2025
Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease. Neurology 2025, 104: e210243. PMID: 39772663, DOI: 10.1212/wnl.0000000000210243.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTreated with IV thrombolysisIn-hospital mortalityMoyamoya disease patientsIV thrombolysisMoyamoya diseasePropensity score matchingIntracranial hemorrhageRisk factors of acute ischemic strokeSelf-careIschemic stroke patientsAcute ischemic stroke patientsStroke patientsTreating acute ischemic strokeNationwide Readmissions DatabaseRisk factorsRate of routine dischargeRoutine dischargeEfficacy outcomesAssociated with different ratesProspective studyBypass surgeryRetrospective analysisEstablished treatmentReadmissions Database
2024
Intravenous Thrombolysis in Patients With Cervical Artery Dissection
Shu L, Akpokiere F, Mandel D, Field T, Leon Guerrero C, Henninger N, Muppa J, Affan M, Haq Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Salehi Omran S, Crandall R, Lester E, López-Mena D, Arauz A, Nehme A, Boulanger M, Touzé E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, Aguiar de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte C, Choi R, MacDonald J, Bavarsad Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego E, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy Rivas R, Aziz Y, Mistry E, Bakradze E, Tran T, Rodrigo-Gisbert M, Requena M, Saleh Velez F, Garcia J, Muddasani V, de Havenon A, Sanchez S, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Krupka D, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Qureshi A, Fridman S, Alvarado A, Khasiyev F, Linares G, Mannino M, Terruso V, Tountopoulou A, Tentolouris-Piperas V, Martinez-Marino M, Carrasco Wall V, Indraswari F, El Jamal S, Liu S, Zhou M, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Mongare N, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Wangqin R, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K, Yaghi S. Intravenous Thrombolysis in Patients With Cervical Artery Dissection. Neurology 2024, 103: e209843. PMID: 39298709, PMCID: PMC11415265, DOI: 10.1212/wnl.0000000000209843.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke symptomsCervical artery dissectionFunctional independenceIntravenous thrombolysisIschemic stroke symptomsStroke symptomsArtery dissectionIncidence of symptomatic intracranial hemorrhageIschemic strokeSymptomatic intracranial hemorrhageSuspected ischemic strokeClass III evidenceMedian ageSymptomatic ICHIntracranial hemorrhageSecondary analysisGuideline recommendationsICH riskIII evidenceFunctional outcomesPatientsThrombolysisCeADYoung adultsDissectionAdjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke
Adeoye O, Broderick J, Derdeyn C, Grotta J, Barsan W, Bentho O, Berry S, Concha M, Davis I, Demel S, Elm J, Gentile N, Graves T, Hoffman M, Huang J, Ingles J, Janis S, Jasne A, Khatri P, Levine S, Majjhoo A, Panagos P, Pancioli A, Pizzella S, Ranasinghe T, Sabagha N, Sivakumar S, Streib C, Vagal A, Wilson A, Wintermark M, Yoo A, Barreto A. Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke. New England Journal Of Medicine 2024, 391: 810-820. PMID: 39231343, PMCID: PMC11528349, DOI: 10.1056/nejmoa2314779.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsArginineCombined Modality TherapyDrug Therapy, CombinationEptifibatideFemaleFibrinolytic AgentsHumansIncidenceInfusions, IntravenousIntracranial HemorrhagesIschemic StrokeMaleMiddle AgedPeptidesPipecolic AcidsPlatelet Aggregation InhibitorsSingle-Blind MethodSulfonamidesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsSymptomatic intracranial hemorrhageIntravenous argatrobanIntravenous thrombolysisAcute ischemic strokeIntracranial hemorrhageIschemic strokeIncidence of symptomatic intracranial hemorrhageSymptom onsetIschemic stroke treated with intravenous thrombolysisAcute ischemic stroke treated with intravenous thrombolysisStroke treated with intravenous thrombolysisAssociated with increased mortalityRankin Scale scoreInitiation of thrombolysisControlled clinical trialsTreatment of acute ischemic strokePlacebo groupEptifibatide groupEfficacy outcomesArgatroban groupStandard treatmentAdjunctive treatmentPlaceboClinical trialsArgatrobanThrombolysis for Wake-Up Stroke Versus Non–Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis
Kamogawa N, Miwa K, Toyoda K, Jensen M, Inoue M, Yoshimura S, Fukuda-Doi M, Kitazono T, Boutitie F, Ma H, Ringleb P, Wu O, Schwamm L, Warach S, Hacke W, Davis S, Donnan G, Gerloff C, Thomalla G, Koga M, Cheng B, Bendszus M, Bladin C, Churilov L, Campbell B, Parsons M, Yassi N, Ebinger M, Endres M, Fiebach J, Kleinig T, Latour L, Lemmens R, Levi C, Leys D, Molina C, Muir K, Nighoghossian N, Pedraza S, Schellinger P, Schwab S, Simonsen C, Song S, Thijs V, Toni D, Hsu C, Wahlgren N. Thrombolysis for Wake-Up Stroke Versus Non–Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis. Stroke 2024, 55: 895-904. PMID: 38456303, PMCID: PMC10978262, DOI: 10.1161/strokeaha.123.043358.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageIntracranial hemorrhageIntravenous thrombolysisFavorable outcomeUnwitnessed strokeNon-WUSFrequency of favorable outcomesIndividual patient-data meta-analysisMultivariate logistic regression analysisModified Rankin Scale scoreSafety of intravenous thrombolysisRankin Scale scoreEffect of intravenous thrombolysisIntravenous thrombolysis groupLogistic regression analysisUnknown-onset strokeRandomized controlled trialsNo significant differencePatient-level dataData meta-analysisStandard treatmentInsufficient statistical powerPatientsSafety outcomesControlled trialsTrends in Stroke Thrombolysis Care Metrics and Outcomes by Race and Ethnicity, 2003-2021
Man S, Solomon N, Mac Grory B, Alhanti B, Saver J, Smith E, Xian Y, Bhatt D, Schwamm L, Uchino K, Fonarow G. Trends in Stroke Thrombolysis Care Metrics and Outcomes by Race and Ethnicity, 2003-2021. JAMA Network Open 2024, 7: e2352927. PMID: 38324315, PMCID: PMC10851100, DOI: 10.1001/jamanetworkopen.2023.52927.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesEthnicityFemaleHumansIschemic StrokeMaleMiddle AgedRacial GroupsRetrospective StudiesThrombolytic TherapyConceptsDoor-to-needleDoor-to-needle timeHispanic patientsWhite patientsAssociated with improvementsThrombolysis rateCohort studyEthnic groupsQuality InitiativeCohort study of patientsCare qualityCare metricsPre-testIschemic strokeEthnic disparitiesRetrospective cohort studyMain OutcomesPatient functionIschemic stroke onsetSecondary outcomesPrimary outcomeStudy of patientsOddsAcute ischemic strokeStroke onset
2023
Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke
Samaniego E, Boltze J, Lyden P, Hill M, Campbell B, Silva G, Sheth K, Fisher M, Hillis A, Nguyen T, Carone D, Favilla C, Deljkich E, Albers G, Heit J, Lansberg M, Aksoy D, Broderick J, Castonguay A, Ghosh S, Grotta J, Harston G, Houser G, Kuchenbecker K, Latour L, Liebeskind D, Kylan Lynch J, Maier C, Mistry E, Mocco J, Nogueira R, Saver J, van Vlimmeren M, Wakhloo A, Wechsler L. Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke. Stroke 2023, 54: 3190-3201. PMID: 37942645, PMCID: PMC10841844, DOI: 10.1161/strokeaha.123.044985.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaHumansIschemic StrokeNeuroimagingStrokeThrombectomyThrombolytic TherapyTreatment OutcomeConceptsAcute strokeDiagnostic workupAcute ischemic stroke treatmentAcute ischemic strokeComprehensive stroke centerHigh-resolution vessel wallCerebral Infarction (TICI) scaleIschemic stroke treatmentMobile stroke unitIschemic strokeStroke centersStroke treatmentStroke unitReperfusion outcomesPatient outcomesEarly ischemiaCone beamStrokeVessel wallWorkupAcademic investigatorsOutcomesTomographyThrombolysisReperfusionTrends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic
Khunte M, Chen H, Khunte A, Payabvash S, Gandhi D, Malhotra A. Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic. Journal Of The American Heart Association 2023, 12: e029579. PMID: 37889182, PMCID: PMC10727381, DOI: 10.1161/jaha.122.029579.Peer-Reviewed Original ResearchMost Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop
Wechsler L, Adeoye O, Alemseged F, Bahr-Hosseini M, Deljkich E, Favilla C, Fisher M, Grotta J, Hill M, Kamel H, Khatri P, Lyden P, Mirza M, Nguyen T, Samaniego E, Schwamm L, Selim M, Silva G, Yavagal D, Yenari M, Zachrison K, Boltze J, Yaghi S, Roundtable O. Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop. Stroke 2023, 54: 3202-3213. PMID: 37886850, DOI: 10.1161/strokeaha.123.044279.Peer-Reviewed Original ResearchIntravenous thrombolysis prior to endovascular thrombectomy in elderly stroke patients: An analysis of the National Inpatient Sample database
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Intravenous thrombolysis prior to endovascular thrombectomy in elderly stroke patients: An analysis of the National Inpatient Sample database. Journal Of The Neurological Sciences 2023, 454: 120842. PMID: 37856997, DOI: 10.1016/j.jns.2023.120842.Peer-Reviewed Original ResearchConceptsNational Inpatient Sample databaseHospital mortalityHemorrhagic complicationsIntravenous thrombolysisEndovascular thrombectomyEVT patientsIVT treatmentThrombectomy centreElderly patientsMultivariable logistic regression modelSample databaseStroke risk factorsElderly stroke patientsCross-sectional studyLarge-scale cross-sectional studyOutcomes of interestHigh rateLogistic regression modelsPatients 80Medical comorbiditiesOnly patientsPatient demographicsStroke etiologyThrombolytic treatmentHemorrhagic riskSafety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions
Rodriguez-Calienes A, Galecio-Castillo M, Farooqui M, Hassan A, Jumaa M, Divani A, Ribo M, Abraham M, Petersen N, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Tekle W, Alhajala H, Ikram A, Rizzo F, Qureshi A, Begunova L, Matsoukas S, Vigilante N, Salazar-Marioni S, Abdalkader M, Gordon W, Soomro J, Turabova C, Vivanco-Suarez J, Mokin M, Yavagal D, Jovin T, Sheth S, Ortega-Gutierrez S. Safety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions. Stroke 2023, 54: 2522-2533. PMID: 37602387, PMCID: PMC10599264, DOI: 10.1161/strokeaha.123.042966.Peer-Reviewed Original ResearchConceptsRisk of sICHParenchymal hematoma type 2Symptomatic intracranial hemorrhageRankin Scale score 0Intravenous antiplatelet therapyIntravenous thrombolysisFavorable functional outcomeMechanical thrombectomyHemorrhagic transformationFunctional outcomeType 2Antiplatelet therapyHospital mortalitySuccessful reperfusionComplete reperfusionScore 0Tandem lesionsAnterior circulation tandem lesionsExcellent functional outcomeIVT treatmentStroke centersMulticenter cohortPrimary outcomeRevascularization techniquesAlone groupSix-Month Outcomes of Mechanical Thrombectomy for Treating Deep Vein Thrombosis: Analysis from the 500-Patient CLOUT Registry
Shaikh A, Zybulewski A, Paulisin J, Bisharat M, Mouawad N, Raskin A, Ichinose E, Abramowitz S, Lindquist J, Azene E, Shah N, Nguyen J, Cockrell J, Khalsa B, Khetarpaul V, Murrey D, Veerina K, Skripochnik E, Maldonado T, Bunte M, Annambhotla S, Schor J, Kado H, Mojibian H, Dexter D. Six-Month Outcomes of Mechanical Thrombectomy for Treating Deep Vein Thrombosis: Analysis from the 500-Patient CLOUT Registry. CardioVascular And Interventional Radiology 2023, 46: 1571-1580. PMID: 37580422, PMCID: PMC10615929, DOI: 10.1007/s00270-023-03509-8.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisSerious adverse eventsMechanical thrombectomyVillalta scorePostthrombotic syndromeAdverse eventsVein thrombosisSymptom severityLarge prospective registryMedian Villalta scoreSix-month outcomesFemoral-popliteal segmentQuality of lifeClotTriever systemComer studyMarder scorePurposeMechanical thrombectomyProspective registryVenous patencyClinical outcomesDVT patientsOutcomes RegistryDuplex ultrasoundLife scoresVenous flowHigh-Risk Pulmonary Embolism: Management for the Intensivist
Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.Peer-Reviewed Original ResearchConceptsHigh-risk pulmonary embolismHigh-risk PE patientsPulmonary embolismRisk stratificationPE patientsTreatment optionsRisk pulmonary embolismMassive pulmonary embolismIntensivist’s perspectiveReperfusion therapySupportive careAcute managementPatientsIntensivistsSupport optionsEmbolismHigh rateCarePhysiological consequencesOutcomesTreatmentOptionsStratificationMorbidityTherapyShorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke
Man S, Solomon N, Mac Grory B, Alhanti B, Uchino K, Saver J, Smith E, Xian Y, Bhatt D, Schwamm L, Hussain M, Fonarow G. Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke. Circulation 2023, 148: 20-34. PMID: 37199147, PMCID: PMC10356148, DOI: 10.1161/circulationaha.123.064053.Peer-Reviewed Original ResearchConceptsIntravenous thrombolytic therapyAcute ischemic strokeGood long-term functional outcomeLong-term functional outcomeShorter DTN timesEndovascular thrombectomyFunctional outcomeDTN timeIschemic strokeCause mortalityNeedle timeThrombolytic therapyCox proportional hazards modelModified Rankin Scale (mRS) 0Older US patientsRankin Scale 0Multivariate logistic regressionProportional hazards modelLongitudinal functional outcomesHome timeEligible patientsEVT candidatesEVT timesGuidelines-StrokeThrombolytic administrationSix-Month Deep Vein Thrombosis Outcomes by Chronicity: Analysis of the Real-World ClotTriever Outcomes Registry
Abramowitz S, Kado H, Schor J, Annambhotla S, Mojibian H, Marino A, Maldonado T, Gandhi S, Paulisin J, Bunte M, Angel W, Roberts J, Veerina K, Long D, Elmasri F, Shaikh A, Beasley R, Dexter D, Investigators F. Six-Month Deep Vein Thrombosis Outcomes by Chronicity: Analysis of the Real-World ClotTriever Outcomes Registry. Journal Of Vascular And Interventional Radiology 2023, 34: 879-887.e4. PMID: 37105663, DOI: 10.1016/j.jvir.2022.12.480.Peer-Reviewed Original ResearchMeSH KeywordsHumansIliac VeinProspective StudiesQuality of LifeRegistriesRetrospective StudiesThrombectomyThrombolytic TherapyTreatment OutcomeVenous ThrombosisConceptsDeep vein thrombosisSerious adverse eventsChronic deep vein thrombosisClotTriever systemMechanical thrombectomyOutcomes RegistryStent placementDevice-related serious adverse eventsLower extremity deep vein thrombosisExtremity deep vein thrombosisComplete thrombus removalMedian Villalta scoreFatal pulmonary embolismReal-world patientsSelf-reported questionnaire scoresChronic thrombusSubacute groupVillalta scorePulmonary embolismVein thrombosisAdverse eventsPhysician's discretionThrombosis outcomesThrombus removalChronic subgroupHemorrhagic Conversion of Acute Ischemic Stroke
Zubair A, Sheth K. Hemorrhagic Conversion of Acute Ischemic Stroke. Neurotherapeutics 2023, 20: 705-711. PMID: 37085684, PMCID: PMC10275827, DOI: 10.1007/s13311-023-01377-1.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHemorrhagic conversionIschemic strokeTreatment of patientsHemorrhagic transformationEndovascular thrombectomySerious complicationsThrombolytic therapyTreatment optionsRisk factorsLeading causePatient outcomesCurrent treatmentTimely managementStrokePatientsTreatmentThrombectomyMorbidityComplicationsReviewPathophysiologyTherapyMortalityDiagnosisEffect of intravenous thrombolysis before endovascular therapy on outcomes in patients with large core infarct
Anadani M, Almallouhi E, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Howard B, Alawieh A, Fragata I, Polifka A, Mascitelli J, Osbun J, Matouk C, Park M, Levitt M, Dumont T, Williamson R, Spiotta A. Effect of intravenous thrombolysis before endovascular therapy on outcomes in patients with large core infarct. Journal Of NeuroInterventional Surgery 2023, 15: jnis-2022-019537. PMID: 36990690, DOI: 10.1136/jnis-2022-019537.Peer-Reviewed Original ResearchConceptsAlberta Stroke Program Early CT ScorePropensity score matching analysisEfficacy of bridging therapyScore matching analysisTreated with MTIntravenous thrombolysisIntracerebral hemorrhageCore infarctBridging therapyMatched cohortMechanical thrombectomyIncreased risk of hemorrhageRisk of hemorrhageMatching analysisEffect of intravenous thrombolysisCT scoreBaseline characteristicsEndovascular therapyFavorable outcomeRetrospective analysisCompare outcomesIncreased riskPatientsSafety outcomesAneurysm RegistryEffect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity
de Havenon A, Abbasi M, Yaghi S, Delic A, Bangad A, Johnston K, Tirschwell D, Sheth K. Effect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity. Annals Of Neurology 2023, 93: 1106-1116. PMID: 36852919, DOI: 10.1002/ana.26621.Peer-Reviewed Original ResearchConceptsIV-tPAHigher NIHSSIschemic strokeAtrial fibrillationNational Inpatient Sample (NIS) 2016Non-Hispanic white raceOlder ageBaseline National InstitutesDEFUSE-3 trialsHealth Stroke ScalePost-stroke mortalityIschemic stroke mortalityEffect of alteplaseRisk of mortalityLogistic regression modelsAnn NeurolFAST-MAGIMS IIISevere ISHospital mortalityIntravenous alteplaseSevere strokeStroke ScaleStroke severityFunctional outcomeVariation in patterns of telestroke usage during the COVID-19 pandemic
Nakamoto C, Wilcock A, Schwamm L, Zachrison K, Uscher-Pines L, Mehrotra A. Variation in patterns of telestroke usage during the COVID-19 pandemic. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107036. PMID: 36791674, PMCID: PMC9899774, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107036.Peer-Reviewed Original ResearchLetter to the Editor Regarding “Drip and Ship versus Mothership Model in the MCA Stroke: A Propensity-Matched Real World Analysis Through NIS Data”
Malhotra A, Khunte M, Wu X, Radmard M. Letter to the Editor Regarding “Drip and Ship versus Mothership Model in the MCA Stroke: A Propensity-Matched Real World Analysis Through NIS Data”. World Neurosurgery 2023, 170: 266. PMID: 36782423, DOI: 10.1016/j.wneu.2022.09.098.Peer-Reviewed Original ResearchAcute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism.
Toma C, Jaber W, Weinberg M, Bunte M, Khandhar S, Stegman B, Gondi S, Chambers J, Amin R, Leung D, Kado H, Brown M, Sarosi M, Bhat A, Castle J, Savin M, Siskin G, Rosenberg M, Fanola C, Horowitz J, Pollak J. Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism. EuroIntervention 2023, 18: 1201-1212. PMID: 36349702, PMCID: PMC9936254, DOI: 10.4244/eij-d-22-00732.Peer-Reviewed Original ResearchMeSH KeywordsFibrinolytic AgentsHumansPulmonary EmbolismRegistriesThrombectomyThrombolytic TherapyTreatment OutcomeConceptsHigh-risk PEDevice-related deathsPulmonary artery pressureMajor adverse eventsAdverse eventsMechanical thrombectomyFlowTriever SystemArtery pressureUS cohortLarge real-world populationMean pulmonary artery pressureImmediate haemodynamic improvementIntraprocedural adverse eventsPrimary safety endpointRight ventricle/Favorable safety profileIntensive care unitPulmonary embolism treatmentReal-world populationDyspnoea improvementHaemodynamic improvementMajor bleedingRisk PECardiac indexCause mortality
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