2025
Outer radial glia promotes white matter regeneration after neonatal brain injury
Jinnou H, Rosko L, Yamashita S, Henmi S, Prasad J, Lam V, Agaronyan A, Tu T, Imamura Y, Kuboyama K, Sawamoto K, Hashimoto-Torii K, Ishibashi N, Gallo V. Outer radial glia promotes white matter regeneration after neonatal brain injury. Cell Reports Medicine 2025, 6: 101986. PMID: 40023165, DOI: 10.1016/j.xcrm.2025.101986.Peer-Reviewed Original ResearchConceptsOuter radial gliaActivating transcription factor 5Oligodendrocyte precursor cellsTreating white matter injuryNeonatal brain injuryWhite matter injuryPeriventricular white matterWhite matter regenerationImprove functional recoveryPopulation of neural stem cellsNeural stem cellsBrain injuryOuter subventricular zoneSubventricular zoneProliferative capacityPostnatal developmentVentricular zoneFunctional recoveryPrecursor cellsStem cellsWhite matterRadial gliaTherapeutic targetNeonatal pigletsInjuryGenetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water
Rodrigue A, Knowles E, Mollon J, Mathias S, Peralta J, Leandro A, Fox P, Kochunov P, Olvera R, Almasy L, Curran J, Blangero J, Glahn D. Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Human Brain Mapping 2025, 46: e70101. PMID: 39757975, PMCID: PMC11702472, DOI: 10.1002/hbm.70101.Peer-Reviewed Original ResearchConceptsGenetic correlationsDiffusion tensor imagingCirculating cytokine levelsPeripheral inflammatory responseWhite matter architectureFA measurementsCytokine levelsCytokine measurementsWhite matter integrityProinflammatory cytokinesSingle-compartment modelIL-8Inflammatory processInflammatory responseFree water volumeFree waterGenetic relationshipsWhite matterWhite matter microstructureExtracellular free waterGenetic associationRadiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
Droby A, Yoffe-Vasiliev A, Atias D, Fraser K, Mabrouk O, Omer N, Bar-Shira A, Gana-Weisz M, Goldstein O, Artzi M, Ben Bashat D, Alcalay R, Orr-Urtreger A, Shirvan J, Cedarbaum J, Giladi N, Mirelman A, Thaler A. Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients. Npj Parkinson's Disease 2025, 11: 7. PMID: 39753572, PMCID: PMC11698941, DOI: 10.1038/s41531-024-00854-4.Peer-Reviewed Original ResearchStriatal binding ratiosLRRK2-PD patientsFunctional connectivityLeft fronto-occipital fasciculusCerebrospinal fluidGray matter volumeDeep gray matter volumesRegional brain volumesWhole-brain gray matterNeuromelanin MRIFronto-occipital fasciculusLRRK2-PDWhite matterParkinson's diseaseLeft caudateMatter volumeReduced FCParkinson's disease patientsWhole-brainBrain volumeRadiological markersHealthy controlsFractional anisotropyRadiological measurementsPatients
2024
Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging dataP2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study
Lehto J, Aarnio R, Tuisku J, Sucksdorff M, Koivumäki E, Nylund M, Helin S, Rajander J, Danon J, Gilchrist J, Kassiou M, Oikonen V, Airas L. P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study. EJNMMI Research 2024, 14: 123. PMID: 39636350, PMCID: PMC11621262, DOI: 10.1186/s13550-024-01186-3.Peer-Reviewed Original ResearchPerilesional rimTracer bindingDisability progressionMS patientsMS brainsLesion rimWhite matterProgressive MS patientsPro-inflammatory microgliaRelapsed patientsSmoldering inflammationT1 lesionsMales compared to femalesNew-onsetProgressive patientsTracer uptakeParent tracerP2XDisease durationProgressive MSHealthy controlsPatientsPET studiesPerilesional areaFree fractionToxic and Metabolic Diseases of the CNS
Subramanian H, Mahajan A. Toxic and Metabolic Diseases of the CNS. What Radiology Residents Need To Know 2024, 231-244. DOI: 10.1007/978-3-031-55124-6_16.ChaptersCentral nervous systemMetabolic disordersBrain parenchymal involvementPredominant site of involvementSite of involvementNonspecific imaging appearancesDeep white matterParenchymal involvementDifferential diagnosisSpinal cordSevere casesImaging appearanceCerebral cortexCorpus callosumWhite matterMetabolic diseasesNervous systemPredominant siteToxic etiologyBasal gangliaSevere disordersDiagnosisDisordersImage patternsImage featuresCerebellar Purkinje Cell Activity Regulates White Matter Response and Locomotor Function after Neonatal Hypoxia
Kundu S, Ghaemmaghami J, Sanidas G, Wolff N, Vij A, Byrd C, Simonti G, Triantafyllou M, Jablonska B, Dean T, Koutroulis I, Gallo V, Kratimenos P. Cerebellar Purkinje Cell Activity Regulates White Matter Response and Locomotor Function after Neonatal Hypoxia. Journal Of Neuroscience 2024, 45: e0899242024. PMID: 39472064, PMCID: PMC11694407, DOI: 10.1523/jneurosci.0899-24.2024.Peer-Reviewed Original ResearchWhite matter injuryNeonatal hypoxiaLocomotor deficitsPurkinje cellsWM injuryOligodendrocyte maturationCerebellar Purkinje cell activityNeuronal activitySurvivors of prematurityPC activityWhite matterTrimester of pregnancyCerebellar Purkinje cellsPurkinje cell activityRestoring neuronal activityLocomotor dysfunctionMultielectrode array recordingsHx miceOligodendrocyte precursor cellsPreterm neonatesPotential therapeutic interventionsNeonatal injuryGABAergic interneuronsCerebellar WMEffect of HXThe White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure
Zhang F, Li Y, Chen R, Shen P, Wang X, Meng H, Du J, Yang G, Liu B, Niu Q, Zhang H, Tan Y. The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure. ENeuro 2024, 11: eneuro.0128-24.2024. PMID: 39142823, PMCID: PMC11360986, DOI: 10.1523/eneuro.0128-24.2024.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentFunctional connectivityCognitive impairmentNeural mechanismsRight inferior frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingInferior frontal gyrusRight anterior cingulateRight temporal poleFunctional connectivity differencesWhite matter integrityRight sagittal stratumFractional anisotropy valuesAnterior cingulateFrontal gyrusDiffusion tensor imagingMontreal Cognitive AssessmentTemporal poleWhite matterWM integrityPlasma Al concentrationParacingulate gyriCognitive AssessmentSagittal stratumThe loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse
Stankewich M, Peters L, Morrow J. The loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse. Frontiers In Neuroscience 2024, 18: 1415115. PMID: 39165342, PMCID: PMC11333264, DOI: 10.3389/fnins.2024.1415115.Peer-Reviewed Original ResearchJa/ja miceGranule layerCerebellar granule layerPostnatal day 8Cortical layers 2Cerebellar granule neuronsPostsynaptic density sizeSpectrin gene familyJaundiced miceMature mouse brainExchange transfusionHemolytic anemiaHemolytic pathologiesHematological consequencesMedial habenulaGranule neuronsFatal hemolytic anemiaDay 8Dentate gyrusNeuropsychiatric disordersSpectrin deficiencyWhite matterJa/jaMiceMouse brainCorrelation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque
Ahmed B, Duque A, Rakic P, Molnár Z. Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque. The Journal Of Comparative Neurology 2024, 532: e25626. PMID: 39031698, PMCID: PMC11262481, DOI: 10.1002/cne.25626.Peer-Reviewed Original ResearchWhite matter interstitial cellsInterstitial neuronsLayer 5Macaque cortexCortical neuronsGyral crownsInterstitial cellsStandardized cell numbersCell numberSulcal regionsDensity of neuronsLinear regionCortical layer thicknessLayer thicknessOverlying cortexCoronal sectionsHistological analysisDensityWhite matterNeuronsLayerCortical layersClinical perspectiveThicknessCortical thicknessStructural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
Male A, Goudzwaard E, Nakahara S, Turner J, Calhoun V, Mueller B, Lim K, Bustillo J, Belger A, Voyvodic J, O'Leary D, Mathalon D, Ford J, Potkin S, Preda A, van Erp T. Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity. Psychiatry Research Neuroimaging 2024, 342: 111843. PMID: 38896909, DOI: 10.1016/j.pscychresns.2024.111843.Peer-Reviewed Original ResearchConceptsSymptom severityFractional anisotropyDiffusion tensor imagingNeurocognitive performanceCognitive performanceAssociated with speed of processingLeft inferior fronto-occipital fasciculusWM abnormalitiesAssociated with neurocognitive performancePathophysiology of schizophreniaCognitive performance deficitsInferior fronto-occipital fasciculusSpeed of processingStructural white matter abnormalitiesMean diffusivityAxial diffusivityFronto-occipital fasciculusHealthy controlsRadial diffusivityRegional WM abnormalitiesNegative symptomsPerformance deficitsWhite matterWhite matter abnormalitiesAssociated with speedTesting the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging
Mendez Colmenares A, Thomas M, Anderson C, Arciniegas D, Calhoun V, Choi I, Kramer A, Li K, Lee J, Lee P, Burzynska A. Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging. Neurobiology Of Aging 2024, 141: 21-33. PMID: 38810596, PMCID: PMC11290458, DOI: 10.1016/j.neurobiolaging.2024.05.013.Peer-Reviewed Original ResearchDisconnection hypothesisVirginia Cognitive Aging ProjectHypothesis of cognitive agingFractional anisotropyAssociated with reduced memory performanceDeterioration of white matterAge-related memory lossPrefrontal white matterGenu of the corpus callosumMyelin water fractionVoxel-wise analysisWhite matterCorpus callosumExecutive functionCognitive agingDiffusion tensor imagingMemory performancePrefrontal WMStructural equation modelingWM microstructureAge differencesProcessing speedStructural disconnectionCognitive declineHealthy participantsDecoupling of gray and white matter functional networks in cognitive impairment induced by occupational aluminum exposure
Zhang F, Li L, Liu B, Shao Y, Tan Y, Niu Q, Zhang H. Decoupling of gray and white matter functional networks in cognitive impairment induced by occupational aluminum exposure. NeuroToxicology 2024, 103: 1-8. PMID: 38777096, DOI: 10.1016/j.neuro.2024.05.001.Peer-Reviewed Original ResearchExecutive control networkFunctional connectivityCognitive impairmentCognitive functionTrail Making Test Part AResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingControl networkDecreased FCsReduced functional connectivityGray matterHuman cognitive functionsCognitive impairment groupExecutive controlNeurobiological mechanismsLimbic networkMontreal Cognitive AssessmentWhite matterCognitive AssessmentImpairment groupFunctional networksMagnetic resonance imagingImpairmentPart ACognitionMacro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis
Schmitzer L, Kaczmarz S, Göttler J, Hoffmann G, Kallmayer M, Eckstein H, Hedderich D, Kufer J, Zimmer C, Preibisch C, Hyder F, Sollmann N. Macro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1629-1642. PMID: 38506325, PMCID: PMC11418673, DOI: 10.1177/0271678x241238935.Peer-Reviewed Original ResearchInternal carotid artery stenosisInternal carotid artery stenosis patientsCerebral blood flowCarotid artery stenosisPeak width of skeletonized mean diffusivitySmall vessel diseaseContralateral alterationsArtery stenosisAsymptomatic internal carotid artery stenosisWhite matterAsymptomatic carotid artery stenosisCapillary transit time heterogeneityCerebral structural alterationsCortical thicknessMagnetic resonance imagingHemodynamic alterationsRisk factorsPatientsDTI metricsResonance imagingDorsal cingulate cortexBlood flowIschemic strokeMean diffusivityStenosisSerum S100B protein and white matter changes in schizophrenia before and after medication
Shi H, Zhang Y, Yang Y, Zhang H, Li W, Zhong Z, Lv L. Serum S100B protein and white matter changes in schizophrenia before and after medication. Brain Research Bulletin 2024, 210: 110927. PMID: 38485004, DOI: 10.1016/j.brainresbull.2024.110927.Peer-Reviewed Original ResearchDecreased FA valuesSchizophrenia patientsFA valuesRight thalamusLeft inferior occipital gyrusPANSS positive scorePANSS positive scoresEffects of quetiapineLeft postcentral cortexLeft parietal cortexInferior occipital gyrusRight temporal cortexHealthy controlsWhite matterAtypical antipsychoticsPANSS scoresQuetiapine treatmentInvestigated WMOccipital gyrusRight cerebellumTemporal cortexParietal cortexWM microstructureBrain regionsSchizophreniaPreliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Mendez Colmenares A, Kramer A, Li K, Lee J, Lee P, Thomas M. Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health. Cerebral Circulation - Cognition And Behavior 2024, 6: 100203. PMID: 38292016, PMCID: PMC10827486, DOI: 10.1016/j.cccb.2024.100203.Peer-Reviewed Original ResearchNeurologically healthy adultsHealthy adultsLow metabolic riskAdult spanNeural targetsSex differencesIntracranial volumeModifiable health risk factorsMetabolic riskMyelin contentHealth risk factorsAlzheimer's diseaseWhite matterNeurite orientation dispersionPeripheral metabolismMRI approachModifiable factorsAdiposity scoreAdultsMetabolic healthRisk factorsMetabolic syndromeVulnerabilityNeurologyWMNoninvasive Gamma Sensory Stimulation May Reduce White Matter and Myelin Loss in Alzheimer’s Disease
Da X, Hempel E, Ou Y, Rowe O, Malchano Z, Hajós M, Kern R, Megerian J, Cimenser A. Noninvasive Gamma Sensory Stimulation May Reduce White Matter and Myelin Loss in Alzheimer’s Disease. Journal Of Alzheimer's Disease 2024, 97: 359-372. PMID: 38073386, PMCID: PMC10789351, DOI: 10.3233/jad-230506.Peer-Reviewed Original ResearchConceptsWhite matter atrophyActive treatment participantsMatter atrophyAlzheimer's diseaseMyelin lossTreatment participantsWhite matterNeuronal network functionT2-weighted MRIEarly disease interventionMRI outcomesClinical trialsEntorhinal regionWhite matter structuresHz stimulationMagnetic resonance imaging dataAfferent connectionsInclusion criteriaTherapeutic approachesAtrophySensory stimulationVolume assessmentDisease interventionDiseaseMyelin content
2023
Lobe‐specific changes in white matter volume and myelination following 6‐month 40 Hz gamma sensory stimulation in patients on the Alzheimer’s disease spectrum
Cimenser A, Da X, Hempel E, Malchano Z, Vaughan B, Megerian J, Hajos M. Lobe‐specific changes in white matter volume and myelination following 6‐month 40 Hz gamma sensory stimulation in patients on the Alzheimer’s disease spectrum. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.073143.Peer-Reviewed Original ResearchWhite matter volumeAlzheimer's diseaseWhite matterPlacebo groupTemporal lobeMatter volumeFrontal lobeParietal lobeWhite matter atrophyGray matter changesMRI T1 imagesTreatment group resultsMonth 3Month 6Neurological comorbiditiesT1w/T2w ratioMatter atrophyAD patientsMagnetic resonance imaging dataPathological changesOccipital lobePlacebo participantsMatter changesNeuronal activityTreatment groupsDecay in Entorhinal White Matter/Gray Matter contrast in Alzheimer’s Disease Patients is reduced by 40Hz sensory stimulation
Da X, Hempel E, Malchano Z, Vaughan B, Megerian J, Hajos M, Cimenser A. Decay in Entorhinal White Matter/Gray Matter contrast in Alzheimer’s Disease Patients is reduced by 40Hz sensory stimulation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.077337.Peer-Reviewed Original ResearchMagnetic resonance imagingEntorhinal regionAlzheimer's diseaseWhite matterPlacebo groupDisease patientsMRI measuresTreatment groupsPlacebo-controlled feasibility studyPhase I/IISensory stimulationMonth 6 visitMonths of treatmentStructural magnetic resonance imagingAlzheimer's disease patientsSignal intensityT1 magnetic resonance imagingLinear mixed-effects modelingMonth 3WM atrophyMyelin lossAD severityWM/GM contrastMixed-effects modelingAD patients
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