2025
Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome?
Mestre-Bach G, Potenza M, Granero R, Håkansson A, Gómez-Peña M, Perales I, Vicó À, Uríszar J, Fernández-Aranda F, Sánchez I, Jiménez-Murcia S. Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome? Journal Of Behavioral Addictions 2025, 14: 465-479. PMID: 40116860, DOI: 10.1556/2006.2025.00023.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyGambling disorderPornography useEmotion regulationGD severityTreatment outcomesCognitive-behavioral therapy approachCognitive-behavioral therapy sessionsTreatment outcomes of individualsCo-occurrence of GDCo-occurrenceMental health concernsImprove treatment adherenceBehavioral addictionsTreatment dropoutOutcomes of individualsWeekly sessionsTreatment adherencePsychopathologyGamblingSessionsDisordersAssociated with higher likelihoodRelapseImpulseIncidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
Barbano R, Jabbari B, Sadeghi M, Ukah A, Yue E, Ifantides K, Huang N, Swope D. Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure. Toxins 2025, 17: 148. PMID: 40137921, PMCID: PMC11945862, DOI: 10.3390/toxins17030148.Peer-Reviewed Original ResearchConceptsIncidence of dysphagiaCervical dystoniaComorbid conditionsContinuous health plan enrollmentCohort entry dateRate of dysphagiaRetrospective cohort studyPre-existing dysphagiaHealth plan enrollmentRisk factors of dysphagiaFactors of dysphagiaReal-world studyPotential adverse eventsPotential risk factorsPatient-level dataReal-world analysisAdverse eventsCD patientsCohort studyComorbid neurological conditionsLongitudinal patient-level dataCD diagnosisDysphagiaDysphagia riskPatientsUric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial
Patel R, Kumskova M, Kodali H, Budnik I, Kuznetsov V, Jain A, Jha A, Thedens D, Dhanesha N, Sutariya B, Nagarkatti K, Lamb J, Kamat P, Shi Y, Avery B, Imai T, Jin X, Chauhan A, Boisserand L, Khan M, Dhandapani K, Sanganahalli B, Sansing L, Hess D, Koehler R, McCullough L, Aronowski J, Ayata C, Diniz M, Lyden P, Planas A, Chamorro A, Chauhan A, Leira E, Investigators O. Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial. Stroke 2025, 56: 965-973. PMID: 40091742, PMCID: PMC11932773, DOI: 10.1161/strokeaha.124.048748.Peer-Reviewed Original ResearchConceptsUA-treated animalsPrimary functional outcomeFunctional outcomesMiddle cerebral artery filament occlusionModified intention-to-treat populationIntention-to-treat populationUric acidHuman clinical trialsImprove functional outcomesStudy drugIntravenous salineEffects of UARelevant to patientsClinical trialsPrimary outcomeSaline controlsSecondary outcomesPreclinical trialsDay 2Survival rateDay 7Filament occlusionGroups of animalsComorbiditiesDiverse comorbiditiesIdentification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities
Loesch D, Garg M, Matelska D, Vitsios D, Jiang X, Ritchie S, Sun B, Runz H, Whelan C, Holman R, Mentz R, Moura F, Wiviott S, Sabatine M, Udler M, Gause-Nilsson I, Petrovski S, Oscarsson J, Nag A, Paul D, Inouye M. Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities. Nature Communications 2025, 16: 2124. PMID: 40032831, PMCID: PMC11876343, DOI: 10.1038/s41467-025-56695-z.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCardiovascular DiseasesComorbidityDiabetes Mellitus, Type 2Extracellular Matrix ProteinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInsulin-Like Growth Factor Binding Protein 2MaleMiddle AgedMultifactorial InheritanceProteomicsRisk FactorsUnited KingdomConceptsPolygenic scoresNon-coding variantsEtiology of type 2 diabetesMolecular dataVariant effectsPathway enrichmentPlasma proteomic markersPotential therapeutic targetType 2 diabetesProteinDisease biologyPolygenic riskUK BiobankProteomic markersTherapeutic targetPathwayCirculating proteinsGenomeRisk of type 2 diabetesCardiometabolic scoreBiologyInteractive portalVariantsEnrichmentDiabetes comorbiditiesImpact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
Sumsuzzman D, Ye Y, Wang Z, Pandey A, Langley J, Galvani A, Moghadas S. Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis. BMC Infectious Diseases 2025, 25: 215. PMID: 39948450, PMCID: PMC11827239, DOI: 10.1186/s12879-025-10610-5.Peer-Reviewed Original ResearchConceptsPopulation settingEffective public health strategiesConfidence intervalsImpact of disease severityModified Newcastle-Ottawa ScalePublic health strategiesHigher secondary attack rateRisk of biasNewcastle-Ottawa ScalePandemic responseGlobal systematic reviewRandom-effects modelFreeman-Tukey double arcsine transformationWeb of ScienceNo significant associationDrivers of SARS-CoV-2 transmissionHealth strategiesSecondary attack rateSARS-CoV-2Disease severityEffective pandemic responseTargeted interventionsDouble arcsine transformationOvid MEDLINESystematic reviewThe Challenging Problems of Cancer and Serious Mental Illness
Grassi L, McFarland D, Riba M, Ferrara M, Zaffarami G, Belvederi Murri M, Cruciata M, Caruso R. The Challenging Problems of Cancer and Serious Mental Illness. Current Psychiatry Reports 2025, 27: 41-57. PMID: 39786658, PMCID: PMC11724792, DOI: 10.1007/s11920-024-01570-9.Peer-Reviewed Original ResearchConceptsSerious mental illnessProblem of cancerMental illnessGeneral populationPhysical health careRates of screeningMental health servicesHealth-care systemMedication side effectsHealth servicesOncology settingUnhealthy lifestyleHealth careCancer preventionStandard cancer treatmentHigher mortalitySomatic disordersCareVulnerable segmentsNegative outcomesIllnessOncologyCancer treatmentDelayed treatmentCancerLGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters
Workman T, Goulet J, Brandt C, Skanderson M, O’Leary J, Gordon K, Treitler-Zeng Q. LGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters. Frontiers In Public Health 2025, 12: 1487866. PMID: 39835315, PMCID: PMC11743380, DOI: 10.3389/fpubh.2024.1487866.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaLGBTQ+ individualsMedical care usagePost-traumatic stress disorderTransgenderSexual traumaMarital statusSubstance use disorder diagnosisMental healthStress disorderContext of post-traumatic stress disorderQueerLGBTQ+CrimeVeterans with post-traumatic stress disorderMaltreatmentVeteransOutpatient encountersPolicySexStatusIncreased riskDemographicsChi-squareDisorder diagnosis
2024
Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss - A Comorbidity Lens.
Leder Macek A, Wang R, Cottrell J, Kay-Rivest E, McMenomey S, Roland J, Ross F. Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss - A Comorbidity Lens. Undersea And Hyperbaric Medicine 2024, 51: 393-402. PMID: 39821768, DOI: 10.22462/730.Peer-Reviewed Original ResearchConceptsSudden sensorineural hearing lossSensorineural hearing lossHearing loss onsetHearing lossHyperbaric oxygen therapyWord discrimination scoresSpeech perception outcomesIntratympanic steroid injectionOxygen therapyOral steroid coursesPerception outcomesTone averageSiegel's criteriaClinical improvementPhysician visitsPatient comorbiditiesRheumatologic disordersDiscrimination scoresAssociated with patient outcomesTreated with hyperbaric oxygen therapyCharlson Comorbidity IndexImpact of patient comorbiditiesTertiary referral centerOutcomes of patientsAdjunct to steroidsCannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013
Hasin D, Mannes Z, Livne O, Fink D, Martins S, Stohl M, Olfson M, Cerdá M, Keyes K, Keyhani S, Wisell C, Bujno J, Saxon A. Cannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013. Substance Use & Misuse 2024, 60: 285-292. PMID: 39533528, PMCID: PMC11710973, DOI: 10.1080/10826084.2024.2423374.Peer-Reviewed Original ResearchConceptsCannabis use disorderPsychiatric disordersCannabis useNon-medical cannabis useCannabis outcomesUse disorderDSM-IV cannabis use disorderRates of cannabis use disordersRates of cannabis useCannabis use disorder prevalenceAntisocial personality disorderU.S. adultsPersonality disorderDSM-IVVeterans AdministrationPatient samplesNon-medical useDisordersPrevalence differencesU.S. general populationNationally representative sampleCannabisVA patientsAdultsDisproportionate increasePrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsTreatment for Co-Occurring Stimulant and Opioid Use Disorders
Howell B, Lin L, Coughlin L. Treatment for Co-Occurring Stimulant and Opioid Use Disorders. JAMA Psychiatry 2024, 81: 853-854. PMID: 38985457, DOI: 10.1001/jamapsychiatry.2024.1775.Peer-Reviewed Original ResearchExternal Validation of an Electronic Phenotyping Algorithm Detecting Attention to High Body Mass Index in Pediatric Primary Care
Barron A, Fenick A, Maciejewski K, Turer C, Sharifi M. External Validation of an Electronic Phenotyping Algorithm Detecting Attention to High Body Mass Index in Pediatric Primary Care. Applied Clinical Informatics 2024, 15: 700-708. PMID: 39197473, PMCID: PMC11387092, DOI: 10.1055/s-0044-1787975.Peer-Reviewed Original ResearchConceptsElectronic health recordsBody mass indexPediatric primary careElevated body mass indexWeight-related comorbiditiesPrimary carePediatric primary care practicesElectronic health record dataBody mass index categoriesMass indexImprove obesity managementPrimary care practicesWell-child visitsHigher body mass indexChart reviewLikelihood of classificationElectronic phenotyping algorithmsFree-text componentsClinician typeCare practicesHealth recordsClinician behaviorLaboratory ordersProgress notesObesity managementAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationSleep apnea in schizophrenia: Estimating prevalence and impact on cognition
Ghazikhanian S, Surti T. Sleep apnea in schizophrenia: Estimating prevalence and impact on cognition. Journal Of Psychiatric Research 2024, 177: 330-337. PMID: 39068777, DOI: 10.1016/j.jpsychires.2024.07.028.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaPrevalence of obstructive sleep apneaCognitive deficits of schizophreniaWorking memory test scoresDeficits of schizophreniaSleep apneaImpaired cognitive domainsSpeed of processingDisabling cognitive deficitsMemory test scoresHigher cognitive capacityFunctional capacity performanceAssociated with lower speedsVerbal learningCognitive domainsCompromised cognitionSchizophreniaRisk of obstructive sleep apneaEffects of sleep apneaCognitive capacityCognitive impairmentPredicting obstructive sleep apneaSelf-reportMedical illnessFunctional capacity assessmentSex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study
Tian X, Liu X, Bai F, Li M, Qiu Y, Jiao Q, Li J, Zhang X. Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study. Brain And Behavior 2024, 14: e3578. PMID: 38844426, PMCID: PMC11156525, DOI: 10.1002/brb3.3578.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleFEDN MDD patientsMDD patientsSuicide attemptsSex differencesDepressive disorderFirst-episodeFactors associated with suicide attemptsRisk of suicide attemptNegative Syndrome ScaleMajor depressive disorderHamilton Depression Scale scoresHamilton Anxiety Scale scoresThyroid peroxidase antibodySubclinical hypothyroidismIncreased suicide attemptsInvestigate sex differencesSignificant sex differencesSyndrome ScalePositive subscaleIncreased riskAnxiety ScaleFEDNPerformance of the Elixhauser Comorbidity Index in Predicting Mortality Among a National US Sample of Hospitalized Homeless Adults
Tsai J, Kim Y. Performance of the Elixhauser Comorbidity Index in Predicting Mortality Among a National US Sample of Hospitalized Homeless Adults. Medical Care 2024, 62: 543-548. PMID: 38838297, DOI: 10.1097/mlr.0000000000002019.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexIn-hospital mortalityBehavioral health conditionsHealth care databasesNational Inpatient Sample (NISComorbidity indexAlcohol-related disordersPredictors of hospital readmissionPredicting mortalityPrediction of in-hospital mortalityClinical Classifications Software Refined (CCSRCare databasePredicting in-hospital mortalitySummary scoreRevision Clinical ModificationNational US sampleClinical ModificationInternational ClassificationSample of inpatientsDiagnostic codesHealth conditionsHomeless adultsHospital readmissionCase-mixAcute myocardial infarctionPredicting clinical outcomes of SARS-CoV-2 infection during the Omicron wave using machine learning
Cogill S, Nallamshetty S, Fullenkamp N, Heberer K, Lynch J, Lee K, Aslan M, Shih M, Lee J. Predicting clinical outcomes of SARS-CoV-2 infection during the Omicron wave using machine learning. PLOS ONE 2024, 19: e0290221. PMID: 38662748, PMCID: PMC11045098, DOI: 10.1371/journal.pone.0290221.Peer-Reviewed Original ResearchConceptsHigh-risk groupSARS-CoV-2 infectionAnticoagulant useAdverse outcomesPredictor of adverse outcomesHigher risk of adverse outcomesLower body mass indexRisk of adverse outcomesVaccination of high-risk groupsOral anticoagulant useOutcome of SARS-CoV-2 infectionRetrospective longitudinal observational studySARS-CoV-2U.S. Veterans Health AdministrationClinical outcomes of SARS-CoV-2 infectionIdentification of patientsBody mass indexVeterans Health AdministrationPredictors of hospitalizationEscalation of careLongitudinal observational studyClinical outcomesOmicron SARS-CoV-2 variantSARS-CoV-2 variantsUnvaccinated patientsNeuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
Gururangan K, Peschansky V, Van Hyfte G, Agarwal P, Blank L, Mathew B, Goldstein J, Kwon C, McCarthy L, Cohen A, Chan A, Deng P, Dhamoon M, Gutzwiller E, Hao Q, He C, Klenofsky B, Lemus H, Marcuse L, Navis A, Heredia Nunez W, Luckey M, Schorr E, Singh A, Tantillo G, Ufongene C, Young J, Balchandani P, Festa J, Naasan G, Charney A, Nadkarni G, Jetté N. Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study. Journal Of Neurology 2024, 271: 3991-4007. PMID: 38656620, DOI: 10.1007/s00415-024-12370-9.Peer-Reviewed Original ResearchConceptsIn-hospital mortalityAssociated with lower oddsHigher odds of mortalityResultsOur study cohortElectronic medical record databaseChart reviewNeuropsychiatric complicationsNew York City health systemOdds of mortalityAssociated with in-hospital mortalityMultivariate logistic regressionMedical record databaseHealth systemLower oddsHigher oddsIndividual chart reviewSerum inflammatory marker levelsCohort studyPre-existing comorbiditiesRecord databaseCOVID-19Logistic regressionTreated with anticoagulationInflammatory marker levelsComplication of coronavirus diseaseAlcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.Peer-Reviewed Original ResearchConceptsAlcohol use disorderChronic painAUD studiesChronic pain disordersChronic pain outcomesRisk of relapseAlcohol withdrawal syndromeAssessment of painHigher levels of alcohol consumptionLevels of alcohol consumptionWithdrawal syndromePain disordersPain outcomesAcute toleranceNeurobiological changesClinical significanceUse disorderPainClinical relevanceSelf-reportAlcohol intoxicationAlcohol consumptionGeneral populationMedical conditionsNarrative reviewAre Cardiac Myosin Inhibitors Useful in Patients With Hypertrophic Obstructive Cardiomyopathy and Comorbid Hypertension? ∗
Sikand N, Sen S. Are Cardiac Myosin Inhibitors Useful in Patients With Hypertrophic Obstructive Cardiomyopathy and Comorbid Hypertension? ∗. JACC Heart Failure 2024, 12: 580-582. PMID: 38448152, DOI: 10.1016/j.jchf.2023.12.021.Commentaries, Editorials and Letters
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply