2025
[18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water.
Fu J, Juttukonda M, Garimella A, Salvatore A, Lois C, Ranasinghe A, Efthimiou N, Sari H, Aye W, Guehl N, El Fakhri G, Johnson K, Dickerson B, Izquierdo-Garcia D, Catana C, Price J. [18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water. Journal Of Nuclear Medicine 2025, 66: 410-417. PMID: 39947916, PMCID: PMC11876731, DOI: 10.2967/jnumed.124.268701.Peer-Reviewed Original ResearchGenetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water
Rodrigue A, Knowles E, Mollon J, Mathias S, Peralta J, Leandro A, Fox P, Kochunov P, Olvera R, Almasy L, Curran J, Blangero J, Glahn D. Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Human Brain Mapping 2025, 46: e70101. PMID: 39757975, PMCID: PMC11702472, DOI: 10.1002/hbm.70101.Peer-Reviewed Original ResearchConceptsGenetic correlationsDiffusion tensor imagingCirculating cytokine levelsPeripheral inflammatory responseWhite matter architectureFA measurementsCytokine levelsCytokine measurementsWhite matter integrityProinflammatory cytokinesSingle-compartment modelIL-8Inflammatory processInflammatory responseFree water volumeFree waterGenetic relationshipsWhite matterWhite matter microstructureExtracellular free waterGenetic association
2024
Self-assembly of malto-oligosaccharide-block-solanesol in aqueous solutions: Investigating morphology and sugar-based physiological compatibility
Lang W, Watanabe T, Lee C, Fukushima S, Li F, Yamamoto T, Tajima K, Tagami T, Borsali R, Takahashi K, Satoh T, Isono T. Self-assembly of malto-oligosaccharide-block-solanesol in aqueous solutions: Investigating morphology and sugar-based physiological compatibility. Carbohydrate Polymers 2024, 352: 123207. PMID: 39843108, DOI: 10.1016/j.carbpol.2024.123207.Peer-Reviewed Original ResearchConceptsWorm-like structureSelf-assemblySolution self-assemblySmall-angle X-ray scatteringDynamic light scattering experimentsX-ray scatteringWorm-like micellesCo-oligomersClick chemistryTransmission electron microscopyNanopatterning applicationsLight scattering experimentsAqueous solutionLectin recognitionMicelle concentrationDiverse morphologiesScattering experimentsElectron microscopyPolarization parametersProbe methodRelaxation timeMicellesCMCGLCMorphologyFully biosourced amphiphilic block copolymer from tamarind seed xyloglucan and solanesol: synthesis, aqueous self-assembly, and drug encapsulation
Lang W, Watanabe T, Lee C, Tagami T, Li F, Yamamoto T, Tajima K, Borsali R, Takahashi K, Satoh T, Isono T. Fully biosourced amphiphilic block copolymer from tamarind seed xyloglucan and solanesol: synthesis, aqueous self-assembly, and drug encapsulation. Carbohydrate Polymers 2024, 352: 123181. PMID: 39843085, DOI: 10.1016/j.carbpol.2024.123181.Peer-Reviewed Original ResearchConceptsAqueous self-assemblyAmphiphilic block copolymersDegree of polymerizationSelf-assemblyBlock copolymersSpherical micellesNumber-average degree of polymerizationSmall-angle X-ray scatteringInvestigated block copolymersX-ray scatteringDynamic light scatteringClick chemistryTransmission electron microscopyHydrophilic blockWormlike structuresAqueous mediaCopolymersStructural analysisWater-insoluble flavonoidLight scatteringMicellesElectron microscopyDrug encapsulationHydrophobic segmentsMulti-angle dynamic light scatteringBeyond the “spine of hydration”: Chiral SFG spectroscopy detects DNA first hydration shell and base pair structures
Perets E, Konstantinovsky D, Santiago T, Videla P, Tremblay M, Velarde L, Batista V, Hammes-Schiffer S, Yan E. Beyond the “spine of hydration”: Chiral SFG spectroscopy detects DNA first hydration shell and base pair structures. The Journal Of Chemical Physics 2024, 161: 095104. PMID: 39230381, PMCID: PMC11377083, DOI: 10.1063/5.0220479.Peer-Reviewed Original ResearchConceptsChiral SFG spectraProbe water moleculeWater moleculesChiral SFG spectroscopyHydration shellSFG spectraMinor grooveSFG spectroscopyHydration shell water moleculesWater structureO-H stretching of waterSum frequency generation spectroscopyShell water moleculesPhosphate backboneN-H stretchingO-H stretchingDNA base pairsDNA minor grooveSpine of hydrationSpectra of DNAN-HVibrational spectroscopyO-HSFG responseSFG signalAssessing the Progress toward a Water-Efficient Economy in the United States from 1985 to 2015
Du Y, Wang R, Zimmerman J. Assessing the Progress toward a Water-Efficient Economy in the United States from 1985 to 2015. Environmental Science And Technology 2024, 58: 8696-8708. PMID: 38717867, DOI: 10.1021/acs.est.3c09219.Peer-Reviewed Original ResearchConceptsAgricultural water use efficiencyWater use efficiencySustainable Development Goal 6Water priceEconomic growthTime series analysisUnited Nations Sustainable Development Goal 6Economic dataEquitable developmentAffluent statesWater withdrawalEffective water planningUS statesWater planningLocal communitiesWater utilitiesSeries analysisUS countiesGoal 6Increasing industrializationUse concernsUnited StatesNational trendsPriceCommunityHigh NaCl Concentrations in Water Are Associated with Developmental Abnormalities and Altered Gene Expression in Zebrafish
Seli D, Prendergast A, Ergun Y, Tyagi A, Taylor H. High NaCl Concentrations in Water Are Associated with Developmental Abnormalities and Altered Gene Expression in Zebrafish. International Journal Of Molecular Sciences 2024, 25: 4104. PMID: 38612913, PMCID: PMC11012806, DOI: 10.3390/ijms25074104.Peer-Reviewed Original ResearchConceptsNaCl concentrationGene expressionIncreasing NaCl concentrationATM signaling pathwayUninflated swim bladderSwim bladder developmentHigh NaCl concentrationsEmbryo growthAssociated with developmental abnormalitiesSwim bladderLarval stageEarly embryo growthEmbryonic deathDevelopmental abnormalitiesSignaling pathwayDevelopment of zebrafishGenes SHHCalcium chlorideGenesSodium chlorideE3 mediumStages of developmentZebrafish embryosAffected ecosystemsPotassium chloride
2023
Rapid, Selective, and Chemical-Free Removal of Dissolved Silica from Water via Electrosorption: Feasibility and Mechanisms
Ma W, Patel S, Marcos−Hernández M, Wang X, Zhou X, Pan W, Shin Y, Villagrán D, Elimelech M. Rapid, Selective, and Chemical-Free Removal of Dissolved Silica from Water via Electrosorption: Feasibility and Mechanisms. Environmental Science And Technology 2023, 58: 947-959. PMID: 38153969, DOI: 10.1021/acs.est.3c08067.Peer-Reviewed Original ResearchThe Future of Municipal Wastewater Reuse Concentrate Management: Drivers, Challenges, and Opportunities
Finnerty C, Childress A, Hardy K, Hoek E, Mauter M, Plumlee M, Rose J, Sobsey M, Westerhoff P, Alvarez P, Elimelech M. The Future of Municipal Wastewater Reuse Concentrate Management: Drivers, Challenges, and Opportunities. Environmental Science And Technology 2023, 58: 3-16. PMID: 38193155, PMCID: PMC10785764, DOI: 10.1021/acs.est.3c06774.Peer-Reviewed Original ResearchIce nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C
Hansen T, Lee J, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies P. Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C. ELife 2023, 12: rp91976. PMID: 38109272, PMCID: PMC10727499, DOI: 10.7554/elife.91976.Peer-Reviewed Original ResearchBiodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol
Novoskoltseva O, Litmanovich E, Loiko N, Nikolaev Y, Yaroslavov A. Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol. International Journal Of Molecular Sciences 2023, 24: 14717. PMID: 37834163, PMCID: PMC10572309, DOI: 10.3390/ijms241914717.Peer-Reviewed Original ResearchConceptsQuaternized hydroxyethyl cellulose ethoxylateInterpolyelectrolyte complexesAnionic sodium alginateHydroxyethyl cellulose ethoxylateBiocidal filmsHomogeneous coatingComposite formulationsIonic polymersCoatingPolycomplex particlesSodium alginateAqueous solutionBiocidal coatingsPolycomplexesPolymerElectrostatic couplingCationic polymersNon-toxicFabricationFilmsGeospatial Assessment of Racial/Ethnic Composition, Social Vulnerability, and Lead Water Service Lines in New York City
Nigra A, Lieberman-Cribbin W, Bostick B, Chillrud S, Carrión D. Geospatial Assessment of Racial/Ethnic Composition, Social Vulnerability, and Lead Water Service Lines in New York City. Environmental Health Perspectives 2023, 131: 087015. PMID: 37646509, PMCID: PMC10467360, DOI: 10.1289/ehp12276.Peer-Reviewed Original ResearchCritical Analysis of the Effects of SGLT2 Inhibitors on Renal Tubular Sodium, Water and Chloride Homeostasis and Their Role in Influencing Heart Failure Outcomes
Packer M, Wilcox C, Testani J. Critical Analysis of the Effects of SGLT2 Inhibitors on Renal Tubular Sodium, Water and Chloride Homeostasis and Their Role in Influencing Heart Failure Outcomes. Circulation 2023, 148: 354-372. PMID: 37486998, PMCID: PMC10358443, DOI: 10.1161/circulationaha.123.064346.Peer-Reviewed Original ResearchConceptsSGLT2 inhibitorsProximal renal tubulesRenal tubulesProximal tubular effectHeart failure outcomesHeart failure eventsSodium-hydrogen exchanger 3Renal tubular sodiumProgressive volume lossLong-term treatmentReabsorption of glucoseTreatment-related changesChronic diuresisPharmacological toleranceTubular effectsClinical courseFractional excretionHeart failureTubular sodiumCardioprotective effectsRenal compensationDiuretic effectIndividual patientsDurable improvementDegree of upregulationAnalysis of brain edema in RHAPSODY
Schleicher R, Vorasayan P, McCabe M, Bevers M, Davis T, Griffin J, Hinduja A, Jadhav A, Lee J, Sawyer R, Zlokovic B, Sheth K, Fedler J, Lyden P, Kimberly W, Investigators O. Analysis of brain edema in RHAPSODY. International Journal Of Stroke 2023, 19: 68-75. PMID: 37382409, PMCID: PMC10789908, DOI: 10.1177/17474930231187268.Peer-Reviewed Original ResearchConceptsNet water uptakeMidline shiftCerebral edemaMarkers of edemaImaging markerClinical outcomesBrain magnetic resonance imaging (MRI) scansMass effectMagnetic resonance imaging (MRI) scansSupratentorial ischemic lesionsAcute ischemic strokeBaseline stroke volumeProtein C treatmentResonance imaging scansCerebrospinal fluid volumeTime courseIschemic strokeBaseline visitIschemic lesionsTrial cohortBrain edemaTreatment armsSecondary complicationsFuture trialsImaging scansThe Role of Water in Uromodulin Regulation
Bakhoum C, Garimella P. The Role of Water in Uromodulin Regulation. Clinical Journal Of The American Society Of Nephrology 2023, 18: 985-987. PMID: 37418253, PMCID: PMC10564335, DOI: 10.2215/cjn.0000000000000233.Peer-Reviewed Original ResearchNon-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
Manz K, Feerick A, Braun J, Feng Y, Hall A, Koelmel J, Manzano C, Newton S, Pennell K, Place B, Godri Pollitt K, Prasse C, Young J. Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 524-536. PMID: 37380877, PMCID: PMC10403360, DOI: 10.1038/s41370-023-00574-6.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryNon-targeted analysisExposure mediaChemical spaceSoils/sedimentsMass spectrometryPolyfluoroalkyl substancesSemi-volatile organic compoundsChemical exposomePolyaromatic hydrocarbonsLiquid chromatographyEnvironmental mediaOrganic compoundsGC-HRMSHuman exposureLC-HRMSAnalytical platformConsumer productsChemical exposureSedimentsPesticidesEnvironmental chemicalsChemicalsExposure sourcesSpectrometryThe landscape of computational approaches for artificial photosynthesis
Yang K, Kyro G, Batista V. The landscape of computational approaches for artificial photosynthesis. Nature Computational Science 2023, 3: 504-513. PMID: 38177419, DOI: 10.1038/s43588-023-00450-1.Peer-Reviewed Original ResearchImaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes
Dhar R, Kumar A, Chen Y, Begunova Y, Olexa M, Prasad A, Carey G, Gonzalez I, Bhatia K, Hamed M, Heitsch L, Mainali S, Petersen N, Lee J. Imaging biomarkers of cerebral edema automatically extracted from routine CT scans of large vessel occlusion strokes. Journal Of Neuroimaging 2023, 33: 606-616. PMID: 37095592, PMCID: PMC10524672, DOI: 10.1111/jon.13109.Peer-Reviewed Original ResearchConceptsLarge vessel occlusion strokeMidline shiftCSF ratioMalignant edemaCerebral edemaOcclusion strokeCerebrospinal fluidAlberta Stroke Program Early CT ScoreCSF volumeTissue plasminogen activator treatmentHealth Stroke ScalePlasminogen activator treatmentRoutine CT scansNet water uptakeDecompressive surgeryInfarct volumeStroke ScaleOsmotic therapyBaseline CTCT scoreHemispheric volumeRoutine CTSerial CTContralateral regionsCT scanEffects of Ethanolic and Aqueous Extracts of Garcinia gardneriana Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet
do Espirito Santo B, Santana L, Kato W, de Araújo F, Tatara M, Croda J, Bogo D, de Cássia Freitas K, de Cássia Avellaneda Guimarães R, Hiane P, Pott A, de Oliveira Filiú W, de Faria B, de Oliveira Figueiredo P, do Nascimento V, Ayres F, de Oliveira Bastos P. Effects of Ethanolic and Aqueous Extracts of Garcinia gardneriana Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet. Nutrients 2023, 15: 1308. PMID: 36986038, PMCID: PMC10051817, DOI: 10.3390/nu15061308.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1 concentrationsChemoattractant protein-1 concentrationsNon-communicable chronic diseasesExperimental modelProtein-1 concentrationsHigh-fat dietHigh-density lipoproteinPossible metabolic alterationsVivo experimental modelsEffect of ethanolicAqueous extractTotal cholesterolInterleukin-10Microvesicular steatosisHepatic steatosisInsulin resistanceBlood glucoseSwiss miceHyperlipidic dietChronic diseasesDensity lipoproteinMetabolic alterationsControl groupWeight gainEthanolic extract
2022
Regulation of glomerulotubular balance. IV. Implication of aquaporin 1 in flow-dependent proximal tubule transport and cell volume
Du Z, Yan Q, Shen E, Weinstein A, Wang T. Regulation of glomerulotubular balance. IV. Implication of aquaporin 1 in flow-dependent proximal tubule transport and cell volume. American Journal Of Physiology. Renal Physiology 2022, 323: f642-f653. PMID: 36108052, PMCID: PMC9705020, DOI: 10.1152/ajprenal.00167.2022.Peer-Reviewed Original ResearchConceptsWater channel aquaporin-1Proximal tubulesKO miceAquaporin-1Water reabsorptionMouse PTNo significant differenceWild-typeTight junctionsRat kidneyAquaporin-1 knockoutSignificant differenceAcid-base parametersKidney proximal tubulesRenal clearance experimentsWT miceKnockout miceUrine flowFlow stimulationFluid absorptionUrine pHClearance experimentsMouse kidneyMiceRats
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