2025
Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoring
2024
Can Artificial Intelligence Deceive Residency Committees? A Randomized Multicenter Analysis of Letters of Recommendation
Simister S, Huish E, Tsai E, Le H, Halim A, Tuason D, Meehan J, Leshikar H, Saiz A, Lum Z. Can Artificial Intelligence Deceive Residency Committees? A Randomized Multicenter Analysis of Letters of Recommendation. Journal Of The American Academy Of Orthopaedic Surgeons 2024, 33: e348-e355. PMID: 39693540, DOI: 10.5435/jaaos-d-24-00438.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceCorrespondence as TopicHumansInternship and ResidencyOrthopedicsPersonnel SelectionSingle-Blind MethodArtificial intelligence-based CT-free quantitative thyroid SPECT for thyrotoxicosis: study protocol of a multicentre, prospective, non-inferiority study
Oh D, Ryoo H, Chung H, Cho S, Kwon K, Kim J, So Y, Moon J, Ahn S, Lee W. Artificial intelligence-based CT-free quantitative thyroid SPECT for thyrotoxicosis: study protocol of a multicentre, prospective, non-inferiority study. BMJ Open 2024, 14: e089552. PMID: 39401965, PMCID: PMC11475049, DOI: 10.1136/bmjopen-2024-089552.Peer-Reviewed Original ResearchMeSH KeywordsAdultArtificial IntelligenceDiagnosis, DifferentialEquivalence Trials as TopicFemaleGraves DiseaseHumansMaleMulticenter Studies as TopicProspective StudiesRepublic of KoreaSingle Photon Emission Computed Tomography Computed TomographySingle-Blind MethodThyroid GlandThyroiditisThyrotoxicosisTomography, Emission-Computed, Single-PhotonConceptsGraves' diseaseDestructive thyroiditisDifferential diagnosisDifferential diagnosis of Graves' diseaseDifferential diagnosis of thyrotoxicosisDiagnosis of Graves' diseaseKonkuk University Medical CenterSingle-photon emission CT/CTSeoul National University Bundang HospitalTc-99m pertechnetateDiagnosis of thyrotoxicosisChonnam National University HospitalHistory of hyperthyroidismAttenuation correctionStudy protocolNational University HospitalNon-inferiority studyUniversity Medical CenterClinical Research Information ServiceInstitutional review boardPrimary endpointThyrotoxicosis patientsSecondary endpointsTechnetium thyroid uptakeThyroid uptakeAdjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
Adeoye O, Broderick J, Derdeyn C, Grotta J, Barsan W, Bentho O, Berry S, Concha M, Davis I, Demel S, Elm J, Gentile N, Graves T, Hoffman M, Huang J, Ingles J, Janis S, Jasne A, Khatri P, Levine S, Majjhoo A, Panagos P, Pancioli A, Pizzella S, Ranasinghe T, Sabagha N, Sivakumar S, Streib C, Vagal A, Wilson A, Wintermark M, Yoo A, Barreto A. Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke. New England Journal Of Medicine 2024, 391: 810-820. PMID: 39231343, PMCID: PMC11528349, DOI: 10.1056/nejmoa2314779.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsArginineCombined Modality TherapyDrug Therapy, CombinationEptifibatideFemaleFibrinolytic AgentsHumansIncidenceInfusions, IntravenousIntracranial HemorrhagesIschemic StrokeMaleMiddle AgedPeptidesPipecolic AcidsPlatelet Aggregation InhibitorsSingle-Blind MethodSulfonamidesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsSymptomatic intracranial hemorrhageIntravenous argatrobanIntravenous thrombolysisAcute ischemic strokeIntracranial hemorrhageIschemic strokeIncidence of symptomatic intracranial hemorrhageSymptom onsetIschemic stroke treated with intravenous thrombolysisAcute ischemic stroke treated with intravenous thrombolysisStroke treated with intravenous thrombolysisAssociated with increased mortalityRankin Scale scoreInitiation of thrombolysisControlled clinical trialsTreatment of acute ischemic strokePlacebo groupEptifibatide groupEfficacy outcomesArgatroban groupStandard treatmentAdjunctive treatmentPlaceboClinical trialsArgatrobanKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbuminEnhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial
Williams A, Cleare S, Borschmann R, Tench C, Gross J, Hollis C, Chapman-Nisar A, Naeche N, Townsend E, Slovak P, Youth O, Creswell C, Fonagy P, Arseneault L, Lloyd E, De Alcantara Mendes J, Holter C, Jirotka M, Lazar Z, Patalay P, Kelly Y, Kandola A, Sonuga-Barke E, Livingstone S, Kostryka-Allchorne K, Bourgaize J, Stoilova M, O’Connor R, Auer D, Lee S, Jawahar N, Etherson M, Greenhalgh C, Sayal K, Warren J, Wanniarachchi V, Glover K, Stallard P, Hall C, Lucassen M, Merry S, Stasiak K, Babbage C, Khan K, Parker A, Lockwood J, Gregory J, Nielsen E, Vallejos E, Woodcock R, Doherty S, Willingham L. Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial. BMJ Open 2024, 14: e079801. PMID: 38195171, PMCID: PMC10806609, DOI: 10.1136/bmjopen-2023-079801.Peer-Reviewed Original ResearchConceptsSelf-harm ideationSelf-harmEmotion dysregulationEmotion regulationRandomised controlled trialsWaitlist controlEnhance emotion regulationExperiences of self-harmSocially assistive robotsSelf-Harm QuestionnaireSelf-harm thoughtsControlled trialsPeer-reviewed open access journalsLGBTQ+ youthPeople’s own viewsAssistive robotsControl participantsIntervention participantsAcceptable interventionSemistructured interviewsLinear mixed modelsPreliminary evidenceEthical approvalKing's College LondonSecondary outcomes
2023
Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial
Adams T, Kelmendi B, George J, Forte J, Hubert T, Wild H, Rippey C, Pittenger C. Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial. Neurobiology Of Learning And Memory 2023, 205: 107825. PMID: 37699439, PMCID: PMC10872945, DOI: 10.1016/j.nlm.2023.107825.Peer-Reviewed Original ResearchMeSH KeywordsExtinction, PsychologicalFearHumansPilot ProjectsPrefrontal CortexSingle-Blind MethodTranscranial Direct Current StimulationConceptsTranscranial direct current stimulationSkin conductance responsesExtinction trainingDirect current stimulationExtinction learningCurrent stimulationReturn of fearFear extinction paradigmInhibition of fearFear extinction learningExposure-based therapyTreatment of anxietyFear inhibitionThreat cuesSafety learningExtinction paradigmFear reactivityFear processingConductance responsesExtinction trialsFunctional connectivityElectrodermal activityMixed ANOVARelated disordersAnxiety
2022
An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study
Geisen C, Kjaer M, Fleck E, Skogen B, Armstrong R, Behrens F, Bhagwagar Z, Braeuninger S, Mortberg A, Olsen K, Gastón Schäfer S, Walter C, Seifried E, Wikman A, Kjeldsen-Kragh J, Koehm M. An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study. Journal Of Thrombosis And Haemostasis 2022, 21: 838-849. PMID: 36696185, DOI: 10.1016/j.jtha.2022.11.041.Peer-Reviewed Original ResearchConceptsFetal/Neonatal Alloimmune ThrombocytopeniaNeonatal alloimmune thrombocytopeniaHPA-1aAlloimmune thrombocytopeniaHuman platelet antigen 1aTreatment-emergent adverse eventsPlacebo 1 hourHPA-1a antibodiesFNAIT casesHyperimmune IgGPrimary endpointAdverse eventsFetus/Healthy menSingle doseAntigen 1aHLA-A2Concept studyCohort 1PlaceboFlow cytometryThrombocytopeniaPlateletsAdministrationWeeksIntegrating Palliative Care Into Self-management of Breast Cancer
Schulman-Green D, Linsky S, Jeon S, Holland ML, Kapo J, Blatt L, Adams C, Chagpar AB. Integrating Palliative Care Into Self-management of Breast Cancer. Cancer Nursing 2022, 46: e169-e180. PMID: 35353749, PMCID: PMC9519806, DOI: 10.1097/ncc.0000000000001078.Peer-Reviewed Original ResearchConceptsBreast cancer patientsPalliative careCancer careRace/ethnicityCancer patientsChronic Disease Self-Efficacy ScaleStage III/IV cancerSingle-blind pilotSymptom management educationSelf-management planFeasibility/acceptabilityAcademic cancer centerMedical Communication Competence ScaleSelf-management outcomesLate-stage cancerEthnic minority patientsEffect sizeClinical characteristicsCancer CenterHospital AnxietyMishel UncertaintyCancer stageIllness ScaleBreast cancerDepression ScaleRationale and design of a pragmatic trial aimed at improving treatment of hyperlipidemia in outpatients with very high risk atherosclerotic cardiovascular disease: A pragmatic trial of messaging to providers about treatment of hyperlipidemia (PROMPT-LIPID)
Shah NN, Ghazi L, Yamamoto Y, Martin M, Simonov M, Riello RJ, Faridi KF, Ahmad T, Wilson FP, Desai NR. Rationale and design of a pragmatic trial aimed at improving treatment of hyperlipidemia in outpatients with very high risk atherosclerotic cardiovascular disease: A pragmatic trial of messaging to providers about treatment of hyperlipidemia (PROMPT-LIPID). American Heart Journal 2022, 253: 76-85. PMID: 35841944, PMCID: PMC9936562, DOI: 10.1016/j.ahj.2022.07.002.Peer-Reviewed Original ResearchConceptsLipid-lowering therapyAtherosclerotic cardiovascular diseaseTreatment of hyperlipidemiaProportion of patientsElectronic health recordsPragmatic trialHigh riskCardiovascular diseaseProprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitorsHigh-risk atherosclerotic cardiovascular diseaseSubtilisin/kexin type 9 inhibitorsLow-density lipoprotein cholesterol reductionImportant public health implicationsEnrollment of patientsPublic health implicationsUsual careSecondary outcomesPrimary outcomeGuideline recommendationsCholesterol reductionPatientsLDLHyperlipidemiaScalable interventionsOutpatients
2021
Effect of the STAMP (Sharing and Talking About My Preferences) Intervention on Completing Multiple Advance Care Planning Activities in Ambulatory Care : A Cluster Randomized Controlled Trial.
Fried TR, Paiva AL, Redding CA, Iannone L, O'Leary JR, Zenoni M, Risi MM, Mejnartowicz S, Rossi JS. Effect of the STAMP (Sharing and Talking About My Preferences) Intervention on Completing Multiple Advance Care Planning Activities in Ambulatory Care : A Cluster Randomized Controlled Trial. Annals Of Internal Medicine 2021, 174: 1519-1527. PMID: 34461035, PMCID: PMC8711627, DOI: 10.7326/m21-1007.Peer-Reviewed Original ResearchMeSH KeywordsAdvance Care PlanningAgedAmbulatory CareFeedbackFemaleHumansMaleMiddle AgedPamphletsSingle-Blind MethodConceptsAdvance care planning activitiesCare planning activitiesAmbulatory care settingsAdvance care planningCare planningCare settingsNon-English speaking participantsSpecialty care practicesUsual care sitesPrespecified subgroup analysisPatient sociodemographic informationNational InstituteParticipant-level analysesQuantity of lifeHealth care agentSecondary outcomesUsual carePrimary outcomeControlled TrialsMean ageSubgroup analysisBlinded interviewersAmbulatory careCare sitesPrint interventionQuantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components
Yousef S, Matsumoto N, Dabe I, Mori M, Landry AB, Lee SR, Kawamura Y, Yang C, Li G, Assi R, Vallabhajosyula P, Geirsson A, Moeckel G, Humphrey JD, Tellides G. Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components. Scientific Reports 2021, 11: 13185. PMID: 34162971, PMCID: PMC8222259, DOI: 10.1038/s41598-021-92659-1.Peer-Reviewed Original ResearchConceptsMedial degenerationAortic aneurysmSporadic thoracic aortic aneurysmMedial cell numberCommon histopathological findingThoracic aortic aneurysmSmooth muscle cellsAortic dilatationHistopathological findingsAscending aortaHistopathological criteriaAneurysmal wallLumen dilatationClinical diagnosisMuscle cellsAneurysmsAortaDegenerationDilatationMural cellsMarked overlapElastic lamellaeMedial componentCell numberMedial tissueA randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial
Lansky AJ, Makkar R, Nazif T, Messé S, Forrest J, Sharma R, Schofer J, Linke A, Brown D, Dhoble A, Horwitz P, Zang M, DeMarco F, Rajagopal V, Dwyer MG, Zivadinov R, Stella P, Rovin J, Parise H, Kodali S, Baumbach A, Moses J. A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial. European Heart Journal 2021, 42: 2670-2679. PMID: 34000004, DOI: 10.1093/eurheartj/ehab213.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEfficacy endpointCerebral embolic protection devicesTranscatheter aortic valve implantationCentral nervous system injuryCerebral embolic lesionsCerebral ischemic lesionsHealth Stroke ScalePrimary efficacy endpointPrimary safety outcomeAortic valve replacementAortic valve implantationEmbolic protection devicesNervous system injuryDiffusion-weighted magnetic resonanceMontreal Cognitive AssessmentEffectiveness endpointCause mortalityCerebral protectionSafety endpointStroke ScaleValve implantationValve replacementI trialIschemic lesionsSingle-Blind and Double-Blind Peer Review: Effects on National Representation
Kalavar M, Watane A, Wu D, Sridhar J, Mruthyunjaya P, Parikh R. Single-Blind and Double-Blind Peer Review: Effects on National Representation. Seminars In Ophthalmology 2021, 37: 11-16. PMID: 33760687, DOI: 10.1080/08820538.2021.1896757.Peer-Reviewed Original ResearchRandomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II
Nazif TM, Moses J, Sharma R, Dhoble A, Rovin J, Brown D, Horwitz P, Makkar R, Stoler R, Forrest J, Messé S, Dickerman S, Brennan J, Zivadinov R, Dwyer MG, Lansky AJ, Investigators R. Randomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II. JACC Cardiovascular Interventions 2021, 14: 515-527. PMID: 33663779, DOI: 10.1016/j.jcin.2020.11.011.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSafety endpointValve replacementProcedure-related ischemic strokeCerebral embolic protectionComposite efficacy endpointPrimary safety endpointCerebral embolizationCerebral protectionEfficacy endpointII trialCerebral injuryIschemic strokeEmbolic protectionPatientsDrug AdministrationUS sitesU.S. FoodEndpointData reviewTrialsMulticenterEmbolizationInjury
2020
Screening, Brief Intervention, and Referral to Treatment for Pain Management for Veterans Seeking Service-Connection Payments for Musculoskeletal Disorders: SBIRT-PM Study Protocol
Martino S, Lazar C, Sellinger J, Gilstad-Hayden K, Fenton B, Barnett PG, Brummett BR, Higgins DM, Holtzheimer P, Mattocks K, Ngo T, Reznik TE, Semiatin AM, Stapley T, Rosen MI. Screening, Brief Intervention, and Referral to Treatment for Pain Management for Veterans Seeking Service-Connection Payments for Musculoskeletal Disorders: SBIRT-PM Study Protocol. Pain Medicine 2020, 21: s110-s117. PMID: 33313731, PMCID: PMC7734657, DOI: 10.1093/pm/pnaa334.Peer-Reviewed Original ResearchMeSH KeywordsAdultChronic PainCrisis InterventionFemaleHumansMaleMass ScreeningMusculoskeletal DiseasesPain ManagementSARS-CoV-2Single-Blind MethodVeteransConceptsPain managementMusculoskeletal disordersSubstance misuseBrief interventionNonpharmacological pain managementSignificant chronic painTelephone-based interventionSingle-blind trialMultimodal pain treatmentVA Medical CenterDegree of disabilitySubstance use treatmentUsual carePain severityPain treatmentPrimary outcomeChronic painStudy protocolClinical trialsService utilizationTwo-armMedical CenterDisability pensionCompensation examinationsCompensation claimsPilot study of fractional CO2 laser therapy for genitourinary syndrome of menopause in gynecologic cancer survivors
Quick AM, Dockter T, Le-Rademacher J, Salani R, Hudson C, Hundley A, Terstriep S, Streicher L, Faubion S, Loprinzi CL, Coleman JS, Wang KC, Lustberg M. Pilot study of fractional CO2 laser therapy for genitourinary syndrome of menopause in gynecologic cancer survivors. Maturitas 2020, 144: 37-44. PMID: 33358206, PMCID: PMC7773136, DOI: 10.1016/j.maturitas.2020.10.018.Peer-Reviewed Original ResearchConceptsGynecologic cancer survivorsFemale Sexual Functioning IndexVaginal Assessment ScaleCancer survivorsLaser therapyTreatment armsSexual functionFractional COMedian total FSFI scoreMedian UDI-6 scoreRandomized sham-controlled trialUDI-6 scoresUrinary Distress InventorySerious adverse eventsSham-controlled trialProportion of patientsMedian VAS scoreTotal FSFI scoreFractional CO2 laser therapyCO2 laser therapyLaser treatmentPreliminary evidenceAdenocarcinoma histologyUrinary symptomsAdverse eventsNo modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
Vosseler A, Zhao D, Fritsche L, Lehmann R, Kantartzis K, Small DM, Peter A, Häring HU, Birkenfeld AL, Fritsche A, Wagner R, Preißl H, Kullmann S, Heni M. No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men. Scientific Reports 2020, 10: 20466. PMID: 33235256, PMCID: PMC7686306, DOI: 10.1038/s41598-020-77430-2.Peer-Reviewed Original ResearchConceptsTranscutaneous auricular vagus nerve stimulationOral glucose tolerance testAuricular vagus nerve stimulationVagus nerve stimulationGlucose tolerance testAutonomic nervous systemNerve stimulationCatecholamine levelsTolerance testNervous systemHealthy lean menCross-over studyHeart rate variability parametersCross-over designWhole-body metabolismHeart rate variabilityMajor regulatory effectsLean menAutonomic innervationAutonomic toneHealthy menPlasma glucoseInsulin sensitivityPeripheral organsInsulin secretionDifferential rates of intravascular uptake and pain perception during lumbosacral epidural injection among adults using a 22-gauge needle versus 25-gauge needle: a randomized clinical trial
Raju R, Mehnert M, Stolzenberg D, Simon J, Conliffe T, Gehret J. Differential rates of intravascular uptake and pain perception during lumbosacral epidural injection among adults using a 22-gauge needle versus 25-gauge needle: a randomized clinical trial. BMC Anesthesiology 2020, 20: 222. PMID: 32883241, PMCID: PMC7469311, DOI: 10.1186/s12871-020-01137-0.Peer-Reviewed Original ResearchConceptsTransforaminal epidural steroid injectionEpidural steroid injectionsLumbosacral transforaminal epidural steroid injectionsIntravascular uptakeSmall-gauge needlesSteroid injectionPain perceptionGauge needleEpidural injectionLess painClinical trialsOutcome measuresAverage numerical rating scale scoresLumbosacral transforaminal epidural injectionsNumerical rating scale scoresPatient reported painStudy 84 patientsSerious neurological complicationsSecondary outcome measuresTransforaminal epidural injectionsPrimary outcome measureRandomized clinical trialsLumbosacral epidural injectionNumerical rating scaleRating Scale scoresA multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy
Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertility And Sterility 2020, 115: 627-637. PMID: 32863013, DOI: 10.1016/j.fertnstert.2020.07.052.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingSustained implantationPredictive valueGenetic testingClinical outcomesTrophectoderm biopsyAge-matched control groupImpact of biopsyPGT-A resultsAntral follicle countRecurrent pregnancy lossBody mass indexDetectable adverse impactAneuploid resultsSecondary outcomesFertilization cyclesFollicle countPrimary outcomeMass indexUsable blastocystsBlastocyst transferFertility centerPregnancy lossClinical error ratesStudy group
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