2025
Patellar tilt calculation utilizing artificial intelligence on CT knee imaging
Sieberer J, Rancu A, Park N, Desroches S, Manafzadeh A, Tommasini S, Wiznia D, Fulkerson J. Patellar tilt calculation utilizing artificial intelligence on CT knee imaging. The Knee 2025, 54: 217-221. PMID: 40086415, DOI: 10.1016/j.knee.2025.02.019.Peer-Reviewed Original ResearchVoxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrainCerebral HemorrhageCohort StudiesFemaleHematomaHumansMaleMiddle AgedTomography, X-Ray ComputedConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageIntegration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology
Erbay M, Manubolu V, Stein-Merlob A, Ferencik M, Mamas M, Lopez-Mattei J, Baldassarre L, Budoff M, Yang E. Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology. Current Cardiology Reports 2025, 27: 51. PMID: 39932640, PMCID: PMC11814013, DOI: 10.1007/s11886-025-02206-x.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCoronary Artery DiseaseHumansNeoplasmsRisk FactorsTomography, X-Ray ComputedConceptsRadiation-induced cardiovascular diseaseCoronary artery diseaseCardiovascular diseaseCardiac massComputed tomographyArtery diseaseChest CT scans of patientsCT scans of patientsIncreased risk of CVDInvasive coronary angiographyRisk of cardiovascular diseaseRisk of complicationsScans of patientsCardiovascular computed tomographySeverity of cardiovascular diseaseNon-invasive imaging toolMonitoring of disease progressionManifestations of diseaseAsymptomatic patientsCardiac deteriorationIschemia evaluationCoronary angiographyPericardial diseaseCardiac changesRisk stratificationLung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement.
Henderson L, Kim R, Tanner N, Tsai E, Begnaud A, Dako F, Gieske M, Kallianos K, Richman I, Sakoda L, Schwartz R, Yeboah J, Fong K, Lam S, Lee P, Pasquinelli M, Smith R, Triplette M, Tanoue L, Rivera M. Lung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 436-451. PMID: 39928329, PMCID: PMC11936151, DOI: 10.1164/rccm.202501-0011st.Peer-Reviewed Original ResearchMeSH KeywordsDelphi TechniqueEarly Detection of CancerFemaleHumansIncidental FindingsLung NeoplasmsMaleMass ScreeningSocieties, MedicalTomography, X-Ray ComputedUnited StatesConceptsLow-dose computed tomographyManagement of incidental findingsLung cancer screeningCancer screeningThree-round modified Delphi processReporting of incidental findingsClinically significant IFsPrioritized questionsDelphi processIncidental findingClinicians' effortsMultidisciplinary panelPatient anxietyResearch questionsPotential harmLDCT examinationsCoronary artery calcificationIncreased awarenessSignificant IFsExcess costsHarmPotential benefitsArtery calcificationKnowledge gapsComputed tomographySpatial Correlates of Dementia and Disability After Intracerebral Hemorrhage.
Chen Y, Rivier C, Mora S, Torres Lopez V, Payabvash S, Sheth K, Harloff A, Falcone G, Rosand J, Mayerhofer E, Anderson C. Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage. Journal Of The American Heart Association 2025, 14: e037930. PMID: 39921496, DOI: 10.1161/jaha.124.037930.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCerebral HemorrhageDementiaDisability EvaluationFemaleHumansMaleMiddle AgedPrognosisRisk FactorsTomography, X-Ray ComputedConceptsFollow-up telephone interviewsElectronic health recordsAssociated with disabilityAssociated with dementiaDevelopment of dementiaDevelopment of disabilityIncident dementiaAssociated with intracerebral hemorrhageIntracerebral hemorrhageHealth recordsTelephone interviewsDementia conversionCohort studyDementiaDisabilityLobar intracerebral hemorrhageIntracerebral hemorrhage locationIntracerebral hemorrhagic lesionsFunctional outcomesNoncontrast computed tomography scanCohortMedian follow-up timeRight posterior limbOutcomesLeft temporo-occipital regionThree-dimensional Analysis of Patellar Instability: A Review of Current Concepts
Park N, Sieberer J, Manafzadeh A, Fulkerson J. Three-dimensional Analysis of Patellar Instability: A Review of Current Concepts. Sports Medicine And Arthroscopy Review 2025, 33: 7-13. PMID: 40145601, DOI: 10.1097/jsa.0000000000000420.Peer-Reviewed Original ResearchHumansImaging, Three-DimensionalJoint InstabilityPatellaPatellar DislocationPatellofemoral JointTomography, X-Ray Computed
2024
Diagnostic performance of neural network algorithms in skull fracture detection on CT scans: a systematic review and meta-analysis
Sharifi G, Hajibeygi R, Zamani S, Easa A, Bahrami A, Eshraghi R, Moafi M, Ebrahimi M, Fathi M, Mirjafari A, Chan J, Dixe de Oliveira Santo I, Anar M, Rezaei O, Tu L. Diagnostic performance of neural network algorithms in skull fracture detection on CT scans: a systematic review and meta-analysis. Emergency Radiology 2024, 32: 97-111. PMID: 39680295, DOI: 10.1007/s10140-024-02300-7.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsHumansNeural Networks, ComputerRadiographic Image Interpretation, Computer-AssistedSensitivity and SpecificitySkull FracturesTomography, X-Ray ComputedConceptsConvolutional neural networkArea under the receiver operating characteristic curveConvolutional neural network modelCT scanSkull fractureComputed tomographyDeep learningProspective clinical trialMeta-analysisReceiver operating characteristic curvePublication biasSkull fracture detectionSystematic reviewNeural network algorithmDetecting skull fracturesImprove diagnosis accuracyDiagnostic hurdlesShortage of radiologistsAutomated diagnostic toolTransfer learningDiagnostic performanceDiagnostic accuracyClinical trialsModel architectureNeural networkCoronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis
Cho S, Lee J, Cho K, Park K, Kim J, Moon J, Kim K, Kim J, Song H. Coronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 1050-1059. PMID: 39404786, PMCID: PMC11754321, DOI: 10.1007/s00259-024-06948-8.Peer-Reviewed Original ResearchConceptsCoronary flow capacityCoronary artery calciumMyocardial blood flowLeft ventricular ejection fraction < 40%Significant ischaemiaStress myocardial blood flowEjection fraction < 40%Coronary artery calcium measurementAcute coronary syndromeNonfatal myocardial infarctionCoronary stent insertionPrognostic significancePrognostic valueStent insertionArtery calciumPrognostic associationBypass surgeryCalcium measurementsHeart failureCardiovascular eventsCoronary syndromeAngina pectorisMultivariate analysisRisk factorsPatientsTrends in visits, imaging, and diagnosis for emergency department abdominal pain presentations in the United States, 2007–2019
Wu R, Adjei‐Poku M, Kelz R, Peck G, Hwang U, Cappola A, Friedman A. Trends in visits, imaging, and diagnosis for emergency department abdominal pain presentations in the United States, 2007–2019. Academic Emergency Medicine 2024, 32: 20-31. PMID: 39313946, PMCID: PMC11726162, DOI: 10.1111/acem.15017.Peer-Reviewed Original ResearchConceptsOlder adultsAbdominal painED visitsComputed tomographyNational Hospital Ambulatory Medical Care SurveyEmergency departmentCT scanTest positivityAdult ED visitsPercentage of visitsAbdominal pain presentingNationally representative dataMiddle-aged adultsAbdominal CT scanCare SurveyPain presentationsAge-specificIncrease imaging ratesPractice patternsSurgical diagnosisAbdominal imagingDiagnostic pathwayRepresentative dataAcute pathologyVisitsDeep-Transfer-Learning–Based Natural Language Processing of Serial Free-Text Computed Tomography Reports for Predicting Survival of Patients With Pancreatic Cancer
Kim S, Kim S, Kim E, Cecchini M, Park M, Choi J, Kim S, Hwang H, Kang C, Choi H, Shin S, Kang J, Lee C. Deep-Transfer-Learning–Based Natural Language Processing of Serial Free-Text Computed Tomography Reports for Predicting Survival of Patients With Pancreatic Cancer. JCO Clinical Cancer Informatics 2024, 8: e2400021. PMID: 39151114, DOI: 10.1200/cci.24.00021.Peer-Reviewed Original ResearchMeSH KeywordsAgedDeep LearningFemaleHumansMaleMiddle AgedNatural Language ProcessingPancreatic NeoplasmsPrognosisRetrospective StudiesROC CurveTomography, X-Ray ComputedConceptsArea under the receiver operating characteristic curveSurvival of patientsCT reportsPancreatic cancerNatural language processingC-indexPredicting survivalOverall survival of patientsTertiary hospitalPredicting 1-year survivalPredicting survival of patientsImproved C-indexSurvival informationPancreatic cancer survivalReceiver operating characteristic curveInternal test data setNLP modelsComputed tomography reportsLanguage processingKorean tertiary hospitalOverall survivalConsecutive patientsActual survivalConcordance indexPatientsMechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model
Lagier D, Zeng C, Kaczka D, Zhu M, Grogg K, Gerard S, Reinhardt J, Ribeiro G, Rashid A, Winkler T, Vidal Melo M. Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model. Science Translational Medicine 2024, 16: eado1097. PMID: 39141699, DOI: 10.1126/scitranslmed.ado1097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaLungPositive-Pressure RespirationPressureRespiration, ArtificialSheepTidal VolumeTomography, X-Ray ComputedConceptsPositive end-expiratory pressureMechanical ventilationFour-dimensional computed tomographyParenchymal strainsVentilator-induced lung injuryAcute respiratory distress syndromeRespiratory system driving pressureManagement of mechanical ventilationPositive end-expiratory pressure valuesRespiratory distress syndromeTidal overdistensionEnd-expiratory pressureAssociated with mortalityPulmonary complicationsLung biomechanicsLung massDistress syndromeClinical outcomesLung injuryComputed tomographyClinical managementGeneral anesthesiaLung collapseDriving pressureLungLate anastomotic perforation of the ileum 3 years after intestinal resection
Shrimanker N, Heller N, Souza F, Kim D. Late anastomotic perforation of the ileum 3 years after intestinal resection. BMJ Case Reports 2024, 17: e260668. PMID: 39142848, DOI: 10.1136/bcr-2024-260668.Peer-Reviewed Original ResearchConceptsAnastomotic perforationIleocolonic anastomosisIntestinal resectionDelayed anastomotic leakSevere abdominal painAppendiceal carcinoid tumorsLife-threatening complicationsRoux-en-YInflammatory bowel diseaseSide-to-side anastomosisPositron emission tomographyEmergency resectionRecurrent malignancyAbdominal painCarcinoid tumorsRight hemicolectomyAnastomotic leakSurgical changesLate perforationPostoperative patientsResectionUnique caseBowel diseaseRisk factorsIntestinal cancerRadiologic-Pathologic Correlation of Cardiac Tumors: Updated 2021 WHO Tumor Classification.
Lorca M, Chen I, Jew G, Furlani A, Puri S, Haramati L, Chaturvedi A, Velez M, Chaturvedi A. Radiologic-Pathologic Correlation of Cardiac Tumors: Updated 2021 WHO Tumor Classification. RadioGraphics 2024, 44: e230126. PMID: 38722782, DOI: 10.1148/rg.230126.Peer-Reviewed Educational MaterialsMeSH KeywordsEchocardiographyHeart NeoplasmsHumansMagnetic Resonance ImagingMultimodal ImagingTomography, X-Ray ComputedWorld Health OrganizationConceptsCardiac tumorsClassification of tumorsCardiac massWorld Health OrganizationCharacterization of cardiac massesWorld Health Organization Classification of TumorsWorld Health Organization tumor classificationWorld Health Organization classificationMalignant cardiac massesPrimary cardiac tumorsPrimary cardiac neoplasmsCardiac metastasisPapillary fibroelastomaThoracoabdominal CTCardiac CTCardiac neoplasmsIntracardiac massesNoncardiac indicationsSurgical managementRadiological investigationsTumor biologyTumor typesCardiac MRIAnatomical variantsTreatment planningImmunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Cinco I, Napier E, Rhoades N, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I. Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection. MBio 2024, 15: e00829-24. PMID: 38771046, PMCID: PMC11237422, DOI: 10.1128/mbio.00829-24.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsFemaleLungMacaca mulattaMaleMicrobiotaMycobacterium Infections, NontuberculousTomography, X-Ray ComputedTranscriptomeConceptsNTM pulmonary diseaseIncreased disease severityNontuberculous mycobacteriaDisease severityBacterial DNAAged animalsAntigen-specific T cellsPulmonary diseaseAssociated with increased disease severityDysregulated macrophage responsePersistence of bacterial DNALack of animal modelsRhesus macaquesSingle-cell RNA sequencingNontuberculous mycobacterial infectionsImmune cell infiltrationRhesus macaque modelBacterial loadAged rhesus macaquesTesting novel therapeuticsRight caudal lobeLower respiratory microbiomeYears of ageMAH infectionMicrobial communitiesA Patient With Type 1 Diabetes and Acute Rhinosinusitis
Roman F, Azar M, Trubin P. A Patient With Type 1 Diabetes and Acute Rhinosinusitis. JAMA 2024, 331: 1586-1587. PMID: 38630502, DOI: 10.1001/jama.2024.0642.Peer-Reviewed Original ResearchVariations in the Anatomic Morphology of the Scapular Spine and Implications on Fracture After Reverse Shoulder Arthroplasty
Archambault S, Kakazu R, Jimenez A, Polisetty T, Cusano A, Berthold D, Muench L, Cote M, Slater M, Levy J, Mazzocca A. Variations in the Anatomic Morphology of the Scapular Spine and Implications on Fracture After Reverse Shoulder Arthroplasty. Journal Of The American Academy Of Orthopaedic Surgeons 2024, 32: 712-718. PMID: 38739868, DOI: 10.5435/jaaos-d-22-00557.Peer-Reviewed Original ResearchConceptsReverse shoulder arthroplastyIntraclass correlation coefficientShoulder arthroplastyFracture riskScapular spineIdentification of high-risk patientsScapular spine fracturesHigh-risk patientsIncreased fracture riskControl groupRegression analysisPilot study dataSpine fracturesSurgical indicationsFracture incidenceFracture groupControl cohortAverage agePatientsScapular measurementsStudy dataSpineAnatomical morphologyType IAcromionEffect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesExerciseFemaleHumansMaleMiddle AgedNeural PathwaysPositron-Emission TomographyRisk FactorsTomography, X-Ray ComputedConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effectsSelective Use of CT Fractional Flow at a Large Academic Medical Center: Insights from Clinical Implementation after 1 Year of Practice.
Randhawa M, Takigami A, Thondapu V, Ranganath P, Zhang E, Parakh A, Goiffon R, Baliyan V, Foldyna B, Lu M, Tower-Rader A, Meyersohn N, Hedgire S, Ghoshhajra B. Selective Use of CT Fractional Flow at a Large Academic Medical Center: Insights from Clinical Implementation after 1 Year of Practice. Radiology Cardiothoracic Imaging 2024, 6: e230073. PMID: 38573127, PMCID: PMC11056747, DOI: 10.1148/ryct.230073.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersConstriction, PathologicFractional Flow Reserve, MyocardialHumansPercutaneous Coronary InterventionTomography, X-Ray ComputedConceptsRate of invasive coronary angiographyCoronary CTAInvasive coronary angiographyCoronary CT angiographyCT-FFR analysisPercutaneous coronary interventionHeart rate controlCT-FFRRetrospective observational studyFractional flow reserveCT angiographyDual-source coronary CT angiographyCT fractional flow reserveFlow reserveObservational studyCoronary bypass graftingEarly diastolic periodBeats per minuteCoronary angiographyPhysician's discretionChart reviewClinical outcomesBypass graftingCTA acquisitionAcademic medical centerIdentifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F‐Fluoromisonidazole and 18F‐Fluorodeoxyglucose Positron Emission Tomography
Okamoto M, Yamaguchi S, Sawaya R, Echizenya S, Ishi Y, Kaneko S, Motegi H, Toyonaga T, Hirata K, Fujimura M. Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F‐Fluoromisonidazole and 18F‐Fluorodeoxyglucose Positron Emission Tomography. BioMed Research International 2024, 2024: 2973407. PMID: 38449509, PMCID: PMC10917478, DOI: 10.1155/2024/2973407.Peer-Reviewed Original ResearchMeSH KeywordsFluorine RadioisotopesFluorodeoxyglucose F18GlioblastomaGlucoseGlucose-6-PhosphataseHumansHypoxiaMisonidazolePositron-Emission TomographyRNA, MessengerTomography, X-Ray ComputedConceptsPositron emission tomographyF-FDGMRNA expressionOverall survivalGlucose metabolismF-FDG positron emission tomographyAssociated with poor overall survivalProtein expressionEmission tomographyGross total resectionPotential key moleculesFluorine-18 fluorodeoxyglucoseHypoxic conditionsDegree of glucose metabolismMolecular mechanisms of glucose metabolismAggressive primary brain tumorPoor overall survivalPrimary brain tumorKey moleculesTotal resectionPreoperative examinationIntratumoral hypoxiaPrognostic valuePoor prognosisBiomarkers of glioblastomaEditorial Commentary: Magnetic Resonance Imaging May Underestimate Hip Femoral Version Versus Computed Tomography Scan: Both May Be Optimized Using 3-Dimensional Imaging
Moran J, Jimenez A. Editorial Commentary: Magnetic Resonance Imaging May Underestimate Hip Femoral Version Versus Computed Tomography Scan: Both May Be Optimized Using 3-Dimensional Imaging. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2024, 40: 2411-2412. PMID: 38253294, DOI: 10.1016/j.arthro.2024.01.011.Peer-Reviewed Original ResearchMeSH KeywordsArthroscopyFemoracetabular ImpingementFemurHip JointHumansImaging, Three-DimensionalMagnetic Resonance ImagingTomography, X-Ray ComputedConceptsMagnetic resonance imagingComputed tomographyPreoperative planningTreatment of femoroacetabular impingement syndromeGold standardComputed tomography scanFemoral version measurementsFemoral versionFemoroacetabular impingement syndromeTomography scanPatient positioningLow dosesHip arthroscopyCT imagesImpingement syndromeResonance imagingOptimal outcomesVersion measurementsPatientsIncreased femoral anteversionThree-dimensional imagesImage qualitySyndromeFemoral anteversionDose
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