2025
Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms
Aminorroaya A, Dhingra L, Pedroso A, Shankar S, Coppi A, Khunte A, Foppa M, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms. European Heart Journal - Digital Health 2025, ztaf034. DOI: 10.1093/ehjdh/ztaf034.Peer-Reviewed Original ResearchDetectable structural heart diseaseStructural heart diseaseCommunity-based screeningLeft-sided valvular diseaseHeart diseaseELSA-BrasilYale-New Haven HospitalAI-ECG algorithmDeep learning algorithmsPopulation-based cohortSevere LVHEchocardiographic dataPredictive biomarkersHospital-based sitesNew Haven HospitalRisk stratificationValvular diseaseEnsemble deep learning algorithmUK BiobankCommunity hospitalLead I ECGEnsemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images PRESENT SHD
Dhingra L, Aminorroaya A, Sangha V, Pedroso A, Shankar S, Coppi A, Foppa M, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images PRESENT SHD. Journal Of The American College Of Cardiology 2025, 85: 1302-1313. PMID: 40139886, DOI: 10.1016/j.jacc.2025.01.030.Peer-Reviewed Original ResearchConceptsStructural heart diseaseYale-New Haven HospitalTransthoracic echocardiogramRisk stratificationHeart failureLeft-sided valvular diseaseSevere left ventricular hypertrophyLeft ventricular ejection fractionReceiver-operating characteristic curveVentricular ejection fractionLeft ventricular hypertrophyHeart disease screeningELSA-BrasilEnsemble deep learning algorithmRisk of deathConvolutional neural network modelEjection fractionEnsemble deep learning approachVentricular hypertrophyDeep learning algorithmsNew Haven HospitalDeep learning approachValvular diseaseNeural network modelClinical cohort
2024
Acute Decompensated Valvular Disease in the Intensive Care Unit
Miller P, Senman B, Gage A, Carnicelli A, Jacobs M, Rali A, Senussi M, Bhatt A, Hollenberg S, Kini A, Menon V, Grubb K, Morrow D, Section A. Acute Decompensated Valvular Disease in the Intensive Care Unit. JACC Advances 2024, 3: 101402. PMID: 39735779, PMCID: PMC11681797, DOI: 10.1016/j.jacadv.2024.101402.Peer-Reviewed Original ResearchIntensive care unitCardiac intensive care unitValvular diseaseCritically ill patientsCare unitIll patientsPrimary cardiac disorderMultidisciplinary heart teamModern cardiac intensive care unitPercutaneous interventional therapyDefinitive treatmentSurgical riskClinical presentationSocietal guidelinesHeart teamValvular disordersTreatment optionsInterventional therapyCardiac disordersDiseasePatientsTreatmentDisordersSurgeryTherapyGuidelines for the Evaluation of Prosthetic Valve Function With Cardiovascular Imaging: A Report From the American Society of Echocardiography Developed in Collaboration With the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography
Zoghbi W, Jone P, Chamsi-Pasha M, Chen T, Collins K, Desai M, Grayburn P, Groves D, Hahn R, Little S, Kruse E, Sanborn D, Shah S, Sugeng L, Swaminathan M, Thaden J, Thavendiranathan P, Tsang W, Weir-McCall J, Gill E. Guidelines for the Evaluation of Prosthetic Valve Function With Cardiovascular Imaging: A Report From the American Society of Echocardiography Developed in Collaboration With the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography. Journal Of The American Society Of Echocardiography 2024, 37: 2-63. PMID: 38182282, DOI: 10.1016/j.echo.2023.10.004.Peer-Reviewed Original ResearchConceptsProsthetic valve functionEvaluation of prosthetic valve functionCardiac magnetic resonanceValve repairComputed tomographyValve functionTransesophageal echocardiographyValve replacementAmerican Society of Echocardiography guidelinesThree-dimensional transesophageal echocardiographyAmerican Society of EchocardiographySociety of Cardiovascular Computed TomographyCardiac computed tomographyPercutaneous valve repairCardiovascular magnetic resonanceCardiovascular computed tomographyValvular heart diseaseCardiac valvular diseaseFirst-line methodAmerican SocietyEchocardiography guidelinesTricuspid regurgitationTransthoracic approachEchocardiographic techniquesValvular disease
2023
Building and Optimizing the Interdisciplinary Heart Team
Lee C, Tully A, Fang J, Sugeng L, Elmariah S, Grubb K, Young M. Building and Optimizing the Interdisciplinary Heart Team. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101067. PMID: 39129880, PMCID: PMC11308725, DOI: 10.1016/j.jscai.2023.101067.Peer-Reviewed Original ResearchHeart team modelHeart teamAdult congenital heart diseaseManagement of heart transplantationCongenital heart diseaseHigh-risk pregnanciesPre-existing cardiovascular diseaseComplex coronary artery diseaseInterdisciplinary heart teamTeam modelCoronary artery diseaseHeart team approachMultidisciplinary care team modelTreatment of valvular diseasePulmonary embolismCare team modelHeart transplantationSocietal guidelinesValvular diseaseCardiogenic shockMultidisciplinary care teamArtery diseaseHeart diseaseCardiovascular diseaseCardiovascular medicineQuantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients
Kwan J, Arbune A, Henry M, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader A, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre L. Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. PLOS ONE 2023, 18: e0286364. PMID: 37252927, PMCID: PMC10228774, DOI: 10.1371/journal.pone.0286364.Peer-Reviewed Original ResearchConceptsBreast cancer patientsSystolic heart failureCardiovascular outcomesCancer patientsHeart failureValvular diseaseStrain abnormalitiesLeft ventricular ejection fraction reductionCancer treatment-related cardiotoxicityCardiovascular magnetic resonance findingsVentricular ejection fraction reductionYale-New Haven HospitalEjection fraction reductionTreatment-related cardiotoxicityAdverse cardiovascular outcomesClinical risk factorsNormal LV functionGlobal longitudinal strainIschemic heart diseaseMagnetic resonance findingsRisk regression modelsNew Haven HospitalSubclinical cardiotoxicityDiastolic dysfunctionStatin use
2022
Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnmet diagnostic needsCardiovascular medicineNeuronal imagingImaging of inflammationHeart failureValvular diseaseTechnical considerationsDiagnostic needsCardiac amyloidosisUnmet ClinicalNew radiotracersCardiovascular imagingPersonalized therapyPerfusion tracerPET perfusion tracerThrombosisRadiotracer developmentRadiotracerPerfusionF-FlurpiridazImagingReviewMedicineKey technical considerationsMolecular characterization
2020
Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association
Mehta LS, Warnes CA, Bradley E, Burton T, Economy K, Mehran R, Safdar B, Sharma G, Wood M, Valente AM, Volgman A, Council O. Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association. Circulation 2020, 141: e884-e903. PMID: 32362133, DOI: 10.1161/cir.0000000000000772.Peer-Reviewed Original ResearchConceptsCardio-obstetrics teamCardiovascular diseaseCardiac conditionsMultidisciplinary cardio-obstetrics teamHistory of preeclampsiaPregnancy-related mortalityPrimary care cliniciansAmerican Heart AssociationScientific statementHypertensive disordersMaternal morbidityPregnant patientsPreconception counselingValvular diseaseCare cliniciansComorbid conditionsThromboembolic diseaseAortic diseaseCardiovascular ConsiderationsCerebrovascular diseaseYear postpartumHeart AssociationMaternal mortalityMaternal ageMyocardial infarctionGlobal, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017
Yadgir S, Johnson CO, Aboyans V, Adebayo OM, Adedoyin RA, Afarideh M, Alahdab F, Alashi A, Alipour V, Arabloo J, Azari S, Barthelemy CM, Benziger CP, Berman AE, Bijani A, Carrero JJ, Carvalho F, Daryani A, Durães AR, Esteghamati A, Farid TA, Farzadfar F, Fernandes E, Filip I, Gad MM, Hamidi S, Hay SI, Ilesanmi OS, Irvani S, Jürisson M, Kasaeian A, Kengne AP, Khan AR, Kisa A, Kisa S, Kolte D, Manafi N, Manafi A, Mensah GA, Mirrakhimov EM, Mohammad Y, Mokdad AH, Negoi RI, Nguyen H, Nguyen TH, Nixon MR, Otto CM, Patel S, Pilgrim T, Radfar A, Rawaf DL, Rawaf S, Rawasia WF, Rezapour A, Roever L, Saad AM, Saadatagah S, Senthilkumaran S, Sliwa K, Tesfay BE, Tran BX, Ullah I, Vaduganathan M, Vasankari TJ, Wolfe CDA, Yonemoto N, Roth GA. Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017. Circulation 2020, 141: 1670-1680. PMID: 32223336, DOI: 10.1161/circulationaha.119.043391.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAortic ValveAortic Valve InsufficiencyAortic Valve StenosisCalcinosisCost of IllnessFemaleGlobal HealthHealth Status DisparitiesHealthcare DisparitiesHumansMaleMitral Valve InsufficiencyMitral Valve ProlapsePrevalenceQuality of LifeRisk AssessmentRisk FactorsTime FactorsConceptsCalcific aortic valve diseaseDegenerative mitral valve diseaseMitral valve diseaseValve diseaseValvular diseaseNational burdenDisease burdenGlobal burdenAge-standardized DALY ratesHigher age-standardized DALY ratesModifiable risk factorsAortic valve diseaseCalcific aortic valvesDisease Study 2017Number of DALYsAdministrative hospital dataHealth-related burdenEpidemiologic survey dataDALY ratesValve repairTreatable diseaseAortic valveRisk factorsOverall burdenPrevalent casesCardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancy
Shapero KS, Desai NR, Elder RW, Lipkind HS, Chou JC, Spatz ES. Cardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancy. Cleveland Clinic Journal Of Medicine 2020, 87: 43-52. PMID: 31990654, DOI: 10.3949/ccjm.87a.18137.Peer-Reviewed Original ResearchConceptsPrimary pulmonary hypertensionCongenital heart disordersCardiovascular complicationsCollaborative interdisciplinary teamHypertensive disordersPeripartum cardiomyopathyPulmonary hypertensionValvular diseaseCardiovascular disordersPregnancyHeart disordersDisordersUnrecognized problemSpecialty trainingInterdisciplinary teamHypertensionComplicationsPatientsCardiomyopathyObstetricsCardiologistsDisease
2018
Anesthetic Treatment of Cardiac Disease During Pregnancy
Cohen KM, Minehart RD, Leffert LR. Anesthetic Treatment of Cardiac Disease During Pregnancy. Current Treatment Options In Cardiovascular Medicine 2018, 20: 66. PMID: 30019160, DOI: 10.1007/s11936-018-0657-4.Peer-Reviewed Original ResearchPhysiologic changesCardiac diseaseCardiac pathologyMaternal-fetal medicine specialistsNormal physiologic changesInterdisciplinary care teamFetal medicine specialistsHemodynamic goalsObstetric indicationsPregnant patientsCesarean deliveryNeuraxial analgesiaAnesthetic managementCoronary diseaseMedical therapyNeuraxial anesthesiaValvular diseaseAnesthetic approachVasoactive agentsPeripartum periodCare teamAnesthetic treatmentMaternal wellbeingMedicine specialistsCardiothoracic surgeonsDistinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy
Liao X, Shen Y, Zhang R, Sugi K, Vasudevan NT, Alaiti MA, Sweet DR, Zhou L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Hu R, Schwartz MA, Fujioka H, Richardson B, Cameron MJ, Hayashi H, Stamler JS, Jain MK. Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e4661-e4669. PMID: 29712858, PMCID: PMC5960298, DOI: 10.1073/pnas.1720065115.Peer-Reviewed Original ResearchConceptsNonischemic cardiomyopathyKruppel-like factor 4Resident macrophage proliferationNonresident macrophagesHeart failureCardiac functionMyeloid cellsBlood-borne macrophagesPreserves cardiac functionMacrophage proliferationPressure overload hypertrophyValvular diseaseOverload hypertrophyMyocardial angiogenesisAdaptive responseFirst weekMajor causeAngiogenic activityGenetic mutationsMacrophagesFactor 4CardiomyopathyKey transcription factorProliferationDistinct roles
2017
Derivation of a Clinical Model to Predict Unchanged Inpatient Echocardiograms
Gunderson CG, Gromisch ES, Chang JJ, Malm BJ. Derivation of a Clinical Model to Predict Unchanged Inpatient Echocardiograms. Journal Of Hospital Medicine 2017, 13: 164-169. PMID: 29073315, DOI: 10.12788/jhm.2866.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute myocardial infarctionCAVE scoreClinical prediction modelKidney diseaseMyocardial infarctionSingle-center retrospective cohort studyRetrospective cohort studyGood discriminationInpatient echocardiogramSubset of studiesCohort studyIndependent predictorsValvular diseaseECG changesElectrocardiogram changesC-statisticCardiothoracic surgeryRepeat studyFull cohortClinical modelDiseaseTTEΒ coefficientsInfarction
2014
ESC
Meier P, Franzen O, Lansky AJ. ESC. Acta Cardiologica 2014, 69: 435-445. PMID: 25181919, DOI: 10.1080/ac.69.4.3036660.Peer-Reviewed Original ResearchHigh riskPercutaneous left atrial appendage closureImportant new treatment optionInterventional cardiologyLeft atrial appendage closureNon-pharmacologic therapiesAtrial appendage closureAortic valve stenosisCoronary artery diseaseAortic valve diseaseSurgical valve repairNew treatment optionsImportant clinical evidenceRecent clinical dataRenal denervationResistant hypertensionStroke preventionAppendage closureElderly patientsArtery diseasePercutaneous treatmentValve stenosisValvular diseaseValve diseaseClinical evidenceAlmanac 2013: novel non-coronary cardiac interventions.
Meier P, Franzen O, Lansky AJ. Almanac 2013: novel non-coronary cardiac interventions. Turk Kardiyoloji Dernegi Arsivi-Archives Of The Turkish Society Of Cardiology 2014, 42: 203-15. PMID: 24643156, DOI: 10.5543/tkda.2014..Peer-Reviewed Original ResearchConceptsHigh riskPercutaneous left atrial appendage closureImportant new treatment optionInterventional cardiologyLeft atrial appendage closureNon-pharmacologic therapiesAtrial appendage closureAortic valve stenosisCoronary artery diseaseAortic valve diseaseSurgical valve repairNew treatment optionsImportant clinical evidenceRecent clinical dataRenal denervationResistant hypertensionStroke preventionAppendage closureElderly patientsArtery diseasePercutaneous treatmentValve stenosisValvular diseaseValve diseaseClinical evidenceAlmanah 2013: Novel non-coronary cardiac interventions the national society journals present selected research that has driven recent advances in clinical cardiology
Meier P, Franzen O, Lansky A. Almanah 2013: Novel non-coronary cardiac interventions the national society journals present selected research that has driven recent advances in clinical cardiology. Srce I Krvni Sudovi 2014, 33: 279-287. DOI: 10.5937/siks1404279m.Peer-Reviewed Original ResearchHigh riskPercutaneous left atrial appendage closureImportant new treatment optionInterventional cardiologyLeft atrial appendage closureNon-pharmacologic therapiesAtrial appendage closureAortic valve stenosisCoronary artery diseaseAortic valve diseaseSurgical valve repairNew treatment optionsImportant clinical evidenceRecent clinical dataRenal denervationResistant hypertensionStroke preventionAppendage closureElderly patientsArtery diseasePercutaneous treatmentValve stenosisValvular diseaseValve diseaseClinical evidenceCardioembolic Stroke: Practical Considerations for Patient Risk Management and Secondary Prevention
Amin H, Nowak RJ, Schindler JL. Cardioembolic Stroke: Practical Considerations for Patient Risk Management and Secondary Prevention. Postgraduate Medicine 2014, 126: 55-65. PMID: 24393752, DOI: 10.3810/pgm.2014.01.2725.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsManagement of patientsCE strokeCardioembolic strokeAtrial fibrillationNew anticoagulation therapiesMonitoring of patientsPatient risk managementAnticoagulation therapyVentricular dysfunctionIschemic strokeSecondary preventionEjection fractionPatent foramenStroke eventsValvular diseaseEarly recurrenceHigh morbidityCardiac mechanismPatient's mechanismPatientsStrokeFibrillationPreventionSecondary risk managementMorbidity
2013
Almanac 2013: novel non-coronary cardiac interventions
Meier P, Franzen O, Lansky AJ. Almanac 2013: novel non-coronary cardiac interventions. Wiener Klinische Wochenschrift 2013, 125: 766-775. PMID: 24337591, DOI: 10.1007/s00508-013-0481-5.Peer-Reviewed Original ResearchConceptsHigh riskPercutaneous left atrial appendage closureImportant new treatment optionInterventional cardiologyLeft atrial appendage closureNon-pharmacologic therapiesAtrial appendage closureAortic valve stenosisCoronary artery diseaseAortic valve diseaseSurgical valve repairNew treatment optionsImportant clinical evidenceRecent clinical dataRenal denervationResistant hypertensionStroke preventionAppendage closureElderly patientsArtery diseasePercutaneous treatmentValve stenosisValvular diseaseValve diseaseClinical evidenceAlmanac 2013: novel non-coronary cardiac interventions
Meier P, Franzen O, Lansky A. Almanac 2013: novel non-coronary cardiac interventions. Seminars In Cardiovascular Medicine 2013, 19: 60-71. DOI: 10.2478/semcard-2013-0008.Peer-Reviewed Original ResearchHigh riskPercutaneous left atrial appendage closureImportant new treatment optionInterventional cardiologyLeft atrial appendage closureNon-pharmacologic therapiesAtrial appendage closureAortic valve stenosisCoronary artery diseaseAortic valve diseaseSurgical valve repairNew treatment optionsImportant clinical evidenceRecent clinical dataRenal denervationResistant hypertensionStroke preventionAppendage closureElderly patientsArtery diseasePercutaneous treatmentValve stenosisValvular diseaseValve diseaseClinical evidenceAlmanac 2013: novel non-coronary cardiac interventions
Meier P, Franzen O, Lansky AJ. Almanac 2013: novel non-coronary cardiac interventions. The Anatolian Journal Of Cardiology 2013, 13: 622-31. PMID: 24064106, DOI: 10.5152/akd.2013.224.Peer-Reviewed Original ResearchConceptsHigh riskPercutaneous left atrial appendage closureImportant new treatment optionInterventional cardiologyLeft atrial appendage closureNon-pharmacologic therapiesAtrial appendage closureAortic valve stenosisCoronary artery diseaseAortic valve diseaseSurgical valve repairNew treatment optionsImportant clinical evidenceRecent clinical dataRenal denervationResistant hypertensionStroke preventionAppendage closureElderly patientsArtery diseasePercutaneous treatmentValve stenosisValvular diseaseValve diseaseClinical evidence
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