2025
Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes
Ferrante N, Hubbard R, Weinfurtner K, Mezina A, Newcomb C, Furth E, Bhattacharya D, Njei B, Taddei T, Singal A, Hoteit M, Park L, Kaplan D, Re V. Validity of Diagnostic Codes and Laboratory Tests to Identify Cholangiocarcinoma and Its Subtypes. Pharmacoepidemiology And Drug Safety 2025, 34: e70154. PMID: 40328444, PMCID: PMC12055315, DOI: 10.1002/pds.70154.Peer-Reviewed Original ResearchConceptsPositive predictive valueVeterans Health AdministrationExtrahepatic cholangiocarcinomaValidity of diagnostic codesInternational Classification of Diseases for OncologyUS Veterans Health AdministrationConfidence intervalsPharmacoepidemiological studiesICD-O-3Days of diagnosisVA dataHealth AdministrationIntrahepatic cholangiocarcinomaDiagnostic codesHistology codesCholangiocarcinomaUnique patientsInclusion criteriaCholangiocarcinoma subtypesTopography codesPredictive valuePatientsEvaluate medicationsSubtypesEvaluate determinantsAGA Living Clinical Practice Guideline on Computer-Aided Detection–Assisted Colonoscopy
Sultan S, Shung D, Kolb J, Foroutan F, Hassan C, Kahi C, Liang P, Levin T, Siddique S, Lebwohl B. AGA Living Clinical Practice Guideline on Computer-Aided Detection–Assisted Colonoscopy. Gastroenterology 2025, 168: 691-700. PMID: 40121061, DOI: 10.1053/j.gastro.2025.01.002.Peer-Reviewed Original ResearchConceptsSessile serrated lesion detection rateSerrated lesion detection rateDetection of colorectal polypsSystematic reviewAdenoma detection rateIntensive surveillance colonoscopyPreferences of patientsClinical practice guidelinesSystematic review of studiesPatient-important outcomesCertainty of evidenceAmerican Gastroenterological Association (AGAAdvanced adenomasSurveillance colonoscopyComputer-aided detectionEffect of computer-aided detectionColorectal polypsProvider trustGuideline methodologistsRecommendations AssessmentReview of studiesMultidisciplinary panelColonoscopyIncreasing burdenContent expertsPathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening
Sato Y, Torii S, Kawai K, Yahagi K, Kutyna M, Kawakami R, Konishi T, Vozenilek A, Jinnouchi H, Sakamoto A, Mori H, Cornelissen A, Mori M, Tanaka T, Sekimoto T, Kutys R, Ghosh S, Forrest J, Reardon M, Romero M, Kolodgie F, Virmani R, Finn A. Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening. Circulation Cardiovascular Interventions 2025, 18: e014523. PMID: 39965045, PMCID: PMC11827688, DOI: 10.1161/circinterventions.124.014523.Peer-Reviewed Original ResearchConceptsHypoattenuated leaflet thickeningLeaflet thickeningHistological findingsClinical trialsEvaluate histological findingsAortic valve proceduresSelf-expanding transcatheter aortic valvesAortic bioprosthetic valvesAortic valve leafletsInfective endocarditisValve proceduresTranscatheter aortic valveValve thrombosisAortic bioprosthesesSurgical explantationInflammation scoreAortic valveAcute thrombusImplant durationOrganized thrombusBioprosthetic valvesDay groupLeaflet thrombosisThrombusValve leafletsQuality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial
Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Rogers C, Patel M, Baloch K, Chow B, Anstrom K, Vemulapalli S, Weir-McCall J, Stone G, Chew D, Douglas P, Investigators O. Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011414. PMID: 39895494, PMCID: PMC11837958, DOI: 10.1161/circoutcomes.124.011414.Peer-Reviewed Original ResearchConceptsQuality of lifeSAQ Summary ScoreSummary scoreOveral quality of lifeAssess quality of lifeGeneric health statusQuality of life outcomesBaseline SAQ scoresCoronary artery diseaseQuality of life assessmentFollow-up time pointsClinically meaningful differencesStable patientsFollow-upArtery diseaseEQ-5DHealth statusMonths postrandomizationSuspected coronary diseaseComponent scoresSatisfaction surveySuspected coronary artery diseaseTrial participantsStable chest painTest groupEconomic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial
Chew D, Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Davidson-Ray L, Baloch K, Rogers C, Patel M, Anstrom K, Curzen N, Vemulapalli S, Douglas P, Investigators O. Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011008. PMID: 39895495, PMCID: PMC11837965, DOI: 10.1161/circoutcomes.123.011008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, StableComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCost SavingsCost-Benefit AnalysisFemaleFractional Flow Reserve, MyocardialHospital CostsHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsChest painObstructive coronary artery diseaseCoronary computed tomographic angiographyStable chest painCoronary artery bypass surgeryLow-risk patientsSecondary end pointsPrimary composite of deathPrecision strategyComputed tomographic angiographyHealth care system perspectiveComposite of deathUS health care system perspectiveArtery bypass surgeryMedical costsMean cost differenceNonfatal myocardial infarctionCoronary artery diseaseIntention-to-treatPercutaneous coronary interventionUsual testsEstimated total medical costTotal medical costsClinical practice guidelinesRisk patientsDiagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments
Travers S, Alexandre J, Baldassarre L, Salem J, Mirabel M. Diagnosis of cancer therapy-related cardiovascular toxicities: A multimodality integrative approach and future developments. Archives Of Cardiovascular Diseases 2025, 118: 185-198. PMID: 39947997, DOI: 10.1016/j.acvd.2024.12.012.Peer-Reviewed Original ResearchConceptsCardio-oncologyCardiovascular toxicityCardiovascular imagingMultimodality cardiovascular imagingCancer risk factorsIncrease diagnostic accuracyPrognostic stratificationNatriuretic peptideSerum biomarkersTherapy schemesDiagnostic accuracyCancer therapyRhythm disordersRisk factorsCardiovascular diseaseBiomarkersMultimodal integrated approachCancerOmics approachesToxicityRhythmTherapyTroponinSerumDiagnosisDevelopment of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting
Wang Y, Gao M, Zhao X, Han P, Zhang L, Dardik A. Development of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting. Annals Of Vascular Surgery 2025, 113: 175-185. PMID: 39855385, DOI: 10.1016/j.avsg.2024.12.068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlloysDecision Support TechniquesEndovascular ProceduresFemaleFemoral ArteryHumansMaleMiddle AgedNomogramsPeripheral Arterial DiseasePredictive Value of TestsRecurrenceReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsSelf Expandable Metallic StentsStentsTime FactorsTreatment OutcomeConceptsIn-stent restenosisSuperficial femoral arteryDecision curve analysisSuperficial femoral artery stentingLogistic regression analysisPeripheral arterial diseaseReceiver operating characteristicNomogram modelClinical utilityCurve analysisMultivariate logistic regression analysisSelf-expanding bare nitinol stentsTreated with stentingReceiver operating characteristic curveRisk of in-stent restenosisNomogram's clinical utilityBare nitinol stentsPrediction of in-stent restenosisExcellent discriminatory powerRegression analysisFemoral artery stentingArtery flow rateRetrospective studyTraining cohortSFA stentingPredicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry
Faridi K, Wang Y, Minges K, Smilowitz N, McNamara R, Kontos M, Wang T, Connors A, Clary J, Osborne A, Pereira L, Curtis J, Blankinship K, Mayfield J, Abbott J. Predicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011259. PMID: 39801472, PMCID: PMC11919567, DOI: 10.1161/circoutcomes.124.011259.Peer-Reviewed Original ResearchConceptsNational Cardiovascular Data Registry Chest Pain-MI RegistryIn-hospital mortalityAcute myocardial infarctionChest Pain-MI RegistryOut-of-hospital cardiac arrestRisk scoreRisk-standardized modelsNational Cardiovascular Data RegistryAcute MI hospitalizationsPatient characteristicsMyocardial infarctionContemporary risk modelsIn-hospital mortality rateMI hospitalizationST-segment elevation MIIndependent predictor of mortalityMortality risk predictionSystolic blood pressureMortality riskPredictors of mortalityHospital volumePatient prognosticationData RegistryRisk modelSimplified risk scoreHow to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology
Khattab M, Baig M, Zarif T, Barac A, Ferencik M, Henry M, Lopez-Mattei J, Redheuil A, Salem J, Scherrer-Crosbie M, Yang E, Baldassarre L. How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology. Circulation Cardiovascular Imaging 2025, 18: e015981. PMID: 39772610, DOI: 10.1161/circimaging.124.015981.Peer-Reviewed Original ResearchConceptsCardio-oncologyCases of atherosclerosisCardiac magnetic resonance imagingCoronary computed tomography angiographySingle-photon emission computed tomographyImmune checkpoint inhibitorsLeft ventricular dysfunctionMultimodality cardiac imagingTyrosine kinase inhibitorsCardiac imaging modalitiesComputed tomography angiographyRisk of cardiovascular diseaseEmission computed tomographyPositron emission tomographyMagnetic resonance imagingCheckpoint inhibitorsVentricular dysfunctionMyocardial inflammationCoronary vasospasmAccelerated atherosclerosisKinase inhibitorsPatient populationDiagnosing such pathologiesCancer therapyCardiac imaging
2024
Accuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator
Sheikh Z, Dhakar M, Fong M, Fang W, Ayub N, Molino J, Haider H, Foreman B, Gilmore E, Mizrahi M, Karakis I, Schmitt S, Osman G, Yoo J, Hirsch L. Accuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator. Neurology 2024, 104: e210234. PMID: 39724534, DOI: 10.1212/wnl.0000000000210234.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedElectroencephalographyFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesSeizuresStatus EpilepticusYoung AdultConceptsElectrographic status epilepticusNegative predictive valueStatus epilepticusTreat nonconvulsive status epilepticusPredictive valueCo-primary outcome measuresNonconvulsive status epilepticusPositive predictive valueRetrospective observational studyClass II evidenceLow-to-moderate sensitivityLimited-resource settingsII evidenceTriage patientsObservational studyPatientsRegional hospitalOutcome measuresExpert reviewEpilepticusScreening toolCommunity hospitalBurden estimatesEEGPPVPrognostic significance of phase analysis using SPECT myocardial perfusion imaging in heart failure: a systematic review and meta-analysis
Lee K, Han S, Ryu J, Cho S, Moon D. Prognostic significance of phase analysis using SPECT myocardial perfusion imaging in heart failure: a systematic review and meta-analysis. The International Journal Of Cardiovascular Imaging 2024, 41: 27-35. PMID: 39535673, DOI: 10.1007/s10554-024-03278-6.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac-Gated Single-Photon Emission Computer-Assisted TomographyFemaleHeart FailureHumansMaleMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular mechanical dyssynchronyMyocardial perfusion SPECTHF patientsCardiac deathHeart failurePrognostic significancePrognostic valueGated SPECTPerfusion SPECTPooled HRMeta-analysisHazard ratioSPECT myocardial perfusion imagingAll-causeVentricular mechanical dyssynchronyAdverse cardiac eventsMyocardial perfusion imagingAdverse cardiovascular eventsPublication biasConfidence intervalsAnalysis of SPECTSystematic reviewRandom-effects modelMechanical dyssynchronyPrognostic factorsA Validated Algorithm to Identify Hepatic Decompensation in the Veterans Health Administration Electronic Health Record System
Haque L, Tate J, Chew M, Caniglia E, Taddei T, Re V. A Validated Algorithm to Identify Hepatic Decompensation in the Veterans Health Administration Electronic Health Record System. Pharmacoepidemiology And Drug Safety 2024, 33: e70024. PMID: 39477692, PMCID: PMC11631147, DOI: 10.1002/pds.70024.Peer-Reviewed Original ResearchConceptsVeterans Health Administration dataHealth administrative dataAdministrative dataElectronic health record systemsHealth record systemsInternational Classification of DiseasesCoding algorithmOutpatient International Classification of DiseasesPositive predictive valueClassification of DiseasesHepatic decompensationDiagnosis codesPharmacoepidemiologic researchMedical recordsVeteransRecording systemValidation algorithmAlgorithmChronic liver diseaseDecompensationLiver diseasePredictive valueRecordsDiagnosisIschemia-Guided Management Using Cardiac SPECT: Reconciling Real-World Evidence in a Post-ISCHEMIA Trial World
Villines T, Hur D. Ischemia-Guided Management Using Cardiac SPECT: Reconciling Real-World Evidence in a Post-ISCHEMIA Trial World. Circulation Cardiovascular Imaging 2024, 17: e017377. PMID: 39247948, PMCID: PMC11408079, DOI: 10.1161/circimaging.124.017377.Peer-Reviewed Original ResearchDiagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
Toljan K, Daboul L, Raza P, Martin M, Cao Q, O’Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. Multiple Sclerosis Journal 2024, 30: 1268-1277. PMID: 39234802, PMCID: PMC11421977, DOI: 10.1177/13524585241271988.Peer-Reviewed Original ResearchConceptsCentral vein signPositive predictive valueOligoclonal bandsDiagnostic performanceMS diagnosisCerebrospinal fluidMultiple sclerosisPredictive valueNegative predictive valueCerebrospinal fluid testingRadiological suspicionDiagnostic accuracyImaging biomarkersDiagnosisDiagnostic biomarkersMonthsSclerosisBiomarkersPilot studyBaselineSelection 3Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIVIs There More to POCUS Than the Heart and Lungs in the Parturient—Venous Excess Ultrasound Score?
Munoz-Acuna R, Charchaflieh J, Deshpande R. Is There More to POCUS Than the Heart and Lungs in the Parturient—Venous Excess Ultrasound Score? Anesthesia & Analgesia 2024, 139: e23-e25. PMID: 39151137, DOI: 10.1213/ane.0000000000007100.Peer-Reviewed Original ResearchRelationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design
Al-Karaghouli M, Ventura-Cots M, Wong Y, Genesca J, Bosques F, Brown R, Mathurin P, Louvet A, Shawcross D, Vargas V, Verna E, Schnabl B, Caballeria J, Shah V, Kamath P, Lucey M, Garcia-Tsao G, Bataller R, Abraldes J. Relationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design. Hepatology Communications 2024, 8: e0495. PMID: 39082963, DOI: 10.1097/hc9.0000000000000495.Peer-Reviewed Original ResearchMeSH KeywordsAdultEnd Stage Liver DiseaseFemaleHepatitis, AlcoholicHumansLiver TransplantationMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesSeverity of Illness IndexConceptsAlcohol-associated hepatitisTrial designRandomized controlled trialsShort-term mortalityInclusion criteriaPredictive valuePrognostic valueControlled trialsShort-term benefitsEfficient trial designTrial outcomesAssociated with significant mortalityCourse of AHCohort of patientsTreatment decisionsSample sizeOrdinal outcomesMortalityOrdinal scaleMELD valuesLandmark analysisTransplant allocationTrialsOutcomesTransplantationEEG for good outcome prediction after cardiac arrest: A multicentre cohort study
Turella S, Dankiewicz J, Ben-Hamouda N, Nilsen K, Düring J, Endisch C, Engstrøm M, Flügel D, Gaspard N, Grejs A, Haenggi M, Haffey S, Imbach L, Johnsen B, Kemlink D, Leithner C, Legriel S, Lindehammar H, Mazzon G, Nielsen N, Peyre A, Stanford B, Roman-Pognuz E, Rossetti A, Schrag C, Valeriánová A, Wendel-Garcia P, Zubler F, Cronberg T, Westhall E, investigators T. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study. Resuscitation 2024, 202: 110319. PMID: 39029579, DOI: 10.1016/j.resuscitation.2024.110319.Peer-Reviewed Original ResearchConceptsMalignant EEG patternsEEG reactivityReactive EEGsCardiac arrestComatose patientsEEG patternsOut-of-hospital cardiac arrest trialModified Rankin Scale scoreMulticentre cohort studyRankin Scale scoreLong-term outcomesOut-of-hospitalCardiac arrest trialsSpecificity of EEGEEG assessmentHospital stayGood outcomeMultimodal prognosticationPrognostic performanceNon-highlyPrognostic abilityCohort studyMalignant patternArrest trialsBurst suppressionElevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement
Feroze R, Kang P, Dallan L, Akula N, Galo J, Yoon S, Ukaigwe A, Filby S, Baeza C, Pelletier M, Rushing G, Rajagopalan S, Al‐Kindi S, Rashid I, Attizzani G. Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2024, 104: 1119-1128. PMID: 38952304, DOI: 10.1002/ccd.31136.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedAged, 80 and overAortic ValveAortic Valve StenosisArea Under CurveAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialFemaleFibrosisHeart Conduction SystemHumansMagnetic Resonance Imaging, CineMaleMyocardiumPacemaker, ArtificialPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementCardiac magnetic resonance imagingLate gadolinium enhancementRight bundle branch blockArea under the receiver operating characteristic curveAortic valve replacementReceiver operating curveMyocardial fibrosisPost-TAVRConduction defectsBundle branch blockAssociations of myocardial fibrosisExtracellular volumeConduction diseaseValve replacementGadolinium enhancementPermanent pacemakerConduction abnormalitiesConduction deficitsHeart blockBranch blockRisk of heart blockSeptal late gadolinium enhancementMyocardial extracellular volume fractionBaseline conduction diseaseArtificial Intelligence Helps Pathologists Increase Diagnostic Accuracy and Efficiency in the Detection of Breast Cancer Lymph Node Metastases
Retamero J, Gulturk E, Bozkurt A, Liu S, Gorgan M, Moral L, Horton M, Parke A, Malfroid K, Sue J, Rothrock B, Oakley G, DeMuth G, Millar E, Fuchs T, Klimstra D. Artificial Intelligence Helps Pathologists Increase Diagnostic Accuracy and Efficiency in the Detection of Breast Cancer Lymph Node Metastases. The American Journal Of Surgical Pathology 2024, 48: 846-854. PMID: 38809272, PMCID: PMC11191045, DOI: 10.1097/pas.0000000000002248.Peer-Reviewed Original ResearchConceptsLymph node metastasisNode metastasisDetection of lymph node metastasesBreast cancer lymph node metastasisMetastasis detection rateWhole slide imagesBreast cancer stageArtificial intelligenceIncrease diagnostic accuracyReading pathologistsCancer stageDiagnostic accuracyMetastasisCancer metastasisAverage reading timeBreastPathologistsDetection rateAI algorithms
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