2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingElastinFemaleHumansMaleMiddle AgedPulmonary ArteryVascular StiffnessYoung AdultConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingTransthoracic Echocardiography–Guided Placement of a Pulmonary Artery Catheter in a Patient With a Known Persistent Left but Unknown Absent Right Superior Vena Cava
Leclerc J, Clemes R, Fuss C, Macon C, Schulman P. Transthoracic Echocardiography–Guided Placement of a Pulmonary Artery Catheter in a Patient With a Known Persistent Left but Unknown Absent Right Superior Vena Cava. Circulation Cardiovascular Imaging 2024, 17: e016301. PMID: 38469718, DOI: 10.1161/circimaging.123.016301.Peer-Reviewed Original Research
2023
Pulmonary Artery Catheter Use and Outcomes in Patients With ST-Elevation Myocardial Infarction and Cardiogenic Shock Treated With Impella (a Nationwide Analysis from the United States)
Ismayl M, Hussain Y, Aboeata A, Walters R, Naidu S, Messenger J, Basir M, Rao S, Goldsweig A, Altin S. Pulmonary Artery Catheter Use and Outcomes in Patients With ST-Elevation Myocardial Infarction and Cardiogenic Shock Treated With Impella (a Nationwide Analysis from the United States). The American Journal Of Cardiology 2023, 203: 304-314. PMID: 37517125, DOI: 10.1016/j.amjcard.2023.06.117.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionCardiogenic shockCatheter useHospital mortalityPA catheterCatheter placementInpatient costsMyocardial infarctionPulmonary artery catheter placementPulmonary artery catheter useNational Inpatient Sample databaseMultivariate logistic regression analysisPA catheter placementUse of ImpellaSimilar complication ratesMechanical circulatory supportLength of stayLogistic regression analysisHospital complicationsHospital lengthBaseline characteristicsComplication rateHematologic complicationsMortality benefitSecondary outcomesPulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit
Kadosh B, Berg D, Bohula E, Park J, Baird-Zars V, Alviar C, Alzate J, Barnett C, Barsness G, Burke J, Chaudhry S, Daniels L, DeFilippis A, Delicce A, Fordyce C, Ghafghazi S, Gidwani U, Goldfarb M, Katz J, Keeley E, Kenigsberg B, Kontos M, Lawler P, Leibner E, Menon V, Metkus T, Miller P, O'Brien C, Papolos A, Prasad R, Shah K, Sinha S, Snell R, So D, Solomon M, Ternus B, Teuteberg J, Toole J, van Diepen S, Morrow D, Roswell R. Pulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit. JACC Heart Failure 2023, 11: 903-914. PMID: 37318422, PMCID: PMC10527413, DOI: 10.1016/j.jchf.2023.04.007.Peer-Reviewed Original ResearchMeSH KeywordsCathetersHeart FailureHospital MortalityHospitalizationHumansIntensive Care UnitsPulmonary ArteryConceptsCardiac intensive care unitPulmonary artery catheterUse of PACHospital mortalityCare unitPAC useCardiac patientsCritical Care Cardiology Trials NetworkPulmonary artery catheter usePatient-level factorsIll cardiac patientsIntensive care unitMechanical circulatory supportCardiac critical careAppropriate useCardiogenic etiologyAdmission diagnosisShock patientsCatheter useArtery catheterCICU admissionHeart failureRandomized trialsCirculatory supportCritical careInvasive Pulmonary Angiogram Performance and Interpretation in the Diagnosis of Pulmonary Thromboembolic Disease
Bae J, Murugiah K. Invasive Pulmonary Angiogram Performance and Interpretation in the Diagnosis of Pulmonary Thromboembolic Disease. Interventional Cardiology Clinics 2023, 12: 299-307. PMID: 37290835, PMCID: PMC10693920, DOI: 10.1016/j.iccl.2023.03.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAngiographyHumansHypertension, PulmonaryPulmonary ArteryPulmonary EmbolismThromboembolismConceptsInvasive pulmonary angiographyPulmonary thromboembolic diseasePulmonary angiographyThromboembolic diseaseGold standard diagnostic testSelective pulmonary angiographyOptimal patient positioningStandard diagnostic testNoninvasive imaging modalityPulmonary vascular anatomyAngiographic patternsCatheter selectionVascular accessVascular anatomyArterial conditionsAngiographyDiagnostic testsPatient positioningImaging modalitiesDiseaseTwenty-Seven-Year Retrospective Review of Hemoptysis from Systemic Collaterals Following Pulmonary Arteriovenous Malformation Embolization
Fish A, Chan S, Pollak J, Schlachter T. Twenty-Seven-Year Retrospective Review of Hemoptysis from Systemic Collaterals Following Pulmonary Arteriovenous Malformation Embolization. CardioVascular And Interventional Radiology 2023, 46: 670-674. PMID: 37052715, DOI: 10.1007/s00270-023-03435-9.Peer-Reviewed Original ResearchConceptsGelatin sponge slurrySystemic collateralsAdverse eventsTreatment outcomesPulmonary arteriovenous malformation (PAVM) embolizationMajor adverse eventsRecurrence of hemoptysisYear retrospective reviewArteriovenous malformation embolizationIncidence of hemoptysisHHT CenterArtery reperfusionICU admissionRight shuntingSystemic embolizationMassive hemoptysisRecurrent hemoptysisSurgical resectionMethodsThe recordsSubsequent patientsClinical featuresEndovascular treatmentMultifocal diseaseRetrospective reviewSecond patient
2022
Vascular pathobiology of pulmonary hypertension
Gallardo-Vara E, Ntokou A, Dave J, Jovin D, Saddouk F, Greif D. Vascular pathobiology of pulmonary hypertension. The Journal Of Heart And Lung Transplantation 2022, 42: 544-552. PMID: 36604291, PMCID: PMC10121751, DOI: 10.1016/j.healun.2022.12.012.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionCell typesSmooth muscle cell proliferationEndothelial cell dysfunctionMuscle cell proliferationKruppel-like factor 4Extracellular matrix remodelingHypoxia-inducible factorBox proteinBlood pressurePulmonary arteryInflammatory cellsPulmonary vasculatureMain cell typesVascular pathogenesisVasoactive moleculesCell dysfunctionClinical impactVascular pathobiologyPathological remodelingIntercellular crosstalkLethal diseaseMesenchymal transitionMatrix remodelingGrowth factorMultiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model.
Qin L, Jiang B, Zsebo K, Duckers H, Simons M, Chen P. Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model. Journal Of Visualized Experiments 2022 PMID: 36440832, DOI: 10.3791/63839.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalHemodynamicsHumansHypertension, PulmonaryHypoxiaMicePulmonary Arterial HypertensionPulmonary ArteryConceptsPulmonary arterial hypertensionInvasive hemodynamic assessmentHemodynamic assessmentPAH modelProgressive life-threatening diseaseGroup 3 diseaseRight ventricle catheterizationSmall pulmonary arteriolesIntravenous bolus dosingNew experimental therapiesLife-threatening diseaseAdministration of compoundsMouse jugular veinHuman clinical manifestationsArterial hypertensionHypertension modelPulmonary arteriolesClinical manifestationsBolus dosingExperimental therapiesIntravenous administrationJugular veinPAH researchMultiple injectionsTime courseTranspleural Systemic Artery-to-Pulmonary Artery Shunts: A Potential Mimicker of Pulmonary Arteriovenous Malformations
Fish A, Chan SM, Pollak J, Schlachter T. Transpleural Systemic Artery-to-Pulmonary Artery Shunts: A Potential Mimicker of Pulmonary Arteriovenous Malformations. Journal Of Vascular And Interventional Radiology 2022, 34: 300-303. PMID: 36283590, DOI: 10.1016/j.jvir.2022.10.028.Peer-Reviewed Original ResearchUsing Routine Chest Computed Tomography to Diagnose Pulmonary Embolism
Chan J, Ho B, Ye K, Haramati L, Jain V. Using Routine Chest Computed Tomography to Diagnose Pulmonary Embolism. Journal Of Computer Assisted Tomography 2022, 46: 888-893. PMID: 36399535, DOI: 10.1097/rct.0000000000001372.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansLungMaleMiddle AgedPulmonary ArteryPulmonary EmbolismThoraxTomography, X-Ray ComputedConceptsPulmonary embolismPulmonary artery enhancementContrast-enhanced chest CT scansHU thresholdContrast-enhanced chest CTAbsence of PEUnsuspected pulmonary embolismContrast-enhanced chestHounsfield unitsChest CT scanLogistic regression analysisPeripheral enhancementPulmonary vasculatureChest CTFemale sexRoutine chestContrast amountCT scanPulmonary enhancementTotal casesOlder ageEmbolismRegression analysisChestDescriptive statisticsDiseases of the pulmonary arteries: imaging appearances and pearls
Cortopassi IO, Gosangi B, Asch D, Bader AS, Gange CP, Rubinowitz AN. Diseases of the pulmonary arteries: imaging appearances and pearls. Clinical Imaging 2022, 91: 111-125. PMID: 36067656, DOI: 10.1016/j.clinimag.2022.08.018.Peer-Reviewed Educational MaterialsMeSH KeywordsHumansMagnetic Resonance ImagingPulmonary ArteryThoraxTomography, X-Ray ComputedVasculitisConceptsContrast-enhanced chest CTChest X-rayPulmonary arteryEnlarged pulmonary arteryPulmonary vascular pathologyPulmonary artery anatomyEveryday clinical practiceAsymptomatic patientsImaging findingsPulmonary vasculatureArtery anatomyChest CTUrgent treatmentMediastinal structuresVascular pathologyArteryClinical practicePhysiologic dataEntire thoraxVessel wallPatientsDetailed evaluationPathologyWide spectrumQuantification of flowCardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits
Romans RA, Lu JC, Balasubramanian S, Whiteside W, Yu S, Aldoss OT, Armstrong AK, Boe BA, Balzer DT, Christensen JT, Jones TK, Keeshan B, McLennan D, Nicholson GT, Patel N, Salavitabar A, Shahanavaz S, Sullivan PM, Turner ME, Zampi JD. Cardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits. JACC Cardiovascular Interventions 2022, 15: 979-988. PMID: 35512922, DOI: 10.1016/j.jcin.2022.02.047.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valve implantationCardiac magnetic resonanceRV-PA conduitCA compressionCoronary artery compressionPulmonary valve implantationArtery compressionValve implantationCoronary anatomyBalloon testingStenotic areaAbnormal coronary anatomyPulmonary artery conduitInstitutional review board approvalDysfunctional right ventricleReview board approvalNegative predictive valueConduit calcificationArtery conduitAbsolute contraindicationPatient selectionRight ventricleSubjective assessmentCMR studiesBoard approvalA rare etiology of tetralogy of Fallot with pulmonary atresia: Renpenning syndrome
Kaymakçalan H, Ercan-Şençiçek AG, Cebeci AN, Dong W, Yalçın A. A rare etiology of tetralogy of Fallot with pulmonary atresia: Renpenning syndrome. The Anatolian Journal Of Cardiology 2022, 26: 149-150. PMID: 35190366, PMCID: PMC8878915, DOI: 10.5152/anatoljcardiol.2021.554.Peer-Reviewed Case Reports and Technical NotesCharacterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension
Goel K, Egersdorf N, Gill A, Cao D, Collum S, Jyothula S, Huang H, Sauler M, Lee P, Majka S, Karmouty-Quintana H, Petrache I. Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension. Respiratory Research 2022, 23: 349. PMID: 36522710, PMCID: PMC9756782, DOI: 10.1186/s12931-022-02267-4.Peer-Reviewed Original ResearchConceptsSmall pulmonary arteriesChronic cigarette smokingPulmonary vascular remodelingPulmonary hypertensionPulmonary arteryLung microvasculatureVascular remodelingEndothelial cellsCOPD-PHMiR126 expressionChronic obstructive pulmonary disease patientsObstructive pulmonary disease patientsCOPD pulmonary hypertensionPulmonary artery sizePulmonary artery remodelingPulmonary disease patientsPulmonary vascular bedPulmonary arterial wallEndothelial cell marker CD31Microvascular endothelial cellsEndothelial cell markersVessel endothelial cellsNon-COPD lungsLarge vessel endothelial cellsArtery remodeling
2021
Prognostic Significance of Pulmonary Artery to Aorta Ratio and Other CT Markers in Pulmonary Fibrosis With and Without Emphysema
Zeba F, Yanning W, Melek J, Duan F, Atalay M, Jankowich M, Rounds S. Prognostic Significance of Pulmonary Artery to Aorta Ratio and Other CT Markers in Pulmonary Fibrosis With and Without Emphysema. Lung 2021, 199: 677-680. PMID: 34741227, DOI: 10.1007/s00408-021-00490-2.Peer-Reviewed Original ResearchMeSH KeywordsAortaEmphysemaHumansPrognosisPulmonary ArteryPulmonary FibrosisRetrospective StudiesTomography, X-Ray ComputedConceptsPulmonary hypertensionPulmonary fibrosisMain pulmonary artery diameterSingle-center retrospective studyAortic diameter ratioCombined pulmonary fibrosisPulmonary artery diameterAorta ratioEchocardiographic diagnosisPulmonary arteryArtery diameterPrognostic significanceRetrospective studyPatient populationCardiac remodelingFibrosisEmphysemaCT markersSpecific markersAA ratioDiameter/MarkersSurvivalHypertensionPatientsPulmonary CTA Reporting: AJR Expert Panel Narrative Review.
Tan S, Nance J, Haramati L, Rajiah P, Sherk W, Le Gal G, Stojanovska J. Pulmonary CTA Reporting: AJR Expert Panel Narrative Review. American Journal Of Roentgenology 2021, 218: 396-404. PMID: 34612678, DOI: 10.2214/ajr.21.26646.Peer-Reviewed Original ResearchConceptsPulmonary embolismPulmonary CTANarrative reviewAJR Expert Panel Narrative ReviewInvasive managementOutpatient basisSignificant thrombusFatal conditionCTA reportsClinical significanceAppropriate managementMedical teamPractice settingsInsignificant findingsRadiology reportsPertinent findingsCTARelevant findingsReportFindingsEmbolismReviewThrombusUbiquitous studiesLong-term Outcomes of Children Operated on for Anomalous Left Coronary Artery From the Pulmonary Artery
Thomas AS, Chan A, Alsoufi B, Vinocur JM, Kochilas L. Long-term Outcomes of Children Operated on for Anomalous Left Coronary Artery From the Pulmonary Artery. The Annals Of Thoracic Surgery 2021, 113: 1223-1230. PMID: 34419434, PMCID: PMC9012605, DOI: 10.1016/j.athoracsur.2021.07.053.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationLong-term outcomesAnomalous left coronary arteryLeft coronary arteryMitral regurgitationHospital deathCoronary reimplantationLV dysfunctionPulmonary arteryCoronary arteryMR severitySevere left ventricular dysfunctionBetter long-term survivalFavorable long-term outcomePediatric Cardiac Care ConsortiumCoronary artery reimplantationPreoperative mitral regurgitationTransplant-free survivalLeft ventricular dysfunctionSevere LV dysfunctionMitral valve operationsNational Death IndexRisk of deathOutcome of childrenLong-term survivalQuantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging
Rahaghi FN, Nardelli P, Harder E, Singh I, Sánchez-Ferrero GV, Ross JC, San José Estépar R, Ash SY, Hunsaker AR, Maron BA, Leopold JA, Waxman AB, San José Estépar R, Washko GR. Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging. CHEST Journal 2021, 160: 2220-2231. PMID: 34270966, PMCID: PMC8692106, DOI: 10.1016/j.chest.2021.06.069.Peer-Reviewed Original ResearchConceptsExercise pulmonary hypertensionPulmonary arterial hypertensionControl subjectsPulmonary hypertensionSmall vessel volumeArterial hypertensionPulmonary arteryPulmonary vasculatureVascular tortuosityVascular volumeArterial volumePrecapillary pulmonary hypertensionCohort of patientsPulmonary vascular volumeVenous manifestationsThromboembolic diseaseCT angiogramArterial tortuosityHypertensionCT scanVessel volumeHeterogeneous diseasePatientsStudy designArteryArterial load and right ventricular-vascular coupling in pulmonary hypertension
Oakland H, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Arterial load and right ventricular-vascular coupling in pulmonary hypertension. Journal Of Applied Physiology 2021, 131: 424-433. PMID: 34043473, PMCID: PMC8325619, DOI: 10.1152/japplphysiol.00204.2021.Peer-Reviewed Original ResearchConceptsPulmonary artery hypertensionRV-PA uncouplingPulmonary vascular resistancePressure waveform analysisRight ventriclePulmonary vascular impedancePulmonary hypertensionVascular impedanceRight heart catheterization dataRight ventricular-vascular couplingRV-pulmonary arterial couplingCpc-PH groupEjection fraction patientsHeart catheterization dataRV pressure curveRV-PA couplingLeft heart diseaseVentricular-vascular couplingSex-matched controlsAfterload parametersCpc-PHIpc-PHPH-HFpEFRV afterloadArtery hypertensionIntegrated Single-Cell Atlas of Endothelial Cells of the Human Lung
Schupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe’er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/circulationaha.120.052318.Peer-Reviewed Original ResearchConceptsDifferential expression analysisPrimary lung endothelial cellsLung endothelial cellsCell typesMarker genesExpression analysisSingle-cell RNA sequencing dataCross-species analysisVenous endothelial cellsEndothelial marker genesSingle-cell atlasMarker gene setsRNA sequencing dataEndothelial cellsSubsequent differential expression analysisDifferent lung cell typesResident cell typesLung cell typesCellular diversityEndothelial cell typesCapillary endothelial cellsHuman lung endothelial cellsPhenotypic diversityEndothelial diversityIndistinguishable populations
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