2025
Transient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke
Chen H, Khunte M, Colasurdo M, Majmundar S, Payabvash S, Chaturvedi S, Malhotra A, Gandhi D. Transient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke. Stroke 2025, 56: 285-293. PMID: 39869710, DOI: 10.1161/strokeaha.124.049278.Peer-Reviewed Original ResearchConceptsRates of vascular risk factorsTransient ischemic attackUS Census Bureau dataAssociated with lower oddsHigher odds of deathIschemic strokeRisk factorsAnnual incidenceTransient neurological symptomsStroke risk factorsOdds of deathLogistic regression modelsVascular risk factorsCensus Bureau dataRate of headacheRetrospective cohort studyLower oddsHigher oddsNeurological symptomsHome dischargeCohort studyIschemic attackHospital incidenceExcess hospitalizationsRisk of hemorrhage
2024
Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program
Xian Y, Li S, Jiang T, Beon C, Poudel R, Thomas K, Reeves M, Smith E, Saver J, Sheth K, Messé S, Schwamm L, Fonarow G. Twenty Years of Sustained Improvement in Quality of Care and Outcomes for Patients Hospitalized With Stroke or Transient Ischemic Attack: Data From The Get With The Guidelines-Stroke Program. Stroke 2024, 55: 2599-2610. PMID: 39429153, PMCID: PMC11518659, DOI: 10.1161/strokeaha.124.048174.Peer-Reviewed Original ResearchConceptsGuidelines-Stroke programEvidence-based stroke careDoor-to-needle timeTransient ischemic attackGuidelines-Stroke hospitalsEvidence-based careQuality of careSmoking cessation counselingSustained improvementQuality improvement initiativesSkilled nursing facilityIndependence of patientsAcute ischemic strokeIschemic strokeRelevant to patientsIschemic attackDoor-to-puncture timeCessation counselingGuidelines-StrokeAssociated with sustained improvementStroke careDysphagia screeningNursing facilitiesHospital characteristicsImprovement initiativesPulmonary Angiography: Arteriovenous Malformation and Pseudoaneurysm
Luhar A, Pollak J. Pulmonary Angiography: Arteriovenous Malformation and Pseudoaneurysm. 2024, 311-324. DOI: 10.1007/978-3-031-52546-9_25.Peer-Reviewed Original ResearchPulmonary arteriovenous malformationsRight-to-left shuntHereditary hemorrhagic telangiectasiaTransient ischemic attackChest painSize of pulmonary arteriovenous malformationsAssociated with hereditary hemorrhagic telangiectasiaDegree of right-to-left shuntingTreatment of pulmonary arteriovenous malformationsAssociated with paradoxical emboliIntrapulmonary right-to-left shuntFeeding artery diameterPulmonary artery pseudoaneurysmLocal mass effectBrain abscessPeripheral emboliIntrapulmonary hemorrhageArteriovenous malformationsHemorrhagic telangiectasiaSymptomatic hypoxemiaPulmonary arterySerious complicationsEndovascular treatmentArtery pseudoaneurysmParadoxical emboliIrregular Cycles, Ovulatory Disorders, and Cardiometabolic Conditions in a US-Based Digital Cohort
Wang Z, Jukic A, Baird D, Wilcox A, Li H, Curry C, Fischer-Colbrie T, Onnela J, Williams M, Hauser R, Coull B, Mahalingaiah S. Irregular Cycles, Ovulatory Disorders, and Cardiometabolic Conditions in a US-Based Digital Cohort. JAMA Network Open 2024, 7: e249657. PMID: 38700861, PMCID: PMC11069087, DOI: 10.1001/jamanetworkopen.2024.9657.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeCardiometabolic conditionsPrevalence odds ratiosAssociated with type 2 diabetesTransient ischemic attackType 2 diabetesAssociation of polycystic ovary syndromeIrregular menstrual cyclesEstimate prevalence odds ratiosCoronary artery diseaseOvulatory disordersHeart attackHigh cholesterolPolycystic ovary syndrome statusIrregular cyclesLower body mass indexCross-sectional studyAge of consentBody mass indexLogistic regression modelsMenstrual cyclePhysical activityLifestyle factorsArtery diseaseEffect modificationTranscarotid Arterial Revascularization of Symptomatic Internal Carotid Artery Disease: A Systematic Review and Study-Level Meta-Analysis
Ghannam M, AlMajali M, Khasiyev F, Dibas M, Al Qudah A, AlMajali F, Ghazaleh D, Shah A, Fayad F, Joudi K, Zaidat B, Childs C, Levy B, Abouainain Y, Brunschot D, Shu L, Goldstein E, Baig A, Roeder H, Henninger N, de Havenon A, Levy E, Matouk C, Derdeyn C, Leira E, Chaturvedi S, Yaghi S. Transcarotid Arterial Revascularization of Symptomatic Internal Carotid Artery Disease: A Systematic Review and Study-Level Meta-Analysis. Stroke 2024, 55: 921-930. PMID: 38299350, DOI: 10.1161/strokeaha.123.044246.Peer-Reviewed Original ResearchSymptomatic internal carotid artery diseaseCarotid artery stentingInternal carotid artery diseaseTranscarotid artery revascularizationTransient ischemic attackCarotid artery diseaseCarotid endarterectomyRate of strokeArtery diseaseIschemic attackMyocardial infarctionOdds ratioStudy-level meta-analysisProspective randomized trialsCranial nerve injurySystematic reviewRates of myocardial infarctionPooled odds ratioSymptomatic carotid stenosisDegree of stenosisNerve injuryPatient cohortArtery revascularizationInterventional therapySubgroup analysisApproval, Evidence, and “Off-Label” Device Utilization: The Patent Foramen Ovale Closure Story
Goldsweig A, Deng Y, Yao X, Desai N, Cohen D, Aronow H, Messé S, Ross J, Lansky A, Savitz S. Approval, Evidence, and “Off-Label” Device Utilization: The Patent Foramen Ovale Closure Story. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010200. PMID: 38189127, PMCID: PMC10844981, DOI: 10.1161/circoutcomes.123.010200.Peer-Reviewed Original ResearchStroke/systemic embolismTransient ischemia attackPFO closureSystemic embolismIschemia attackRetrospective cohort studyTransient ischemic attackHalf of patientsOptumLabs Data WarehouseCommercial insurance enrolleesRegulatory approvalClinical trial publicationsIschemic attackRecurrent strokeCohort studyPatent foramenUnderwent closureAtrial fibrillationClinical trialsInsurance enrolleesDecompression illnessTrial publicationsOff labelPatientsProcedure volumeReal-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events
Sico J, Hu X, Myers L, Levine D, Bravata D, Arling G. Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events. Stroke And Vascular Neurology 2024, 9: 519-529. PMID: 38191185, PMCID: PMC11732840, DOI: 10.1136/svn-2023-002759.Peer-Reviewed Original ResearchTransient ischemic attackSystolic blood pressureVeterans Administration Medical CenterStroke/transient ischemic attackIntensive SBP goalRecurrent vascular eventsCardiovascular eventsVascular eventsSBP goalSBP groupRecurrent stroke/transient ischemic attackMultivariable Cox proportional hazards regressionGoal systolic blood pressureIndex emergency department visitStroke/TIA patientsSystolic blood pressure goalAverage systolic blood pressureLower systolic blood pressureCox proportional hazards regressionBlood pressure goalsRecurrent cerebrovascular eventsRetrospective cohort studyEmergency department visitsProportional hazards regressionSignificant higher riskPatient Insights on Integrating Sleep Apnea Testing into Routine Stroke and TIA Care
Rattray N, Story K, Burrone L, Sexson A, Koo B, Bravata D, Perkins A, Myers L, Daggy J, Taylor S, Fields B, Kunisaki K, Daley J, Palacio S, Hermann L, Sico J. Patient Insights on Integrating Sleep Apnea Testing into Routine Stroke and TIA Care. Journal Of Patient Experience 2024, 11: 23743735241310263. PMID: 39742072, PMCID: PMC11686624, DOI: 10.1177/23743735241310263.Peer-Reviewed Original ResearchObstructive sleep apnea testingObstructive sleep apneaTransient ischemic attackSleep testPrevalence of obstructive sleep apneaPatients expressed higher levelsSleep apnea testingCerebrovascular diseaseGuideline-concordant screeningSleep apneaApnea testingIschemic attackPatientsImprove outcomesAHA/ASA guidelinesIschemic strokeStroke/TIAVeterans Affairs facilitiesAcute stroke/TIARoutine partExperience of careThematic analysis of semi-structured interviewsCerebrovascularAnalysis of semi-structured interviewsDisease
2023
Characteristics and outcomes of elderly patients undergoing protected percutaneous coronary intervention with impella mechanical circulatory support
Jakob P, Falah B, Abu-Much A, Lansky A, Basir M, Schonning M, Zhou Z, Batchelor W, Grines C, O'neill W, Stahli B. Characteristics and outcomes of elderly patients undergoing protected percutaneous coronary intervention with impella mechanical circulatory support. European Heart Journal 2023, 44: ehad655.2209. DOI: 10.1093/eurheartj/ehad655.2209.Peer-Reviewed Original ResearchHigh-risk percutaneous coronary interventionPercutaneous coronary interventionMechanical circulatory supportYears of ageCirculatory supportMyocardial infarctionCoronary interventionElderly patientsClinical outcomesStroke/transient ischemic attackMain percutaneous coronary interventionMultivariable Cox regression modelsSevere valvular heart diseaseLeft ventricular ejection fractionLower body mass indexBaseline SYNTAX scoreTransient ischemic attackHigh-risk patientsGlomerular filtration ratePrior myocardial infarctionVentricular ejection fractionValvular heart diseaseBody mass indexCox regression modelRisk of mortalityComparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.
Kim D, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Jones R, Marcantonio E, Inouye S. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study. Annals Of Internal Medicine 2023, 176: 1153-1162. PMID: 37665998, PMCID: PMC10625498, DOI: 10.7326/m22-3021.Peer-Reviewed Original ResearchConceptsTransient ischemic attackAdverse clinical eventsHospital deathMajor surgeryClinical eventsPostoperative deliriumCohort studyOlder patientsAntipsychotic drugsArrhythmia eventsCardiac arrhythmia eventsHospital adverse clinical eventsModerate-dose treatmentPremier Healthcare DatabaseHospital adverse eventsNationwide cohort studyRetrospective cohort studyAtypical antipsychotic useOral antipsychotic drugsSignificant differencesHaloperidol useIschemic attackOral antipsychoticsAdverse eventsOral haloperidolSex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study
Shah T, Abu-Much A, Batchelor W, Grines C, Baron S, Zhou Z, Li Y, Maini A, Redfors B, Hussain Y, Wollmuth J, Basir M, O'Neill W, Lansky A. Sex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study. JACC Cardiovascular Interventions 2023, 16: 1721-1729. PMID: 37409991, DOI: 10.1016/j.jcin.2023.04.036.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionFemale patientsIII studySex-based differencesImmediate PCISYNTAX scoreClinical outcomesMyocardial infarctionStroke/transient ischemic attackWorse renal functionAcute limb ischemiaTransient ischemic attackSex differencesPercutaneous coronary interventionAcute myocardial infarctionHigher ejection fractionCause deathCoronary complicationsIschemic attackMajor bleedingNonfemoral accessPercutaneous CoronaryPrior strokeCerebrovascular eventsVascular complicationsTrends in Disparities in Advanced Neuroimaging Utilization in Acute Stroke: A Population-Based Study
Vagal A, Sucharew H, Wang L, Kissela B, Alwell K, Haverbusch M, Woo D, Ferioli S, Mackey J, La Rosa F, Mistry E, Demel S, Coleman E, Jasne A, Walsh K, Khatri P, Slavin S, Star M, Stephens C, Kleindorfer D. Trends in Disparities in Advanced Neuroimaging Utilization in Acute Stroke: A Population-Based Study. Stroke 2023, 54: 1001-1008. PMID: 36972349, DOI: 10.1161/strokeaha.122.040790.Peer-Reviewed Original ResearchConceptsPopulation-based studyAdvanced imagingSocioeconomic statusAcute strokeOlder patientsAdvanced neuroimagingStroke/transient ischemic attack eventsTransient ischemic attack eventsUS census tractsTransient ischemic attackLow SES patientsMultivariable logistic regressionHospital admission dateHigher socioeconomic statusIschemic attackYounger patientsSES patientsWhite patientsBlack patientsAdmission dateMultivariable modelAttack onsetSES-related disparitiesPatientsSecondary objectiveClinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness
Tu L, Malhotra A, Venkatesh A, Taylor R, Sheth K, Yaesoubi R, Forman H, Sureshanand S, Navaratnam D. Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. PLOS ONE 2023, 18: e0280752. PMID: 36893103, PMCID: PMC9997874, DOI: 10.1371/journal.pone.0280752.Peer-Reviewed Original ResearchConceptsAcute vascular pathologyEmergency departmentVascular pathologyNegative predictive valueDizzy patientsStroke codeCTA headPredictive valueAdult ED encountersTransient ischemic attackHalf of patientsLong-term smokersLarge vessel occlusionCoronary artery diseasePast medical historySeparate validation cohortCross-sectional analysisIschemic attackAnalysis cohortArterial dissectionArtery diseaseClinical factorsED encountersMedication useChief complaintSmoking-Cessation Pharmacotherapy After Stroke and Transient Ischemic Attack: A Get With The Guidelines-Stroke Analysis
Parikh N, Zhang C, Omran S, Restifo D, Carpenter M, Schwamm L, Kamel H. Smoking-Cessation Pharmacotherapy After Stroke and Transient Ischemic Attack: A Get With The Guidelines-Stroke Analysis. Stroke 2023, 54: e63-e65. PMID: 36727507, PMCID: PMC9992306, DOI: 10.1161/strokeaha.122.041532.Peer-Reviewed Original ResearchConceptsSmoking cessation pharmacotherapyTransient ischemic attackIschemic attackPharmacotherapyStrokeDiagnosis, Workup, Risk Reduction of Transient Ischemic Attack in the Emergency Department Setting: A Scientific Statement From the American Heart Association
Amin H, Madsen T, Bravata D, Wira C, Johnston S, Ashcraft S, Burrus T, Panagos P, Wintermark M, Esenwa C, Disease O. Diagnosis, Workup, Risk Reduction of Transient Ischemic Attack in the Emergency Department Setting: A Scientific Statement From the American Heart Association. Stroke 2023, 54: e109-e121. PMID: 36655570, DOI: 10.1161/str.0000000000000418.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic attackMaximal medical therapyHigh-risk patientsCorrect clinical diagnosisRisk stratification scaleAmerican Heart AssociationEmergency department settingFuture cerebrovascular eventsScientific statementTime of evaluationCerebrovascular eventsSecondary preventionStroke riskMedical therapyNeurological examinationAcute phaseIndex eventHeart AssociationDepartment settingPatient educationAncillary testingCerebral vasculatureConfirmatory testingClinical diagnosis
2022
Erratum to ‘Blood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack’ The American Journal of Medicine, Volume 135 (2022), Issue 7, 889-896.e1
Arling G, Perkins A, Myers L, Sico J, Bravata D. Erratum to ‘Blood Pressure Trajectories and Outcomes for Veterans Presenting at VA Medical Centers with a Stroke or Transient Ischemic Attack’ The American Journal of Medicine, Volume 135 (2022), Issue 7, 889-896.e1. The American Journal Of Medicine 2022, 136: 215. PMID: 36428161, DOI: 10.1016/j.amjmed.2022.11.003.Peer-Reviewed Original ResearchComparative Safety of Transcatheter LAAO With the First-Generation Watchman and Next-Generation Watchman FLX Devices
Price M, Friedman D, Du C, Wang Y, Lin Z, Curtis J, Freeman J. Comparative Safety of Transcatheter LAAO With the First-Generation Watchman and Next-Generation Watchman FLX Devices. JACC Cardiovascular Interventions 2022, 15: 2115-2123. PMID: 36357014, DOI: 10.1016/j.jcin.2022.09.002.Peer-Reviewed Original ResearchConceptsHospital major adverse eventsMajor adverse eventsWatchman FLXMajor vascular complicationsMajor bleedingPericardial effusionCardiac arrestDevice embolizationVascular complicationsMyocardial infarctionLower ratesSystemic arterial embolismComposite of deathTransient ischemic attackAtrial appendage occlusionSignificant lower rateBalance of risksHospital mortalityIschemic attackArterial embolismHospital outcomesPrimary endpointStroke preventionAdverse eventsProcedural complicationsResidual stroke risk despite oral anticoagulation in patients with atrial fibrillation
Carlisle M, Shrader P, Fudim M, Pieper K, Blanco R, Fonarow G, Naccarelli G, Gersh B, Reiffel J, Kowey P, Steinberg B, Freeman J, Ezekowitz M, Singer D, Allen L, Chan P, Pokorney S, Peterson E, Piccini J, Patients and Investigators O. Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation. Heart Rhythm O2 2022, 3: 621-628. PMID: 36589908, PMCID: PMC9795305, DOI: 10.1016/j.hroo.2022.09.018.Peer-Reviewed Original ResearchTransient ischemic attackPermanent atrial fibrillationOral anticoagulationAtrial fibrillationVASc scoreIschemic attackThromboembolic eventsFemale sexPrevious stroke/transient ischemic attackStroke/transient ischemic attackTransient ischemic attack eventsCox proportional hazard modelingResidual riskResidual stroke riskBetter Informed TreatmentRisk of thromboembolismProportional hazard modelingSystemic embolismPrevious strokeStroke riskOutcomes RegistryMean ageRisk markersOutcome eventsThromboembolismIndications for Left Atrial Appendage Occlusion in the United States and Associated In-Hospital Outcomes: Results From the NCDR LAAO Registry
Daimee UA, Wang Y, Masoudi FA, Varosy PD, Friedman DJ, Du C, Koutras C, Reddy VY, Saw J, Price MJ, Kusumoto FM, Curtis JP, Freeman JV. Indications for Left Atrial Appendage Occlusion in the United States and Associated In-Hospital Outcomes: Results From the NCDR LAAO Registry. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008418. PMID: 35959677, PMCID: PMC9388561, DOI: 10.1161/circoutcomes.121.008418.Peer-Reviewed Original ResearchConceptsHospital adverse eventsHigh fall riskNational Cardiovascular Data RegistryProcedural indicationsAtrial appendage occlusionAdverse eventsWatchman implantationFall riskMajor bleedsThromboembolic riskAppendage occlusionData registryAbnormal renal/liver functionLeft atrial appendage occlusionIn-Hospital OutcomesMean patient ageTransient ischemic attackMajority of patientsInternational normalized ratioIschemic attackMean CHAOral anticoagulationPrior strokeVASc scoreWATCHMAN procedureTrends in characteristics of neurologists who provide stroke consultations in the USA, 2008–2021
Nakamoto C, Wilcock A, Schwamm L, Majersik J, Zachrison K, Mehrotra A. Trends in characteristics of neurologists who provide stroke consultations in the USA, 2008–2021. Stroke And Vascular Neurology 2022, 8: 86-88. PMID: 35902139, PMCID: PMC9985800, DOI: 10.1136/svn-2022-001662.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTransient ischemic attackVascular neurologistsPatient's homeAIS/transient ischemic attackHigh-volume providersNeurologist consultationTIA episodesIschemic attackIschemic strokeStroke consultationsNeurologistsService MedicarePhysician practicesStudy periodConsultsPatientsEpisodesConsultationHomeHospitalStrokeProportion
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