2025
Virtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge
Li J, Reuter M, Schmidt J, Moore N, Forget N, Carron J, Ernest J, Williams M. Virtual Patient-PCP-Hospitalist Care Transition Meeting Before Hospital Discharge. JAMA Network Open 2025, 8: e2515848. PMID: 40512492, PMCID: PMC12166488, DOI: 10.1001/jamanetworkopen.2025.15848.Peer-Reviewed Original ResearchConceptsPrimary care practitionersAcceptability of Intervention MeasureIntervention appropriateness measureQuality improvement studyImprovement studyPerceptions of care coordinationCenters for Medicare & Medicaid ServicesHospital dischargeHealth care systemIncrease patient confidenceOpen-ended questionsFamily caregiversCare coordinationRelational EmpathyDischarge planningPatient feedbackCare practitionersCare questionsCare systemPatients' perceptionsMedicaid ServicesPatient confidenceHospital settingHospitalistsMain OutcomesMultilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study
Whittemore R, Jeon S, Akyirem S, Chen H, Lipson J, Minchala M, Wagner J. Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study. JMIR Formative Research 2025, 9: e67293. PMID: 40131327, DOI: 10.2196/67293.Peer-Reviewed Original ResearchConceptsCommunity health centersPatient portal useDigital health literacyPortal useHealth literacyMultilevel interventionsType 2 diabetesSocial determinants of healthDiabetes self-management educationCommunity health workersImprove health equityDeterminants of healthSelf-management educationDiabetes self-efficacyHealth-related outcomesBarriers to clinical integrationPre-post designHemoglobin A<sub>1c</sub> levelDiabetes distressHealth equityPatient portalsSocial determinantsDeliver carePortal accountHealth appsThe effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study
Devroey M, Orbegozo Cortes D, Gaspard N, Foucart J, Preiser J, Taccone F. The effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study. Journal Of Critical Care 2025, 87: 155044. PMID: 40036993, DOI: 10.1016/j.jcrc.2025.155044.Peer-Reviewed Original ResearchConceptsMusic intervention groupMusic interventionMV weaningIntervention groupVisual analog scaleCalm musicMusicCritically ill patientsAnxiety levelsIll patientsPilot studyMechanical ventilationReduce anxietyCriticismCortisol blood levelsEfficacy of hypnosisDistressing symptomsEffects of hypnosisHypnosis groupInclusion criteriaPrimary outcomeEligible patientsInterventionSpontaneous breathing trialAnalog scaleOtoacoustic Emissions Testing to Identify Hearing Loss in the ICU: A Feasibility Study
Kaushik R, Reed N, Ferrante L. Otoacoustic Emissions Testing to Identify Hearing Loss in the ICU: A Feasibility Study. Critical Care Explorations 2025, 7: e1223. PMID: 40028925, PMCID: PMC11878990, DOI: 10.1097/cce.0000000000001223.Peer-Reviewed Original ResearchConceptsOtoacoustic emission testingOtoacoustic emissionsHearing lossHearing impairmentIdentification of hearing lossAbsence of otoacoustic emissionsTreatment of hearing lossPost-ICU recoveryPrimary outcome of feasibilityOlder ICU survivorsOutcomes of feasibilitySevere hearing impairmentMedical ICUAssociated with deliriumICU survivorsTertiary medical centerImprove communicationResponse to auditory stimulationTest completionAverage timePrimary outcomeMedical CenterIllness severityComplete dataAuditory stimulationBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthChronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoringObservational pilot using a Data to Care intervention strategy to promote HCV re-engagement and cure for persons with HIV/HCV co-infection who are out of care
Wegener M, Gosselin D, Brooks R, Speers S, Villanueva M. Observational pilot using a Data to Care intervention strategy to promote HCV re-engagement and cure for persons with HIV/HCV co-infection who are out of care. BMC Health Services Research 2025, 25: 140. PMID: 39856760, PMCID: PMC11763122, DOI: 10.1186/s12913-025-12307-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiviral AgentsCoinfectionConnecticutFemaleHepatitis CHIV InfectionsHumansMaleMiddle AgedPilot ProjectsConceptsDepartment of Public HealthHepatitis C virus treatment initiationHIV/HCV co-infectionHepatitis C virusPublic health strategiesConnecticut Department of Public HealthRe-engagementMethodsIn partnershipOutreach outcomesCare engagementCo-infectionHealth strategiesTreatment initiationHIV/HCV co-infected personsHepatitis C virus cureFollow-up approachHepatitis C virus treatmentCo-infected personsDirect-acting antiviralsIntervention strategiesPublic healthOutreach effortsPersons co-infectedHIVObservational pilotAuthors' Reply: Commentary on “Protecting User Privacy and Rights in Academic Data-Sharing Partnerships: Principles From a Pilot Program at Crisis Text Line”
Pisani A, Gallo C, Gould M, Kanuri N, Marcotte J, Pascal B, Rousseau D, Ranney M, Filbin B, Turner S. Authors' Reply: Commentary on “Protecting User Privacy and Rights in Academic Data-Sharing Partnerships: Principles From a Pilot Program at Crisis Text Line”. Journal Of Medical Internet Research 2025, 27: e59734. PMID: 39842004, PMCID: PMC11799806, DOI: 10.2196/59734.Peer-Reviewed Original ResearchConceptsProtection of vulnerable populationsEthical data sharingRefining best practicesInstitutional review boardVulnerable populationsEthical conductData sharingEthical research practiceHealth researchEthical processJudgment callsDigital ageNonprofit organizationsReview boardAcademic researchBest practicesCommentaryEvolving natureCrisis Text LineInformation usersDigital health researchOriginal workPilot programSafeguardsResearch purposesPredicting Elevated Postvoid Residual Urine Volume Following OnabotulinumtoxinA Treatment for Overactive Bladder: A Pilot Study
Franco I, Schwartz M, Cline K, Glazier D, Patel A. Predicting Elevated Postvoid Residual Urine Volume Following OnabotulinumtoxinA Treatment for Overactive Bladder: A Pilot Study. LUTS Lower Urinary Tract Symptoms 2025, 17: e70004. PMID: 39800349, PMCID: PMC11725389, DOI: 10.1111/luts.70004.Peer-Reviewed Original ResearchConceptsOveractive bladderUrine flow rateOnabotulinumtoxinA treatmentPatient ageElevated postvoid residual urine volumeElevated postvoid residual volumePostvoid residual urine volumePeak urine flow rateSymptoms of overactive bladderAverage urine flow ratePostvoid residual volumeIdiopathic overactive bladderResidual urine volumeOveractive bladder treatmentEvaluate potential predictorsLogistic regression analysisMedical chart dataOnabotulinumtoxinA administrationIndex therapyUrinary urgencyRetrospective reviewUrine volumeUrology clinicPVR valuesUrinary conditionPregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic functionDirect oral anticoagulants or warfarin in patients with left ventricular thrombus after ST-elevation myocardial infarction: a pilot trial and a prespecified meta-analysis of randomised trials.
Jenab Y, Sadeghipour P, Mohseni-Badalabadi R, Kaviani R, Hosseini K, Pasebani Y, Khederlou H, Rafati A, Mohammadi Z, Jamalkhani S, Talasaz A, Firouzi A, Ariannejad H, Alemzadeh-Ansari M, Ahmadi-Renani S, Maadani M, Farrashi M, Bakhshandeh H, Piazza G, Krumholz H, Mehran R, Lip G, Bikdeli B. Direct oral anticoagulants or warfarin in patients with left ventricular thrombus after ST-elevation myocardial infarction: a pilot trial and a prespecified meta-analysis of randomised trials. EuroIntervention 2025, 21: 82-92. PMID: 39773831, PMCID: PMC11684328, DOI: 10.4244/eij-d-24-00527.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionLeft ventricular thrombusLeft ventricular thrombus resolutionRandomised clinical trialsPooled analysisVentricular thrombusTreatment of left ventricular thrombusTwo-dimensional transthoracic echocardiographyMyocardial infarctionDirect oral anticoagulantsImaging core laboratoryWarfarin-based anticoagulationMeta-analysis of randomised trialsTransthoracic echocardiographyOpen-labelOral anticoagulantsBleeding eventsAdult patientsDOACsCore laboratoryWarfarinClinical trialsRandomised trialsPatientsBleeding
2024
HPV Status and Oral Health Symptom Patterning During Treatment and Survivorship in Patients With Head and Neck Cancer: A Longitudinal Analysis.
Dunnack Yackel H, Xu W, Wun Lee J, Cong X, Salner A, Duffy V, Judge M. HPV Status and Oral Health Symptom Patterning During Treatment and Survivorship in Patients With Head and Neck Cancer: A Longitudinal Analysis. Oncology Nursing Forum 2024, 51: 565-575. PMID: 39431692, DOI: 10.1188/24.onf.565-575.Peer-Reviewed Original ResearchConceptsHead and neck cancerOral health symptomsHuman papillomavirusNeck cancerHPV-negative head and neck cancersHealth symptomsHuman papillomavirus statusRetrospective longitudinal chart reviewSocial determinants of healthRegional cancer instituteDeterminants of healthLongitudinal chart reviewConcurrent chemotherapyHPV statusRadiation therapyLatent transition analysisChart reviewSymptom patternsSocial determinantsImprove outcomesCancer InstitutePatientsTime pointsEarly interventionLongitudinal analysisIntensive, Real-Time Data Collection of Psychological and Physiological Stress During a 96-Hour Field Training Exercise at a Senior Military College: Feasibility and Acceptability Cohort Study
Pojednic R, Welch A, Thornton M, Garvey M, Grogan T, Roberts W, Ash G. Intensive, Real-Time Data Collection of Psychological and Physiological Stress During a 96-Hour Field Training Exercise at a Senior Military College: Feasibility and Acceptability Cohort Study. JMIR Formative Research 2024, 8: e60925. PMID: 39422988, PMCID: PMC11530722, DOI: 10.2196/60925.Peer-Reviewed Original ResearchConceptsField training exercisePhysical fitnessArmy Reserve Officers' Training Corps cadetsDiagnosis of mental health disordersTraining exercisesPsychological resiliencePoor physical fitnessReserve Officer Training Corps cadetsSelf-reported injuriesMental health disordersField-based trainingData collectionDaily wear timeMilitary field training exercisePhysical readinessTesting adherenceParticipant acceptabilityWear timeHealth disordersMilitary readinessAcceptability surveyOccupational stressorsCohort studyProspective pilot studyEconomic burdenPre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates
Jansen C, Pagadala M, Cardenas M, Prabhu R, Goyal S, Zhou C, Chappa P, Vo B, Ye C, Hopkins B, Zhong J, Klie A, Daniels T, Admassu M, Green I, Pfister N, Neill S, Switchenko J, Prokhnevska N, Hoang K, Torres M, Logan S, Olson J, Nduom E, del Balzo L, Patel K, Burri S, Asher A, Wilkinson S, Lake R, Kesarwala A, Higgins K, Patel P, Dhere V, Sowalsky A, Carter H, Khan M, Kissick H, Buchwald Z. Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates. Nature Communications 2024, 15: 8854. PMID: 39402027, PMCID: PMC11473782, DOI: 10.1038/s41467-024-53034-6.Peer-Reviewed Original ResearchConceptsPre-operative stereotactic radiosurgeryCD8 T cellsEffector-like cellsT cellsStereotactic radiosurgeryBrain metastasesCD8 T cell responsesEndpoint of overall survivalDistant brain failureResected brain metastasesEfficacy of immunotherapyT cell responsesAntigen presenting cellsSecondary clinical endpointsLocal recurrenceLeptomeningeal diseaseOverall survivalImmune compositionProspective trialsImmune nichePrimary endpointImmunological correlatesPresenting cellsClinical outcomesPilot studyDevelopment and feasibility of the peer and nurse-led HIV Self-Testing Education and Promotion (STEP) intervention among social networks of men in Dar es Salaam, Tanzania: application of the ADAPT-ITT model
Conserve D, Abu-Ba’are G, Janson S, Mhando F, Munisi G, Drezgic B, Rehani A, Sims W, Ritchwood T, Choko A, Mushy S, Johnson C, Jennings Mayo-Wilson L, Komba A, Urasa P, Nelson L, Mbita G. Development and feasibility of the peer and nurse-led HIV Self-Testing Education and Promotion (STEP) intervention among social networks of men in Dar es Salaam, Tanzania: application of the ADAPT-ITT model. BMC Health Services Research 2024, 24: 1166. PMID: 39358728, PMCID: PMC11445879, DOI: 10.1186/s12913-024-11586-9.Peer-Reviewed Original ResearchConceptsHIV self-testingFollow-up servicesADAPT-ITT modelHealthcare facilitiesADAPT-ITTPeer educatorsPromote HIV self-testingHIV self-test kitsDistribution of HIVST kitsTanzania HIV Impact SurveyIncrease HIV testingImplementation science projectSocial networks of menFollow-up surveyNational testing strategySelf-test resultsHIV testingHIVST kitsSelf-testingCommunity settingsMethodsThe developmentHIV statusDar es SalaamImpact SurveyNetworks of menBuilding Frontline Capability for Shared Decision-Making (SDM) in a Major Academic Oncology Center Caring for People With Non–Small Cell Lung Cancer: Performance Outcomes of a SDM Simulation Training Program
Alexander C, Hakim H, Rudell E, Ingram M, Agrawal T, Peterson P, Davies M, Adelson K, Oliver B. Building Frontline Capability for Shared Decision-Making (SDM) in a Major Academic Oncology Center Caring for People With Non–Small Cell Lung Cancer: Performance Outcomes of a SDM Simulation Training Program. The Permanente Journal 2024, 28: 200-211. PMID: 39269220, PMCID: PMC11404653, DOI: 10.7812/tpp/23.160.Peer-Reviewed Original ResearchConceptsShared decision-makingPractice settingsImplementation of shared decision-makingSDM trainingTraining programSimulation training programMultidisciplinary cliniciansCentered carePatient goalsPost-trainingClinician experienceFocus groupsClinical careSelf-efficacyParticipants' understandingClinician awarenessPostinterventionPilot studyActive participationParticipantsProgram designCareCliniciansBody of evidenceGrowing body of evidenceEvaluating the impact of a year-long external mentorship pilot program in classical hematology
Qureshy Z, Nair P, Vesely S, King A, Lee A, Connell N, von Drygalski A, Wong-Sefidan I, Murphy M, Mistry R, Zon R, Reid E, Fritz J, Park S. Evaluating the impact of a year-long external mentorship pilot program in classical hematology. Blood Advances 2024, 8: 4833-4844. PMID: 39087874, PMCID: PMC11416643, DOI: 10.1182/bloodadvances.2024013218.Peer-Reviewed Original ResearchMeSH KeywordsFellowships and ScholarshipsFemaleHematologyHumansMaleMentoringMentorsPilot ProjectsSurveys and QuestionnairesConceptsMentorship programMixed-methods sequential explanatory designScholarly projectsPerceived positive impactSequential explanatory designFocus groupsHematology/oncology fellowsMentee focus groupMedical education institutionsPilot programMentorship opportunitiesMentor respondentsEffective mentorshipMedical oncologyExplanatory designMentor surveysFaculty mentorsMentee perceptionsMentorshipProfessional identityMenteesDiagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis
Toljan K, Daboul L, Raza P, Martin M, Cao Q, O’Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. Multiple Sclerosis Journal 2024, 30: 1268-1277. PMID: 39234802, PMCID: PMC11421977, DOI: 10.1177/13524585241271988.Peer-Reviewed Original ResearchConceptsCentral vein signPositive predictive valueOligoclonal bandsDiagnostic performanceMS diagnosisCerebrospinal fluidMultiple sclerosisPredictive valueNegative predictive valueCerebrospinal fluid testingRadiological suspicionDiagnostic accuracyImaging biomarkersDiagnosisDiagnostic biomarkersMonthsSclerosisBiomarkersPilot studyBaselineSelection 3Leveraging an Electronic Health Record Patient Portal to Help Patients Formulate Their Health Care Goals: Mixed Methods Evaluation of Pilot Interventions
Naimark J, Tinetti M, Delbanco T, Dong Z, Harcourt K, Esterson J, Charpentier P, Walker J. Leveraging an Electronic Health Record Patient Portal to Help Patients Formulate Their Health Care Goals: Mixed Methods Evaluation of Pilot Interventions. JMIR Formative Research 2024, 8: e56332. PMID: 39207829, PMCID: PMC11393498, DOI: 10.2196/56332.Peer-Reviewed Original ResearchConceptsPatient portalsPatient prioritiesElectronic health record patient portalEnd-of-life carePatient Priorities CareFamily medicine practiceMixed methods evaluationHealth care goalsComplex medication regimensEnd-of-lifeMedian completion timeMedian session timePrevisit questionnaireCare goalsInvited patientsPilot interventionPriority careSession timeHealth priorityFocus groupsPhone interviewsYears of ageMedication regimensMedicine practiceEPIC questionnaireThe Effectiveness and Safety of Stellate Ganglion Block in the Treatment of Symptoms from Long COVID-19: A Pilot Study.
Levey A, Chen G, Ngyuen A, Ostrosky-Zeichner L, Hasoon J, Saroukhani S, Lin M. The Effectiveness and Safety of Stellate Ganglion Block in the Treatment of Symptoms from Long COVID-19: A Pilot Study. Psychopharmacology Bulletin 2024, 54: 8-17. PMID: 39263197, PMCID: PMC11385263.Peer-Reviewed Original ResearchConceptsStellate ganglion blockGanglion blockTreatment of symptomsFatigue severity scoresCOMPASS-31Degree of symptomatic improvementEffect of stellate ganglion blockSafety of stellate ganglion blockNo significant differenceSymptomatic improvementPost-procedureAdjunctive treatmentPre-procedurePilot studyLong COVID-19Severity scoreLow riskPatientsGAD-7 scoresFSS scoresEffective procedureSignificant differenceHeart ratePost-intervention surveysCOVID infection
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