2024
Direct analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting
Choucair I, Shang E, Tran M, Cassella-McLane G, El-Khoury J. Direct analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting. Clinica Chimica Acta 2024, 564: 119939. PMID: 39197698, DOI: 10.1016/j.cca.2024.119939.Peer-Reviewed Original ResearchDART-MS/MSMass spectrometryReal time mass spectrometryTime mass spectrometrySample preparationLC-MS/MSEfficient sample preparationTandem mass spectrometryDirect analysisLiquid chromatography-tandem mass spectrometryChromatography-tandem mass spectrometryAnalytical measurement rangeVortex timeSpectrometryOpioid drugsTurnaround timeUrine samplesOpioidClinical settingDrug testingUrineDefinitive testsNorfentanylDrugPreparationAbbreviated MRI in the evaluation of dizziness: report turnaround times and impact on length of stay compared to CT, CTA, and conventional MRI
Tu L, Tegtmeyer K, de Oliveira Santo I, Venkatesh A, Forman H, Mahajan A, Melnick E. Abbreviated MRI in the evaluation of dizziness: report turnaround times and impact on length of stay compared to CT, CTA, and conventional MRI. Emergency Radiology 2024, 31: 705-711. PMID: 39034381, DOI: 10.1007/s10140-024-02273-7.Peer-Reviewed Original ResearchLength of stayEvaluation of dizzinessAbbreviated MRIConventional MRIMRI protocolEmergency departmentNon-contrast CT headConventional MRI protocolHead and neckPosterior circulation strokeAnalysis of length of stayTurnaround timeED length of stayCT headNo significant differenceAcute dizzinessCirculation strokeRetrospective analysisDizzinessAcute settingAssociated with greater impactMRI studiesImaging modalitiesMRIPatients
2023
Retrospective evaluation of clinical decision support for within-laboratory optimization of SARS-CoV-2 NAAT workflow
Durant T, Peaper D. Retrospective evaluation of clinical decision support for within-laboratory optimization of SARS-CoV-2 NAAT workflow. Journal Of Clinical Microbiology 2023, 62: e00785-23. PMID: 38132702, PMCID: PMC10865785, DOI: 10.1128/jcm.00785-23.Peer-Reviewed Original ResearchCurrent Clinical Practices and Challenges in Molecular Testing: A GOAL Consortium Hematopathology Working Group Report
Lee T, Aisner D, David M, Eno C, Gagan J, Gocke C, Guseva N, Haley L, Jajosky A, Jones D, Mansukhani M, Mroz P, Murray S, Newsom K, Paulson V, Roy S, Rushton C, Segal J, Senaratne T, Siddon A, Starostik P, Van Ziffle J, Wu D, Xian R, Yohe S, Kim A. Current Clinical Practices and Challenges in Molecular Testing: A GOAL Consortium Hematopathology Working Group Report. Blood Advances 2023, 7: 4599-4607. PMID: 37236162, PMCID: PMC10425685, DOI: 10.1182/bloodadvances.2023010149.Peer-Reviewed Original ResearchConceptsMolecular testingAcute casesHematologic malignanciesRapid turnaround timeTertiary care laboratoryAcute myeloid leukemiaCurrent clinical practiceMyeloid leukemiaTurnaround timeLymphoid processesClinical practicePatient careNGS panelCalendar daysClinical expectationsWorking Group ReportMost survey respondentsMalignancyCareReimbursementCase reimbursementSurvey respondentsGroup ReportTesting practicesDays
2022
Global disparities in SARS-CoV-2 genomic surveillance
Brito A, Semenova E, Dudas G, Hassler G, Kalinich C, Kraemer M, Ho J, Tegally H, Githinji G, Agoti C, Matkin L, Whittaker C, Howden B, Sintchenko V, Zuckerman N, Mor O, Blankenship H, de Oliveira T, Lin R, Siqueira M, Resende P, Vasconcelos A, Spilki F, Aguiar R, Alexiev I, Ivanov I, Philipova I, Carrington C, Sahadeo N, Branda B, Gurry C, Maurer-Stroh S, Naidoo D, von Eije K, Perkins M, van Kerkhove M, Hill S, Sabino E, Pybus O, Dye C, Bhatt S, Flaxman S, Suchard M, Grubaugh N, Baele G, Faria N. Global disparities in SARS-CoV-2 genomic surveillance. Nature Communications 2022, 13: 7003. PMID: 36385137, PMCID: PMC9667854, DOI: 10.1038/s41467-022-33713-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 genomic surveillanceMiddle-income countriesHigh-income countriesGenomic surveillanceSARS-CoV-2Global pandemic preparednessPublic health responseCOVID-19 casesPandemic preparednessHealth responseMolecular testsSocioeconomic inequalitiesTurnaround timeIncome countriesSurveillanceGlobal disparitiesDaysGenomic sequencingVaccineTesting for COVID-19 is Much More Effective When Performed Immediately Prior to Social Mixing
Wells CR, Gokcebel S, Pandey A, Galvani AP, Townsend JP. Testing for COVID-19 is Much More Effective When Performed Immediately Prior to Social Mixing. International Journal Of Public Health 2022, 67: 1604659. PMID: 35967267, PMCID: PMC9363582, DOI: 10.3389/ijph.2022.1604659.Peer-Reviewed Original ResearchUse of artificial intelligence in emergency radiology: An overview of current applications, challenges, and opportunities
Al-Dasuqi K, Johnson MH, Cavallo JJ. Use of artificial intelligence in emergency radiology: An overview of current applications, challenges, and opportunities. Clinical Imaging 2022, 89: 61-67. PMID: 35716432, DOI: 10.1016/j.clinimag.2022.05.010.Peer-Reviewed Original ResearchQuality Management to Improve CSF Gram Stain Turnaround Time
Kerantzas CA, Merwede JP, Fadlallah H, Durant TJS, Peaper DR. Quality Management to Improve CSF Gram Stain Turnaround Time. The Journal Of Applied Laboratory Medicine 2022, 7: 782-787. PMID: 35018424, DOI: 10.1093/jalm/jfab165.Peer-Reviewed Original Research
2021
Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics.
Mackow NA, Abi-Raad R, Kerantzas CA, Hui P, Malinis M, Azar MM. Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics. American Journal Of Tropical Medicine And Hygiene 2021, 105: 1657-1661. PMID: 34544041, PMCID: PMC8641361, DOI: 10.4269/ajtmh.21-0104.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCulture TechniquesFemaleHumansLungLymph NodesMaleMiddle AgedMycobacterium tuberculosisPleuraReal-Time Polymerase Chain ReactionReference StandardsRetrospective StudiesSensitivity and SpecificitySputumTuberculosisTuberculosis, Lymph NodeTuberculosis, Multidrug-ResistantTuberculosis, PleuralTuberculosis, PulmonaryConceptsComposite reference standardMTB PCRAFB cultureMycobacterium tuberculosisPolymerase chain reactionAcid-fast bacilli smearMycobacterium tuberculosis diseasePositive AFB cultureChain reactionReal-time polymerase chain reactionStandard diagnosticsBacilli smearMTB casesTuberculosis diseaseClinical sensitivityLong turnaround timeXpertClinical performanceReference standardPCRVariable sensitivityTurnaround timeLymphPatientsTuberculosis
2020
Deep learning assistance for the histopathologic diagnosis of Helicobacter pylori
Zhou S, Marklund H, Blaha O, Desai M, Martin B, Bingham D, Berry G, Gomulia E, Ng A, Shen J. Deep learning assistance for the histopathologic diagnosis of Helicobacter pylori. Intelligence-Based Medicine 2020, 1: 100004. DOI: 10.1016/j.ibmed.2020.100004.Peer-Reviewed Original ResearchAn Analysis of the Effect of the COVID-19 Pandemic on Case Volumes in an Academic Subspecialty-Based Anatomic Pathology Practice
Sinard JH. An Analysis of the Effect of the COVID-19 Pandemic on Case Volumes in an Academic Subspecialty-Based Anatomic Pathology Practice. Academic Pathology 2020, 7: 2374289520959788. PMID: 33088911, PMCID: PMC7545513, DOI: 10.1177/2374289520959788.Peer-Reviewed Original ResearchSubspecialty servicesInpatient censusSARS-CoV-2 testingPre-pandemic volumeAnatomic pathology practicePre-pandemic levelsCase volumeMain hospitalsCytology specimensSpecimen volumeHealth systemPathology practiceSignificant decreaseGynecologic cytologyGranular fashionSignificant increaseCOVID-19 pandemicNumber of peopleWeeksSpecimen typesHome directivesPandemicClinical operationsCOVID pandemicTurnaround time
2019
Effects of Real-time EMS Direction on Optimizing EMS Turnaround and Load-balancing Between Neighboring Hospital Campuses
Felice J, Coughlin RF, Burns K, Chmura C, Bogucki S, Cone DC, Joseph D, Parwani V, Li F, Saxa T, Ulrich A. Effects of Real-time EMS Direction on Optimizing EMS Turnaround and Load-balancing Between Neighboring Hospital Campuses. Prehospital Emergency Care 2019, 23: 788-794. PMID: 30798628, DOI: 10.1080/10903127.2019.1587123.Peer-Reviewed Original ResearchConceptsNurse navigator programSingle healthcare systemNavigator programHealthcare systemEmergency medical services (EMS) providersHealth system capacityNurse navigatorChief complaintEmergency departmentMedical service providersED volumeInpatient facilitiesTurnaround timeNeighboring hospitalRegistered NursesHospitalHospital campusSignificant decreaseED capacityIncidenceReal-time assessmentProgram implementationPrimary objectiveSignificant improvementPatients
2018
Evaluation of a Streamlined Oncologist-Led BRCA Mutation Testing and Counseling Model for Patients With Ovarian Cancer.
Colombo N, Huang G, Scambia G, Chalas E, Pignata S, Fiorica J, Van Le L, Ghamande S, González-Santiago S, Bover I, Graña Suárez B, Green A, Huot-Marchand P, Bourhis Y, Karve S, Blakeley C. Evaluation of a Streamlined Oncologist-Led BRCA Mutation Testing and Counseling Model for Patients With Ovarian Cancer. Journal Of Clinical Oncology 2018, 36: 1300-1307. PMID: 29558274, PMCID: PMC6804908, DOI: 10.1200/jco.2017.76.2781.Peer-Reviewed Original ResearchConceptsOvarian cancerTesting pathwayFaster treatment decisionsManagement of patientsGenetic counselorsBRCA mutation testingMedian turnaround timeOvarian Cancer StudyOncologist satisfactionOncology teamAnalysis populationPatient satisfactionTest counselingPretest counselingTreatment decisionsBRCA testingTurnaround timePatientsMutation testingBRCAmCancerENGAGE studyTesting guidelinesWeeksCancer studies
2017
Reducing STAT Portable Chest Radiograph Turnaround Times: A Pilot Study
Rachh P, Levey A, Lemmon A, Marinescu A, Auffermann W, Haycook D, Berkowitz E. Reducing STAT Portable Chest Radiograph Turnaround Times: A Pilot Study. Current Problems In Diagnostic Radiology 2017, 47: 156-160. PMID: 28705527, DOI: 10.1067/j.cpradiol.2017.05.012.Peer-Reviewed Original ResearchConceptsPatient safety errorsMultispecialty medical centerIntensive care units RESULTSMedian turnaround timeLimitations of radiologyFrontline cliniciansHealth systemExam orderMultidisciplinary teamStudy implementationRetrospective chart reviewClinical urgencyMedical CenterPortable chest radiographsService linesExam completionChart reviewPilot studyPreimplementationRadiologists' image interpretationTurnaround timeProvidersTeamIll patientsCritically ill patientsImplementation of surgeon-initiated Oncotype DX ordering among patients with breast cancer to reduce chemotherapy wait times.
Losk K, Freedman R, Lin N, Golshan M, Lester S, Pochebit S, Natsuhara K, Camuso K, King T, Bunnell C. Implementation of surgeon-initiated Oncotype DX ordering among patients with breast cancer to reduce chemotherapy wait times. Journal Of Clinical Oncology 2017, 35: 166-166. DOI: 10.1200/jco.2017.35.8_suppl.166.Peer-Reviewed Original ResearchOncotype DX testingChemotherapy initiationMedical oncologistsBreast cancerConsecutive breast cancer patientsAdjuvant chemotherapy initiationBreast cancer patientsOncotype DX resultsPathology reviewClinical outcomesTumor characteristicsMedical oncologyOncotype DXCancer patientsPatient satisfactionSurgery dateSurgical oncologyPatientsTurnaround timeSurgeryIntervention implementationMean timeOncologistsSignificant reductionOrder date
2016
Ambulatory redesign: Strategies for quality improvement in patient care.
Sinanis N, Lyons C, Smith N, McGlennon M, Parker T, Truini C, Major-Campos M, Lacy J, Michaels K, Dest V, Lisitano R, Adelson K, Lilenbaum R. Ambulatory redesign: Strategies for quality improvement in patient care. Journal Of Clinical Oncology 2016, 34: 85-85. DOI: 10.1200/jco.2016.34.7_suppl.85.Peer-Reviewed Original ResearchPatient satisfactionVisit volumeMultidisciplinary teamOutpatient volumeTotal visit volumeLab turnaround timeProvider educationAcademic medical practiceProcess improvement changesPatient careTurnaround timePatient accessClinical programsProvider productivityPatient flowProvider rolesNational benchmarksMedical practiceWait timePreliminary findingsImprovement changesFY 2015FY 2014Volume increaseNext-Generation Molecular Testing of Newborn Dried Blood Spots for Cystic Fibrosis
Lefterova MI, Shen P, Odegaard JI, Fung E, Chiang T, Peng G, Davis RW, Wang W, Kharrazi M, Schrijver I, Scharfe C. Next-Generation Molecular Testing of Newborn Dried Blood Spots for Cystic Fibrosis. Journal Of Molecular Diagnostics 2016, 18: 267-282. PMID: 26847993, PMCID: PMC4816703, DOI: 10.1016/j.jmoldx.2015.11.005.Peer-Reviewed Original ResearchMeSH KeywordsCosts and Cost AnalysisCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDNA Copy Number VariationsDNA PrimersDried Blood Spot TestingGenetic TestingHigh-Throughput Nucleotide SequencingHumansInfant, NewbornMultiplex Polymerase Chain ReactionNeonatal ScreeningQuality ControlReproducibility of ResultsSensitivity and SpecificityConceptsMultiplex next-generation sequencingCost-effective assayHigh-throughput screeningLengthy turnaround timeNewborn Dried Blood SpotsAmplification methodUnique designSample processingGenomic DNAMolecular assaysHigh costTurnaround timeGenetic diseasesBlood spotsCFTR analysisComplete concordanceDried Blood SpotsSingle runAssaysScreen-positive newbornsCostDetection
2010
Emergency Department Patient Volume and Troponin Laboratory Turnaround Time
Hwang U, Baumlin K, Berman J, Chawla NK, Handel DA, Heard K, Livote E, Pines JM, Valley M, Yadav K. Emergency Department Patient Volume and Troponin Laboratory Turnaround Time. Academic Emergency Medicine 2010, 17: 501-507. PMID: 20536804, PMCID: PMC10570502, DOI: 10.1111/j.1553-2712.2010.00738.x.Peer-Reviewed Original ResearchConceptsED patient volumeLaboratory turnaround timePatient volumeTroponin testTertiary care EDRetrospective cohort reviewEmergency department visitsLength of stayEmergency department (ED) patient volumePrimary predictor variableNumber of boardersAdjusted covariatesAdult patientsCohort reviewDepartment visitsHospital-based laboratoriesPatient characteristicsAppropriate therapyIll patientsVolume measuresTurnaround timeSubstantial burdenTimely treatmentTriage severityED beds
2003
Emergency radiology coverage: technical and clinical feasibility of an international teleradiology model
Kalyanpur A, Weinberg J, Neklesa V, Brink JA, Forman HP. Emergency radiology coverage: technical and clinical feasibility of an international teleradiology model. Emergency Radiology 2003, 10: 115-118. PMID: 15290497, DOI: 10.1007/s10140-003-0284-5.Peer-Reviewed Original ResearchMean turnaround timeConsecutive emergency room patientsEmergency room patientsAbdomen/pelvis CTComputed tomography studyHospital PACS systemClinical diagnostic reportsRoom patientsHead CTCT examinationsPelvis CTCT studiesStudy reportsAge groupsThree-point scaleClinical feasibilityStudy typeRadiology coverageTomography studyDay shiftTurnaround timeSubsequent reviewDiagnostic reportsTranscribed reportsReport
1998
Impact of filmless imaging on the frequency of clinician review of radiology images
Reiner B, Siegel E, Hooper F, Protopapas Z. Impact of filmless imaging on the frequency of clinician review of radiology images. Journal Of Imaging Informatics In Medicine 1998, 11: 149-150. PMID: 9735455, PMCID: PMC3453391, DOI: 10.1007/bf03168288.Peer-Reviewed Original ResearchConceptsIntensive care unitBaltimore VA Medical CenterClinicians' perceptionsPatient carePercent of cliniciansVA Medical CenterOverall patient careCare unitClinicians' estimatesMedical CenterPhysician preferenceClinician reviewCliniciansSignificant increaseRadiology imagesHospitalObjective measurementsImage reviewCareUse of PACSTurnaround timeReport turnaround timeReviewAverage number
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