2025
Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes
Zohora F, Nazari M, Sinusas A. Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes. Current Cardiology Reports 2025, 27: 61. PMID: 40009333, DOI: 10.1007/s11886-025-02197-9.Peer-Reviewed Original ResearchConceptsSudden cardiac deathImplantable cardioverter defibrillatorPositron emission tomographyImplantable cardioverter defibrillator placementMyocardial sympathetic denervationRisk stratificationSympathetic denervationIschemic heart diseaseHeart failurePrevention of sudden cardiac deathRisk stratification of patientsHeart diseaseOptimal risk stratificationLow ejection fractionStratification of patientsSympathetic nerve densityImprove risk stratificationHeart failure patientsPositron emission tomography radiotracersPredicting sudden cardiac deathPositron emission tomography tracersPrognostic benefitEjection fractionClinically practical approachNerve densityInheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study
Cristin L, Dixit S, Bibby D, Tang J, Fang Q, Tastet L, Rich A, Jhawar R, Nagata Y, Higuchi S, Levine R, Hsia H, Tseng Z, Schiller N, Delling F. Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study. Circulation Cardiovascular Imaging 2025, 18: e017051. PMID: 39764632, PMCID: PMC11753933, DOI: 10.1161/circimaging.124.017051.Peer-Reviewed Original ResearchConceptsMitral valve prolapseMitral annular disjunctionSudden cardiac arrestPostsystolic shortening indexAnnular disjunctionNormal mitral valveSudden cardiac deathValve prolapseMitral valveLongitudinal strainShortening indexArrhythmic mitral valve prolapseGlobal longitudinal strainExperience sudden cardiac arrestSpeckle-tracking echocardiographyFamilial mitral valve prolapsePeak longitudinal strainGlobal strain parametersBileaflet involvementGenetic myopathiesArrhythmic riskVentricular ectopyCardiac deathCardiac arrestHealthy controls
2024
Do relationships between ambient temperature and serious adverse health outcomes vary among users of different antidiabetes drugs? A retrospective cohort study of US Medicaid beneficiaries with type 2 diabetes
Leonard C, Bogar K, Brensinger C, Bilker W, Bell M, Flory J, Shi C, Chen C, Hennessy S. Do relationships between ambient temperature and serious adverse health outcomes vary among users of different antidiabetes drugs? A retrospective cohort study of US Medicaid beneficiaries with type 2 diabetes. BMJ Open 2024, 14: e085139. PMID: 39433419, PMCID: PMC11499775, DOI: 10.1136/bmjopen-2024-085139.Peer-Reviewed Original ResearchConceptsAdverse health outcomesZone Improvement PlanHealth outcomesSudden cardiac arrestMedicaid beneficiariesType 2 diabetesLinear associationResidential zip codeModified Poisson regressionCardiac arrestInverse linear associationPerson-daysUsers of sulfonylureasNon-insulin usersPositive linear associationHealth plan enrollmentRetrospective cohort studyEffect modificationPoisson regressionZip codesHospital presentationHealthcare claimsUS MedicaidCohort studyCalculated age-Vigorous Exercise in Patients With Congenital Long QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study
Lampert R, Day S, Ainsworth B, Burg M, Marino B, Salberg L, Tome Esteban M, Abrams D, Aziz P, Barth C, Behr E, Bell C, Berul C, Bos J, Bradley D, Cannom D, Cannon B, Concannon M, Cerrone M, Czosek R, Dubin A, Dziura J, Erickson C, Estes N, Etheridge S, Goldenberg I, Gray B, Haglund-Turnquist C, Harmon K, James C, Johnsrude C, Kannankeril P, Lara A, Law I, Li F, Link M, Molossi S, Olshansky B, Noseworthy P, Saarel E, Sanatani S, Shah M, Simone L, Skinner J, Tomaselli G, Ware J, Webster G, Zareba W, Zipes D, Ackerman M. Vigorous Exercise in Patients With Congenital Long QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study. Circulation 2024, 150: 516-530. PMID: 39051104, DOI: 10.1161/circulationaha.123.067590.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildDeath, Sudden, CardiacExerciseFemaleHumansLong QT SyndromeMaleMiddle AgedProspective StudiesRisk FactorsYoung AdultConceptsVigorous exerciseLong QT syndromeGenotyped long QT syndromeCongenital long QT syndromeClinical events committeeComposite end pointHazard ratioNational Death Index searchCompetitive sports participationQT syndromeDecision-making discussionsEvents committeeVentricular arrhythmiasFollow-upEvent ratesBlinded clinical events committeeMetabolic equivalentsPhysical activityExercise groupEnd pointsRisk of ventricular arrhythmiasMultivariate Cox regression analysisSudden cardiac arrestSports participationCardiac event rateThe Science Behind the Standardization of Chest Protectors: Is Marketing Alone Enough to Sell Chest Protectors?... Not Anymore!
Trejo-Paredes C, Lampert R. The Science Behind the Standardization of Chest Protectors: Is Marketing Alone Enough to Sell Chest Protectors?... Not Anymore! Circulation Arrhythmia And Electrophysiology 2024, 17: e012844. PMID: 38497218, DOI: 10.1161/circep.124.012844.Peer-Reviewed Original ResearchDevices and Athletics Decision-Making Around Return to Play
Kay B, Lampert R. Devices and Athletics Decision-Making Around Return to Play. Cardiac Electrophysiology Clinics 2024, 16: 81-92. PMID: 38280816, DOI: 10.1016/j.ccep.2023.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAthletesDeath, Sudden, CardiacDefibrillators, ImplantableHumansRegistriesReturn to SportSportsConceptsSports participationSafety of sports participationSports-related deathsEmergency action planImplantable cardioverter defibrillatorAthletic cohortObservational registry dataCompetitive athletesAthletic activityRegistry dataAthletesExternal resuscitationOptimization of medical therapyAction planSocietal recommendationsSportsParticipantsCardioverter defibrillatorMedical therapyResuscitationCohortDevice settingsInappropriate shocksRecommendationsDefibrillationSports Participation by Athletes With Cardiovascular Disease
Martinez M, Ackerman M, Annas G, Baggish A, Day S, Harmon K, Kim J, Levine B, Putukian M, Lampert R. Sports Participation by Athletes With Cardiovascular Disease. Journal Of The American College Of Cardiology 2024, 83: 865-868. PMID: 38383101, DOI: 10.1016/j.jacc.2023.12.021.Peer-Reviewed Original Research
2023
Utilization and Outcomes of Primary Prevention Implantable Cardioverter‐Defibrillators in Patients With Hypertrophic Cardiomyopathy
Goldstein S, Kennedy K, Friedman D, Al‐Khatib S, Wang A. Utilization and Outcomes of Primary Prevention Implantable Cardioverter‐Defibrillators in Patients With Hypertrophic Cardiomyopathy. Journal Of The American Heart Association 2023, 12: e029293. PMID: 37586066, PMCID: PMC10492935, DOI: 10.1161/jaha.122.029293.Peer-Reviewed Original ResearchConceptsNew York Heart Association classPrimary prevention implantable cardioverter-defibrillatorHistory of nonsustained ventricular tachycardiaImplantable cardioverter-defibrillatorImplantable cardioverter-defibrillator utilizationNonsustained ventricular tachycardiaHypertrophic cardiomyopathyAssociation classVentricular tachycardiaOlder patientsCardioverter-defibrillatorLeft ventricular ejection fractionRisk factorsNational Cardiovascular Data Registry ICD RegistryFactors associated with mortalityImplantable cardioverter-defibrillator implantationAssociated with postdischarge mortalityVentricular ejection fractionPrevalence of risk factorsSudden cardiac deathPostdischarge hospitalizationAssociated with hospitalizationCenters for MedicareEjection fractionICD RegistryClinical presentation of calmodulin mutations: the International Calmodulinopathy Registry
Crotti L, Spazzolini C, Nyegaard M, Overgaard M, Kotta M, Dagradi F, Sala L, Aiba T, Ayers M, Baban A, Barc J, Beach C, Behr E, Bos J, Cerrone M, Covi P, Cuneo B, Denjoy I, Donner B, Elbert A, Eliasson H, Etheridge S, Fukuyama M, Girolami F, Hamilton R, Horie M, Iascone M, Jiménez-Jaimez J, Jensen H, Kannankeril P, Kaski J, Makita N, Muñoz-Esparza C, Odland H, Ohno S, Papagiannis J, Porretta A, Prandstetter C, Probst V, Robyns T, Rosenthal E, Rosés-Noguer F, Sekarski N, Singh A, Spentzou G, Stute F, Tfelt-Hansen J, Till J, Tobert K, Vinocur J, Webster G, Wilde A, Wolf C, Ackerman M, Schwartz P. Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. European Heart Journal 2023, 44: 3357-3370. PMID: 37528649, PMCID: PMC10499544, DOI: 10.1093/eurheartj/ehad418.Peer-Reviewed Original ResearchMeSH KeywordsCalmodulinChildDeath, Sudden, CardiacHumansLong QT SyndromeMutationRegistriesTachycardia, VentricularConceptsClinical presentationPrimary neurological manifestationsCardiac structural abnormalitiesLife-threatening arrhythmia syndromesArrhythmic event rateAbsence of symptomsLife-threatening arrhythmiasSodium channel blockersCongenital heart defectsAntiadrenergic interventionsCardiac eventsHeart failureNeurological manifestationsUnderlying molecular mechanismsDefinitive recommendationsClinical severityChannel blockersObservational studySudden deathIndex caseArrhythmia syndromesHeart defectsPrevalent phenotypeStructural abnormalitiesCurrent managementOptimizing pre-participation screening to prevent tragedy in young athletes: moving from if to how
Beach C, Lampert R. Optimizing pre-participation screening to prevent tragedy in young athletes: moving from if to how. European Heart Journal 2023, 44: 1093-1095. PMID: 36760103, DOI: 10.1093/eurheartj/ehad015.Peer-Reviewed Original Research
2022
Devices and Athletics Decision-Making Around Return to Play
Kay B, Lampert R. Devices and Athletics Decision-Making Around Return to Play. Cardiology Clinics 2022, 41: 81-92. PMID: 36368813, DOI: 10.1016/j.ccl.2022.08.007.ChaptersConceptsImplantable cardioverter defibrillatorObservational registry dataSports-related deathsSports participationMedical therapyInappropriate shocksRegistry dataCardioverter defibrillatorSocietal recommendationsAthletic activityAthlete cohortCompetitive athleticsEmergency action planAthletesDevice settingsContraindicationsResuscitationTherapyCohortDefibrillatorLife-threatening cardiac arrhythmia and sudden death during electronic gaming: An international case series and systematic review
Lawley C, Tester M, Sanatani S, Prendiville T, Beach C, Vinocur J, Horie M, Uhm J, Khongphatthanayothin A, Ayers M, Starling L, Yoshida Y, Shah M, Skinner J, Turner C. Life-threatening cardiac arrhythmia and sudden death during electronic gaming: An international case series and systematic review. Heart Rhythm 2022, 19: 1826-1833. PMID: 37850595, DOI: 10.1016/j.hrthm.2022.08.003.Peer-Reviewed Original ResearchMeSH KeywordsArrhythmias, CardiacChildDeath, SuddenDeath, Sudden, CardiacHeartHumansMaleTachycardia, VentricularVideo GamesConceptsInternational case seriesLife-threatening cardiac arrhythmiasCardiac arrhythmiasCase seriesSystematic reviewCatecholaminergic polymorphic ventricular tachycardiaPolymorphic ventricular tachycardiaLong QT syndromeLethal cardiac arrhythmiasCardiac eventsCoronary ischemiaCardiac surgeryVentricular arrhythmiasCardiac arrestSusceptible childrenVentricular tachycardiaVentricular fibrillationSudden deathCardiac conditionsArrhythmic triggersCardiac diagnosisPatientsQT syndromeSusceptible individualsArrhythmiasClimate Change and Ambient Temperature Extremes: Association With Serious Hypoglycemia, Diabetic Ketoacidosis, and Sudden Cardiac Arrest/Ventricular Arrhythmia in People With Type 2 Diabetes.
Bogar K, Brensinger C, Hennessy S, Flory J, Bell M, Shi C, Bilker W, Leonard C. Climate Change and Ambient Temperature Extremes: Association With Serious Hypoglycemia, Diabetic Ketoacidosis, and Sudden Cardiac Arrest/Ventricular Arrhythmia in People With Type 2 Diabetes. Diabetes Care 2022, 45: e171-e173. PMID: 36205432, PMCID: PMC9679254, DOI: 10.2337/dc22-1161.Peer-Reviewed Original ResearchSurvival Probability and Survival Benefit Associated With Primary Prevention Implantable Cardioverter‐Defibrillator Generator Changes
Bilchick KC, Wang Y, Curtis JP, Shadman R, Dardas TF, Anand I, Lund LH, Dahlström U, Sartipy U, Levy WC. Survival Probability and Survival Benefit Associated With Primary Prevention Implantable Cardioverter‐Defibrillator Generator Changes. Journal Of The American Heart Association 2022, 11: e023743. PMID: 35766293, PMCID: PMC9333379, DOI: 10.1161/jaha.121.023743.Peer-Reviewed Original ResearchConceptsSeattle Heart Failure ModelHeart failure modelHeart failure patientsResynchronization therapyGenerator changeSurvival benefitWorse survivalFailure patientsNational Cardiovascular Data Registry ICD RegistryGC survivalSurvival Benefit AssociatedPrimary prevention indicationVentricular ejection fractionAnnual mortalityICD therapyConclusions PatientsPrevention indicationEjection fractionICD RegistryImproved survivalPrimary preventionPatient deathGreater effect sizeLVEFPatientsArrhythmia Monitoring and Outcomes in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium
Bressi E, Crawford T, Bogun F, Gu X, Ellenbogen K, Chicos A, Roukoz H, Zimetbaum P, Kalbfleisch S, Murgatroyd F, Steckman D, Rosenfeld L, Garlitski A, Soejima K, Bhan A, Vedantham V, Dickfeld T, De Lurgio D, Platonov P, Zipse M, Nishiuchi S, Ortman M, Narasimhan C, Patton K, Rosenthal D, Mukerji S, Hoogendoorn J, Zeppenfeld K, Sauer W, Kron J, Bressi E, Crawford T, Bogun F, Gu X, Ellenbogen K, Chicos A, Roukoz H, Zimetbaum P, Kalbfleisch S, Murgatroyd F, Steckman D, Rosenfeld L, Garlitski A, Soejima K, Bhan A, Vedantham V, Dickfeld T, De Lurgio D, Platonov P, Zipse M, Nishiuchi S, Ortman M, Narasimhan C, Patton K, Rosenthal D, Mukerji S, Hoogendoorn J, Zeppenfeld K, Sauer W, Kron J. Arrhythmia Monitoring and Outcomes in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium. Journal Of The American Heart Association 2022, 11: e024924. PMID: 35730638, PMCID: PMC9333370, DOI: 10.1161/jaha.121.024924.Peer-Reviewed Original ResearchMeSH KeywordsArrhythmias, CardiacCardiomyopathiesDeath, Sudden, CardiacDefibrillators, ImplantableHumansSarcoidosisCardiac Status Among Heart Failure Patients With Implantable Cardioverter Defibrillators Before, During, and After COVID-19 Lockdown
Lu Y, Jones PW, Murugiah K, Caraballo C, Mahajan S, Massey D, Ahmed R, Bader E, Krumholz H. Cardiac Status Among Heart Failure Patients With Implantable Cardioverter Defibrillators Before, During, and After COVID-19 Lockdown. Journal Of Cardiac Failure 2022, 28: 1372-1374. PMID: 35690314, PMCID: PMC9187866, DOI: 10.1016/j.cardfail.2022.05.012.Peer-Reviewed Original ResearchMeSH KeywordsCommunicable Disease ControlCOVID-19Death, Sudden, CardiacDefibrillators, ImplantableElectric CountershockHeart FailureHumansConceptsImplantable cardioverter defibrillatorHeart failure patientsCRT-D devicesCardiac statusFailure patientsHeart failureCardioverter defibrillatorCardiac resynchronization therapy defibrillatorAcute cardiac conditionsMedical care deliveryInpatient careCardiac conditionsPhysiologic markersInpatient servicesPatientsCardiac healthCare deliveryMarked restrictionImplanted ICDsMinneapolis/Saint PaulSex subgroupsDefibrillatorCOVID-19Telemedicine servicesCOVID-19 lockdownFrequency of QTc Interval Prolongation in Children and Adults with Williams Syndrome
Brink BD, Feinn R, Kozel BA, Billington CJ, Liu D, Yu E, Sindhar S, He J, Rouse C, Lampert R, Pober BR, Elder RW. Frequency of QTc Interval Prolongation in Children and Adults with Williams Syndrome. Pediatric Cardiology 2022, 43: 1559-1567. PMID: 35366065, DOI: 10.1007/s00246-022-02883-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultChildDeath, Sudden, CardiacElectrocardiographyHeart RateHumansLong QT SyndromeRetrospective StudiesWilliams SyndromeConceptsSudden cardiac deathHeart rateBazett's formulaCardiac deathWilliams syndromeRetrospective chart reviewQTc interval prolongationBundle branch blockMean heart rateHigher heart rateChart reviewQTc prolongationInterval prolongationSinus rhythmBranch blockGeneral populationNormal rangePatientsQTcWS patientsQTcBEKGProlongationSyndromePotential causesLongitudinal Outcomes of Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators in Older Patients
Friedman DJ, Qin L, Parzynski C, Heist EK, Russo AM, Ranasinghe I, Zeitler EP, Minges KE, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Longitudinal Outcomes of Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators in Older Patients. Journal Of The American College Of Cardiology 2022, 79: 1050-1059. PMID: 35300816, DOI: 10.1016/j.jacc.2021.12.033.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacDeath, Sudden, CardiacDefibrillators, ImplantableFemaleHumansMaleMedicareRetrospective StudiesTreatment OutcomeUnited StatesConceptsOlder patientsCause readmissionS-ICDNational Cardiovascular Data Registry ICD RegistryDevice removalTransvenous implantable cardioverter defibrillatorTV-ICD patientsRisk of deathS-ICD patientsService Medicare beneficiariesAnderson-Gill modelsImplantable cardioverter defibrillatorRepresentative national cohortCompeting-risks modelTV-ICDCardiovascular readmissionCause mortalityICD implantationYounger patientsICD RegistryNonfatal outcomesTransvenous ICDAtrial fibrillationNational cohortCardioverter defibrillatorClinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome
Roston TM, Wei J, Guo W, Li Y, Zhong X, Wang R, Estillore JP, Peltenburg PJ, Noguer FRI, Till J, Eckhardt LL, Orland KM, Hamilton R, LaPage MJ, Krahn AD, Tadros R, Vinocur JM, Kallas D, Franciosi S, Roberts JD, Wilde AAM, Jensen HK, Sanatani S, Chen SRW. Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome. JAMA Cardiology 2022, 7: 84-92. PMID: 34730774, PMCID: PMC8567190, DOI: 10.1001/jamacardio.2021.4458.Peer-Reviewed Original ResearchConceptsCatecholaminergic polymorphic ventricular tachycardiaExercise stress testingDeficiency syndromeRYR2 variantsVentricular tachyarrhythmiasArrhythmic eventsVentricular fibrillationLife-threatening arrhythmic eventsMulticenter observational cohort studyFunction variantsCardiac ryanodine receptor 2Complex ventricular tachyarrhythmiasPrevious arrhythmic eventsΒ-blocker therapyObservational cohort studyPolymorphic ventricular tachycardiaLife-threatening eventsSpectrum of diseaseVentricular fibrillation episodesFirst clinical seriesRyanodine receptor 2Better diagnostic toolsCohort studyVentricular arrhythmiasClinical series
2021
Risk and predictors of mortality after implantable cardioverter-defibrillator implantation in patients with sarcoid cardiomyopathy
Higgins AY, Annapureddy AR, Wang Y, Minges KE, Bellumkonda L, Lampert R, Rosenfeld LE, Jacoby DL, Curtis JP, Miller EJ, Freeman JV. Risk and predictors of mortality after implantable cardioverter-defibrillator implantation in patients with sarcoid cardiomyopathy. American Heart Journal 2021, 246: 21-31. PMID: 34968442, DOI: 10.1016/j.ahj.2021.12.011.Peer-Reviewed Original ResearchConceptsNon-ischemic cardiomyopathyAtrial fibrillation/flutterChronic lung diseaseCardiac sarcoidosisHeart failureCS patientsNICM patientsICD implantationLung diseaseNew York Heart Association class III heart failureNational Cardiovascular Data Registry ICD RegistryNYHA class IV heart failureClass III heart failureClass IV heart failureImplantable cardioverter defibrillator implantationKaplan-Meier survival curvesCox proportional hazards modelPredictors of mortalityCardioverter-defibrillator implantationVentricular ejection fractionMultivariable logistic regressionPrior ventricular arrhythmiasProportional hazards modelRate of deathTime of implantation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply