2025
Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
D'Aoust T, Clocchiatti‐Tuozzo S, Rivier C, Mishra A, Hachiya T, Grenier‐Boley B, Soumaré A, Duperron M, Le Grand Q, Bouteloup V, Proust‐Lima C, Samieri C, Neuffer J, Sargurupremraj M, Chêne G, Helmer C, Thibault M, Amouyel P, Lambert J, Kamatani Y, Jacqmin‐Gadda H, Tregouët D, Inouye M, Dufouil C, Falcone G, Debette S. Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification. Alzheimer's & Dementia 2025, 21: e70014. PMID: 40042447, PMCID: PMC11881617, DOI: 10.1002/alz.70014.Peer-Reviewed Original ResearchConceptsOlder community-dwelling peopleCommunity-dwelling peopleDementia risk stratificationVascular contribution to dementiaAssociated with dementia riskGenetic riskDementia clinical trialsApo E4Polygenic risk scoresGenetic risk groupsHigh-risk individualsDementia riskImprove risk predictionEast Asian ancestryAD-PRSPopulation-basedPolygenic scoresRisk stratificationMemory-clinic patientsPrevention programsClinical risk factorsDementiaClinical participantsRisk scoreAlzheimer's diseaseNovel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes
Zohora F, Nazari M, Sinusas A. Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes. Current Cardiology Reports 2025, 27: 61. PMID: 40009333, DOI: 10.1007/s11886-025-02197-9.Peer-Reviewed Original ResearchConceptsSudden cardiac deathImplantable cardioverter defibrillatorPositron emission tomographyImplantable cardioverter defibrillator placementMyocardial sympathetic denervationRisk stratificationSympathetic denervationIschemic heart diseaseHeart failurePrevention of sudden cardiac deathRisk stratification of patientsHeart diseaseOptimal risk stratificationLow ejection fractionStratification of patientsSympathetic nerve densityImprove risk stratificationHeart failure patientsPositron emission tomography radiotracersPredicting sudden cardiac deathPositron emission tomography tracersPrognostic benefitEjection fractionClinically practical approachNerve densityElevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection
Dylla L, Reisz J, Poisson S, Herson P, Sansing L, Monte A. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108268. PMID: 40015349, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108268.Peer-Reviewed Original ResearchConceptsPost-stroke infectionsAssociated with increased oddsTryptophan metabolitesHistory of diabetes mellitusEnd stage renal diseaseNIH Stroke Scale scoreConcentrations of kynurenineAcute ischemic stroke patientsMultivariate logistic regressionStage renal diseaseStroke Scale scoreCirculating kynurenineIschemic stroke onsetIschemic stroke patientsKynurenine concentrationsConcentrations of tryptophanEmergency department admissionsKynurenic acidDiabetes mellitusMortality of ischemic strokeRenal diseaseTryptophan metabolismOdds ratioQuinolinic acidImmune responseImplementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchMeSH KeywordsAgedCohort StudiesExercise TestFeasibility StudiesFemaleHumansMaleMiddle AgedPreoperative CareRisk AssessmentConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived exertionMET assessmentStructured surveyCapacity surveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteriaThe role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment
Tatsuoka Y, He Z, Lin H, Notarianni A, Carr Z. The role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment. Brazilian Journal Of Anesthesiology 2025, 75: 844597. PMID: 39971234, PMCID: PMC11914786, DOI: 10.1016/j.bjane.2025.844597.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressurePostoperative pulmonary complicationsArea under the curveARISCAT scoreVentricular systolic pressureReceiver operating characteristic curvePulmonary hypertensionRespiratory failureHigh-risk populationPrimary endpointRisk stratificationSurgical proceduresSystolic pressurePostoperative pulmonary complications incidenceSource of increased morbidityAssess Respiratory RiskDiagnosis of PHPreoperative risk assessmentAdjusted multivariable logistic regression modelsMultivariate logistic regression modelComposite of pneumoniaPulmonary complicationsPreoperative investigationsSecondary endpointsPulmonary aspirationAcute Myeloid Leukemia: 2025 Update on Diagnosis, Risk‐Stratification, and Management
Shimony S, Stahl M, Stone R. Acute Myeloid Leukemia: 2025 Update on Diagnosis, Risk‐Stratification, and Management. American Journal Of Hematology 2025, 100: 860-891. PMID: 39936576, PMCID: PMC11966364, DOI: 10.1002/ajh.27625.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDisease ManagementHumansLeukemia, Myeloid, AcuteNeoplasm, ResidualPrognosisRisk AssessmentConceptsAcute myeloid leukemiaTherapeutic management of acute myeloid leukemiaManagement of acute myeloid leukemiaEuropean Leukemia NetworkStem cell cancerTherapeutic decision-makingImmature leukemia cellsExtra-medullary tissuesMRD findingsPrognostic factorsCell cancerTherapeutic algorithmRisk classification algorithmApproved therapiesMyeloid leukemiaResponse assessmentRisk stratificationBone marrowTherapeutic managementMonitoring of disease statusPathophysiological understandingDisease characteristicsMolecular findingsTherapeutic approachesDisease statusSilent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial.
Ridha M, Zhang C, McCullough S, Viscoli C, Sharma R, Kamel H, Merkler A. Silent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial. Journal Of The American Heart Association 2025, 14: e037663. PMID: 39921499, DOI: 10.1161/jaha.124.037663.Peer-Reviewed Original ResearchConceptsSilent MISilent myocardial infarctionStroke recurrenceClinical MIAssociated with stroke recurrenceFirst-ever strokeMyocardial infarctionIschemic strokeTailored prevention strategiesRecurrent strokeVascular risk factorsHistory of hospitalizationRisk of stroke recurrenceEvidence of MIUnadjusted analysisPrevention strategiesInclusion criteriaSecondary outcomesECG evidence of MIPrimary outcomeRisk factorsMultivariate Cox regression analysisPost hoc analysisStrokeRegression analysisQuality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial
Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Rogers C, Patel M, Baloch K, Chow B, Anstrom K, Vemulapalli S, Weir-McCall J, Stone G, Chew D, Douglas P, Investigators O. Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011414. PMID: 39895494, PMCID: PMC11837958, DOI: 10.1161/circoutcomes.124.011414.Peer-Reviewed Original ResearchConceptsQuality of lifeSAQ Summary ScoreSummary scoreOveral quality of lifeAssess quality of lifeGeneric health statusQuality of life outcomesBaseline SAQ scoresCoronary artery diseaseQuality of life assessmentFollow-up time pointsClinically meaningful differencesStable patientsFollow-upArtery diseaseEQ-5DHealth statusMonths postrandomizationSuspected coronary diseaseComponent scoresSatisfaction surveySuspected coronary artery diseaseTrial participantsStable chest painTest groupEconomic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial
Chew D, Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Davidson-Ray L, Baloch K, Rogers C, Patel M, Anstrom K, Curzen N, Vemulapalli S, Douglas P, Investigators O. Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011008. PMID: 39895495, PMCID: PMC11837965, DOI: 10.1161/circoutcomes.123.011008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, StableComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCost SavingsCost-Benefit AnalysisFemaleFractional Flow Reserve, MyocardialHospital CostsHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsChest painObstructive coronary artery diseaseCoronary computed tomographic angiographyStable chest painCoronary artery bypass surgeryLow-risk patientsSecondary end pointsPrimary composite of deathPrecision strategyComputed tomographic angiographyHealth care system perspectiveComposite of deathUS health care system perspectiveArtery bypass surgeryMedical costsMean cost differenceNonfatal myocardial infarctionCoronary artery diseaseIntention-to-treatPercutaneous coronary interventionUsual testsEstimated total medical costTotal medical costsClinical practice guidelinesRisk patientsPerioperative Pulmonary Complications in the Older Adults The Forgotten System
Carr Z, Siller S, McDowell B. Perioperative Pulmonary Complications in the Older Adults The Forgotten System. Clinics In Geriatric Medicine 2025, 41: 1-18. PMID: 39551535, DOI: 10.1016/j.cger.2024.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansLung DiseasesPerioperative CarePostoperative ComplicationsRisk AssessmentRisk FactorsDiagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments
Travers S, Alexandre J, Baldassarre L, Salem J, Mirabel M. Diagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments. Archives Of Cardiovascular Diseases 2025, 118: 185-198. PMID: 39947997, DOI: 10.1016/j.acvd.2024.12.012.Peer-Reviewed Original ResearchConceptsCardio-oncologyCardiovascular toxicityCardiovascular imagingMultimodality cardiovascular imagingCancer risk factorsIncrease diagnostic accuracyPrognostic stratificationNatriuretic peptideSerum biomarkersTherapy schemesDiagnostic accuracyCancer therapyRhythm disordersRisk factorsCardiovascular diseaseBiomarkersMultimodal integrated approachCancerOmics approachesToxicityRhythmTherapyTroponinSerumDiagnosisExposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study
Guo X, Qian J, Ren H, Ding E, Ma X, Zhang J, Qiu T, Lu Y, Sun P, Li C, Li C, Xu Y, Cao K, Lin X, Mao C, Tong S, Tang S, Shi X. Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study. Journal Of Hazardous Materials 2025, 488: 137365. PMID: 39869979, DOI: 10.1016/j.jhazmat.2025.137365.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChinaCosmeticsEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaleMiddle AgedRisk AssessmentConceptsPersonal care productsHealthy older adultsHealth risksOlder adultsExposure to ambient PM<sub>2.5</sub>Benzophenone-2Ambient PM<sub>2.5</sub>Care productsHealth risks associated with exposureRisks associated with exposureAssociated health risksRisk of chemicalsHealth risks of chemicalsIncreased physical activityAssessment of older adultsMinimal health risksPhysical well-beingPredominant chemicalsMedian concentrationsPhysical activityExposure assessmentExposure profilesRisk assessmentExposure levelsMethyl parabenAssessing cardiovascular disease risk and social determinants of health: A comparative analysis of five risk estimation instruments using data from the Eastern Caribbean Health Outcomes Research Network
Schwartz J, Howitt C, Raman S, Nair S, Hassan S, Oladele C, Hambleton I, Sarpong D, Adams O, Maharaj R, Nazario C, Nunez M, Nunez-Smith M. Assessing cardiovascular disease risk and social determinants of health: A comparative analysis of five risk estimation instruments using data from the Eastern Caribbean Health Outcomes Research Network. PLOS ONE 2025, 20: e0316577. PMID: 39854547, PMCID: PMC11760610, DOI: 10.1371/journal.pone.0316577.Peer-Reviewed Original ResearchConceptsCardiovascular disease riskSocial determinants of healthDeterminants of healthSocial determinantsRisk estimation toolsCardiovascular diseaseEstimate 10-year CVD riskCVD riskEastern Caribbean Health Outcomes Research NetworkCardiovascular disease risk estimatesHigh riskHigher level of educationHistory of cardiovascular diseaseHigher CVD riskMultivariate logistic regression modelEthnically diverse populationsResource-constrained settingsLogistic regression modelsNon-professional occupationsSDoH variablesLevel of educationSDoHPerceived social statusRisk toolFraminghamOutcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial
Malas M, Hamouda M, Farber A, Menard M, Conte M, Rosenfield K, Strong M, Doros G, Powell R, Mena-Hurtado C, Gasper W, Schermerhorn M, Allievi S, Smolderen K, Dake M, Rymer J, Tuttle K. Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial. Journal Of Vascular Surgery 2025, 81: 945-956.e3. PMID: 39846933, DOI: 10.1016/j.jvs.2024.12.128.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalChronic Limb-Threatening IschemiaEndovascular ProceduresFemaleGlomerular Filtration RateHumansIschemiaKidneyLimb SalvageMaleMiddle AgedPeripheral Arterial DiseaseProspective StudiesRenal DialysisRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsChronic limb-threatening ischemiaChronic kidney diseaseDialysis-dependent patientsBEST-CLIChronic kidney disease stagePrimary trial outcomeRisk of amputationAssociated with lower mortalityEndovascular therapyAll-cause mortalityHigh risk of poor outcomesRisk of poor outcomesEndovascular revascularizationKidney diseaseBEST-CLI trialOutcomes of lower extremity revascularizationAssociated with better survivalMultivariate Cox regression analysisBest Surgical TherapyIncreased reintervention rateStage 4 CKD patientsRisk of reinterventionGroup C patientsAdverse limb eventsChronic kidney disease severityDevelopment of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting
Wang Y, Gao M, Zhao X, Han P, Zhang L, Dardik A. Development of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting. Annals Of Vascular Surgery 2025, 113: 175-185. PMID: 39855385, DOI: 10.1016/j.avsg.2024.12.068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlloysDecision Support TechniquesEndovascular ProceduresFemaleFemoral ArteryHumansMaleMiddle AgedNomogramsPeripheral Arterial DiseasePredictive Value of TestsRecurrenceReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsSelf Expandable Metallic StentsStentsTime FactorsTreatment OutcomeConceptsIn-stent restenosisSuperficial femoral arteryDecision curve analysisSuperficial femoral artery stentingLogistic regression analysisPeripheral arterial diseaseReceiver operating characteristicNomogram modelClinical utilityCurve analysisMultivariate logistic regression analysisSelf-expanding bare nitinol stentsTreated with stentingReceiver operating characteristic curveRisk of in-stent restenosisNomogram's clinical utilityBare nitinol stentsPrediction of in-stent restenosisExcellent discriminatory powerRegression analysisFemoral artery stentingArtery flow rateRetrospective studyTraining cohortSFA stentingA Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation
Nogueira A, Felix N, Kalil F, Tramujas L, Godoi A, Miyawaki I, Bellavia A, Moura F, Cardoso R, d'Avila A, Fernandes G. A Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2025, 36: 617-624. PMID: 39834105, DOI: 10.1111/jce.16552.Peer-Reviewed Original ResearchConceptsBayesian analysisTreatment effect distributionAdverse cardiovascular outcomesAll-cause mortalityCardiovascular outcomesRandomized controlled trialsFrequentist estimatorsCatheter ablationMedical therapyAtrial fibrillationBayesian interpretationImpact of catheter ablationControlled trialsAnalysis of randomized controlled trialsProbability distributionAtrial fibrillation patientsReduce adverse cardiovascular outcomesImpact of ablationEffective distributionRandom-effects modelBayes' theoremTrial-level dataProbabilistic understandingSurvival outcomesFibrillation patientsDeterminants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy
Cameron N, Huang X, Petito L, Ning H, Shah N, Yee L, Perak A, Haas D, Mercer B, Parry S, Saade G, Silver R, Simhan H, Reddy U, Varagic J, Licon E, Greenland P, Lloyd-Jones D, Kershaw K, Grobman W, Khan S. Determinants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011217. PMID: 39807595, PMCID: PMC11919558, DOI: 10.1161/circoutcomes.124.011217.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCardiovascular DiseasesFemaleHealth Status DisparitiesHispanic or LatinoHumansMaternal HealthPregnancyPregnancy Trimester, FirstRace FactorsResidence CharacteristicsRisk AssessmentRisk FactorsSocial Determinants of HealthSocioeconomic FactorsUnited StatesWhiteWhite PeopleYoung AdultConceptsNon-Hispanic blacksNon-Hispanic whitesNeighborhood-level factorsNon-Hispanic black groupsCardiovascular health scoreMaternal cardiovascular healthNon-Hispanic White groupCardiovascular healthEthnic differencesLife's Essential 8 scoreSuboptimal cardiovascular healthContributions of individual-Public health effortsYears of educationNulliparous individualsReduce disparitiesHealth effortsProportion of differencesCohort studyOffspring outcomesEducational attainmentIndividual-Higher scoresAssess factorsSingleton pregnanciesPredicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry
Faridi K, Wang Y, Minges K, Smilowitz N, McNamara R, Kontos M, Wang T, Connors A, Clary J, Osborne A, Pereira L, Curtis J, Blankinship K, Mayfield J, Abbott J. Predicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011259. PMID: 39801472, PMCID: PMC11919567, DOI: 10.1161/circoutcomes.124.011259.Peer-Reviewed Original ResearchConceptsNational Cardiovascular Data Registry Chest Pain-MI RegistryIn-hospital mortalityAcute myocardial infarctionChest Pain-MI RegistryOut-of-hospital cardiac arrestRisk scoreRisk-standardized modelsNational Cardiovascular Data RegistryAcute MI hospitalizationsPatient characteristicsMyocardial infarctionContemporary risk modelsIn-hospital mortality rateMI hospitalizationST-segment elevation MIIndependent predictor of mortalityMortality risk predictionSystolic blood pressureMortality riskPredictors of mortalityHospital volumePatient prognosticationData RegistryRisk modelSimplified risk scoreRisk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.
Mosher C, Osazuwa-Peters O, Nanna M, MacIntyre N, Que L, Palmer S, Jones W, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal Of The American Heart Association 2025, 14: e035010. PMID: 39791395, DOI: 10.1161/jaha.124.035010.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseSecondary prevention cohortPrevention cohortASCVD hospitalizationRisk of atherosclerotic cardiovascular diseaseHazard ratioHospital outcomesHigh riskRisk factorsCardiovascular disease eventsCardiovascular diseasePrimary prevention cohortIdentified multiple risk factorsRisk of cardiovascular disease eventsMultiple risk factorsPulmonary disease hospitalizationsObstructive pulmonary diseaseOlder AdultsHigh-risk patient cohortASCVD eventsDisease eventsHigh-risk patientsMeta-analysesPrediction of Aneurysm Sac Shrinkage After Endovascular Aortic Repair Using Machine Learning-Based Decision Tree Analysis
Nishibe T, Iwasa T, Matsuda S, Kano M, Akiyama S, Fukuda S, Koizumi J, Nishibe M, Dardik A. Prediction of Aneurysm Sac Shrinkage After Endovascular Aortic Repair Using Machine Learning-Based Decision Tree Analysis. Journal Of Surgical Research 2025, 306: 197-202. PMID: 39793306, DOI: 10.1016/j.jss.2024.11.049.Peer-Reviewed Original ResearchConceptsAneurysm sac shrinkageEndovascular aortic repairAbdominal aortic aneurysmSac shrinkageType II endoleakAortic repairII endoleakUnivariate analysisElective endovascular aortic repairTokyo Medical University HospitalMedical University HospitalDecision tree analysisPulse wave velocityAortic aneurysmUniversity HospitalCurrent smokingAneurysmPatientsStratification modelEndoleakLow likelihoodVariables of ageSmokingRepair
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