2025
Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchMeSH KeywordsAdultConnectomeFemaleHumansIsraelLongitudinal StudiesMachine LearningMagnetic Resonance ImagingMaleMiddle AgedPrognosisStress Disorders, Post-TraumaticSurvivorsWounds and InjuriesConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkImplications of gene × environment interactions in post-traumatic stress disorder risk and treatment
Seah C, Sidamon-Eristoff A, Huckins L, Brennand K. Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment. Journal Of Clinical Investigation 2025, 135: e185102. PMID: 40026250, PMCID: PMC11870735, DOI: 10.1172/jci185102.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleRisk FactorsStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderGene x environment interactionsGenetic component of riskLimitations of genetic studiesTreating post-traumatic stress disorderExposure to traumatic stressPost-traumatic stress disorder riskInteraction of traumaGenetic screeningGenetic studiesGenetic componentEnvironment interactionMolecular mechanismsStress disorderPTSD riskTraumatic exposureTraumatic stressTraumatic experiencesDisorder riskGenetic factorsNovel therapeuticsBiological mechanismsGWASGeneral populationGenesLGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters
Workman T, Goulet J, Brandt C, Skanderson M, O’Leary J, Gordon K, Treitler-Zeng Q. LGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters. Frontiers In Public Health 2025, 12: 1487866. PMID: 39835315, PMCID: PMC11743380, DOI: 10.3389/fpubh.2024.1487866.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedComorbidityDemographyFemaleHumansMaleMiddle AgedOutpatientsSexual and Gender MinoritiesStress Disorders, Post-TraumaticUnited StatesVeteransConceptsMilitary sexual traumaLGBTQ+ individualsMedical care usagePost-traumatic stress disorderTransgenderSexual traumaMarital statusSubstance use disorder diagnosisMental healthStress disorderContext of post-traumatic stress disorderQueerLGBTQ+CrimeVeterans with post-traumatic stress disorderMaltreatmentVeteransOutpatient encountersPolicySexStatusIncreased riskDemographicsChi-squareDisorder diagnosisSupportive Touch in Psychedelic Assisted Therapy
Neitzke-Spruill L, Beit C, Averill L, McGuire A. Supportive Touch in Psychedelic Assisted Therapy. The American Journal Of Bioethics 2025, 25: 29-39. PMID: 39804300, DOI: 10.1080/15265161.2024.2433428.Peer-Reviewed Original ResearchMeSH KeywordsHallucinogensHarm ReductionHumansN-Methyl-3,4-methylenedioxyamphetaminePsychotherapyStress Disorders, Post-TraumaticTherapeutic TouchTouchUnited StatesUnited States Food and Drug AdministrationConceptsPost-traumatic stress disorderPsychedelic-assisted therapyTreating post-traumatic stress disorderPsychedelic assisted therapyMDMA-ATStress disorderPsychological interventionsUnlicensed therapistsIncidents of misconductPsychedelicsCases of misconductFuture abuseSexual misconductHarm reductionAssisted therapyClinical contextMisconductWhole clothU.S. Food and Drug AdministrationMDMADrug AdministrationTherapistsAbuseDisordersFood and Drug Administration
2024
Incidence and antecedents of emergent suicidal ideation and behavior among Veterans with serious mental illness receiving intensive case management
Browne J, Mohamed S. Incidence and antecedents of emergent suicidal ideation and behavior among Veterans with serious mental illness receiving intensive case management. Journal Of Psychiatric Research 2024, 181: 607-613. PMID: 39740616, DOI: 10.1016/j.jpsychires.2024.12.018.Peer-Reviewed Original ResearchConceptsEmergent suicidal ideationSuicidal ideationMental illnessBehavior groupCommunity-based treatment programsAffective disorder diagnosesSix-month follow-up assessmentFollow-up assessmentService useSubjective distressDisorder diagnosisLifetime hospitalizationsQuality of lifeIdeationProgram evaluation dataTreatment programsVeteransVeterans Health AdministrationBaseline quality of lifePrimary study aimSix-month incidenceBehavioral patternsHealth AdministrationIllnessHigh-risk groupMDMA and MDMA-Assisted Therapy
Wolfgang A, Fonzo G, Gray J, Krystal J, Grzenda A, Widge A, Kraguljac N, McDonald W, Rodriguez C, Nemeroff C. MDMA and MDMA-Assisted Therapy. American Journal Of Psychiatry 2024, 182: 79-103. PMID: 39741438, DOI: 10.1176/appi.ajp.20230681.Peer-Reviewed Original ResearchMeSH KeywordsHallucinogensHumansN-Methyl-3,4-methylenedioxyamphetaminePsychotherapyStress Disorders, Post-TraumaticConceptsMDMA-assisted therapyPosttraumatic stress disorderControlled clinical settingRecreational useMDMA administrationNeurobiological mechanismsStress disorderEgo functionsSelf-compassionMDMAEfficacious treatmentPreliminary evidenceHeightened trustTherapeutic settingNonclinical settingsDiagnostic criteriaFood and Drug AdministrationBreakthrough therapiesClinical settingNonmedical settingsConsiderable bodyPsychotherapyPsychedelicsLong-term follow-upDrug AdministrationEpigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts
Katrinli S, Wani A, Maihofer A, Ratanatharathorn A, Daskalakis N, Montalvo-Ortiz J, Núñez-Ríos D, Zannas A, Zhao X, Aiello A, Ashley-Koch A, Avetyan D, Baker D, Beckham J, Boks M, Brick L, Bromet E, Champagne F, Chen C, Dalvie S, Dennis M, Fatumo S, Fortier C, Galea S, Garrett M, Geuze E, Grant G, Hauser M, Hayes J, Hemmings S, Huber B, Jajoo A, Jansen S, Kessler R, Kimbrel N, King A, Kleinman J, Koen N, Koenen K, Kuan P, Liberzon I, Linnstaedt S, Lori A, Luft B, Luykx J, Marx C, McLean S, Mehta D, Milberg W, Miller M, Mufford M, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff C, Nugent N, Orcutt H, Qin X, Rauch S, Ressler K, Risbrough V, Rutembesa E, Rutten B, Seedat S, Stein D, Stein M, Toikumo S, Ursano R, Uwineza A, Verfaellie M, Vermetten E, Vinkers C, Ware E, Wildman D, Wolf E, Young R, Zhao Y, van den Heuvel L, Uddin M, Nievergelt C, Smith A, Logue M. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts. Genome Medicine 2024, 16: 147. PMID: 39696436, PMCID: PMC11658418, DOI: 10.1186/s13073-024-01417-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultCpG IslandsDNA MethylationEpigenesis, GeneticEpigenomeFemaleGenome-Wide Association StudyHumansMaleMilitary PersonnelStress Disorders, Post-TraumaticConceptsEpigenome-wide association studiesDNA methylationPsychiatric Genomics ConsortiumPost-traumatic stress disorderAssociation studiesMeta-analysis of epigenome-wide association studiesMethylation levelsGenome-wide expression dataEpigenetic gene regulationBrain regionsPGC-PTSDAnnotated genesBlood cell proportionsCpG lociGene regulationSusceptibility to post-traumatic stress disorderExpression dataAssociated with post-traumatic stress disorderIllumina HumanMethylation450Genomics ConsortiumOccurrence of post-traumatic stress disorderAssociated with biological differencesCpGMultiple brain regionsPostmortem brain samplesVoice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure
Lofthouse K, Beeson E, Dalgleish T, Danese A, Hodgekins J, Mahoney-Davies G, Smith P, Stallard P, Wilson J, Meiser-Stedman R. Voice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure. European Journal Of Psychotraumatology 2024, 15: 2435790. PMID: 39691055, PMCID: PMC11656750, DOI: 10.1080/20008066.2024.2435790.Peer-Reviewed Original ResearchConceptsNegative post-traumatic cognitionsPosttraumatic stress disorderPost-traumatic cognitionsPosttraumatic stress disorder symptom severityHearing groupPrevalence of sexual traumaVoice hearingPanic symptomsSymptom severitySexual traumaSecondary analysisExposure to multiple traumatic eventsCognitive phenotype of childrenHearing voicesExposure to multiple traumasPosttraumatic stress disorder diagnosisTrauma memory qualityMental health difficultiesMethods:</b> ParticipantsMultiple traumatic eventsMultiple trauma exposuresExploratory secondary analysisCognitive-behavioral factorsPhenotype of childrenHealth difficultiesPsilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic
Back A, Freeman-Young T, Morgan L, Sethi T, Baker K, Myers S, McGregor B, Harvey K, Tai M, Kollefrath A, Thomas B, Sorta D, Kaelen M, Kelmendi B, Gooley T. Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2449026. PMID: 39636638, PMCID: PMC11621983, DOI: 10.1001/jamanetworkopen.2024.49026.Peer-Reviewed Original ResearchMeSH KeywordsAdultBurnout, ProfessionalCOVID-19DepressionDouble-Blind MethodFemaleHallucinogensHumansMaleMiddle AgedPandemicsPsilocybinSARS-CoV-2Stress Disorders, Post-TraumaticTreatment OutcomeConceptsAdvanced practice practitionersSymptoms of depressionMontgomery-Asberg Depression Rating ScalePosttraumatic stress disorderSymptoms of burnoutMontgomery-Asberg Depression Rating Scale scoreSymptoms of posttraumatic stress disorderFrontline carePsilocybin therapyRandomized clinical trialsSevere symptoms of depressionMental health diagnosesScore changesImprove symptoms of depressionCOVID-19 pandemicPCL-5Intention-to-treat principleMedication sessionsDepression Rating ScalePCL-5 scoresPsychological morbidityHealth diagnosisMain OutcomesPractice practitionersUS cliniciansSuicide Risk Among Veterans Who Receive Evidence-Based Therapy for Posttraumatic Stress Disorder
Saulnier K, Brabbs S, Szymanski B, Harpaz-Rotem I, McCarthy J, Sripada R. Suicide Risk Among Veterans Who Receive Evidence-Based Therapy for Posttraumatic Stress Disorder. JAMA Network Open 2024, 7: e2452144. PMID: 39724372, PMCID: PMC11672158, DOI: 10.1001/jamanetworkopen.2024.52144.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCognitive Behavioral TherapyCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsStress Disorders, Post-TraumaticSuicideUnited StatesUnited States Department of Veterans AffairsVeteransConceptsVeterans Health AdministrationPosttraumatic stress disorder diagnosisVeterans Health Administration carePosttraumatic stress disorderSuicide riskStress disorderAdequate courseDeath certificate dataAssociated with lower suicide riskCohort study of veteransMortality Data RepositoryPopulation-based sampleStudy of veteransLower suicide riskReceipt of evidence-based treatmentsEvidence-based psychotherapiesMultivariable proportional hazards regressionProportional hazards regressionEvidence-based treatmentsAssociated with suicideEvidence-based therapiesCertificate dataSuicide mortalityHealth AdministrationMain OutcomesNovel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence
Sippel L, Hamblen J, Kelmendi B, Alpert J, Carpenter L, Grzenda A, Kraguljac N, McDonald W, Rodriguez C, Widge A, Nemeroff C, Schnurr P, Holtzheimer P, Biomarkers and Treatments T. Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence. American Journal Of Psychiatry 2024, 181: 1045-1058. PMID: 39616450, DOI: 10.1176/appi.ajp.20230950.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsCombined Modality TherapyEvidence-Based MedicineHumansHyperbaric OxygenationPsychotherapyStress Disorders, Post-TraumaticTranscranial Magnetic StimulationConceptsPosttraumatic stress disorderStress disorderPathophysiology of posttraumatic stress disorderNon-trauma-focused psychotherapyTrauma-focused psychotherapySomatic treatment approachesEvidence-based treatmentsAntidepressant medicationSomatic treatmentsPsychiatric disordersSomatic interventionsTranscranial magnetic stimulationPsychotherapyMagnetic stimulationTreatment approachesDisordersRecommended first-line treatmentAdultsFirst-line treatmentMedicationMechanism of actionMonotherapy strategySalienceSpecific treatmentEvidencePrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedComorbidityCost of IllnessDepressive Disorder, MajorFemaleHumansMaleMiddle AgedPrevalenceStress Disorders, Post-TraumaticUnited StatesVeteransYoung AdultConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaEmotionsFemaleHumansMagnetic Resonance ImagingMalePainReceptor, Cannabinoid, CB1Stress Disorders, Post-TraumaticYoung AdultMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnhedoniaBrainFemaleHumansLipopolysaccharidesMaleMicrogliaMiddle AgedNeuroimmunomodulationPositron-Emission TomographyReceptors, GABAStress Disorders, Post-TraumaticConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaNegative Life Events and Emotional Symptoms From Ages 2 to 30 Years
Copeland W, Keen R, Tong G, Shanahan L. Negative Life Events and Emotional Symptoms From Ages 2 to 30 Years. JAMA Network Open 2024, 7: e2429448. PMID: 39207754, PMCID: PMC11362870, DOI: 10.1001/jamanetworkopen.2024.29448.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnxietyChildChild, PreschoolCohort StudiesDepressionFemaleHumansLife Change EventsMaleStress Disorders, Post-TraumaticYoung AdultConceptsCross-sectional analysisEmotional symptomsNegative life eventsAssociated with emotional symptomsLife eventsYoung adulthoodAssociated with increased mental health symptomsCohort study analyzed dataStressful eventsTraumatic eventsMental health symptomsCross-sectional associationsLongitudinal analysisAged 2Years of follow-upStudy analyzed dataDevelopmental periodIndividuals aged 2Lifetime traumatic eventsHealth symptomsMain OutcomesLate adolescenceEmotional functioningCohort studyPrimary outcomePost-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study
Sharp T, Chideya Y, Giuliani A, Hunt X, Tomlinson M, Seedat S, Creswell C, Fearon P, Hamilton-Giachritsis C, Hiller R, Meiser-Stedman R, Du Toit S, Stewart J, Halligan S. Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study. BMJ Open 2024, 14: e085129. PMID: 38991675, PMCID: PMC11624694, DOI: 10.1136/bmjopen-2024-085129.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaregiversChildFemaleHumansLongitudinal StudiesMalePsychological TraumaResearch DesignSouth AfricaStress Disorders, Post-TraumaticConceptsMental health outcomesPost-traumatic stress disorderChildren aged 8Caregiver supportHealth outcomesAssociation of psychosocial factorsAdverse mental health outcomesAged 8Traumatic eventsChildren’s post-traumatic stress disorderDepartment of HealthMiddle-income countriesTrauma-related mental healthPsychological risk factorsHigh-income countriesStress disorder symptomsFollow-up assessmentPost-traumatic stress disorder symptomsCape TownMotor vehicle accidentsHealthcare clinicsPsychosocial factorsMental healthPsychological recoveryEthical approvalSelf-stigma mediates the relationships between childhood maltreatment and symptom levels of PTSD, depression, and anxiety
Haim-Nachum S, Lazarov A, Zabag R, Martin A, Bergman M, Neria Y, Amsalem D. Self-stigma mediates the relationships between childhood maltreatment and symptom levels of PTSD, depression, and anxiety. European Journal Of Psychotraumatology 2024, 15: 2370174. PMID: 38985020, PMCID: PMC11238652, DOI: 10.1080/20008066.2024.2370174.Peer-Reviewed Original ResearchMeSH KeywordsAdultAdult Survivors of Child AbuseAnxietyChild AbuseDepressionFemaleHumansMaleMiddle AgedRisk FactorsSelf ConceptSocial StigmaStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderChildhood maltreatmentSelf-stigmaChildhood abuseSymptom severity of depressionSymptom typeSubtypes of childhood maltreatmentSurvivors of childhood abuseChildhood trauma survivorsSeverity of depressionChildhood maltreatment experiencesSymptoms of depressionEffects of self-stigmaInternalization of negative stereotypesIncreased self-stigmaMental health problemsSignificant mediation effectAnxiety symptomsStress disorderChildhood neglectSymptom levelsMaltreatment experiencesTrauma survivorsSymptom severityPhysical neglectThe Psychological Impact of Wrongful Convictions: Exploring Retrospective Trajectories of Distress in Exonerees
Thomas K, Hoyt W. The Psychological Impact of Wrongful Convictions: Exploring Retrospective Trajectories of Distress in Exonerees. Psychological Trauma Theory Research Practice And Policy 2024, 16: 872-880. PMID: 36689380, DOI: 10.1037/tra0001425.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansMaleMiddle AgedPersonal SatisfactionPsychological DistressRetrospective StudiesStress Disorders, Post-TraumaticYoung AdultConceptsTrajectories of distressPositive world assumptionsGeneralized Anxiety Disorder-7Levels of PTSDPosttraumatic Growth InventorySatisfaction with Life ScaleRates of PTSDPresence of meaningFour-factor solutionPatient Health Questionnaire-9Satisfaction with lifePsychological impactWrongful convictionsDSM-5PTSD ChecklistAnxiety symptomsDepressive symptomsIntense distressWorld beliefsChronic distressBody of researchPTSDLife ScalePsychological experienceDistressEnhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records
Miranda O, Kiehl S, Qi X, Brannock M, Kosten T, Ryan N, Kirisci L, Wang Y, Wang L. Enhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records. BMC Medical Informatics And Decision Making 2024, 24: 154. PMID: 38835009, PMCID: PMC11151516, DOI: 10.1186/s12911-024-02554-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultElectronic Health RecordsFemaleHumansMaleMiddle AgedNatural Language ProcessingStress Disorders, Post-TraumaticConceptsNatural language processingPost-traumatic stress disorderPost-traumatic stress disorder patientsRDoC domainsLanguage processingAbnormal instancesLeverage natural language processingDiagnosis of post-traumatic stress disorderDomain criteriaSimilarity threshold valueF1-macro scorePositive valence systemsHeightened cue reactivityElectronic medical recordsClinical notesF1 scoreCue reactivityStress disorderRDoCValence systemsReal-timeMental health improvementDisease trajectoryExtraction researchSensorimotor disturbancesHelping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War
Kang H, Fischer I, Esterlis I, Kolyshkina A, Ponomarenko L, Chobanian A, Vus V, Pietrzak R. Helping the Helpers: Mental Health Challenges of Psychosocial Support Workers During the Russian-Ukrainian War. Disaster Medicine And Public Health Preparedness 2024, 18: e95. PMID: 38829179, DOI: 10.1017/dmp.2024.68.Peer-Reviewed Original ResearchMeSH KeywordsAdultBurnout, ProfessionalFemaleHumansMaleMental HealthMiddle AgedPrevalencePsychosocial Support SystemsRussiaStress Disorders, Post-TraumaticSuicidal IdeationSurveys and QuestionnairesUkraineConceptsPsychosocial support workersPosttraumatic stress disorderAssociated with greater oddsPresence of meaning in lifeMeaning in lifeSuicidal ideationMental health challengesGreater oddsMental healthLow optimismSupport workersHealth challengesMental health problemsCorrelates of burnoutPromote social connectednessStress disorderPsychosocial characteristicsGreater distressWar exposureGeneral populationHealth problemsSocial connectednessBurnoutOddsSocial relationships
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