2025
The development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas
Jester N, Singh M, Lorr S, Tommasini S, Wiznia D, Buono F. The development of an artificial intelligence auto-segmentation tool for 3D volumetric analysis of vestibular schwannomas. Scientific Reports 2025, 15: 5918. PMID: 39966622, PMCID: PMC11836447, DOI: 10.1038/s41598-025-88589-x.Peer-Reviewed Original ResearchConceptsGround-truth datasetDice scoreVestibular schwannomaImage processing accuracyVolumetric analysisML-based algorithmsMeasuring tumor sizeMean dice scoreAuto-segmentation toolAccurate AIAI modelsTumor sizeTumor modelVS tumorsTumor growthTesting stageAI-LTumorImage processing softwareClinical practicePatient recruitmentProcessing softwareSchwannomaDatasetManual segmentation
2024
Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment
Singh K, Abdou H, Panth N, Chiang V, Buono F, Schwartz N, Mahajan A. Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment. Otology & Neurotology 2024, 46: 196-200. PMID: 39792983, DOI: 10.1097/mao.0000000000004392.Peer-Reviewed Original ResearchConceptsTumor volume assessmentABC/2 methodVestibular schwannomaVolume assessmentPlanimetry methodTumor volumeTumor volume changesFollow-up scansOverestimate tumor volumePatients' quality of lifeTumor sizeRetrospective reviewIntracranial tumorsImprove clinical decision makingSubgroup analysisVolumetric assessmentTumorClinical decision makingQuality of lifePatients' qualityPatientsClinical settingPlanimetryImaging techniquesPositive correlationComparing Cochlear Implant Outcomes in 100 Patients With Sporadic Vestibular Schwannoma Managed With Observation, Radiosurgery, or Microsurgery: A Multi-Institutional Review
Dornhoffer J, Marinelli J, Lohse C, Cottrell J, McMenomey S, Roland J, Thompson N, Brown K, Lucas J, Babu S, Lindquist N, Perkins E, Rahne T, Plontke S, Tan D, Hunter J, Harvey E, Deep N, Cerasiello S, Kircher M, Espahbodi M, Tooker E, Lloyd S, Carlson M. Comparing Cochlear Implant Outcomes in 100 Patients With Sporadic Vestibular Schwannoma Managed With Observation, Radiosurgery, or Microsurgery: A Multi-Institutional Review. Otology & Neurotology 2024, 45: e719-e726. PMID: 39514427, DOI: 10.1097/mao.0000000000004298.Peer-Reviewed Original ResearchConceptsOpen-set speech perceptionCochlear implantationSpeech perceptionSpeech perception test scoresSpeech perception outcomesSpeech perception scoresCochlear implant outcomesPure-tone thresholdsPure-tone averageImplant outcomesSporadic VSVestibular schwannomaIpsilateral CIPerception outcomesVestibular schwannoma managementTreated with observationPerception scoresMulti-institutional reviewSporadic vestibular schwannomaMicrosurgical resectionPatient counselingMultimodal therapyTumor managementRadiosurgeryPatients
2023
Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology
Qureshi H, Tabor J, Pickens K, Lei H, Vasandani S, Jalal M, Vetsa S, Elsamadicy A, Marianayagam N, Theriault B, Fulbright R, Qin R, Yan J, Jin L, O’Brien J, Morales-Valero S, Moliterno J. Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology. Journal Of Neuro-Oncology 2023, 164: 299-308. PMID: 37624530, PMCID: PMC10522517, DOI: 10.1007/s11060-023-04416-1.Peer-Reviewed Original ResearchBrain tumor patientsTumor patientsPostoperative outcomesFrailty indexSystematic reviewBrain tumorsPrimary intracranial tumorsMethodsSystematic literature reviewPrognostic valueVestibular schwannomaPostsurgical outcomesBenign tumorsIntracranial tumorsLesion etiologyTumor outcomeExclusion criteriaMalignant lesionsPRISMA guidelinesPatientsConclusionOur reviewTumor pathologyUnique etiologyTumor typesFrailtyNeurosurgical oncologyCyberKnife Stereotactic Radiosurgery for Growing Vestibular Schwannoma: Longitudinal Tumor Control, Hearing Outcomes, and Predicting Post‐Treatment Hearing Status
Hildrew D, Perez P, Mady L, Li J, Nilsen M, Hirsch B. CyberKnife Stereotactic Radiosurgery for Growing Vestibular Schwannoma: Longitudinal Tumor Control, Hearing Outcomes, and Predicting Post‐Treatment Hearing Status. The Laryngoscope 2023, 134: s1-s12. PMID: 37178050, DOI: 10.1002/lary.30731.Peer-Reviewed Original ResearchConceptsTumor control rateCyberKnife stereotactic radiosurgeryHearing outcomesVestibular schwannomaControl rateStereotactic radiosurgeryRetrospective case series reviewCase series reviewThird of patientsProportional hazard modelingMaximum radiation doseSeries reviewTumor controlAvailable audiogramsOtolaryngology-HeadTumor volumeEffective treatmentClass APatientsHearing statusAmerican AcademyHazard modelingVolumetric analysisRadiation doseOutcomesTreatment of Vestibular Schwannomas Refractory to Primary Therapy: Considerations for Subsequent Microsurgery and Radiation
Cottrell J, Kay-Rivest E, Rotman L, Friedmann D, Jethanamest D, McMenomey S, Pacione D, Sen C, Golfinos J, Roland T. Treatment of Vestibular Schwannomas Refractory to Primary Therapy: Considerations for Subsequent Microsurgery and Radiation. Journal Of Neurological Surgery Part B Skull Base 2023, 84: s1-s344. DOI: 10.1055/s-0043-1762141.Peer-Reviewed Original Research
2022
Endoscopic Endonasal Eustachian Tube Obliteration as a Treatment for Tension Pneumocephalus After Translabyrinthine Resection of Vestibular Schwannoma
Ji KSY, Rimmer R, Dogan A, Cetas JS, Ciporen JN, Sanusi O, Gupta S, Geltzeiler M. Endoscopic Endonasal Eustachian Tube Obliteration as a Treatment for Tension Pneumocephalus After Translabyrinthine Resection of Vestibular Schwannoma. Otology & Neurotology 2022, 43: e856-e860. PMID: 35970161, DOI: 10.1097/mao.0000000000003606.Peer-Reviewed Original ResearchConceptsEustachian tube obliterationCerebrospinal fluid leakV-Loc sutureTranslabyrinthine resectionVestibular schwannomaMental statusThird ventricleComputed tomographyFluid leakTension pneumocephalusCerebellopontine angle massPatient's mental statusLateral skull base surgeryRight frontal lobeOriginal surgical siteSkull base surgeryTranslabyrinthine excisionDevastating complicationLateral ventricleResection cavityMAIN OUTCOMESurgical siteFrontal lobePneumocephalusSuture techniqueEndoscopic Endonasal Eustachian Tube Obliteration for Cerebrospinal Fluid Rhinorrhea: A Case Series and Scoping Review
Rimmer R, Lilly G, Gupta S, Ciporen J, Detwiller K, Cetas J, Dogan A, Geltzeiler M. Endoscopic Endonasal Eustachian Tube Obliteration for Cerebrospinal Fluid Rhinorrhea: A Case Series and Scoping Review. Operative Neurosurgery 2022, 22: 345-354. PMID: 35867077, DOI: 10.1227/ons.0000000000000158.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid rhinorrheaEustachian tube obliterationLateral skull base surgeryCase seriesSkull base surgeryPrior surgical attemptsRetrospective chart reviewSmall case seriesInitial success rateBarbed suture techniqueNew case seriesTranslabyrinthine resectionChart reviewRetrospective seriesVestibular schwannomaRevision surgeryLumbar drainSurgical attemptsRevision casesPatientsBarbed sutureSuture techniqueSurgeryValuable option
2020
Manual segmentation versus semi-automated segmentation for quantifying vestibular schwannoma volume on MRI
McGrath H, Li P, Dorent R, Bradford R, Saeed S, Bisdas S, Ourselin S, Shapey J, Vercauteren T. Manual segmentation versus semi-automated segmentation for quantifying vestibular schwannoma volume on MRI. International Journal Of Computer Assisted Radiology And Surgery 2020, 15: 1445-1455. PMID: 32676869, PMCID: PMC7419453, DOI: 10.1007/s11548-020-02222-y.Peer-Reviewed Original ResearchConceptsManual segmentationHigh quality softwareTime-intensive taskGeneric softwareIntensive tasksSegmentation accuracySegmentation timeSegmentation approachVestibular schwannomaSegmentationSegmentation effortsApplicable solutionSoftwareReference approachCurrent clinical practiceVestibular schwannoma volumeAccuracyContrast agent injectionVolumetric measurementsEqual performanceTumor sizeVS sizeClinical practiceMore frustrationAgent injectionThe Clinical Implications of Spontaneous Hemorrhage in Vestibular Schwannomas
Hong CS, Jin L, David WB, Shear B, Zhao AY, Zhang Y, Erson-Omay EZ, Fulbright RK, Huttner A, Kveton J, Moliterno J. The Clinical Implications of Spontaneous Hemorrhage in Vestibular Schwannomas. Journal Of Neurological Surgery Part B Skull Base 2020, 82: e22-e32. PMID: 34306914, PMCID: PMC8289498, DOI: 10.1055/s-0040-1701676.Peer-Reviewed Original ResearchExtent of resectionVestibular schwannomaFacial weaknessSpontaneous hemorrhageLarge tumorsManagement of VSRetrospective case review seriesThin-walled vascular channelsBlood-thinning medicationHemorrhagic vestibular schwannomaPreoperative facial weaknessHalf of patientsFacial nerve dysfunctionRelevant clinical factorsPatient health outcomesRapid symptom onsetHigh mortality rateCase review seriesFacial numbnessNerve dysfunctionPerioperative mortalityClinical factorsSymptom onsetBenign pathologyPoor prognosis
2019
HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE
Zhao A, Fomchenko E, Tyrtova E, Huttner A, Zhang Y, Fulbright R, Erson-Omay E, Jin L, Moliterno J. HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE. Neuro-Oncology 2019, 21: vi112-vi112. PMCID: PMC6846905, DOI: 10.1093/neuonc/noz175.468.Peer-Reviewed Original ResearchVestibular schwannomaSurgical resectionClinical outcomesTumor sizeLarge tumorsExact testPre-operative tumor sizeSignificant associationProgression-free survival timeMost vestibular schwannomasFacial nerve functionPost-operative complicationsBetter clinical outcomesLow recurrence rateClinical outcome dataBilateral vestibular schwannomasDifferent surgical approachesFisher's exact testSlow growth potentialIntra-tumoral hemorrhageWhole-exome sequencingNerve functionRecurrence rateVS tumorsSurgical approach
2016
Development of an evidence-based decision pathway for vestibular schwannoma treatment options
Linkov F, Valappil B, McAfee J, Goughnour SL, Hildrew DM, McCall AA, Linkov I, Hirsch B, Snyderman C. Development of an evidence-based decision pathway for vestibular schwannoma treatment options. American Journal Of Otolaryngology 2016, 38: 57-64. PMID: 27780583, DOI: 10.1016/j.amjoto.2016.09.019.Peer-Reviewed Original ResearchConceptsVestibular schwannomaGroup of patientsPost-operative symptomsEvidence-based dataPittsburgh Medical CenterEffectiveness of treatmentQuality of lifeComplex medical problemsHealth care systemTreatment Decision Support SystemVS patientsTreatment optionsTreatment pathwaysTreatment decisionsMedical CenterClinical informationTreatment selectionFocus groupsSide effectsPatient valuesPatientsPatient feedbackClinical investigatorsTreatment alternativesMedical problems
2015
3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma
Schneider T, Chapiro J, Lin M, Geschwind JF, Kleinberg L, Rigamonti D, Jusué-Torres I, Marciscano AE, Yousem DM. 3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma. European Radiology 2015, 26: 849-857. PMID: 26139318, PMCID: PMC4698362, DOI: 10.1007/s00330-015-3895-9.Peer-Reviewed Original ResearchConceptsSingle-session stereotactic radiosurgeryTotal tumor volumeSignificant tumor shrinkageVestibular schwannomaTumor shrinkageStereotactic radiotherapyTumor volumeRadiation therapyStereotactic radiosurgeryT1-weighted contrast-enhanced MRISubsequent microsurgical resectionTumor-related symptomsSporadic vestibular schwannomaContrast-enhanced MRIFSRT groupRadiological progressionMicrosurgical resectionClinical outcomesSRS groupRetrospective analysisResponse assessmentPatientsVolumetric assessmentFSRTSchwannoma
2013
Rapidly Progressive Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Vestibular Nerve
Kuzmik GA, Michaelides EM, Chiang VL, Nonaka Y, Fukushima T, Vortmeyer AO, Bulsara KR. Rapidly Progressive Epithelioid Malignant Peripheral Nerve Sheath Tumor of the Vestibular Nerve. Otology & Neurotology 2013, 34: 1739-1742. PMID: 23988994, DOI: 10.1097/mao.0b013e31829ab8be.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorEpithelioid malignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsMagnetic resonance imagingNerve sheath tumorsVestibular nerveSheath tumorsMalignant natureInternal auditory canal massRepeat magnetic resonance imagingGood initial optionSubsequent microsurgical resectionFacial nerve palsyAtypical clinical courseGamma knife radiosurgerySensorineural hearing lossRetroauricular painNerve palsyClinical courseComplete resectionMicrosurgical resectionVestibular schwannomaRare lesionsHistopathologic confirmationKnife radiosurgerySecondary Neoplasms After Stereotactic Radiosurgery
Patel TR, Chiang VL. Secondary Neoplasms After Stereotactic Radiosurgery. World Neurosurgery 2013, 81: 594-599. PMID: 24148883, DOI: 10.1016/j.wneu.2013.10.043.Peer-Reviewed Original ResearchConceptsStereotactic radiosurgerySecondary neoplasmsCentral nervous system diseaseLong-term surveillance imagingNervous system diseasesRadiation-induced neoplasmsLong-term riskInitial diagnosisSurveillance imagingVestibular schwannomaTreatment paradigmSubsequent riskSystem diseasesNeoplasmsMedical radiationRadiation exposureRadiosurgeryRiskPatientsSchwannomaYearsDiseaseDiagnosis
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