2025
Aortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study
Abdollahi A, Sani M, Shabani M, Matuck B, Blaha M, Wu C, Ambale-Venkatesh B, Budoff M, Strom J, Rotter J, Post W, Blumenthal R, Bluemke D, Ghahramani N, Lima J, Whelton S. Aortic valve calcium as a novel risk marker for kidney function deterioration: The MESA study. European Journal Of Internal Medicine 2025, 136: 49-55. PMID: 40263084, DOI: 10.1016/j.ejim.2025.03.037.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisRisk of incident chronic kidney diseaseIncident chronic kidney diseaseAortic valve calciumInternational Classification of DiseasesChronic kidney diseaseCardiac CT scansAdjusted Cox proportional hazards regression modelsMultivariable adjusted Cox proportional hazards regression modelsParticipants free of chronic kidney diseaseCardiovascular diseaseMulti-Ethnic Study of Atherosclerosis studyValve calciumCT scanCVD risk factorsHistory of cardiovascular diseaseCategorized as 0Higher risk of incident CKDFree of chronic kidney diseaseAssociated with increased risk of mortalityMulti-Ethnic StudyAtherosclerotic CVD risk factorsMulti-ethnic cohortAPOE-e4 genotypeClassification of DiseasesSocioeconomic and demographic disparities in the impact of digestive diseases in the middle East and North Africa (MENA) region
Al Ta’ani O, Al-Ajlouni Y, Lahoud C, Almasaid S, Alhalalmeh Y, Oweis Z, Danpanichkul P, Baidoun A, Alsakarneh S, Dahiya D, Njei B. Socioeconomic and demographic disparities in the impact of digestive diseases in the middle East and North Africa (MENA) region. International Journal For Equity In Health 2025, 24: 85. PMID: 40148874, PMCID: PMC11951616, DOI: 10.1186/s12939-025-02448-9.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsEstimated annual percentage changeSocio-demographic indexAge-standardized incidence rateDisability-adjusted life year ratesGlobal Burden of DiseaseMiddle East and North AfricaGender Inequality IndexHuman Development IndexMiddle East and North Africa regionImpact of socioeconomic disparitiesIncidence rateAge-standardized mortalityAge-standardized ratesAnnual percentage changePercentage changeInfluence disease burdenBurden of DDBurden of diseasePublic health challengeHighest incidence rateSocioeconomic disparitiesDD incidenceTargeted interventionsNorth AfricaIncidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
Barbano R, Jabbari B, Sadeghi M, Ukah A, Yue E, Ifantides K, Huang N, Swope D. Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure. Toxins 2025, 17: 148. PMID: 40137921, PMCID: PMC11945862, DOI: 10.3390/toxins17030148.Peer-Reviewed Original ResearchConceptsIncidence of dysphagiaCervical dystoniaComorbid conditionsContinuous health plan enrollmentCohort entry dateRate of dysphagiaRetrospective cohort studyPre-existing dysphagiaHealth plan enrollmentRisk factors of dysphagiaFactors of dysphagiaReal-world studyPotential adverse eventsPotential risk factorsPatient-level dataReal-world analysisAdverse eventsCD patientsCohort studyComorbid neurological conditionsLongitudinal patient-level dataCD diagnosisDysphagiaDysphagia riskPatientsThe burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study
Alhuneafat L, Al Ta'ani O, Arriola-Montenegro J, Al-Ajloun Y, Naser A, Chaponan-Lavalle A, Ordaya-Gonzales K, Pertuz G, Maaita A, Jabri A, Altibi A, Al-Abdouh A, Van't Hof J, Gutierrez Bernal A. The burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study. International Journal Of Cardiology 2025, 428: 133143. PMID: 40064205, DOI: 10.1016/j.ijcard.2025.133143.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsGlobal Burden of DiseaseBurden of cardiovascular diseaseCardiovascular diseaseRisk factorsMortality-to-incidence ratioGlobal burdenIschemic heart diseaseAge-standardized disability-adjusted life yearsGlobal Burden of Disease StudyDisability-adjusted life year ratesBurden of Disease StudyAge-standardized prevalenceComparative risk assessment frameworkCardiovascular disease prevalenceCardiovascular disease burdenBurden of diseaseLeading risk factorHeart diseaseTailored interventionsCountry-specific variationsElevated BMIRate of strokeHealthcare infrastructureSocio-economic factorsUsing Radiology as a Screening Tool to Identify Intimate Partner Violence
Lenehan P, Tang A, Watane G, Gujrathi R, Park H, Gosangi B, Thomas R, Franco F, Patel K, Warsofsky I, Rosner B, Khurana B. Using Radiology as a Screening Tool to Identify Intimate Partner Violence. Journal Of The American College Of Radiology 2025, 22: 395-404. PMID: 40044319, PMCID: PMC11887577, DOI: 10.1016/j.jacr.2025.01.003.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratiosEmergency departmentRetrospective case-control studyImaging utilization patternsEvident injuriesCox proportional hazards regressionRace-matched controlsCase-control studyTime-to-event analysisProportional hazards regressionImaging utilizationIncidence rate ratiosCumulative incidenceAnatomical sitesScreening mammogramsHazards regressionOdds ratioImaging studiesIntimate partner violencePatientsInjury patternsLogistic regressionInjuryOrgan systemsPoisson regressionGLP-1RA Use and Thyroid Cancer Risk
Brito J, Herrin J, Swarna K, Ospina N, Montori V, Toro-Tobon D, Umpierrez G, Galindo R, Deng Y, Mickelson M, Shao H, Polley E, McCoy R. GLP-1RA Use and Thyroid Cancer Risk. JAMA Otolaryngology - Head & Neck Surgery 2025, 151: 243-252. PMID: 39847346, PMCID: PMC11907303, DOI: 10.1001/jamaoto.2024.4852.Peer-Reviewed Original ResearchConceptsDipeptidyl peptidase-4 inhibitorsModified intention-to-treatSodium-glucose cotransporter 2 inhibitorsTarget trial emulationGLP-1RA initiationComparative effectiveness studiesGLP-1RAThyroid cancerType 2 diabetesSecondary analysisMedicare fee-for-service planTrial emulationHazard ratioAssociated with increased overall riskIncident thyroid cancerDipeptidyl peptidase-4 inhibitor groupTreated with GLP-1RAGlucagon-like peptide-1 receptor agonistsHistory of thyroid cancerFee-for-service plansModified intention-to-treat analysisPeptide-1 receptor agonistsEnhanced early detectionGLP-1RA therapyPeptidase-4 inhibitorsExamining multimorbidity contributors to dementia over time
Klee M, Markwardt S, Elman M, Han L, Leist A, Allore H, Quiñones A. Examining multimorbidity contributors to dementia over time. Alzheimer's & Dementia 2025, 21: e14589. PMID: 39988573, PMCID: PMC11847647, DOI: 10.1002/alz.14589.Peer-Reviewed Original ResearchConceptsAverage attributable fractionDementia incidenceDementia riskAttributable fractionChronic conditionsAssociated with increased risk of dementiaHealth and Retirement Study participantsMedicare fee-for-service beneficiariesAcute myocardial infarctionFee-for-service beneficiariesRetirement Study participantsRisk of dementiaPatterns of comorbiditiesAssociated with increased riskDementia casesMyocardial infarctionClaims algorithmIncident casesADRDStudy participantsIschemic heart diseaseDementiaConfidence intervalsMultimorbidityHeart diseaseHIV Trends in Metropolitan US Cities From 2014 to 2021: Baseline Data for the Ending the HIV Epidemic Initiative.
Gupta R, Vermund S. HIV Trends in Metropolitan US Cities From 2014 to 2021: Baseline Data for the Ending the HIV Epidemic Initiative. American Journal Of Public Health 2025, 115: 217-220. PMID: 39778137, PMCID: PMC11715565, DOI: 10.2105/ajph.2024.307890.Peer-Reviewed Original ResearchConceptsDifference-in-differences analysisMetropolitan statistical areasHIV Epidemic initiativeMetropolitan US cityReduce HIV incidenceHIV diagnosisHIV incidenceHIV trendsEpidemic initiativeHIV casesHIV epidemicProgrammatic evaluationIncident infectionsProgrammatic effectivenessHIVStatistical areasDiagnostic rateUS citiesBaseline trendsRate trendsBaselineEHEBaseline datasUnited StatesIncidenceEvaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh
Khanam F, Rickett N, Ahmmed F, Islam M, Mbae C, Im J, Aziz A, Ongadi B, Chowdhury F, Khan A, Akter A, Firoj M, Rahman S, Haile K, Park S, Mwebia M, Mwangi M, Ngugi B, Behute M, Kering K, Agampodi S, Kanungo S, Liu X, Pollard A, Zaman K, Kim D, Kariuki S, Qadri F, Clemens J. Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh. BMC Infectious Diseases 2025, 25: 149. PMID: 39891051, PMCID: PMC11786536, DOI: 10.1186/s12879-025-10548-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, BacterialBangladeshChildChild, PreschoolCohort StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GIncidenceInfantMaleMiddle AgedPolysaccharides, BacterialSalmonella typhiSeroepidemiologic StudiesTyphoid FeverTyphoid-Paratyphoid VaccinesYoung AdultConceptsAnti-Vi antibodiesTyphoid feverReceiver operating characteristicTyphoid riskIncidence of typhoid feverCulture-confirmed typhoid feverAntibody titersResultsThe ROC analysisCox proportional hazards modelsRisk of typhoidTyphoid infectionEnzyme-linked immunosorbent assayProportional hazards modelMethodsWe analyzed dataPresence of antibodiesTyphoidCohort studyTyphoid vaccineROC analysisAntibody levelsCrude analysisIncreased seroprevalenceFeverHazards modelNatural immunityTransient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke
Chen H, Khunte M, Colasurdo M, Majmundar S, Payabvash S, Chaturvedi S, Malhotra A, Gandhi D. Transient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke. Stroke 2025, 56: 285-293. PMID: 39869710, DOI: 10.1161/strokeaha.124.049278.Peer-Reviewed Original ResearchConceptsRates of vascular risk factorsTransient ischemic attackUS Census Bureau dataAssociated with lower oddsHigher odds of deathIschemic strokeRisk factorsAnnual incidenceTransient neurological symptomsStroke risk factorsOdds of deathLogistic regression modelsVascular risk factorsCensus Bureau dataRate of headacheRetrospective cohort studyLower oddsHigher oddsNeurological symptomsHome dischargeCohort studyIschemic attackHospital incidenceExcess hospitalizationsRisk of hemorrhagePredictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients?
Seddio A, Vasudevan R, Gouzoulis M, Jabbouri S, Grauer J, Fram B. Predictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients? JAAOS Global Research And Reviews 2025, 9: e24.00246. PMID: 39823200, PMCID: PMC11745856, DOI: 10.5435/jaaosglobal-d-24-00246.Peer-Reviewed Original ResearchConceptsOdds of venous thromboembolismDirect oral anticoagulantsVenous thromboembolismHeightened oddsHFx patientsIncreased odds of VTEPredictors of venous thromboembolismRisk factors of venous thromboembolismIncidence of venous thromboembolismRate of venous thromboembolismAssociated with considerable morbidityAssociated with reduced oddsFactors of venous thromboembolismEffective therapeutic optionIndependent risk factorClinical risk factorsHip fracture patientsRetrospective cohort studyFemur fracture fixationCoagulopathy disordersOral anticoagulantsElixhauser Comorbidity IndexSurgical managementActive cancerDistal femur fracture fixationTime series data on typhoid fever incidence during outbreaks from 2000 to 2022
Koh D, Duong M, Kipshidze N, Pitzer V, Kim J. Time series data on typhoid fever incidence during outbreaks from 2000 to 2022. Scientific Data 2025, 12: 94. PMID: 39821093, PMCID: PMC11739417, DOI: 10.1038/s41597-024-04289-7.Peer-Reviewed Original ResearchA comprehensive analysis of serotype-specific invasive capacity, clinical presentations, and mortality trends of invasive pneumococcal disease
Yildirim M, Keskinocak P, Hinderstein S, Tran K, Dasthagirisaheb Y, Madoff L, Pelton S, Yildirim I. A comprehensive analysis of serotype-specific invasive capacity, clinical presentations, and mortality trends of invasive pneumococcal disease. Vaccine 2025, 47: 126692. PMID: 39778476, DOI: 10.1016/j.vaccine.2024.126692.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal conjugate vaccineClinical presentationInvasive diseasePneumococcal diseaseAnnual incidence of invasive pneumococcal diseaseIncidence of invasive pneumococcal diseaseInvasive capacityInvasive pneumococcal disease serotypesPost-PCV13 eraReduced invasive diseasePneumococcal nasopharyngeal colonizationYears of ageNP carriageSerotype 35BPost-PCV13Respiratory seasonsCarriage prevalenceNasopharyngeal colonizationStreptococcus pneumoniaeConjugate vaccineSerotype 18CAnnual incidenceVaccination strategiesNP isolatesThe Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic
Amram T, Duek O, Golan‐Tripto I, Goldbart A, Greenberg D, Hazan G. The Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID‐19 Pandemic. Pediatric Pulmonology 2025, 60: e27474. PMID: 39760467, PMCID: PMC11748096, DOI: 10.1002/ppul.27474.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusYears of ageSyncytial virusRespiratory syncytial virus bronchiolitisRespiratory syncytial virus infectionRespiratory syncytial virus exposureRSV-induced inflammationRespiratory syncytial virus activityMultivariate logistic regressionAirway changesAsthma inceptionRetrospective studyAsthma surrogateIncreased riskLogistic regressionAsthmaCause of asthmaCOVID-19 pandemicHealthcare organizationsPredispositionIncreased rateChildrenCOVID-19AgeVirusHuman mobility and malaria risk in peri-urban and rural communities in the Peruvian Amazon
Gomez J, Grosso A, Guzman-Guzman M, Castillo S, Castro M, Torres K, Vinetz J, Gamboa D. Human mobility and malaria risk in peri-urban and rural communities in the Peruvian Amazon. PLOS Neglected Tropical Diseases 2025, 19: e0012058. PMID: 39761298, PMCID: PMC11737848, DOI: 10.1371/journal.pntd.0012058.Peer-Reviewed Original ResearchConceptsMalaria transmissionMalaria casesBurden of malaria casesSources of malaria transmissionPlasmodium sppHeterogeneity of malaria transmissionMalaria incidence dataLogistic multivariate regressionMalaria parasitesMalaria riskMalaria eradicationMalariaWorking outdoorsPopulation screeningTravel historyMultivariate regressionGlobal burdenHuman mobilitySocio-demographic characteristicsInfectionRural communitiesIncidence dataSocial network analysisPatterns of human mobilityCommunity-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda
Ediriweera D, Hakizimana D, Diggle P, Schurer J. Community-based snakebite risk mapping for resource prioritisation in Eastern Province, Rwanda. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2025, 119: 310-316. PMID: 39749566, DOI: 10.1093/trstmh/trae069.Peer-Reviewed Original ResearchConceptsSnakebite incidenceHealth worker trainingResource prioritisationEvidence-based decisionsEastern ProvinceResource-poor countriesHousehold visitsSnakebite preventionSnakebite eventsSurveillance of peopleSnakebite riskWorker trainingWell-trained personnelMedical emergencyHigh riskLow riskRisk mapsSnakebite envenomingRiskPrediction mapsSnakebitePrioritisationGeostatistical modelSpatial variationLow incidenceComparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry
Mori M, Shioda K, Waldron C, Huang C, Gaudino M, George I, Takayama H, Geirsson A. Comparison of Outcomes Between Low-Risk Aortic Valve Replacement Trials and a Surgical Registry. JAMA Network Open 2025, 8: e2453267. PMID: 39761046, PMCID: PMC11704974, DOI: 10.1001/jamanetworkopen.2024.53267.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLow-risk trialsSTS ACSDLow riskSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseSAVR armPARTNER 3Evolut Low Risk TrialAdult Cardiac Surgery DatabaseCompare 30-day mortalityConcomitant cardiac operationsCardiac Surgery DatabaseLow surgical riskMortality rateAortic valve replacementSevere aortic stenosisStroke rateIncidence of patientsTrial exclusion criteriaRisk of mortalitySAVR cohortCross-sectional studyComparison of outcomesIncidence of strokeNontrial setting
2024
Incidence and antecedents of emergent suicidal ideation and behavior among Veterans with serious mental illness receiving intensive case management
Browne J, Mohamed S. Incidence and antecedents of emergent suicidal ideation and behavior among Veterans with serious mental illness receiving intensive case management. Journal Of Psychiatric Research 2024, 181: 607-613. PMID: 39740616, DOI: 10.1016/j.jpsychires.2024.12.018.Peer-Reviewed Original ResearchConceptsEmergent suicidal ideationSuicidal ideationMental illnessBehavior groupCommunity-based treatment programsAffective disorder diagnosesSix-month follow-up assessmentFollow-up assessmentService useSubjective distressDisorder diagnosisLifetime hospitalizationsQuality of lifeIdeationProgram evaluation dataTreatment programsVeteransVeterans Health AdministrationBaseline quality of lifePrimary study aimSix-month incidenceBehavioral patternsHealth AdministrationIllnessHigh-risk groupType 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers
Moura F, Kamanu F, Wiviott S, Giugliano R, Udler M, Florez J, Ellinor P, Sabatine M, Ruff C, Marston N. Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers. Diabetes Obesity And Metabolism 2024, 27: 1287-1295. PMID: 39696834, DOI: 10.1111/dom.16123.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntibodies, Monoclonal, HumanizedAnticholesteremic AgentsCardiovascular DiseasesCholesterol, LDLDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGlycated HemoglobinHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedMultifactorial InheritancePCSK9 InhibitorsPolymorphism, Single NucleotideProprotein Convertase 9Risk FactorsConceptsT2D polygenic scoreBody mass indexProprotein convertase subtilisin/kexin type 9Incident diabetesPolygenic scoresGenetic riskIncident T2DHazard ratioStable atherosclerotic cardiovascular diseaseProprotein convertase subtilisin/kexin type 9 inhibitionYears of median follow-upFurther Cardiovascular Outcomes ResearchRisk factorsMean body mass indexCases of incident diabetesMedian follow-upLower body mass indexPredictor of incident diabetesEffects of evolocumabGenetic risk categoriesLDL cholesterol levelsT2D genetic riskDiabetes risk factorsType 2 diabetes genetic riskAtherosclerotic cardiovascular diseaseEpidemiology, treatment and outcomes of gastroenteropancreatic neuroendocrine neoplasms
Uhlig J, Nie J, Gibson J, Cecchini M, Stein S, Lacy J, Kunz P, Kim H. Epidemiology, treatment and outcomes of gastroenteropancreatic neuroendocrine neoplasms. Scientific Reports 2024, 14: 30536. PMID: 39690170, PMCID: PMC11652651, DOI: 10.1038/s41598-024-81518-4.Peer-Reviewed Original ResearchConceptsGEP-NEN patientsGastroenteropancreatic neuroendocrine neoplasmsOverall survivalGEP-NENsTreatment patternsSystemic therapyNeuroendocrine neoplasmsAssociated with improved survivalLow-grade diseaseNational Cancer DatabaseLonger overall survivalSite-specific incidenceDisease specific factorsG3 NENSurgical resectionCancer DatabaseImproved survivalLow-stageCox regressionImprove outcomesPatientsIncidence increasesInternational guidelinesInvestigate incidenceSurvival
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