2025
Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkGambling in Connecticut adolescents: Prevalence, socio-demographic characteristics, trauma exposure, suicidality, and other risk behaviors
Stefanovics E, Zhai Z, Potenza M. Gambling in Connecticut adolescents: Prevalence, socio-demographic characteristics, trauma exposure, suicidality, and other risk behaviors. PLOS ONE 2025, 20: e0290589. PMID: 39908256, PMCID: PMC11798454, DOI: 10.1371/journal.pone.0290589.Peer-Reviewed Original ResearchConceptsSocial supportRisk behaviorsCorrelates of gamblingTraumatic experiencesPoor health outcomesAssociated with traumatic experiencesImplement tailored interventionsReceipt of social supportHealth risk behaviorsConnecticut high school studentsSocio-demographic characteristicsFamily social supportAcademic performanceAssociated with suicideInfluence gambling behaviorPublic health concernTailored interventionsHealth outcomesPast-year gamblingYouth Risk Behavior SurveyPoor academic performanceTrauma exposureRisk Behavior SurveyCurrent prevalenceHigh school studentsA Preliminary Investigation of Associations Between Traumatic Events Experienced During Pregnancy and Salivary Diurnal Cortisol Levels of Brazilian Adolescent Mothers and Infants
Wiley K, Gouveia G, Camilo C, Euclydes V, Panter‐Brick C, Matijasevich A, Ferraro A, Fracolli L, Chiesa A, Miguel E, Polanczyk G, Brentani H. A Preliminary Investigation of Associations Between Traumatic Events Experienced During Pregnancy and Salivary Diurnal Cortisol Levels of Brazilian Adolescent Mothers and Infants. American Journal Of Human Biology 2025, 37: e70004. PMID: 39905640, DOI: 10.1002/ajhb.70004.Peer-Reviewed Original ResearchConceptsLifetime trauma exposureSalivary diurnal cortisolTrauma exposureTraumatic eventsDiurnal cortisolAdolescent mothersEvening cortisolCortisol levelsExposure to traumatic eventsHome visiting interventionInterpersonal violenceAssaultive violence exposureMaternal trauma historyBedtime cortisol levelsExperiences of interpersonal violenceEvening cortisol levelsTrauma history variablesIntergenerational transmission of traumaCohort of adolescent mothersBrazilian adolescent mothersModel of fetal programmingMorning cortisol levelsStudy investigated associationsTransmission of traumaIntervention groupAssociations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study
Bailey M, Fairchild G, Hammerton G, Bauer A, Carpena M, Murray J, Santos I, Barros A, Tovo-Rodrigues L, Danese A, Halligan S, Matijasevich A. Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study. The Lancet Global Health 2025, 13: e309-e318. PMID: 39890231, DOI: 10.1016/s2214-109x(24)00452-2.Peer-Reviewed Original ResearchConceptsLow-income and-middle-income countriesPopulation attributable fractionPelotas Birth CohortAdolescent psychiatric disordersAnxiety disordersPsychiatric disordersTrauma exposureCumulative traumaBirth cohortLongitudinal associationsChildhood traumaMood disordersComputed population attributable fractionsTrauma loadPopulation-based birth cohort studyMental disordersRisk of mental disordersAnd Middle-Income CountriesExposure to childhood traumaPrevalence of trauma exposureAssociated with increased oddsAssociated with mental disordersBirth cohort studyIncreased exposure to traumaBurden of traumaTrauma-informed HIV prevention for forcibly displaced adolescents and young adults
Chantre C, Kershaw T, Lowe S, Davis J, Suleman A, Vermund S, Mootz J. Trauma-informed HIV prevention for forcibly displaced adolescents and young adults. The Lancet HIV 2025, 12: e234-e238. PMID: 39884299, DOI: 10.1016/s2352-3018(24)00313-8.Peer-Reviewed Original ResearchConceptsBurden of mental ill healthMental ill-healthHIV preventionIll healthYoung adultsConflict-affected populationsHIV careHIV interventionsMental healthPoor engagementHIV acquisitionHIV epidemicHIV riskTrauma exposureVulnerable populationsLevel of vulnerabilityHIVHealthSocioenvironmental contextAdolescent girlsDevelopmental periodMigration stressAdultsDocumented associationAdolescentsPosttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets
Mitchell K, Scioli E, Galovski T, Belfer P, Cooper Z. Posttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets. 2025, 95-109. DOI: 10.4324/9781003607403-10.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderComorbid posttraumatic stress disorderPosttraumatic stress disorder symptomsExposure to interpersonal traumaCognitive behavioral theoryHistory of eating disordersLow self-worthEvidence-based treatmentsEmotion dysregulationHyperarousal symptomsInterpersonal traumaBinge eatingTrauma exposureED behaviorsLifetime historyEating disordersSelf-criticismSelf-worthEvidence-based therapiesTreatment of EDCoping strategiesBidirectional relationshipTreatment targetDisordersDifferential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females
Heyn S, Keding T, Cisler J, McLaughlin K, Herringa R. Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females. Scientific Reports 2025, 15: 651. PMID: 39753729, PMCID: PMC11698963, DOI: 10.1038/s41598-024-84616-5.Peer-Reviewed Original ResearchConceptsGray matter volumeVoxel-based morphometryInternalizing psychopathologyChildhood abuseAbuse experiencesPrefrontal cortexCingulate cortexAssociated with increased GMVVoxel-based morphometry analysisInterpersonal violenceDorsal prefrontal cortexDevelopment of psychopathologyAnterior cingulate cortexChildhood abuse historyChildhood abuse exposureT1 structural MRIDifferentiating gray matterPredictive of abuseAdolescent femalesSeverity of abuseDegree of overlapSupramarginal gyrusTrauma exposureStudy of interpersonal violenceIndividual psychopathology
2024
Psychometric properties, factor structure, and functional correlates of the PTSD checklist for DSM-5 in a U.S. national sample of older veterans
Cook J, Bovin M, Günak M, Lawrence K, Pietrzak R. Psychometric properties, factor structure, and functional correlates of the PTSD checklist for DSM-5 in a U.S. national sample of older veterans. International Psychogeriatrics 2024, 37: 100027. PMID: 40086904, DOI: 10.1016/j.inpsyc.2024.100027.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic Stress Disorder ChecklistDSM-5PCL-5Psychometric propertiesOlder veteransSymptoms of posttraumatic stress disorderSubthreshold posttraumatic stress disorderAdult trauma exposurePCL-5 scoresMeasure PTSD symptomsSample of older veteransExcellent internal consistencyRates of childhoodNationally representative web-based surveyU.S. national sampleAssociated with measuresDysphoric symptomsPTSD symptomsStress disorderTrauma exposureFactor structureCommunity-dwelling older veteransAssessment measuresInternal consistencyTrauma-related nightmares among U.S. veterans: Findings from a nationally representative study
Worley C, Meshberg-Cohen S, Fischer I, Pietrzak R. Trauma-related nightmares among U.S. veterans: Findings from a nationally representative study. Sleep Medicine 2024, 126: 159-166. PMID: 39672095, DOI: 10.1016/j.sleep.2024.11.031.Peer-Reviewed Original ResearchTrauma-related nightmaresNationally representative sampleSuicidal ideationTreatment of trauma-related nightmaresRepresentative sampleAssociated with adverse mental healthExposure to adverse childhood eventsTrauma-exposed veteransAssociated with elevated oddsAdverse mental healthIncreased suicide riskNationally representative studyAdverse childhood eventsUS military veteransTransdiagnostic assessmentNightmare severityTrauma exposureHealth historySociodemographic factorsMental healthSuicide riskTrauma typesPsychiatric conditionsSociodemographic characteristicsPsychosocial functioningCrisis, Confidence, and Conserving Resources: Examining How Adult Education Students Navigate Stressors and Marginalization
Griffith F, Simmons S, Schrader S, Miller-Roenigk B, Crouch M, Gordon D. Crisis, Confidence, and Conserving Resources: Examining How Adult Education Students Navigate Stressors and Marginalization. Adult Learning 2024 DOI: 10.1177/10451595241291888.Peer-Reviewed Original ResearchCOVID-19-related stressAdult basic education studentsTrauma exposureTraumatic experiencesAlcohol useOutcomes of alcohol useStress-related risk factorsAdult basic educationStructural equation modelingNavigating stressorsSystemic stressorsConservation of resources theoryPsychoeducational resourcesEquation modelingVocational goalsStressorsStress responseResources theoryStudentsPractice recommendationsEconomic marginalizationK-12 educationTraumaConvenience sampleProgram developmentDevelopmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure
Kribakaran S, DeCross S, Odriozola P, McLaughlin K, Gee D. Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024 PMID: 39368629, DOI: 10.1016/j.jaac.2024.07.928.Peer-Reviewed Original ResearchSafety signal learningInterpersonal trauma exposureTrauma exposureFunctional connectivityHippocampal activityNeural correlatesConditioned safetyFunctional magnetic resonance imaging dataAnterior hippocampal activationDevelopment of psychopathologyAnterior cingulate subregionsTask-based functional magnetic resonance imaging dataExploratory analysisMagnetic resonance imaging dataMental health sequelaeAmygdala activationAge-related associationsAnterior hippocampalContingency awarenessPTSD symptomsInhibit fearAttenuating fearCingulate subregionsSignal learningFear reductionLongitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study
Hyatt C, Reddi P, Sharpe B, Michopoulos V, van Rooij S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, McLean S, Kessler R, Ressler K, Koenen K, Maples-Keller J. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study. Journal Of Research In Personality 2024, 112: 104524. DOI: 10.1016/j.jrp.2024.104524.Peer-Reviewed Original ResearchImpulsive personality traitsPTSD symptomsPersonality traitsOne-year post-traumaSevere PTSD symptomsPost-traumaFactor modelNegative urgencyLow agreeablenessLow conscientiousnessTrauma exposurePersonality assessmentPTSD riskProspective linksSymptom TotalPTSDLongitudinal associationsAURORA studyIncremental predictorNeuroticismTime pointsSymptomsTraitsAgreeablenessConscientiousnessTrauma exposure among young children in rural Pakistan: Associations with gender, mental health, and cognitive skills
Frost A, Collins A, Chung E, Escobar Carias M, Hagaman A, Gupta S, Bibi A, Sikander S, Maselko J. Trauma exposure among young children in rural Pakistan: Associations with gender, mental health, and cognitive skills. BMC Psychology 2024, 12: 454. PMID: 39183356, PMCID: PMC11346172, DOI: 10.1186/s40359-024-01944-x.Peer-Reviewed Original ResearchConceptsChild mental healthMental healthLow-resource settingsAssociated with increased mental health difficultiesRural PakistanMental health difficultiesTrauma exposureMental health problemsStrength of associationSample of mother-child dyadsIncreased anxiety scoresChildren's lifetime exposureTrauma-informed interventionsMother-child dyadsCognitive healthAssociated with genderHealth difficultiesBackgroundThe burdenAnxiety scoresHealth problemsHealthLifetime exposureExperience traumaChildren's cognitive skillsCognitive skillsCerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder
Blithikioti C, Duek O, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D, Perl O. Cerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder. The Cerebellum 2024, 23: 2332-2340. PMID: 39180693, DOI: 10.1007/s12311-024-01731-9.Peer-Reviewed Original ResearchPost-traumatic stress disorderFunctional magnetic resonance imagingRight cerebellar lobule VICerebellar lobule VIAutobiographical memoryTraumatic eventsAutobiographical recallStress disorderLobule VIRe-experiencing of traumatic eventsChronic post-traumatic stress disorderDebilitating mental health conditionPTSD pathophysiologyProcessing negative emotionsNegative affective statesCerebellar Crus IIMental health conditionsCerebellar engagementRe-experiencingTrauma exposureCerebellar contributionReactivity paradigmNegative emotionsAffective statesCrus IITraumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America
Vargas L, Sammel M, Richmond T, Ulrich C, Giano Z, Berkowitz L, Epperson C. Traumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America. PLOS ONE 2024, 19: e0302363. PMID: 38875238, PMCID: PMC11178180, DOI: 10.1371/journal.pone.0302363.Peer-Reviewed Original ResearchConceptsHome countryLatin AmericaU.S. southern borderLatin American migrantsU.S.-Mexico borderCountry of originAmerican migrantsIncreased violenceMigration journeySexual assaultImmigrant adultsEconomic instabilitySexual traumaMigrantsGender differencesExposed to traumatic eventsSouthern borderCountriesAnalysis of sex differencesTraumatic experiencesTrauma exposureLatinTraumatic exposureCombat exposureHomeThe impact of intuitive eating on the association between posttraumatic stress disorder (PTSD) symptoms and disordered eating among women who have experienced intimate partner violence (IPV)
Holmes S, Norton M, Fogwell N, Temes E, Carr M, Johnson D. The impact of intuitive eating on the association between posttraumatic stress disorder (PTSD) symptoms and disordered eating among women who have experienced intimate partner violence (IPV). Eating Disorders 2024, ahead-of-print: 1-17. PMID: 38796861, DOI: 10.1080/10640266.2024.2353475.Peer-Reviewed Original ResearchPosttraumatic stress disorder symptomsPosttraumatic stress disorderBinge eatingIntuitive eatingDisordered eatingIntimate partner violenceBinge frequencyCompensatory behaviorsMeasures of binge eatingAssociated with disordered eatingBinge eating frequencyLevels of intuitive eatingDisordered eating behaviorsPartner violenceTrauma exposureStress disorderProximal predictorsEating frequencyEating behaviorsDomestic violence sheltersBingeEatingModerating roleDichotomous measuresProtective factorsPrepandemic Resilience to Trauma and COVID-19 Infection in Older Women
Scoglio A, Choi K, Nishimi K, Sampson L, Koenen K, Roberts A, Jha S, Kubzansky L. Prepandemic Resilience to Trauma and COVID-19 Infection in Older Women. Psychosomatic Medicine 2024, 86: 625-632. PMID: 38573019, PMCID: PMC11371542, DOI: 10.1097/psy.0000000000001304.Peer-Reviewed Original ResearchPsychological resilienceSelf-reportLifetime trauma exposureAssociated with lower riskLow psychological resilienceTrauma exposureCOVID-19-related risk factorsLifetime traumaPsychosocial interventionsNurses' Health Study IIPsychological healthPsychological assetsImprove health outcomesLow riskPhysical healthResilience scoresProtective factorsStudy IIPositive COVID-19 test resultSymptomsCOVID-19 test resultsHealth outcomesCohort participantsCOVID-19 infectionSocio-demographicAssociations between trauma exposure and irritability within the family unit: a network approach
Cotter G, Morreale K, Valdegas A, Fish M, Beebe R, Grasso D, Stover C, Tseng W. Associations between trauma exposure and irritability within the family unit: a network approach. Journal Of Child Psychology And Psychiatry 2024, 65: 1501-1512. PMID: 38710637, DOI: 10.1111/jcpp.13998.Peer-Reviewed Original ResearchPost-traumatic stress disorderTrauma-exposed childrenTrauma exposureIntimate partner violencePediatric irritabilityTrauma historyPost-traumatic stress disorder severityPost-traumatic stress disorder symptomsTreatment of irritabilityAdulthood trauma exposureChild trauma exposurePrevalence of irritabilityParent self-reportConnecticut Department of ChildrenParental intimate partner violenceReduce intimate partner violenceFamily unitPTSD severityParental psychopathologyPsychotherapy interventionsStress disorderChild irritabilityPsychiatric symptomsDepartment of ChildrenAssessed pre-interventionIntensive longitudinal assessment following index trauma to predict development of PTSD using machine learning
Horwitz A, McCarthy K, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Joormann J, Harte S, Koenen K, McLean S, Sen S. Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning. Journal Of Anxiety Disorders 2024, 104: 102876. PMID: 38723405, PMCID: PMC11215748, DOI: 10.1016/j.janxdis.2024.102876.Peer-Reviewed Original ResearchTraumatic exposureIntensive longitudinal assessmentDevelopment of PTSDTrauma-related symptomsExposure to traumaFollow-up careTrauma exposureIndex traumaEmergency carePTSDAssess symptomsLongitudinal assessmentAssessment protocolCareParticipantsSymptomsFollow-upInterventionMachine learning analysisTraumaRiskIndividualsWeeksLearning analysisNervousnessIntergenerational trauma transmission through family psychosocial factors in adult children of Rwandan survivors of the 1994 genocide against the Tutsi
Bonumwezi J, Grapin S, Uddin M, Coyle S, Habintwali D, Lowe S. Intergenerational trauma transmission through family psychosocial factors in adult children of Rwandan survivors of the 1994 genocide against the Tutsi. Social Science & Medicine 2024, 348: 116837. PMID: 38579628, DOI: 10.1016/j.socscimed.2024.116837.Peer-Reviewed Original ResearchConceptsFamily psychosocial factorsPsychosocial factorsDepressive symptomsChild PTSDMaternal PTSDAdverse mental health outcomesChildren of survivorsMaternal trauma exposureCross-sectional online surveyAssociated with child anxietyMental health outcomesPaternal parenting stylesIntergenerational trauma transmissionIntergenerational transmission of traumaParent-child dyadsHealth outcomesTrauma communicationFamily communication stylesSurvivor mothersTransmission of traumaPTSD symptomsTrauma exposureChild anxietyFamily communicationTrauma interventions
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