synthesis
Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI. Hypophosphatemia promotes lower rates of muscle ATP synthesis. The FASEB Journal 2016, 30: 3378-3387. PMID: 27338702, PMCID: PMC5024687, DOI: 10.1096/fj.201600473r.Peer-Reviewed Original ResearchConceptsMuscle ATP synthesisATP synthesisMuscle weaknessIsolated muscle mitochondriaSolute carrier familyWild-type littermate controlsSolute carrier family 34Carrier familyLower ratesInsulin-stimulated ratesMuscle mitochondriaChronic hypophosphatemiaHeart failureHypophosphatemic groupHypophosphatemic miceHypophosphatemiaLittermate controlsKnockout miceBlood PLow ratePlasma PPatientsSimilar findingsMember 1Plasma inorganic phosphateRestricting Symptoms Before and After Admission to Hospice
Cheraghlou S, Gahbauer EA, Leo-Summers L, Stabenau HF, Chaudhry SI, Gill TM. Restricting Symptoms Before and After Admission to Hospice. The American Journal Of Medicine 2016, 129: 754.e7-754.e15. PMID: 26968471, PMCID: PMC4914433, DOI: 10.1016/j.amjmed.2016.02.017.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overChest PainCognitive DysfunctionCohort StudiesDepressionDiarrheaDizzinessDyspneaEdemaFatigueFemaleHospice CareHospicesHumansIndependent LivingLongitudinal StudiesMaleMemory DisordersMuscle WeaknessMusculoskeletal PainNauseaPatient AdmissionPrevalenceProspective StudiesSleep Wake DisordersUnited StatesUrologic DiseasesVision DisordersVomitingConceptsHospice admissionEnd of lifeDistressing symptomsMean numberCommunity-dwelling older personsMonthly telephone interviewsOngoing cohort studyMonths of lifeEffect of hospiceHospice treatmentAdmission diagnosisEarly referralMedian durationCohort studySymptom prevalenceSuch symptomsSymptom increasesAdmissionPsychological symptomsSymptomsOlder personsRestricted activityHospiceTelephone interviewsPrevalence
2015
Effects of Psoas Muscle Thickness on Outcomes of Lumbar Fusion Surgery
Verla T, Adogwa O, Elsamadicy A, Moreno JR, Farber H, Cheng J, Bagley CA. Effects of Psoas Muscle Thickness on Outcomes of Lumbar Fusion Surgery. World Neurosurgery 2015, 87: 283-289. PMID: 26619920, DOI: 10.1016/j.wneu.2015.11.022.Peer-Reviewed Original ResearchConceptsPsoas muscle thicknessLumbar fusion surgeryFusion surgeryMuscle thicknessPsoas muscleSpinal stabilizationVisual analog scale pain scoreHip flexor weaknessScale pain scoresPreoperative magnetic resonanceInterbody fusion surgeryLumbar intervertebral spaceSpecific clinical outcomesWarrants further investigationEarly ambulationPain scoresAdult patientsFlexor weaknessPostoperative rehabilitationRetrospective reviewClinical outcomesHospital recordsSurgical optionsLumbar pathologyFunctional outcomeElevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress
Koutsoulidou A, Kyriakides TC, Papadimas GK, Christou Y, Kararizou E, Papanicolaou EZ, Phylactou LA. Elevated Muscle-Specific miRNAs in Serum of Myotonic Dystrophy Patients Relate to Muscle Disease Progress. PLOS ONE 2015, 10: e0125341. PMID: 25915631, PMCID: PMC4411125, DOI: 10.1371/journal.pone.0125341.Peer-Reviewed Original ResearchConceptsDM1 patientsMuscle-specific miRNAsMuscle wastingNatural historySensitive blood biomarkersPotential future therapiesDisease natural historyMyotonic dystrophy patientsAdult-onset muscular dystrophyMyotonic dystrophy type 1Useful molecular biomarkersParticipant seraSerum levelsMuscle weaknessBlood biomarkersClinical conditionsMuscle atrophyFuture therapiesPatientsPotential biomarkersDystrophy patientsMiR-133aType 1Progressive muscleMolecular biomarkers
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