2024
Prognostic Value of Bone Scintigraphy in Cardiac Amyloidosis
Cho S, Han S. Prognostic Value of Bone Scintigraphy in Cardiac Amyloidosis. Clinical Nuclear Medicine 2024, 50: e34-e40. PMID: 39086069, DOI: 10.1097/rlu.0000000000005376.Peer-Reviewed Original ResearchConceptsHigher cardiac uptakeCardiac uptakeBone scintigraphySuspected CACardiac amyloidosisHazard ratioPrognostic valueAssociated with increased mortalityIncreased risk of mortalityCochrane Library databasesPredictive of mortalityOutcomes of all-causeRisk of mortalityPrognostic factorsPrognostic significanceCardiac deathLibrary databasesScintigraphyIncreased riskAll-causeStudy populationMeta-analysisPatientsVisual gradingSemiquantitative measureUnderstanding osteokine biology
Zaidi M, Zaidi S, Yuen T. Understanding osteokine biology. Cell Metabolism 2024, 36: 888-890. PMID: 38718755, PMCID: PMC11705590, DOI: 10.1016/j.cmet.2024.04.008.Peer-Reviewed Original ResearchMitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis
Zhu M, Zeiss C, Hamrick M, Weinstein R, Sun B, Brotto M, Liu X, Siu E, Huttner A, Tommasini S, Simpson C, Insogna K. Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis. Bone 2024, 184: 117086. PMID: 38552893, DOI: 10.1016/j.bone.2024.117086.Peer-Reviewed Original ResearchConceptsDeletion of Mfn2Bone mineral densityMitofusin 2Reduced expression of Mfn2Myofiber atrophySpinal cordTransgenic mice expressing CreMice expressing CreNon-redundant roleSkeletal muscle histologyLumbar spinal cordTrabecular bone massLean body massExpression of Mfn2Mitochondrial reticulumMFN2 geneDisruption of cellular architectureImpaired osteoblast differentiationOsteoblast lineage commitmentMfn2Mitochondrial sizeMitofusinMineral densityCo-expressionDisorganized sarcomeres
2023
Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes
Yankee T, Oh S, Winchester E, Wilderman A, Robinson K, Gordon T, Rosenfeld J, VanOudenhove J, Scott D, Leslie E, Cotney J. Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes. Nature Communications 2023, 14: 4623. PMID: 37532691, PMCID: PMC10397224, DOI: 10.1038/s41467-023-40363-1.Peer-Reviewed Original ResearchConceptsGene co-expression analysisSingle-cell RNA-seqCraniofacial disordersSet of genesCo-expression analysisTranscriptome dynamicsDevelopmental enhancersRegulatory hubEpigenomic dataCraniofacial developmentRNA-seqDe novo mutationsDisease genesGene expressionIntegrative analysisCraniofacial tissuesGenesNovo mutationsHuman tissuesMutationsDevelopment identifiesCommon congenital defectsWeeks post conceptionPost conceptionCraniofacial regionDecreased Bone Density and Strength in Young People After Bariatric Surgery: How Much Matters?
Hornick M, Van Name M. Decreased Bone Density and Strength in Young People After Bariatric Surgery: How Much Matters? Journal Of Bone And Mineral Research 2023, 38: 931-932. PMID: 37314023, DOI: 10.1002/jbmr.4831.Commentaries, Editorials and LettersThree-Dimensional Bioprinting Applications for Bone Tissue Engineering
Maresca J, DeMel D, Wagner G, Haase C, Geibel J. Three-Dimensional Bioprinting Applications for Bone Tissue Engineering. Cells 2023, 12: 1230. PMID: 37174630, PMCID: PMC10177443, DOI: 10.3390/cells12091230.Peer-Reviewed Original ResearchMeSH KeywordsBioprintingBone and BonesHumansHydrogelsPrinting, Three-DimensionalQuality of LifeTissue EngineeringConceptsBone tissue engineeringThree-dimensional (3D) bioprinting applicationsTissue engineeringSupport structureAdditional support structuresUse of hydrogelsBioprinting applicationsBone replacementNormal bone physiologyQuality of lifeBioprintingKey support structuresBone physiologyInjurySkeletal systemEngineeringMultiple directionsBiological materialsForeign objectsHydrogelsNew techniquePrinterPatientsPathophysiologyDegenerationDifferences in bone accrual over one year in young girls with obesity compared to Normal weight controls
Singhal V, Kaur S, Haidar L, Lee H, Bredella M, Misra M. Differences in bone accrual over one year in young girls with obesity compared to Normal weight controls. Bone 2023, 172: 116757. PMID: 37030498, PMCID: PMC10198942, DOI: 10.1016/j.bone.2023.116757.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAdolescentAdultBone and BonesBone DensityFemaleFractures, BoneHumansObesityRadiusTibiaYoung AdultConceptsNormal-weight controlsBone mineral densityBone accrualVolumetric BMDBone healthTotal hip bone mineral densityPeak bone mass acquisitionDual-energy X-ray absorptiometryHip bone mineral densityIncreased risk of fractureAreal bone mineral densityModerate to severe obesityHigher bone mineral densityVolumetric bone mineral densityHigh-resolution peripheral quantitative computed tomographyNormal-weight womenBone mass acquisitionX-ray absorptiometryPeripheral quantitative computed tomographyYoung womenRisk of fractureResolution peripheral quantitative computed tomographyImpact of obesityYounger menarcheal ageQuantitative computed tomographyVitamin D and Bone Fractures Revisited
Malaeb H, El-Khoury J. Vitamin D and Bone Fractures Revisited. Clinical Chemistry 2023, 69: 209-209. PMID: 36724482, DOI: 10.1093/clinchem/hvac196.Peer-Reviewed Original ResearchUpdate of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone
Wang A, Maloney E, Al-Dasuqi K, Irshaid L, Ahmed A, Haims A, Porrino J. Update of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone. Skeletal Radiology 2023, 52: 1443-1463. PMID: 36656343, DOI: 10.1007/s00256-023-04286-8.Peer-Reviewed Original ResearchConceptsUndifferentiated small round cell sarcomaSmall round cell sarcomasBone tumorsRound cell sarcomasPediatric populationCell sarcomaMesenchymal tumorsHematopoietic neoplasmsWorld Health Organization classificationGiant cell-rich tumorsPediatric bone tumorsOsteogenic tumorsOrganization classificationVascular tumorsNotochordal tumorsTumorsGenetic sequencing techniquesChondrogenic tumorsCertain lesionsSoft tissueBoneSarcomaNeoplasmsSeparate manuscriptDetailed updateOptimization of Radium-223 Treatment of Castration-resistant Prostate Cancer Based on the Burden of Skeletal Metastasis and Clinical Parameters
Shariftabrizi A, Kothari S, George S, Attwood K, Levine E, Lamonica D. Optimization of Radium-223 Treatment of Castration-resistant Prostate Cancer Based on the Burden of Skeletal Metastasis and Clinical Parameters. The Oncologist 2023, 28: 246-251. PMID: 36651837, PMCID: PMC10020806, DOI: 10.1093/oncolo/oyac245.Peer-Reviewed Original ResearchMeSH KeywordsBone and BonesBone NeoplasmsHumansMaleProstatic Neoplasms, Castration-ResistantRadiumRetrospective StudiesConceptsBaseline BSIBone scan indexMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerProstate cancerOverall survivalSkeletal metastasesRa-223 therapyRa-223 treatmentRadium-223 treatmentTreatment-associated reductionChemotherapy-naïve patientsMedian overall survivalAbsolute neutrophil countRadium-223 dichlorideHigh serum PSANovel treatment modalitiesAlkaline phosphatase levelsChemotherapy-naïveTreatment tolerabilityNeutrophil countSerum PSABone scanLaboratory parametersPatient selection
2022
Hypophosphatemia: A Practical Guide to Evaluation and Management
Tebben P. Hypophosphatemia: A Practical Guide to Evaluation and Management. Endocrine Practice 2022, 28: 1091-1099. PMID: 35940468, DOI: 10.1016/j.eprac.2022.07.005.Peer-Reviewed Original ResearchMeSH KeywordsBone and BonesFibroblast Growth FactorsHumansHypophosphatemiaOsteomalaciaParathyroid HormonePhosphatesConceptsClinical manifestationsNormal phosphate homeostasisParathyroid hormoneFibroblast growth factorFunction of phosphateRange of symptomsCell membrane integrityEnzyme functionGrowth factorPhosphate balanceSkeletal mineralizationMembrane integrityChronic causesGastrointestinal tractPhosphate homeostasisDiverse rolesEnergy homeostasisHypophosphatemiaChanges in Sex Steroids and Enteric Peptides After Sleeve Gastrectomy in Youth in Relation to Changes in Bone Parameters
Nimmala S, Kaur S, Singhal V, Mitchell D, Stanford F, Bouxsein M, Lauze M, Huynh C, Pedreira C, Lee H, Bredella M, Misra M. Changes in Sex Steroids and Enteric Peptides After Sleeve Gastrectomy in Youth in Relation to Changes in Bone Parameters. The Journal Of Clinical Endocrinology & Metabolism 2022, 107: e3747-e3758. PMID: 35689793, PMCID: PMC9387701, DOI: 10.1210/clinem/dgac361.Peer-Reviewed Original ResearchConceptsBody mass indexFree androgen indexSleeve gastrectomyVolumetric BMDEnteric peptidesSex steroidsLean massModerate-to-severe obesityDual-energy X-ray absorptiometry measurementsMeasurements of areal bone mineral densityBody compositionAreal bone mineral densityZ-scoreAssociated with changesMeasures of volumetric BMDImpaired bone healthBone turnover markersABMD Z-scoresFasting peptide YYBone mineral densityPeripheral quantitative computed tomographyResolution peripheral quantitative computed tomographyTertiary-care hospitalQuantitative computed tomographyMicrofinite element analysisFossil biomolecules reveal an avian metabolism in the ancestral dinosaur
Wiemann J, Menéndez I, Crawford JM, Fabbri M, Gauthier JA, Hull PM, Norell MA, Briggs DEG. Fossil biomolecules reveal an avian metabolism in the ancestral dinosaur. Nature 2022, 606: 522-526. PMID: 35614213, DOI: 10.1038/s41586-022-04770-6.Peer-Reviewed Original ResearchConceptsHigh metabolic rateCretaceous mass extinctionTerminal Cretaceous mass extinctionLate Cretaceous taxaMetabolic rateCrown mammalsAvian lineagesAncestral stateEcological nichesGiant sauropodsCretaceous taxaMammalsMetabolic abilitiesMetabolic performanceMass extinctionBirdsPhysiological activityEndothermyAvian metabolismCostly adaptationsMetabolismVivo accumulationTheropodsOrnithischiansEctotherms
2021
Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review)
Turrubiates-Hernández F, Sánchez-Zuno G, González-Estevez G, Hernández-Bello J, Macedo-Ojeda G, Muñoz-Valle J. Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review). International Journal Of Molecular Medicine 2021, 47: 32. PMID: 33537824, PMCID: PMC7891829, DOI: 10.3892/ijmm.2021.4865.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyD deficiencyVitamin DPotential immunomodulatory effectsD recommendationsPrevention of COVID-19 complicationsPrevalence of vitamin D deficiencyImmunomodulatory effectsImmunomodulatory effect of vitamin DAcute respiratory distress syndromePoor prognosis of COVID-19Effects of vitamin DRespiratory distress syndromeVitamin D recommendationsNovel treatment optionsPrognosis of COVID-19Severe coronavirus diseaseGlobal health problemCOVID-19 complicationsDistress syndromePoor prognosisBone healthSevere acute respiratory syndrome coronavirus 2Treatment optionsAcute respiratory syndrome coronavirus 2
2020
Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice
Masters EA, Hao SP, Kenney HM, Morita Y, Galloway CA, de Mesy Bentley K, Ricciardi BF, Boyce BF, Schwarz EM, Oh I. Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice. Journal Of Orthopaedic Research® 2020, 39: 389-401. PMID: 33336806, PMCID: PMC7882123, DOI: 10.1002/jor.24962.Peer-Reviewed Original ResearchConceptsS. aureus osteomyelitisBone infectionS. agalactiaeAnimal modelsS. aureus bone infectionImplant looseningSoft tissueImplant-associated osteomyelitisQuantitative animal modelCortical boneAdjacent soft tissuesGroup B streptococciS. aureusSeptic implant looseningS. agalactiae infectionAssessment of miceS. aureus virulenceGreater body weightDevastating complicationClinical featuresAbscess formationLocal inflammationAggressive osteolysisLess osteolysisPreclinical modelsCatalysis‐Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass
Zimmerman K, Liu X, von Kroge S, Stabach P, Lester ER, Chu EY, Srivastava S, Somerman MJ, Tommasini SM, Busse B, Schinke T, Carpenter TO, Oheim R, Braddock DT. Catalysis‐Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass. Journal Of Bone And Mineral Research 2020, 37: 1733-1749. PMID: 35773783, PMCID: PMC9709593, DOI: 10.1002/jbmr.4640.Peer-Reviewed Original ResearchConceptsHeterotopic mineralizationBone massFibroblast growth factor 23Growth factor 23Low bone massSoft tissue calcificationEarly-onset osteoporosisFrizzled-related protein 1Soluble Wnt inhibitorsTrabecular bone microarchitectureENPP1 deficiencyΒ-catenin signalingFactor 23Plasma FGF23Vascular calcificationArterial calcificationNuclear β-cateninPlasma PPiBone microarchitectureMurine modelTissue calcificationPlasma PiWnt inhibitorsCalcificationMiceImportance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
Serna J, Bergwitz C. Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging. Nutrients 2020, 12: 3001. PMID: 33007883, PMCID: PMC7599912, DOI: 10.3390/nu12103001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDietary phosphorusReduced bioavailabilityHealthy agingHigh dietary phosphorusSources of dietary phosphorusReduced longevityAbundance of phosphorusBone metabolismWestern dietPhosphorusTissue calcificationMetabolic changesEndocrine regulationBioavailabilityNormal amountsTissueCurrent knowledgeAbundanceDifferent tissuesExcessive lossOsteomalaciaBiomarkers of bone disease in persons with haemophilia
Goldscheitter G, Recht M, Sochacki P, Manco‐Johnson M, Taylor J. Biomarkers of bone disease in persons with haemophilia. Haemophilia 2020, 27: 149-155. PMID: 32856388, DOI: 10.1111/hae.13986.Peer-Reviewed Original ResearchConceptsLevels of TNF-aFVIII deficiencyCTX-1Factor VIII (FVIII)-deficient miceBone metabolismIL-10TNF-aHealthy controlsSkeletal healthBone diseaseIncreased risk of fractureMarkers of bone metabolismSevere FVIII deficiencyPlasma samplesLow bone densityCirculating cytokine levelsInterleukin (IL)-12Risk of fractureIL-10 levelsBone-related cytokinesEvaluated plasma samplesRegulate bone metabolismFVIII replacementCytokine levelsFactor deficiencyPhylogeny and chemistry of biological mineral transport
Schlesinger PH, Braddock DT, Larrouture QC, Ray EC, Riazanski V, Nelson DJ, Tourkova IL, Blair HC. Phylogeny and chemistry of biological mineral transport. Bone 2020, 141: 115621. PMID: 32858255, PMCID: PMC7771281, DOI: 10.1016/j.bone.2020.115621.Peer-Reviewed Original ResearchConceptsImportant evolutionary relationshipsTissue-nonspecific alkaline phosphataseJawless fishEvolutionary relationshipsMineral accumulationKey biological elementsCellular organizationNonspecific alkaline phosphataseCross-linked collagen fibrilsMembrane vesiclesMineral transportSkeletal elementsAmorphous aggregatesDefinitive stageBone physiologyHigh expressionTooth formationMetabolic featuresEpithelial transportAge‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population
Yu F, Xu Y, Hou Y, Lin Y, Jiajue R, Jiang Y, Wang O, Li M, Xing X, Zhang L, Qin L, Hsieh E, Xia W. Age‐, Site‐, and Sex‐Specific Normative Centile Curves for HR‐pQCT‐Derived Microarchitectural and Bone Strength Parameters in a Chinese Mainland Population. Journal Of Bone And Mineral Research 2020, 35: 2159-2170. PMID: 32564403, PMCID: PMC9719438, DOI: 10.1002/jbmr.4116.Peer-Reviewed Original ResearchConceptsHigh-resolution peripheral quantitative computed tomographyPeripheral quantitative computed tomographyVolumetric bone mineral densityCortical bone lossHR-pQCT parametersBone mineral densityHealthy Chinese menNormative reference rangesQuantitative computed tomographyHR-pQCT scansLatest-generation scannersYears of ageHR-pQCT measuresFracture risk assessmentBone strength parametersDifferent disease statesBone lossCortical porosityMineral densityBone microarchitectureEarly diagnosisComputed tomographyChinese menReference rangeNutritional status
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