2024
Performance Status and End-of-Life Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer Treated With Androgen Receptor Targeted Therapy
Mellgard G, Saffran N, Chakrani Z, McCroskery S, Taylor N, Patel M, Liaw B, Galsky M, Oh W, Tsao C, Patel V. Performance Status and End-of-Life Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer Treated With Androgen Receptor Targeted Therapy. American Journal Of Clinical Oncology 2024, 47: 459-464. PMID: 39087466, DOI: 10.1097/coc.0000000000001115.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerPerformance statusProstate cancerOverall survivalAndrogen receptor-targeted therapiesCompare overall survivalReceptor-targeted therapyReduced performance statusSingle-institution studyCompare baseline characteristicsAssessment of PSFisher's exact testWilcoxon signed-rank testTaxane chemotherapyShorter OSCompare OSSigned-rank testTargeted therapyTreatment courseAndrogen receptorBaseline characteristicsExact testCox regressionART treatmentRNA-Seq based gene expression profiling of baseline and on-treatment breast tumors to predict response to HER2-directed therapy, without chemotherapy (TBCRC026).
Hennessy M, Fernández A, Huang C, Cimino-Mathews A, Denbow R, Abramson V, Rimawi M, Specht J, Storniolo A, Valero V, Vaklavas C, Winer E, Krop I, Wolff A, Wahl R, Thompson E, Stearns V, Perou C, Carey L, Connolly R. RNA-Seq based gene expression profiling of baseline and on-treatment breast tumors to predict response to HER2-directed therapy, without chemotherapy (TBCRC026). Journal Of Clinical Oncology 2024, 42: 530-530. DOI: 10.1200/jco.2024.42.16_suppl.530.Peer-Reviewed Original ResearchRelapse-free survivalB cell signaturesGene expression signaturesHER2-directed therapyPET/CT parametersER-negativeHER2 subtypeClinical outcomesEarly stage HER2-positive breast cancerResponse to HER2-directed therapyAssociated with lack of responseHER2-positive breast cancerGene expression changesUnivariate logistic regression analysisHER2-positive cohortIncreased immune signalingMetabolic changesAssociated with pCRNatural killer cellsNested Cox modelsLogistic regression analysisWilcoxon signed-rank testHER2 ampliconFDG-PET/CTHER2- tumorsCINDERELLA clinical trial: Using artificial intelligence–driven healthcare to enhance breast cancer locoregional treatment decisions.
Bonci E, Kaidar-Person O, Antunes M, Ciani O, Cruz H, Di Micco R, Gentilini O, Heil J, Kabata P, Romariz M, Gonçalves T, Martins H, Borsoi L, Mika M, Pfob A, Romem N, Schinkoethe T, Silva G, Bobowicz M, Cardoso M. CINDERELLA clinical trial: Using artificial intelligence–driven healthcare to enhance breast cancer locoregional treatment decisions. Journal Of Clinical Oncology 2024, 42: tps621-tps621. DOI: 10.1200/jco.2024.42.16_suppl.tps621.Peer-Reviewed Original ResearchPatient expectationsQuality of lifeResults post-interventionPatient-centred careCancer patients' expectationsBreast cancer expertsOverall quality of lifeImprove patient satisfactionWeighted Cohen's kappaPsychological well-beingBreast cancer treatmentPost-interventionNon-metastatic breast cancer patientsWilcoxon signed-rank testApp contentClinical study sitesLocoregional treatment decisionsCancer expertsBreast cancer patientsPatient satisfactionSigned-rank testPatient informationAesthetic outcomesEligibility criteriaOutcome levelReal-World Multicenter Study of PD-1 Blockade in HIV-Associated Classical Hodgkin Lymphoma Across the United States
Lurain K, Zarif T, Ramaswami R, Nassar A, Adib E, Abdel-Wahab N, Chintapally N, Drolen C, Feldman T, Haykal T, Nebhan C, Thiruvengadam S, Li M, Mittra A, Lorentsen M, Kim C, Drakaki A, Morse M, Johnson D, Mangla A, Dittus C, Ravi P, Baiocchi R, Chiao E, Rubinstein P, Yellapragada S, LaCasce A, Sonpavde G, Naqash A, Herrera A. Real-World Multicenter Study of PD-1 Blockade in HIV-Associated Classical Hodgkin Lymphoma Across the United States. Clinical Lymphoma Myeloma & Leukemia 2024, 24: 523-530. PMID: 38714474, PMCID: PMC11283942, DOI: 10.1016/j.clml.2024.03.011.Peer-Reviewed Original ResearchConceptsPD-1 blockadeCD4<sup>+</sup> T-cell countImmune-mediated adverse eventsOverall response rateT-cell countsHodgkin lymphomaBaseline CD4<sup>+</sup> T-cell countEfficacy of PD-1 blockadeMedian duration of responseCancer therapyClassical Hodgkin lymphomaProgression-free survivalDuration of responseProportion of patientsEnd-of-treatmentWilcoxon signed-rank testLugano classificationCheckpoint inhibitorsComplete responsePD-1Brentuximab vedotinTreatment discontinuationMedian durationSigned-rank testAdverse eventsQuantitative Evaluation of Large Language Models to Streamline Radiology Report Impressions: A Multimodal Retrospective Analysis.
Doshi R, Amin K, Khosla P, Bajaj S, Chheang S, Forman H. Quantitative Evaluation of Large Language Models to Streamline Radiology Report Impressions: A Multimodal Retrospective Analysis. Radiology 2024, 310: e231593. PMID: 38530171, DOI: 10.1148/radiol.231593.Peer-Reviewed Original ResearchConceptsLanguage modelReport impressionsRadiology reportsRetrospective comparative analysisWilcoxon signed-rank testReading grade levelMedical Information Mart for Intensive Care (MIMIC)-IV databaseElectronic health recordsNonparametric Wilcoxon signed-rank testSigned-rank testRetrospective analysisPrimary outcomeComplex medical terminologyImaging modalitiesHealth recordsPatientsRadiologyAnatomical regionsReadabilityIncrease accessModalitiesQuantitative evaluationReadability indicesReadability scoresReportsThe role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas
Najem E, Marin T, Zhuo Y, Lahoud R, Tian F, Beddok A, Rozenblum L, Xing F, Moteabbed M, Lim R, Liu X, Woo J, Lostetter S, Lamane A, Chen Y, Ma C, El Fakhri G. The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas. Radiotherapy And Oncology 2024, 194: 110186. PMID: 38412906, PMCID: PMC11042980, DOI: 10.1016/j.radonc.2024.110186.Peer-Reviewed Original ResearchGross tumor volume delineationGross tumor volumeDice similarity coefficientF-FDG PET imagingSoft tissue sarcomasInter-reader variabilityGTV delineationRadiation therapy treatment planningF-FDGF-FDG PETTherapy treatment planningPerformance level estimationTumor volume delineationTissue sarcomasPET imagingVolume delineationSimultaneous truthHausdorff distanceDice similarity coefficient scoreAccurate gross tumor volumeImaging modality groupsWilcoxon signed-rank testStatistically significant decreaseSigned-rank testTumor volume
2023
Longitudinal Assessment of Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination
NV B, McCollum S, Faherty E, Steele J, Karnik R. Longitudinal Assessment of Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination. Pediatric Cardiology 2023, 45: 1524-1532. PMID: 37294336, PMCID: PMC10251331, DOI: 10.1007/s00246-023-03200-2.Peer-Reviewed Original ResearchLeft ventricular longitudinal strainMRNA COVID-19 vaccinationCOVID-19 vaccinationSubclinical myocardial injuryEjection fractionFractional shorteningInitial presentationMyocardial injurySingle-center reviewMedian ejection fractionLeft ventricular functionVentricular longitudinal strainTime 0Area-length methodWilcoxon signed-rank testAcute illnessDiastolic functionVentricular functionDiastolic parametersLV functionRisk stratificationMyocardial recoveryTissue DopplerSigned-rank testMyopericarditisThe effect of rifampin on serum etonogestrel concentrations and biomarkers of ovulation among contraceptive implant users: A pharmacokinetic and pharmacodynamic study
Lazorwitz A, Sheeder J, Teal S. The effect of rifampin on serum etonogestrel concentrations and biomarkers of ovulation among contraceptive implant users: A pharmacokinetic and pharmacodynamic study. Contraception 2023, 123: 110035. PMID: 36997081, PMCID: PMC10461170, DOI: 10.1016/j.contraception.2023.110035.Peer-Reviewed Original ResearchConceptsContraceptive implant usersSerum etonogestrel concentrationsStrong CYP3A inducersENG implant usersEtonogestrel concentrationsMedian ageImplant usersCYP3A inducersP4 concentrationsMedian body mass indexSerum E2 concentrationsBody mass indexSignificant decreaseParticipants' median ageSuppression of ovulationSerum P4 concentrationsEffect of rifampinDrug-drug interactionsLiquid chromatography-mass spectrometry assayOnly short exposuresWilcoxon signed-rank testBaseline E2Rifampin 600Rifampin exposureRifampin therapyPercutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical data
2022
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)
Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH). BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.Peer-Reviewed Original ResearchConceptsT cell responsesAnti-spike IgGVisit 3SARS-CoV-2Older PWHVisit 2Immune responseSingle-center longitudinal observational studyVirus-specific T cell responsesVaccine-induced humoral immunityLong-term protective immunityT cell immune responsesOlder peopleMedian age 61RBD IgG levelsPrimary study outcomeCOVID-19 vaccinationImmune response evaluationLongitudinal observational studyCOVID-19 vaccineWilcoxon signed-rank testBNT162b2 boosterBNT162b2 vaccinationCD8 responsesDetectable CD4Obstetrician/Gynecologists' Knowledge, Attitudes, and Practice Regarding Suicide Screening Among Women
Stacy M, Dwyer E, Kremer M, Schulkin J. Obstetrician/Gynecologists' Knowledge, Attitudes, and Practice Regarding Suicide Screening Among Women. Journal Of Women's Health 2022, 31: 1481-1489. PMID: 35984865, DOI: 10.1089/jwh.2021.0646.Peer-Reviewed Original ResearchConceptsSuicide risk assessmentSuicide riskEdinburgh Postnatal Depression ScaleInadequate mental health servicesFrequency of screeningMental health referralsPostnatal Depression ScaleObstetrician/gynecologistsMental health servicesOB/GYNsPublic health issueSuicide ideation/behaviorWilcoxon signed-rank testPregnant patientsPostpartum patientsRisk patientsGynecologists' knowledgeHealth referralsSigned-rank testCommon interventionDepression ScaleSuicide screeningResponse rateHealth servicesPatientsCharacterization of the microbial resistome in a prospective trial of CBM588 in metastatic renal cell carcinoma (mRCC) offers mechanism for interplay between antibiotic (abx) use and immune checkpoint inhibitor (ICI) activity.
Dizman N, Meza L, Bergerot P, Dorff T, Lyou Y, Frankel P, Llamas M, Hsu J, Zengin Z, Malhotra J, Govindarajan A, Castro D, Gillece J, Reining L, Trent J, Takahashi M, Oka K, Higashi S, Highlander S, Pal S. Characterization of the microbial resistome in a prospective trial of CBM588 in metastatic renal cell carcinoma (mRCC) offers mechanism for interplay between antibiotic (abx) use and immune checkpoint inhibitor (ICI) activity. Journal Of Clinical Oncology 2022, 40: 4510-4510. DOI: 10.1200/jco.2022.40.16_suppl.4510.Peer-Reviewed Original ResearchInternational Multicenter Registry for Hyperbaric Oxygen Therapy: Results through June 2021.
Harlan NP, Ptak JA, Rees JR, Cowan DR, Fellows AM, Moses RA, Kertis JA, Hannigan PM, Juggan SA, Peacock J, Bennett M, Buckey JC. International Multicenter Registry for Hyperbaric Oxygen Therapy: Results through June 2021. Undersea And Hyperbaric Medicine 2022, 49: 275-287. PMID: 36001560, DOI: 10.22462/05.06.2022.1.Peer-Reviewed Original ResearchConceptsInternational multicenter registryHyperbaric oxygen therapyQuality of lifeMulticenter registryOxygen therapyIdiopathic sudden sensorineural hearing lossSudden sensorineural hearing lossMultiple centersProspective data collectionSensorineural hearing lossHyperbaric Medical SocietyNon-healing woundsWilcoxon signed-rank testCarbon monoxide poisoningComplication rateComplication dataProspective dataTherapy indicationsSigned-rank testWound scoreRadiation injuryHearing lossPost-treatment dataOutcome dataControl groupImproved Clinical Outcomes and Patient Satisfaction of In-Office Needle Arthroscopy for the Treatment of Posterior Ankle Impingement
Mercer N, Samsonov A, Dankert J, Gianakos A, Stornebrink T, Delmonte R, Kerkhoffs G, Kennedy J. Improved Clinical Outcomes and Patient Satisfaction of In-Office Needle Arthroscopy for the Treatment of Posterior Ankle Impingement. Arthroscopy Sports Medicine And Rehabilitation 2022, 4: e629-e638. PMID: 35494297, PMCID: PMC9042901, DOI: 10.1016/j.asmr.2021.12.004.Peer-Reviewed Original ResearchPosterior ankle impingement syndromeClinical outcomesPatient satisfactionMedian timeOutcome scoresNeedle arthroscopyOutcomes Measurement Information System (PROMIS) pain interferenceShort-term clinical outcomesExcellent patient-reported outcomesTherapeutic case seriesRetrospective cohort studySignificant pain reductionAnkle impingement syndromePain intensity scoresPostoperative outcome scoresAnkle Outcome ScoreLow complication ratePosterior ankle impingementPatient-reported outcomesSports activitiesImproved clinical outcomesHigh patient satisfactionQuality of lifeOffice needle arthroscopyWilcoxon signed-rank testClinical Outcomes of Nano Arthroscopy in the Office Setting for the Treatment of Posterior Ankle Impingement
Mercer N, Samsonov A, Dankert J, Delmonte R, Stornebrink T, Gianakos A, Kerkhoffs G, Kennedy J, Dahmen J. Clinical Outcomes of Nano Arthroscopy in the Office Setting for the Treatment of Posterior Ankle Impingement. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00363. PMCID: PMC8793393, DOI: 10.1177/2473011421s00363.Peer-Reviewed Original ResearchBody mass indexPosterior ankleClinical outcomesOutcome scoresPatient satisfactionT-scoreOutcomes Measurement Information System (PROMIS) pain interferencePain interference T-scoresMean body mass indexExcellent patient-reported outcomesPain intensity domainsWork/sportRetrospective cohort studySignificant pain reductionPostoperative outcome scoresAnkle Outcome ScoreLow complication ratePosterior ankle impingementPatient-reported outcomesSports activitiesHigh patient satisfactionSport-specific activitiesStandard arthroscopic proceduresWilcoxon signed-rank testMean followThe Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients
Trant A, Chagpar A, Wei W, Neumeister V, Rimm D, Stavris K, Lurie B, Frederick C, Andrejeva L, Raghu M, Killelea B, Horowitz N, Lannin D, Knill-Selby E, Sturrock T, Hofstatter E. The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients. Integrative Cancer Therapies 2022, 21: 15347354221137290. PMID: 36444764, PMCID: PMC9716631, DOI: 10.1177/15347354221137290.Peer-Reviewed Original ResearchConceptsTumor volumeBlack cohoshSitu patientsDuctal carcinomaAnti-inflammatory effectsTumor cellular proliferationBreast cancer treatmentCellular proliferationWilcoxon signed-rank testDCIS patientsAdverse eventsEligible subjectsWindow trialsCore biopsyInvasive diseaseKi67 expressionSigned-rank testBreast cancerGrade 3Hormone changesPatientsQuantitative immunofluorescenceBC extractSignificant toxicityCancer treatment
2021
Safety and Glycemic Outcomes During the MiniMed™ Advanced Hybrid Closed-Loop System Pivotal Trial in Adolescents and Adults with Type 1 Diabetes
Carlson AL, Sherr JL, Shulman DI, Garg SK, Pop-Busui R, Bode BW, Lilenquist DR, Brazg RL, Kaiserman KB, Kipnes MS, Thrasher JR, Reed JHC, Slover RH, Philis-Tsimikas A, Christiansen M, Grosman B, Roy A, Vella M, Jonkers RAM, Chen X, Shin J, Cordero TL, Lee SW, Rhinehart AS, Vigersky RA. Safety and Glycemic Outcomes During the MiniMed™ Advanced Hybrid Closed-Loop System Pivotal Trial in Adolescents and Adults with Type 1 Diabetes. Diabetes Technology & Therapeutics 2021, 24: 178-189. PMID: 34694909, PMCID: PMC8971997, DOI: 10.1089/dia.2021.0319.Peer-Reviewed Original ResearchConceptsAdvanced hybrid closed-loop systemMulticenter single-arm studyPredictive low glucose managementDiabetic ketoacidosis eventsSingle-arm studySensor-augmented pumpType 1 diabetesWilcoxon signed-rank testStudy phaseKetoacidosis eventsTreat populationHybrid closed-loop systemMean A1CGlycemic targetsGlucose targetsPivotal trialsStudy endpointGlucose managementGlycemic outcomesSigned-rank testAge groupsStudy participantsType 1Safety eventsA1CConventional Hepatic Volumetry May Lead to Inaccurate Segmental Yttrium-90 Radiation Dosimetry
Stein SI, Soliman MM, Sparapani J, Doustaly R, Cobb BW, Malhotra A, Charalel R, May BJ, Lee KS, Madoff DC, Talenfeld AD. Conventional Hepatic Volumetry May Lead to Inaccurate Segmental Yttrium-90 Radiation Dosimetry. CardioVascular And Interventional Radiology 2021, 44: 1973-1985. PMID: 34414494, DOI: 10.1007/s00270-021-02898-y.Peer-Reviewed Original ResearchConceptsMedical Internal Radiation DosimetryCone-beam CTCT/MRI scansSegmental volumesVariant arterial anatomyCT/MRIWilcoxon signed-rank testY90 radioembolizationZone volumeArterial anatomyVenous anatomyTumor locationSigned-rank testInternal radiation dosimetryHepatic volumetryMRI scansLobar volumesVolumetric differencesCouinaudDose targetsPersonalized dosimetryBeam CTAngiogramsDosesVolumetry
2020
Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD
Copetti M, Lopes A, Requena G, Johnson I, Greenberg B, Noren G, McLaughlin N, Shavitt R, Miguel E, Batistuzzo M, Hoexter M. Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD. Frontiers In Psychiatry 2020, 10: 936. PMID: 31998155, PMCID: PMC6962231, DOI: 10.3389/fpsyt.2019.00936.Peer-Reviewed Original ResearchGamma ventral capsulotomyPersonality disorder symptomsIntractable obsessive-compulsive disorderObsessive-compulsive disorderDisorder symptomsOCD patientsTreatment responseDisorder symptom changeSymptom changeStructured Clinical InterviewWorse treatment responseDSM-IV personality disordersWilcoxon signed-rank testPoorer ResponseClinical responseTreatment optionsInternal capsuleSigned-rank testTreatment attemptsAnterior limbClinical InterviewRadiosurgical proceduresPatientsSymptomsVentral part
2019
The feasibility of contrast echocardiography in the assessment of right ventricular size and function
Pereira JB, Essa M, Ugonabo I, Hur DJ, Crandall I, Vaccarelli M, Sugeng L. The feasibility of contrast echocardiography in the assessment of right ventricular size and function. Echocardiography 2019, 36: 1979-1988. PMID: 31633241, DOI: 10.1111/echo.14504.Peer-Reviewed Original ResearchConceptsRight ventricular evaluationRight ventricular sizeSegmental wall motionRight ventricular imagingRV-focused viewWall motionRight ventricle evaluationContrast enhancementWilcoxon signed-rank testInter-observer agreementRV dimensionsEchocardiography studyIntra-observer reproducibilityVentricular sizeSigned-rank testContrast echocardiographyRV imagingAnatomical assessmentVentricular imagingPatientsPercent agreementIrregular rhythmTotal segmentsIndependent observersSample t-test
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