2025
Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018
Sanchez-Pinto L, Daniels L, Atreya M, Faustino E, Farris R, Geva A, Khemani R, Rogerson C, Shah S, Weiss S, Bennett T. Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018. Pediatric Critical Care Medicine 2025, 26: e155-e165. PMID: 39982153, PMCID: PMC11792981, DOI: 10.1097/pcc.0000000000003675.Peer-Reviewed Original ResearchConceptsInternational Pediatric Sepsis Consensus ConferenceInternational Pediatric Sepsis Consensus Conference criteriaPhoenix criteriaCritically ill childrenSepsis criteriaPICU admissionCohort of critically ill childrenOrgan dysfunction scoreIll childrenMulticenter cohort studyHigher risk of mortalityMortality of patientsAge groupsIn-hospital mortalityRisk of mortalitySeverity of illnessDiscrimination of mortalityBloodstream infectionsSuspected infectionMulticenter cohortSeptic shockSepsis scoreDysfunction scorePatient subgroupsRetrospective analysisPredicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry
Faridi K, Wang Y, Minges K, Smilowitz N, McNamara R, Kontos M, Wang T, Connors A, Clary J, Osborne A, Pereira L, Curtis J, Blankinship K, Mayfield J, Abbott J. Predicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011259. PMID: 39801472, PMCID: PMC11919567, DOI: 10.1161/circoutcomes.124.011259.Peer-Reviewed Original ResearchConceptsNational Cardiovascular Data Registry Chest Pain-MI RegistryIn-hospital mortalityAcute myocardial infarctionChest Pain-MI RegistryOut-of-hospital cardiac arrestRisk scoreRisk-standardized modelsNational Cardiovascular Data RegistryAcute MI hospitalizationsPatient characteristicsMyocardial infarctionContemporary risk modelsIn-hospital mortality rateMI hospitalizationST-segment elevation MIIndependent predictor of mortalityMortality risk predictionSystolic blood pressureMortality riskPredictors of mortalityHospital volumePatient prognosticationData RegistryRisk modelSimplified risk scoreImpact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study
Elsamadicy A, Serrato P, Belkasim S, Ghanekar S, Khalid S, Lo S, Sciubba D. Impact of patient age on morbidity and mortality in adults with acute traumatic cervical spinal cord injury: An ACS trauma quality programs database study. Clinical Neurology And Neurosurgery 2025, 249: 108740. PMID: 39813756, DOI: 10.1016/j.clineuro.2025.108740.Peer-Reviewed Original ResearchConceptsIn-hospital mortalityAcute CSCI patientsLength of stayCSCI patientsTreatment modalitiesCervical SCIAcute traumatic cervical spinal cord injuryTraumatic cervical spinal cord injuryAssociated with increased morbidityImpact of patient ageAcute cervical SCICervical spinal cord injuryRetrospective cohort studyMultivariate logistic regressionPredictors of AEYears of ageSpinal cord injuryCervicothoracic fusionAssociated with AECervical fusionPatient ageIndependent predictorsInjury typePatient demographicsProgram databaseMechanical Circulatory Support in Patients Without Cardiogenic Shock Undergoing Percutaneous Coronary Intervention.
Miller P, Gordon A, Liu Y, Ahmad T, Bromfield S, Girotra S, Davila C, Crawford G, Whitney J, Desai N. Mechanical Circulatory Support in Patients Without Cardiogenic Shock Undergoing Percutaneous Coronary Intervention. Journal Of The American Heart Association 2025, 14: e037424. PMID: 39791394, DOI: 10.1161/jaha.124.037424.Peer-Reviewed Original ResearchConceptsMicroaxial left ventricular assist deviceIntra-aortic balloon pump usePercutaneous coronary interventionIntra-aortic balloon pumpBalloon pump useCardiogenic shockLeft ventricular assist deviceTotal health care costsIndex admissionBalloon pumpIncident dialysisHealth care costsCoronary interventionAssociated with lower mortalityPump useLVAD useHigh-risk percutaneous coronary interventionAssociated with higher costsInverse probability treatmentCare costsMechanical circulatory supportInsured populationSecondary outcomesPrimary outcomeRetrospective studyEfficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease. Neurology 2025, 104: e210243. PMID: 39772663, DOI: 10.1212/wnl.0000000000210243.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTreated with IV thrombolysisIn-hospital mortalityMoyamoya disease patientsIV thrombolysisMoyamoya diseasePropensity score matchingIntracranial hemorrhageRisk factors of acute ischemic strokeSelf-careIschemic stroke patientsAcute ischemic stroke patientsStroke patientsTreating acute ischemic strokeNationwide Readmissions DatabaseRisk factorsRate of routine dischargeRoutine dischargeEfficacy outcomesAssociated with different ratesProspective studyBypass surgeryRetrospective analysisEstablished treatmentReadmissions Database
2024
International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients
Tangel V, Hoeks S, Stolker R, Brown S, Pryor K, de Graaff J, Committee M, Pace N, Domino K, Muehlschlegel J, Kheterpal S, Vaughan M, Mathis M, Jiang S, Obembe S, Freundlich R, Schonberger R, Kim D. International multi-institutional external validation of preoperative risk scores for 30-day in-hospital mortality in paediatric patients. British Journal Of Anaesthesia 2024, 133: 1222-1233. PMID: 39477712, DOI: 10.1016/j.bja.2024.09.003.Peer-Reviewed Original ResearchConceptsSurgical risk scoresPediatric risk assessmentArea under the receiver operating characteristic curveIn-hospital mortalityRisk scoreMulticenter Perioperative Outcomes GroupPreoperative risk scoreDecision curve analysisReceiver operating characteristic curvePhysical status scoreExternal validationAssess model discriminationRisk prediction scoreASA physical status scoreClinical decision-makingPaediatric patientsLow probability of mortalityDutch hospitalsOutcome groupPatient-specific risk scoresPrimary outcomeClustering of casesCurve analysisStatus scoreCharacteristic curveRight Ventricular Dysfunction in Patients Undergoing High-Risk PCI with Impella
Rommel K, Bonnet G, Bellumkonda L, Lansky A, Zhao D, Thompson J, Zhang Y, Redfors B, Lurz P, Granada J, Bharadwaj A, Basir M, O'Neill W, Burkhoff D. Right Ventricular Dysfunction in Patients Undergoing High-Risk PCI with Impella. Journal Of Cardiac Failure 2024, 30: 1244-1254. PMID: 39389734, DOI: 10.1016/j.cardfail.2024.08.001.Peer-Reviewed Original ResearchConceptsRight ventricular dysfunctionHigh-risk percutaneous coronary interventionVentricular dysfunctionAssociated with right ventricular dysfunctionTricuspid annular plane systolic excursionConcomitant right ventricular dysfunctionLower left ventricular ejection fractionUnfavorable long-term prognosisAnnular plane systolic excursionClinical outcomes of patientsAbsence of right ventricular dysfunctionImpella supportPredictor of 1-year mortalityMultivariate Cox regression analysisIncidence of hypotensive episodesEchocardiography core laboratorySevere RV dilatationBlood urea nitrogen levelsRV function assessmentVentricular ejection fractionOutcomes of patientsRates of in-hospital mortalityHigher blood urea nitrogen levelsLong-term prognosisProportion of patientsEarly Warning Scores With and Without Artificial Intelligence
Edelson D, Churpek M, Carey K, Lin Z, Huang C, Siner J, Johnson J, Krumholz H, Rhodes D. Early Warning Scores With and Without Artificial Intelligence. JAMA Network Open 2024, 7: e2438986. PMID: 39405061, PMCID: PMC11544488, DOI: 10.1001/jamanetworkopen.2024.38986.Peer-Reviewed Original ResearchConceptsEarly Warning ScoreWarning ScoreCohort studyYale New Haven Health SystemClinical deterioration eventsHigh-risk thresholdHealth systemRetrospective cohort studyPatient encountersDeteriorating patientsOverall PPVMain OutcomesInpatient encountersEDI scoresHospital encountersDeterioration eventsClinical deteriorationIntensive care unitEarly warning toolCare unitDecision support toolArtificial intelligenceScoresReceiver operating characteristic curveNEWS2Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis
Fallahtafti P, Soleimani H, Ebrahimi P, Ghaseminejad‐Raeini A, Karimi E, Shirinezhad A, Sabri M, Mehrani M, Taheri H, Siegel R, Shah N, Nanna M, Hakim D, Hosseini K. Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis. Clinical Cardiology 2024, 47: e24324. PMID: 39054901, PMCID: PMC11272956, DOI: 10.1002/clc.24324.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCoronary artery diseasePercutaneous coronary interventionIn-hospital mortalityNetwork meta-analysisMyocardial infarctionAortic stenosisAssociated with worse 30-day outcomeMeta-analysisIncreased risk of 1-year mortalityAssociated with higher 1-year mortalityRisk of 1-year mortalitySevere aortic stenosisFrequentist network meta-analysisRates of myocardial infarctionPercutaneous coronary intervention timeTime of revascularizationAortic valve implantationSevere ASNo significant differencePacemaker implantationPost-TAVIValve implantationPatient characteristicsArtery diseaseUse of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity score matching analysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically ventilated patientsCritically ill patientsPerformance of the Elixhauser Comorbidity Index in Predicting Mortality Among a National US Sample of Hospitalized Homeless Adults
Tsai J, Kim Y. Performance of the Elixhauser Comorbidity Index in Predicting Mortality Among a National US Sample of Hospitalized Homeless Adults. Medical Care 2024, 62: 543-548. PMID: 38838297, DOI: 10.1097/mlr.0000000000002019.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexIn-hospital mortalityBehavioral health conditionsHealth care databasesNational Inpatient Sample (NISComorbidity indexAlcohol-related disordersPredictors of hospital readmissionPredicting mortalityPrediction of in-hospital mortalityClinical Classifications Software Refined (CCSRCare databasePredicting in-hospital mortalitySummary scoreRevision Clinical ModificationNational US sampleClinical ModificationInternational ClassificationSample of inpatientsDiagnostic codesHealth conditionsHomeless adultsHospital readmissionCase-mixAcute myocardial infarctionIn-hospital outcomes and postdischarge mortality in patients with acute coronary syndrome and atrial fibrillation
Saleh M, Coleman K, Fishbein J, Gandomi A, Yang B, Kossack A, Varrias D, Jauhar R, Lasic Z, Kim M, Mihelis E, Ismail H, Sugeng L, Singh V, Epstein L, Kuvin J, Mountantonakis S. In-hospital outcomes and postdischarge mortality in patients with acute coronary syndrome and atrial fibrillation. Heart Rhythm 2024, 21: 1658-1668. PMID: 38823670, DOI: 10.1016/j.hrthm.2024.05.045.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePostdischarge mortalityAtrial fibrillationIn-hospital outcomesPostdischarge adverse outcomesOral anticoagulantsPatients admitted with acute coronary syndromeNorthwell Health hospitalsCoronary syndromeAdverse outcomesRisk of in-hospitalIntroduction of novel oral anticoagulantsIncreased risk of in-hospitalAcute coronary syndrome patientsManagement of acute coronary syndromesConcomitant atrial fibrillationNovel oral anticoagulantsHealth HospitalIndependent risk factorHierarchical generalized linear mixed modelsLinear mixed modelsIncidence of AFIn-hospital mortalityMarginal Cox regression modelsIn-hospital bleedingSOFA score performs worse than age for predicting mortality in patients with COVID-19
Sherak R, Sajjadi H, Khimani N, Tolchin B, Jubanyik K, Taylor R, Schulz W, Mortazavi B, Haimovich A. SOFA score performs worse than age for predicting mortality in patients with COVID-19. PLOS ONE 2024, 19: e0301013. PMID: 38758942, PMCID: PMC11101117, DOI: 10.1371/journal.pone.0301013.Peer-Reviewed Original ResearchConceptsCrisis standards of careIn-hospital mortalityIntensive care unitAcademic health systemSequential Organ Failure Assessment scoreCohort of intensive care unitSequential Organ Failure AssessmentStandard of careLogistic regression modelsMortality predictionPredicting in-hospital mortalityHealth systemUnivariate logistic regression modelCrisis standardsDisease morbidityCOVID-19Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchConceptsEarly enteral nutritionIn-hospital deathCritically ill adultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcomeNeuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
Gururangan K, Peschansky V, Van Hyfte G, Agarwal P, Blank L, Mathew B, Goldstein J, Kwon C, McCarthy L, Cohen A, Chan A, Deng P, Dhamoon M, Gutzwiller E, Hao Q, He C, Klenofsky B, Lemus H, Marcuse L, Navis A, Heredia Nunez W, Luckey M, Schorr E, Singh A, Tantillo G, Ufongene C, Young J, Balchandani P, Festa J, Naasan G, Charney A, Nadkarni G, Jetté N. Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study. Journal Of Neurology 2024, 271: 3991-4007. PMID: 38656620, DOI: 10.1007/s00415-024-12370-9.Peer-Reviewed Original ResearchConceptsIn-hospital mortalityAssociated with lower oddsHigher odds of mortalityResultsOur study cohortElectronic medical record databaseChart reviewNeuropsychiatric complicationsNew York City health systemOdds of mortalityAssociated with in-hospital mortalityMultivariate logistic regressionMedical record databaseHealth systemLower oddsHigher oddsIndividual chart reviewSerum inflammatory marker levelsCohort studyPre-existing comorbiditiesRecord databaseCOVID-19Logistic regressionTreated with anticoagulationInflammatory marker levelsComplication of coronavirus diseaseSeverity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults
Surie D, Yuengling K, DeCuir J, Zhu Y, Lauring A, Gaglani M, Ghamande S, Peltan I, Brown S, Ginde A, Martinez A, Mohr N, Gibbs K, Hager D, Ali H, Prekker M, Gong M, Mohamed A, Johnson N, Srinivasan V, Steingrub J, Leis A, Khan A, Hough C, Bender W, Duggal A, Bendall E, Wilson J, Qadir N, Chang S, Mallow C, Kwon J, Exline M, Shapiro N, Columbus C, Vaughn I, Ramesh M, Mosier J, Safdar B, Casey J, Talbot H, Rice T, Halasa N, Chappell J, Grijalva C, Baughman A, Womack K, Swan S, Johnson C, Lwin C, Lewis N, Ellington S, McMorrow M, Martin E, Self W. Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults. JAMA Network Open 2024, 7: e244954. PMID: 38573635, PMCID: PMC11192181, DOI: 10.1001/jamanetworkopen.2024.4954.Peer-Reviewed Original ResearchConceptsInvasive mechanical ventilationRespiratory syncytial virusSeverity of RSV diseaseInfluenza diseaseVaccinated patientsIn-hospital deathUnvaccinated patientsRSV diseaseSyncytial virusClinical decision-makingComposite of invasive mechanical ventilationOutcome of invasive mechanical ventilationSeverity of respiratory syncytial virusLaboratory-confirmed respiratory syncytial virusHospitalized US adultsInfluenza vaccination statusVaccination statusAcute respiratory illnessMultivariate logistic regressionCenters for Disease Control and PreventionSeverity of COVID-19Disease Control and PreventionInfluenza infectionInfluenza severityClinical outcomesPre-COVID-19 hospital quality and hospital response to COVID-19: examining associations between risk-adjusted mortality for patients hospitalised with COVID-19 and pre-COVID-19 hospital quality
Peter D, Li S, Wang Y, Zhang J, Grady J, McDowell K, Norton E, Lin Z, Bernheim S, Venkatesh A, Fleisher L, Schreiber M, Suter L, Triche E. Pre-COVID-19 hospital quality and hospital response to COVID-19: examining associations between risk-adjusted mortality for patients hospitalised with COVID-19 and pre-COVID-19 hospital quality. BMJ Open 2024, 14: e077394. PMID: 38553067, PMCID: PMC10982775, DOI: 10.1136/bmjopen-2023-077394.Peer-Reviewed Original ResearchMeSH KeywordsAgedCOVID-19Hospital MortalityHospitalsHumansMedicarePandemicsRetrospective StudiesUnited StatesConceptsHospital qualityPatient experiencePre-COVID-19Medicare patientsShort-term acute care hospitalsCritical access hospitalsAcute care hospitalsFuture public health emergenciesHigher odds of mortalityIn-hospitalRisk-adjusted mortalityOdds of mortalityCare deliveryAccess hospitalsEffective careCOVID-19-related deathsAssociated with mortalityCare structuresHospital characteristicsPublic health emergencySummary scoreMedicare beneficiariesHigher oddsHospital responseRSMRsPropofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol groupReal-Time Machine Learning Alerts to Prevent Escalation of Care: A Nonrandomized Clustered Pragmatic Clinical Trial*
Levin M, Kia A, Timsina P, Cheng F, Nguyen K, Kohli-Seth R, Lin H, Ouyang Y, Freeman R, Reich D. Real-Time Machine Learning Alerts to Prevent Escalation of Care: A Nonrandomized Clustered Pragmatic Clinical Trial*. Critical Care Medicine 2024, 52: 1007-1020. PMID: 38380992, DOI: 10.1097/ccm.0000000000006243.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical DeteriorationFemaleHospital MortalityHospital Rapid Response TeamHumansMachine LearningMaleMiddle AgedProspective StudiesConceptsIntervention groupPatient bed-daysBed daysRelative riskAdjusted incidence rate ratiosMedical-surgical unitsAssignment to interventionFront-line providersAdjusted relative risksIncidence rate ratiosIn-hospitalMedication ordersAdjusted RRClinical careRate ratiosStabilized inverse probabilityControl armPropensity score modelSecondary outcomesPrimary outcomePredicting clinical deteriorationActivation criteriaProspective dataLikelihood of deteriorationProvider discretionImpact of concomitant surgical interventions on outcomes of septal myectomy in obstructive hypertrophic cardiomyopathy
Altibi A, Sapru A, Ghanem F, Zhao Y, Alani A, Cigarroa J, Nazer B, Song H, Masri A. Impact of concomitant surgical interventions on outcomes of septal myectomy in obstructive hypertrophic cardiomyopathy. International Journal Of Cardiology 2024, 400: 131790. PMID: 38242508, DOI: 10.1016/j.ijcard.2024.131790.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathyMitral valve replacementCoronary artery bypass graftingConcomitant surgical interventionIn-hospital mortalitySeptal myectomyAdverse in-hospital eventsIn-hospital eventsSurgical interventionMV repairValve replacementHypertrophic cardiomyopathyOutcomes of septal myectomyAssociated with increased in-hospital mortalityOutcomes of patientsAortic valve replacementIn-hospital adverse eventsAdverse clinical eventsIsolated SMArtery bypass graftingIn-hospital deathNational Readmission DatabaseSymptomatic patientsMedical therapyAdverse events
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