2025
Person-centered analyses reveal that developmental adversity at moderate levels and neural threat/safety discrimination are associated with lower anxiety in early adulthood
Sisk L, Keding T, Ruiz S, Odriozola P, Kribakaran S, Cohodes E, McCauley S, Zacharek S, Hodges H, Haberman J, Pierre J, Caballero C, Baskin-Sommers A, Gee D. Person-centered analyses reveal that developmental adversity at moderate levels and neural threat/safety discrimination are associated with lower anxiety in early adulthood. Communications Psychology 2025, 3: 31. PMID: 40044923, PMCID: PMC11882445, DOI: 10.1038/s44271-025-00193-x.Peer-Reviewed Original ResearchNeural activityAdverse exposuresMiddle childhoodLower anxietyAssociated with lower anxietyWithin-person combinationsPerson-centered analysesPerson-centered approachHigher neural activityPatterns of adversity exposureCorticolimbic circuitryModerate adversityParsing heterogeneityAnxiety symptomsSafety learningDevelopmental adversityLatent profilesLifetime adversityNeurobiological functionsFuture anxietyAnxietyEarly adulthoodAssociated with processesAdversityYoung adultsChronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoringPrediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks
Agarwal K, Chaudhary S, Tomasi D, Volkow N, Joseph P. Prediction of alcohol intake patterns with olfactory and gustatory brain connectivity networks. Neuropsychopharmacology 2025, 1-9. PMID: 39962224, DOI: 10.1038/s41386-025-02058-7.Peer-Reviewed Original ResearchVentral attention networkBrain connectivity patternsHuman Connectome ProjectResting-state fMRI dataConnectivity patternsRisk of AUDYoung adultsBrain network connectivityAlcohol intake patternsAlcohol intakeAlcohol consumption behaviorOlfactory perceptionFMRI dataFunctional connectomePast-weekLongitudinal researchAttention networkYoung adult cohortChemosensory cuesBrain connectivity networksConnectome ProjectPast-yearConnectivity networksAlcohol drinkersAlcoholOpioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review
Cance J, Hairgrove S, Saavedra L, Bonar E, Walton M, Patel S, Yule A, King C, Chavez L, Slesnick N, Fernandes C. Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review. Journal Of Adolescent Health 2025 PMID: 39945684, DOI: 10.1016/j.jadohealth.2024.10.026.Peer-Reviewed Original ResearchSuicide-related outcomesOpioid misuseSystematic reviewYoung adultsHigh risk of biasRisk of biasBoolean search strategyAdministrative dataConfounding biasInclusion criteriaReporting biasEligible publicationsObservational studyLongitudinal researchHigh riskAdultsOpioidAssociationSearch strategyOutcomesMisuseData studiesPotential mechanismsYouthConfoundingSensation Seeking, Impulsivity, and Nicotine Dependence among Adolescents and Young Adults who Vape Nicotine and Cannabis
Ouellette R, Morean M, Lee J, Kong G. Sensation Seeking, Impulsivity, and Nicotine Dependence among Adolescents and Young Adults who Vape Nicotine and Cannabis. Drug And Alcohol Dependence 2025, 267: 112209. DOI: 10.1016/j.drugalcdep.2024.112209.Peer-Reviewed Original ResearchDepression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D’Onofrio G, Pilote L, Lichtman J. Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction. 2025, 87: 129-137. PMID: 39909011, DOI: 10.1097/psy.0000000000001363.Peer-Reviewed Original ResearchConceptsLow social supportCardiac-specific quality of lifeNatural direct effectSocial supportMonths post-AMIQuality of lifeAcute myocardial infarctionMarital stressComprehensive secondary preventive strategySignificant depressive symptomsPost-AMISecondary prevention strategiesYoung adultsMyocardial infarctionSociodemographic factorsDepressive symptomsAMI survivorsCovariate adjustmentPrevention strategiesSelf-reportContinuous scoresQoLBaseline QoLCategorical depressionDepressionTrauma-informed HIV prevention for forcibly displaced adolescents and young adults
Chantre C, Kershaw T, Lowe S, Davis J, Suleman A, Vermund S, Mootz J. Trauma-informed HIV prevention for forcibly displaced adolescents and young adults. The Lancet HIV 2025, 12: e234-e238. PMID: 39884299, DOI: 10.1016/s2352-3018(24)00313-8.Peer-Reviewed Original ResearchConceptsBurden of mental ill healthMental ill-healthHIV preventionIll healthYoung adultsConflict-affected populationsHIV careHIV interventionsMental healthPoor engagementHIV acquisitionHIV epidemicHIV riskTrauma exposureVulnerable populationsLevel of vulnerabilityHIVHealthSocioenvironmental contextAdolescent girlsDevelopmental periodMigration stressAdultsDocumented associationAdolescentsHypothalamic resting-state functional connectivity and self-evaluated aggression in young adults
Yao Y, Chen Y, Li C. Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults. Journal Of Psychiatric Research 2025, 182: 421-429. PMID: 39889403, PMCID: PMC11834083, DOI: 10.1016/j.jpsychires.2025.01.045.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAggression scoresLateral hypothalamusSex differencesHuman Connectome ProjectFunctional connectivityAchenbach Adult Self-ReportAdult Self-ReportYoung adultsManifestations of aggressionVoxel-wise regressionPublished routinesMotivated behaviorOccipital gyriAggressive behaviorSelf-reportMental healthAggressionConnectome ProjectNeural pathwaysBehavioral traitsRSFCHypothalamusScoresAdultsMediating roles of weight stigma and physical activity avoidance in the associations between severity of gaming disorder and levels of physical activity among young adults.
Saffari M, Huang C, Huang P, Chang Y, Chen J, Poon W, Potenza M, Griffiths M, Lin C. Mediating roles of weight stigma and physical activity avoidance in the associations between severity of gaming disorder and levels of physical activity among young adults. Journal Of Behavioral Addictions 2025, 14: 289-303. PMID: 39853322, DOI: 10.1556/2006.2024.00083.Peer-Reviewed Original ResearchConceptsPhysical activityWeight stigmaModerate to high PALevels of physical activityPerceived weight stigmaCross-sectional surveyGaming disorderYoung adultsSeverity of gaming disorderStructural equation modelingMultinomial logistic regressionPA levelsLow PAHigh PAAssociated with higher levelsStigmaLogistic regressionMediation analysisTaiwanese young adultsRisk of gaming disorderBehavioral symptomsAssociationClinical groupsActive avoidanceAdultsSexual trauma and compulsive sexual behavior in young men and women: A network analysis involving two samples.
Scoglio A, Chen Y, Huang K, Borgogna N, Potenza M, Blycker G, Kraus S. Sexual trauma and compulsive sexual behavior in young men and women: A network analysis involving two samples. Journal Of Behavioral Addictions 2025, 14: 166-177. PMID: 39841161, DOI: 10.1556/2006.2024.00074.Peer-Reviewed Original ResearchCompulsive sexual behaviorSexual trauma historySexual traumaSexual behaviorTrauma historyPsychological distressSubstance useSample of young adultsCo-occurring psychopathologyGender differencesSignificant gender differencesTime of traumaSample 1Young adultsDistressSupportive relationshipsTransactional sexNegative healthCentral nodeClinical concernPsychopathologyTraumaBehaviorSocial conditionsSexPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structuresDrift‐Diffusion Modeling of Attentional Shifting During Frustration: Associations With State Frustration and Trait Irritability
Bellaert N, Castagna P, Deveney C, Crowley M, Tseng W. Drift‐Diffusion Modeling of Attentional Shifting During Frustration: Associations With State Frustration and Trait Irritability. Depression And Anxiety 2025, 2025 DOI: 10.1155/da/1618163.Peer-Reviewed Original ResearchDrift diffusion model parametersTrait irritabilityFrustrative nonrewardDrift-diffusion modelAssociated with individual differencesLatent cognitive processesMechanisms of irritabilityModel of attentionMechanism-based interventionsAnxiety disordersCognitive mechanismsIndividual differencesCognitive processesImpairment symptomsNonrewardClinical levelYoung adultsHealthy adult populationTraitsAP metricNonfrustrationIrritationFrustrationMoodAnxiety
2024
US mortality trends from alcohol‐associated hepatitis by sex, age, race, and ethnicity, 1999–2020
Banini B, Chauhan S, Amatya A, Dashti F, Zahrawi K, Zahrawi F, Mehal W, McKee S. US mortality trends from alcohol‐associated hepatitis by sex, age, race, and ethnicity, 1999–2020. Alcohol Clinical And Experimental Research 2024, 49: 358-367. PMID: 39739407, DOI: 10.1111/acer.15515.Peer-Reviewed Original ResearchAmerican Indians/Alaska NativesMortality rate ratiosIndians/Alaska NativesCenters for Disease Control and Prevention Wide-ranging Online DataUS Centers for Disease Control and Prevention Wide-ranging ONline DataWide-ranging Online DataMortality rateUS mortality trendsAlcohol-associated hepatitisJoinpoint regression analysisYoung adultsCross-sectional studyAlcohol-associated liver diseaseYoung adult femalesHigh-risk populationOnline DataMortality trendsSteepest increaseUnited StatesYear compared to baselineCalendar trendsSociodemographic factorsRacial/ethnic groupsEpidemiological researchRate ratiosEditorial: From adolescence into young adulthood – the importance of a longitudinal perspective across development in child and adolescent mental health
Koenig J, Farhat L, Bloch M. Editorial: From adolescence into young adulthood – the importance of a longitudinal perspective across development in child and adolescent mental health. Journal Of Child Psychology And Psychiatry 2024, 66: 1-3. PMID: 39690123, DOI: 10.1111/jcpp.14094.Peer-Reviewed Original ResearchConceptsDevelopmental trajectoriesYoung adulthoodJournal of Child PsychologyYoung adultsAdolescent mental healthRomantic partnersPsychiatric disordersChild psychologyIndividual well-beingDevelopmental periodMental healthEnvironmental demandsSocial interactionAdolescentsAdulthoodWell-beingLongitudinal perspectiveMaturational changesPersonsAdultsBiological changesPersonal lifePsychologyPsychiatryDisordersFlavored E-Cigarette Sales Restrictions and Young Adult Tobacco Use
Friedman A, Pesko M, Whitacre T. Flavored E-Cigarette Sales Restrictions and Young Adult Tobacco Use. JAMA Health Forum 2024, 5: e244594. PMID: 39729302, PMCID: PMC11681375, DOI: 10.1001/jamahealthforum.2024.4594.Peer-Reviewed Original ResearchConceptsBehavioral Risk Factor Surveillance SystemElectronic nicotine delivery systemsDaily cigarette smokingQuasi-experimental analysisTobacco useCigarette smokingBurden of tobacco-related diseaseRisk Factor Surveillance SystemSurvey dataDaily vapingFlavor restrictionsTobacco control policiesTobacco-related diseasesNoninstitutionalized civilian adultsAdult tobacco useCross-sectional surveyElectronic nicotine delivery systems usePublic health gainsYoung adult tobacco useCombustible tobacco useYoung adultsRespondents' demographic characteristicsAssociated with statistically significant reductionsIncreased cigarette smokingReduce youth vapingDifferential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample.
Carlisi C, Fielder J, Knodt A, Romer A, Hariri A, Viding E. Differential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample. Journal Of Personality Disorders 2024, 38: 535-558. PMID: 39705101, DOI: 10.1521/pedi.2024.38.6.535.Peer-Reviewed Original ResearchConceptsPsychopathic traitsAntisocial facet of psychopathyBehavioral features of psychopathyFacets of psychopathyFeatures of psychopathySample of young adultsYoung adult sampleMental health problemsU.S. undergraduate studentsAntisocial facetPersonality disorderLifestyle facetGeneral psychopathologyAffective facetsAntisocial behaviorExternalizing behaviorsAdult samplesPsychopathologyPsychopathyInternalizing behaviorsBehavioral featuresUndergraduate studentsYoung adultsLifestyle traitsDifferential mappingNatural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults
Griffith F, Ash G, Augustine M, Latimer L, Verne N, Redeker N, O’Malley S, DeMartini K, Fucito L. Natural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults. Npj Digital Medicine 2024, 7: 342. PMID: 39613828, PMCID: PMC11606959, DOI: 10.1038/s41746-024-01321-3.Peer-Reviewed Original ResearchYoung adultsLanguage processingEvaluating young adultsControl participantsHeavy drinkingSleep factorsImprove sleepNatural language processingPersonalized feedbackParticipation motivationParticipantsSleepAdultsMixed-methods evaluationControl interventionsInterventionConvergent mixed methodsMotivationIncreased awarenessAlcoholAssociation Between Exposure to LGBTQ-Targeted Tobacco Marketing and Tobacco Use Behaviors Among US Young Adults
Lee J, Kong G, Krishnan-Sarin S, Morean M. Association Between Exposure to LGBTQ-Targeted Tobacco Marketing and Tobacco Use Behaviors Among US Young Adults. Substance Use & Misuse 2024, 60: 414-420. PMID: 39610016, DOI: 10.1080/10826084.2024.2434011.Peer-Reviewed Original ResearchGender minority young adultsExposure to tobacco marketingMinority young adultsTobacco marketingLGBTQ young adultsGender minority individualsGender minority peopleUS young adultsTobacco useTobacco marketing regulationsPride festivalAssociated with current tobacco useYoung adultsMinority individualsMinority peopleLGBTQCurrent tobacco useMarket regulationTobacco marketing exposureGenderLogistic regression analysisVenuesMarket exposureMarketRisk factorsAlcohol use and cannabis craving in daily life: Sex differences and associations among young adults
Davis C, Ramer N, Squeglia L, Gex K, McRae‐Clark A, McKee S, Roberts W, Gray K, Baker N, Tomko R. Alcohol use and cannabis craving in daily life: Sex differences and associations among young adults. Alcohol Clinical And Experimental Research 2024, 48: 2331-2340. PMID: 39579151, PMCID: PMC11629456, DOI: 10.1111/acer.15461.Peer-Reviewed Original ResearchCannabis cravingAlcohol useMomentary levelWeeks of ecological momentary assessmentYoung adultsEcological momentary assessmentCo-used substancesFemale participantsPatterns of substance useMale participantsLevels of alcohol consumptionConditioned cuesMomentary assessmentAlcohol quantityCravingNaturalistic conditionsCannabisSubstance useSex differencesCo-useAlcohol consumptionNegative associationAlcoholParticipantsFrequent pairsA Deep Dynamic Causal Learning Model to Study Changes in Dynamic Effective Connectivity During Brain Development
Wang Y, Qiao C, Qu G, Calhoun V, Stephen J, Wilson T, Wang Y. A Deep Dynamic Causal Learning Model to Study Changes in Dynamic Effective Connectivity During Brain Development. IEEE Transactions On Biomedical Engineering 2024, 71: 3390-3401. PMID: 38968024, PMCID: PMC11700232, DOI: 10.1109/tbme.2024.3423803.Peer-Reviewed Original ResearchDynamic effective connectivityEffective connectivityBrain developmentBrain developmental trajectoriesPhiladelphia Neurodevelopmental CohortLearning modelsNeurodevelopmental CohortBrain regionsDevelopmental trajectoriesSpatio-temporal dataInformation processing capabilitiesFuse informationCausal LearnerYoung adults
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