2025
Emerging autism and Fragile X syndrome treatments
Parkhill M, Salmaso N, D'Angiulli A, Lee V, Aguilar-Valles A. Emerging autism and Fragile X syndrome treatments. Trends In Pharmacological Sciences 2025 PMID: 40102109, DOI: 10.1016/j.tips.2025.02.004.Peer-Reviewed Original ResearchFragile X syndromeCore symptoms of autismSymptom-focused treatmentTreating core symptomsSymptoms of autismFragile X syndrome treatmentBiology of autismEndocannabinoid modulationCore symptomsDisorder heterogeneityX syndromeAutismPersonalized treatment approachesPharmacological interventionsTreatment approachesDisordersLate-phase trialsAnti-inflammatory approachesEndocannabinoidEffective therapyRecent trialsClinical trialsInterventionTrialsMicrobiome therapiesKleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women
Munguía L, Baenas-Soto I, Granero R, Fábregas-Balcells M, Gaspar-Pérez A, Rosinska M, Potenza M, Cuquerella Á, Tapia-Martínez J, Cabús-Grange R, Taranilla-Castro A, Macharé-Alberni M, Talón-Navarro M, Fernández-Aranda F, Jiménez-Murcia S. Kleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women. Scientific Reports 2025, 15: 7886. PMID: 40050325, PMCID: PMC11885670, DOI: 10.1038/s41598-025-85705-9.Peer-Reviewed Original ResearchConceptsImpulsive-compulsive spectrumDSM-5 criteriaClinical groupsDSM-5Personality featuresSemi-structured clinical interviewTreatment outcomesHarm avoidance scoresCognitive behavioral treatmentHealthy control individualsSample of female patientsImpact treatment outcomesPoor treatment outcomesCompulsive featuresBehavioral treatmentHigher impulsivityAvoidance scoresClinical interviewKleptomaniaInvestigate treatment outcomesCharacteristics of peopleFemale participantsPsychopathologyClinical samplesTreatment approachesMultimodality imaging review of retroperitoneal fibrosis
Czerniak S, Mathur M. Multimodality imaging review of retroperitoneal fibrosis. Abdominal Radiology 2025, 1-19. PMID: 40035807, DOI: 10.1007/s00261-025-04847-6.Peer-Reviewed Original ResearchRetroperitoneal fibrosisSecondary causesEvaluation of retroperitoneal fibrosisAssociated with autoimmune diseasesNonspecific clinical presentationIgG4 related diseasePotential diagnostic pitfallsDiffusion weighted imagingMagnetic resonance imagingAdvanced imaging techniquesPET/CT imagingClinical presentationMultimodality imaging reviewVenous stenosisClinical featuresDiagnostic pitfallsFibroinflammatory diseaseImaging findingsAutoimmune diseasesImaging reviewInflammatory disordersIdiopathic diseaseTreatment approachesImaging appearanceImaging modalitiesAcceptability of long-acting antiretroviral therapy among people living with HIV who use drugs in Vancouver, Canada: A qualitative study
Chayama K, Ng C, Brohman I, Mansoor M, Small W, Philbin M, Collins A, McNeil R. Acceptability of long-acting antiretroviral therapy among people living with HIV who use drugs in Vancouver, Canada: A qualitative study. PLOS ONE 2025, 20: e0319010. PMID: 40019916, PMCID: PMC11870339, DOI: 10.1371/journal.pone.0319010.Peer-Reviewed Original ResearchConceptsAdherence to antiretroviral therapyLong-acting antiretroviral therapyLA-ARTAntiretroviral therapySuboptimal adherence to antiretroviral therapyAdherence barriersProspective cohort studySuboptimal ART adherenceAdverse side effectsPill burdenTreatment optionsSubstance useCohort studyART adherenceTreatment advancesSide effectsTreatment changesPLHIVTreatment approachesTherapyCredible sources of informationPopulation-level benefitsDrugHIVSocial-structural inequitiesIdentification and external validation of a problem cannabis risk network
Lichenstein S, Kiluk B, Potenza M, Garavan H, Chaarani B, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Paillère Martinot M, Artiges E, Nees F, Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Pearlson G, Yip S. Identification and external validation of a problem cannabis risk network. Biological Psychiatry 2025 PMID: 39909136, DOI: 10.1016/j.biopsych.2025.01.022.Peer-Reviewed Original ResearchAlcohol use outcomesCannabis useNeural mechanismsSample of treatment-seeking adultsNeural mechanisms of riskTreatment-seeking adultsCannabis use disorderNon-clinical sampleMechanisms of riskFunctional connectivity dataSample of adolescentsTreatment outcomesAssociated with harmful outcomesPoor treatment outcomesAddiction severityUse disorderEmerging adulthoodWhole-brainCannabisCollege studentsBrain developmentConnectivity dataIdentified networksTreatment approachesAdultsThe Use of Extended-Release Buprenorphine in the Treatment of Adolescent Opioid Use Disorder: A Case Series.
Neptune A, Kaliamurthy S. The Use of Extended-Release Buprenorphine in the Treatment of Adolescent Opioid Use Disorder: A Case Series. Journal Of Addiction Medicine 2025 PMID: 39898524, DOI: 10.1097/adm.0000000000001447.Peer-Reviewed Original ResearchExtended-release buprenorphineOpioid use disorderCase seriesUse disorderOpioid abstinenceMedical recordsTreatment of opioid use disorderChart review periodNo significant complicationsDuration of treatmentOnset of treatmentMedical records of adolescentsRecords of adolescentsExtended-releaseSublingual buprenorphinePatient ageSignificant complicationsSubcutaneous injectionOpioidBuprenorphinePatientsOutpatient settingTreatment approachesElectronic medical recordsTreatment retentionOpen Access: Addressing dissociation symptoms with trauma-focused mentalization-based treatment
Rüfenacht E, Shaverin L, Stubley J, Smits M, Bateman A, Fonagy P, Luyten P. Open Access: Addressing dissociation symptoms with trauma-focused mentalization-based treatment. 2025, 173-197. DOI: 10.4324/9781003560616-8.Peer-Reviewed Original ResearchMentalization-based treatmentDissociative symptomsHistory of traumatic experiencesPost-traumatic stress symptomsExpressions of dissociationMental health careMentalization theoryStress symptomsTraumatic experiencesTreatment approachesSymptomsMentalTherapeutic objectivesHealth careClinical settingClinical symptomsAttachmentDissociation
2024
Parent-Only Treatment of Children and Adolescents
Etkin R, Shimshoni Y, Lebowitz E. Parent-Only Treatment of Children and Adolescents. CBT: Science Into Practice 2024, 207-228. DOI: 10.1007/978-3-031-74838-7_9.Peer-Reviewed Original ResearchAdolescent obsessive-compulsive disorderObsessive-compulsive disorderTreatment of ChildrenIllustrative case vignetteEtiology of childrenAnxious distressChildhood anxietyAnxiety disordersChild anxietyParental behavior changeAccommodation behaviorAnxietyCase vignettesSupportive responsesBehavioral changesCultural considerationsTreatment approachesDisordersChildrenParentsEmpirical researchSystems perspectiveAdolescentsDistressVignettesCutaneous sarcoidosis: clinical and pathologic features, molecular pathogenesis, and treatment
Damsky W, King B. Cutaneous sarcoidosis: clinical and pathologic features, molecular pathogenesis, and treatment. Clinics In Dermatology 2024 PMID: 39694198, DOI: 10.1016/j.clindermatol.2024.12.017.Peer-Reviewed Original ResearchCutaneous manifestations of sarcoidosisManifestation of sarcoidosisMultisystem inflammatory disorderFDA-approved therapiesLevel of evidenceCutaneous involvementCutaneous sarcoidosisCutaneous manifestationsHistopathological findingsInflammatory disordersSarcoidosisLymphatic systemTreatment approachesDisease pathogenesisRecommended evaluationDiseasePrednisoneCorticotropinTherapyPatientsMultisystemLungPathogenesisImpact of Treatment of Pudendal Neuralgia on Pain: A Systematic Review and Meta-Analysis
Andiman S, Maron J, Dandolu V, Drugge E, Cosgro R, Vasey M, Spaulding G, Ricciardi F, Yaskhi G, Toal C, Shatkin J, Loike-Weinstein D, Mahmood S, Glass M, Phillips D, Sciarrino M, Sacks A, Baruch D, Cohen M, Huang A, Pollack B, Grimes C. Impact of Treatment of Pudendal Neuralgia on Pain: A Systematic Review and Meta-Analysis. International Urogynecology Journal 2024, 36: 35-58. PMID: 39607531, DOI: 10.1007/s00192-024-06004-x.Peer-Reviewed Original ResearchPulsed radiofrequency treatmentPudendal neuralgiaPost-intervention pain scoresSystematic reviewPain measurement instrumentsPreferred Reporting ItemsRadiofrequency treatmentAdverse eventsPoor-quality studiesTreatment of pudendal neuralgiaMethodsFollowing Preferred Reporting ItemsShort-term follow-upTreatment approachesChronic pelvic painReporting ItemsAssess qualityHeterogeneous patient populationMeta-analysesEligibility criteriaConfidence intervalsStatistically significant differenceNon-standard treatmentMeta-analysisPelvic painPain scoresRegulation of Cardiac Function by the Autonomic Nervous System
Hafez O, Chang R. Regulation of Cardiac Function by the Autonomic Nervous System. Physiology 2024, 40: 000-000. PMID: 39585760, DOI: 10.1152/physiol.00018.2024.Peer-Reviewed Original ResearchAutonomic nervous systemNervous systemNeurocardiac axisIntrinsic cardiac nervous systemRegulation of cardiac functionCardiac nervous systemAutonomic control of the heartRegulating cardiovascular physiologyAutonomic dysfunctionSensory neuronsCardiac functionParasympathetic nervous systemClinical conditionsCardiac reflexesThe heartNeuronal populationsTreatment approachesCardiovascular diseaseCardiovascular physiologyMotor circuitsPhysiological roleAutonomic controlClinical fieldHeartDysfunctionNovel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence
Sippel L, Hamblen J, Kelmendi B, Alpert J, Carpenter L, Grzenda A, Kraguljac N, McDonald W, Rodriguez C, Widge A, Nemeroff C, Schnurr P, Holtzheimer P, Biomarkers and Treatments T. Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence. American Journal Of Psychiatry 2024, 181: 1045-1058. PMID: 39616450, DOI: 10.1176/appi.ajp.20230950.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of posttraumatic stress disorderNon-trauma-focused psychotherapyTrauma-focused psychotherapySomatic treatment approachesEvidence-based treatmentsAntidepressant medicationSomatic treatmentsPsychiatric disordersSomatic interventionsTranscranial magnetic stimulationPsychotherapyMagnetic stimulationTreatment approachesDisordersRecommended first-line treatmentAdultsFirst-line treatmentMedicationMechanism of actionMonotherapy strategySalienceSpecific treatmentEvidenceRenovascular hypertension – a primer for the radiologist
Dixe de Oliveira Santo I, Sindoni J, Czeyda-Pommersheim F, Solomon N, Sailer A, Bhatt S, Fananapazir G, Pellerito J, Revzin M. Renovascular hypertension – a primer for the radiologist. Abdominal Radiology 2024, 1-13. PMID: 39542950, DOI: 10.1007/s00261-024-04677-y.Peer-Reviewed Original ResearchRenovascular hypertensionRenal arteryCause of renovascular hypertensionComputed tomography angiographyMagnetic resonance angiographyDiagnosing RVHExtrinsic compressionSecondary hypertensionRare conditionImaging findingsPolyarteritis nodosaSurgical interventionFibromuscular dysplasiaAnatomical variantsPage kidneyPictorial reviewHypertension casesAccurate diagnosisMedical managementDiagnostic criteriaTreatment approachesImaging modalitiesHypertensionImpact diagnosisYoung femalesUpdate on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum
Cheema P, Wheatley-Price P, Cecchini M, Ellis P, Louie A, Moore S, Sheffield B, Spicer J, Villeneuve P, Leighl N. Update on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum. Current Oncology 2024, 31: 6979-6999. PMID: 39590145, PMCID: PMC11592966, DOI: 10.3390/curroncol31110514.Peer-Reviewed Original ResearchNon-small cell lung cancerEarly-stage non-small cell lung cancerImmune checkpoint inhibitorsCell lung cancerLung cancerManagement of early-stage non-small cell lung cancerPre-meeting surveyTreatment approachesReview practice patternsAdjuvant settingCheckpoint inhibitorsRadiation therapyOntario cancer centersTargeted therapySurgical considerationsTreatment algorithmReview recent dataClinical dataBiomarker testingCancer CenterTherapeutic strategiesPractice patternsCancerTherapyPatientsTreatment “non-responders”: the experience of short-term psychoanalytic psychotherapy among depressed adolescents, their parents and therapists
Fiorini G, Khoe Z, Fonagy P, Midgley N. Treatment “non-responders”: the experience of short-term psychoanalytic psychotherapy among depressed adolescents, their parents and therapists. Frontiers In Psychology 2024, 15: 1389833. PMID: 39364088, PMCID: PMC11447700, DOI: 10.3389/fpsyg.2024.1389833.Peer-Reviewed Original ResearchShort-term psychoanalytic psychotherapyPsychoanalytic psychotherapyShort-term psychotherapyTreatment non-responseEvidence-based treatmentsDepressed adolescentsPsychotherapyTherapy processShort-term treatmentYoung peopleTherapistsNon-respondersDescriptive-interpretive approachTreatment approachesNegative viewsAdolescentsNon-responseParentsPerspectives of young peopleDepressionPeopleSemi-structured interviewsStudy findingsFindingsPoor experiencePharmacogenomics polygenic risk score: Ready or not for prime time?
Singh S, Stocco G, Theken K, Dickson A, Feng Q, Karnes J, Mosley J, Rouby N. Pharmacogenomics polygenic risk score: Ready or not for prime time? Clinical And Translational Science 2024, 17: e13893. PMID: 39078255, PMCID: PMC11287822, DOI: 10.1111/cts.13893.Peer-Reviewed Original ResearchConceptsGenome wide association studiesDisease-associated variantsPharmacogenetic phenotypesPharmacogenomic researchPolygenic risk scoresDisease geneticsGenomic dataAssociation studiesPhenotypic inconsistenciesPolygenic natureGenetic variantsGenetic associationStratified treatment approachDrug responseClinical decision toolPrecision medicineClinical predictorsPhenotypeClinical useClinical implementationTreatment approachesRisk scoreVariantsGenomePatient educationCurrent understanding and new insights in the treatment of IgA nephropathy
Zhang Y, Zhang H. Current understanding and new insights in the treatment of IgA nephropathy. Nephrology 2024, 29: 75-79. PMID: 38958055, DOI: 10.1111/nep.14340.Peer-Reviewed Original ResearchIgA nephropathyProgression to end-stage kidney diseaseRisk of progression to end-stage kidney diseaseTreatment of IgA nephropathyEra of targeted treatmentCurrent treatment strategiesEnd-stage kidney diseaseDownstream complement activationDevelopment of IgANRandomized controlled trialsImmunosuppressive approachesPotential therapeutic targetPrimary glomerulonephritisKDIGO guidelinesOff-labelTreatment strategiesKidney diseaseIgANPathogenic mechanismsControlled trialsTreatment approachesComplement activationDisease pathogenesisTherapeutic targetNephropathyA Systematic Review Evaluating PTSD Treatment Effects on Intermediate Phenotypes of PTSD
Palmisano A, Meshberg-Cohen S, Petrakis I, Sofuoglu M. A Systematic Review Evaluating PTSD Treatment Effects on Intermediate Phenotypes of PTSD. Psychological Trauma Theory Research Practice And Policy 2024, 16: 768-783. PMID: 36595460, DOI: 10.1037/tra0001410.Peer-Reviewed Original ResearchPosttraumatic stress disorderBehavioral treatment outcomesEvidence-based treatmentsCognitive controlThreat processingBody of researchPTSD outcomesPTSD treatmentPaucity of researchStress disorderPreliminary supportIntermediate phenotypesTreatment dropoutMethodological limitationsStudy limitationsTreatment effectsCurrent researchTreatment approachesStrong conclusionsNovel treatment approachesEmpirical studyTreatment outcomesTreatment efficacyResearchMemoryGene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence
Kranzler H, Davis C, Feinn R, Jinwala Z, Khan Y, Oikonomou A, Silva-Lopez D, Burton I, Dixon M, Milone J, Ramirez S, Shifman N, Levey D, Gelernter J, Hartwell E, Kember R. Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence. Nature Human Behaviour 2024, 8: 1616-1627. PMID: 38834750, DOI: 10.1038/s41562-024-01885-w.Peer-Reviewed Original ResearchAdverse childhood eventsSubstance dependenceMood/anxiety disordersAnxiety disordersChildhood eventsIndirect associationsGenetic riskExposure to adverse childhood eventsDevelopment of moodSubstance use disordersAssociations of adverse childhood eventsUse disorderMediation modelMood/anxietyDisorder factorsPolygenic scoresIndirect pathsDisordersEuropean ancestry individualsMoodTreatment approachesAnxietySelf-medicationEuropean ancestryLatent variablesExploring systemic treatment approaches for advanced pure large cell neuroendocrine carcinoma (LCNEC): A multicenter retrospective analysis.
Nassar A, Matteson K, Ardeshir F, Gray J, Baena Espinar J, Kwiatkowski D, Aboubakar Nana F, Grohe C, Citarella F, Pancirer D, Cheung J, Watson A, Sridhar A, Crowley F, Kaldas D, Kim C, Sankar K, Awosika N, Naqash A, Chiang A. Exploring systemic treatment approaches for advanced pure large cell neuroendocrine carcinoma (LCNEC): A multicenter retrospective analysis. Journal Of Clinical Oncology 2024, 42: 8106-8106. DOI: 10.1200/jco.2024.42.16_suppl.8106.Peer-Reviewed Original ResearchLarge cell neuroendocrine carcinomaProgression-free survivalTreatment-related adverse eventsPD-L1 statusOverall survivalPD-L1Systemic therapyRetrospective analysisGrades treatment-related adverse eventsTreatment approachesCell neuroendocrine carcinomaMedian follow-upMulticenter retrospective analysisTreated with chemotherapySystemic treatment approachesChemo-regimenPlatinum-etoposideNeuroendocrine carcinomaOS outcomesLine treatmentToxicity profileClinical outcomesAdverse eventsImmunotherapyIO group
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