2025
Cardiac Magnetic Resonance Imaging in Immune Checkpoint Inhibitor–Related Myocarditis
Hammer M, Tysarowski M, Fuss C, Bader A. Cardiac Magnetic Resonance Imaging in Immune Checkpoint Inhibitor–Related Myocarditis. Echocardiography 2025, 42: e70131. PMID: 40067334, DOI: 10.1111/echo.70131.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsImmune checkpoint inhibitorsCardiac magnetic resonance imagingMagnetic resonance imagingAssociated with immune-related adverse eventsCardiac immune-related adverse eventsMechanisms of immune checkpoint inhibitorsICI-associated myocarditisICI-related myocarditisResonance imagingPersonalized cancer immunotherapySevere cardiovascular complicationsImmune tolerance pathwayCheckpoint inhibitorsCancer immunotherapyCardiac complicationsCombination therapyTumor cytotoxicityClinical presentationCardiovascular complicationsAdverse eventsTherapeutic efficacyOncological treatmentTherapeutic strategiesMyocarditis
2018
Organoid Modeling of the Tumor Immune Microenvironment
Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Liao L, Zemek AJ, Zhao F, Karlsson K, Schultz LM, Metzner TJ, Nadauld LD, Tseng YY, Alkhairy S, Oh C, Keskula P, Mendoza-Villanueva D, De La Vega FM, Kunz PL, Liao JC, Leppert JT, Sunwoo JB, Sabatti C, Boehm JS, Hahn WC, Zheng GXY, Davis MM, Kuo CJ. Organoid Modeling of the Tumor Immune Microenvironment. Cell 2018, 175: 1972-1988.e16. PMID: 30550791, PMCID: PMC6656687, DOI: 10.1016/j.cell.2018.11.021.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesPatient-derived organoidsImmune checkpoint blockadePrimary tumor epitheliumTumor epitheliumTumor microenvironmentAntigen-specific tumor-infiltrating lymphocytesTumor immune microenvironmentAir-liquid interface methodSyngeneic immunocompetent hostsImmune stromaCheckpoint blockadeImmunocompetent hostsImmune microenvironmentNeoplastic epitheliumImmune cellsTumor TTumor cytotoxicityMouse tumorsHuman biopsiesImmune repertoireCancer culturesEpitheliumThree-dimensional organoidsOrganoid modeling
1983
Role of macrophage lipids in regulating tumoricidal activity
Schlager S, Madden L, Meltzer M, Bara S, Mamula M. Role of macrophage lipids in regulating tumoricidal activity. Cellular Immunology 1983, 77: 52-68. PMID: 6301697, DOI: 10.1016/0008-8749(83)90006-0.Peer-Reviewed Original ResearchConceptsM phiTumoricidal activityCellular lipidsTumor cellsTumor cytotoxicityPhagocytic activitySuperoxide releaseTransient increaseMaximal tumoricidal activityPeritoneal M phiFatty acid contentP815 tumor cellsEarly transient increaseRole of cholesterolChol enrichmentTumor target bindingProtein synthesizingProtein synthesisMacrophage lipidsInflammatory functionsCell binding capacityCellular contentControl supernatantsP815 cellsEndogenous levels
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