2025
Outcomes of Mechanical Thrombectomy for Acute Limb Ischemia at a Tertiary Referral Center
Loh S, Nasir A, Strosberg D, Ochoa Chaar C, Guzman R, Tonnessen B. Outcomes of Mechanical Thrombectomy for Acute Limb Ischemia at a Tertiary Referral Center. Journal Of Vascular Surgery 2025 PMID: 40024380, DOI: 10.1016/j.jvs.2025.02.027.Peer-Reviewed Original ResearchTertiary referral centerAcute limb ischemiaAdverse cardiovascular eventsReferral centerMechanical thrombectomyOpen surgeryThirty-dayCardiovascular eventsConversion to open surgeryLimb ischemiaTreated with mechanical thrombectomyMedian follow-upCatheter-directed thrombolysisManagement of acute limb ischemiaDuration of symptomsThirty-day complicationsOutcomes of mechanical thrombectomyRisk of limb lossHigh risk of limb lossAcute limb ischemia casesMechanical thrombectomy devicesBleeding eventsMulticenter trialThrombosed bypassesThrombosed stent
2024
Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss - A Comorbidity Lens.
Leder Macek A, Wang R, Cottrell J, Kay-Rivest E, McMenomey S, Roland J, Ross F. Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss - A Comorbidity Lens. Undersea And Hyperbaric Medicine 2024, 51: 393-402. PMID: 39821768, DOI: 10.22462/730.Peer-Reviewed Original ResearchConceptsSudden sensorineural hearing lossSensorineural hearing lossHearing loss onsetHearing lossHyperbaric oxygen therapyWord discrimination scoresSpeech perception outcomesIntratympanic steroid injectionOxygen therapyOral steroid coursesPerception outcomesTone averageSiegel's criteriaClinical improvementPhysician visitsPatient comorbiditiesRheumatologic disordersDiscrimination scoresAssociated with patient outcomesTreated with hyperbaric oxygen therapyCharlson Comorbidity IndexImpact of patient comorbiditiesTertiary referral centerOutcomes of patientsAdjunct to steroidsGastric Cancer at a Nigerian Tertiary Referral Center: Experiences With Establishing an Institutional Cancer Registry
Yibrehu B, Mohammed T, Murthy S, Aderibigbe A, Daramola O, Arije O, Owoade I, Wuraola F, Olasehinde O, Betiku O, Folorunso S, Omoyiola O, Aderounmu A, Adisa A, Kingham P, Alatise O. Gastric Cancer at a Nigerian Tertiary Referral Center: Experiences With Establishing an Institutional Cancer Registry. Journal Of Surgical Oncology 2024 PMID: 39558548, DOI: 10.1002/jso.27993.Peer-Reviewed Original ResearchInstitutional cancer registryGastric cancerCancer RegistryTreatment modalitiesSuspected gastric cancerManagement of gastric cancerQuality of registry dataTertiary referral centerGastric cancer registryHigh-risk patientsDatabase of patientsGastric cancer databasePeriodic chart reviewMetastatic diseaseAdvanced diseaseReferral centerCancer DatabaseAvailability of robust dataMedian timeChart reviewFollow-upDeadly malignancyBlood workPatientsRegistry dataP27.10.B FACTORS INFLUENCING TIMELY DIAGNOSIS IN NEUROLYMPHOMATOSIS
Doubrovinskaia S, Egert A, Karschnia P, Scheffler G, Huttner A, Fulbright R, Baehring J, Kaulen L. P27.10.B FACTORS INFLUENCING TIMELY DIAGNOSIS IN NEUROLYMPHOMATOSIS. Neuro-Oncology 2024, 26: v138-v139. PMCID: PMC11485484, DOI: 10.1093/neuonc/noae144.472.Peer-Reviewed Original ResearchNon-Hodgkin's lymphomaPeripheral nervous systemNerve root lesionsDiagnostic intervalRelapse of NHLSymptom onsetAssociated with early diagnosisTertiary referral centerAtypical clinical presentationRoot lesionsCerebrospinal fluid examinationDiagnostic work-upYale Cancer CenterPainful polyneuropathyAsymmetric neuropathyClinical presentationReferral centerFluid examinationQuality control databaseDiagnostic delayFDG-PETPrimary diseaseUnivariate analysisConventional CTNeurolymphomatosisCochlear Apex Triangulation Utilizing Ct Measures And Middle Ear Landmarks
Cottrell J, Landsberger D, Breen M, Lebowitz J, Hagiwara M, Moonis G, Shapiro W, Friedmann D, Jethanamest D, McMenomey S, Roland J. Cochlear Apex Triangulation Utilizing Ct Measures And Middle Ear Landmarks. Otology & Neurotology Open 2024, 4: e060-e060. PMID: 39328867, PMCID: PMC11424059, DOI: 10.1097/ono.0000000000000060.Peer-Reviewed Original ResearchCochlear apexRound windowCochlear implant recipientsCochleariform processTemporal bone CT scansComputed tomographyMiddle ear landmarksImplant recipientsPreoperative computed tomographyTertiary referral centerSurgically relevant landmarksSuperior-inferior distanceImprove procedural successReferral centerSurgical approachCT scanOval windowAnteroposterior distanceMultiplanar reformattingCT measurementsCritical structuresReduce traumaSurrounding structuresPromontory boneElectrode placement
2023
Assessing National Trends and Perceived Safety of Off‐Label Ciprofloxacin‐Dexamethasone Use by Pediatric Otolaryngologists
Shah H, Shah R, Lockwood D, Yang N, Rohrbaugh T, Rutter M, Maurrasse S. Assessing National Trends and Perceived Safety of Off‐Label Ciprofloxacin‐Dexamethasone Use by Pediatric Otolaryngologists. The Laryngoscope 2023, 134: 2922-2930. PMID: 38149706, DOI: 10.1002/lary.31211.Peer-Reviewed Original ResearchLabel usePediatric otolaryngologistsAdverse eventsCommon indicationMost common indicationTertiary referral centerMultivariate logistic regressionPediatric Otolaryngology (ASPO) membersNational trendsCross-sectional surveyDexamethasone useReferral centerComplete responseChildren's HospitalSafety profileUnivariate analysisChoanal atresiaTracheal granulationAnecdotal successLogistic regressionOtolaryngologistsPractice typeEase of accessCPD usePrivate practiceImpact of COVID-19 on the gastrointestinal surgical oncology patient population
Bakkila B, Marks V, Kerekes D, Kunstman J, Salem R, Billingsley K, Ahuja N, Laurans M, Olino K, Khan S. Impact of COVID-19 on the gastrointestinal surgical oncology patient population. Heliyon 2023, 9: e18459. PMID: 37534012, PMCID: PMC10391949, DOI: 10.1016/j.heliyon.2023.e18459.Peer-Reviewed Original ResearchGI cancer surgeryPreoperative chemotherapyCancer surgerySurgical careCOVID-19 pandemicCOVID-19Tertiary referral centerOncology patient populationFirst COVID-19 waveGI cancer casesCOVID-19 burdenHigh COVID-19 burdenEmergency surgeryReferral centerCOVID-19 waveOncology visitsGastrointestinal cancerGI cancersPatient populationStudy criteriaCancer careTreatment characteristicsCancer casesCase volumePatientsOsteonecrosis in Gaucher disease in the era of multiple therapies: Biomarker set for risk stratification from a tertiary referral center
Basiri M, Ghaffari M, Ruan J, Murugesan V, Kleytman N, Belinsky G, Akhavan A, Lischuk A, Guo L, Klinger K, Mistry P. Osteonecrosis in Gaucher disease in the era of multiple therapies: Biomarker set for risk stratification from a tertiary referral center. ELife 2023, 12: e87537. PMID: 37249220, PMCID: PMC10317498, DOI: 10.7554/elife.87537.Peer-Reviewed Original ResearchConceptsEnzyme replacement therapySubstrate reduction therapyAvascular osteonecrosisTertiary referral centerGaucher diseaseReferral centerTreatment initiationGD patientsImiglucerase enzyme replacement therapyResidual disease activityAnti-drug antibodiesYears of treatmentType of therapyRare inborn errorMixed-effects logistic modelGD1 patientsSpleen statusDisease activityClinical outcomesRisk stratificationReplacement therapyIndependent correlatesMultiple therapiesReduction therapyHigh risk
2022
P11.54.A Factors effecting early diagnosis in neurolymphomatosis
Egert A, Karschnia P, Huttner A, Baehring J, Kaulen L. P11.54.A Factors effecting early diagnosis in neurolymphomatosis. Neuro-Oncology 2022, 24: ii70-ii70. PMCID: PMC9443184, DOI: 10.1093/neuonc/noac174.243.Peer-Reviewed Original ResearchNon-Hodgkin lymphomaEarly diagnosisSymptom onsetPathological findingsDiffuse large B-cell lymphomaCase of neurolymphomatosisDiagnosis of neurolymphomatosisYale Cancer CenterTertiary referral centerFDG-PET imagingPeripheral nervous systemB-cell lymphomaImaging gold standardSPSS version 27Painful polyneuropathyPainless polyneuropathySecondary neurolymphomatosisAutonomic neuropathyCranial neuropathiesMedian intervalReferral centerAutonomic nervesClinical suspicionFDG-PETCancer CenterKetamine Boluses Are Associated with a Reduction in Intracranial Pressure and an Increase in Cerebral Perfusion Pressure: A Retrospective Observational Study of Patients with Severe Traumatic Brain Injury
Dengler BA, Karam O, Barthol CA, Chance A, Snider LE, Mundy CM, Bounajem MT, Johnson WC, Maita MM, Mendez-Gomez PM, Seifi A, Hafeez S. Ketamine Boluses Are Associated with a Reduction in Intracranial Pressure and an Increase in Cerebral Perfusion Pressure: A Retrospective Observational Study of Patients with Severe Traumatic Brain Injury. Critical Care Research And Practice 2022, 2022: 3834165. PMID: 35637760, PMCID: PMC9148235, DOI: 10.1155/2022/3834165.Peer-Reviewed Original ResearchCerebral perfusion pressureSevere traumatic brain injuryTraumatic brain injuryKetamine bolusGlasgow Coma ScaleRefractory intracranial pressureIntracranial pressureBrain injuryPerfusion pressureRetrospective reviewSingle tertiary referral centerTraumatic brain injury populationSustained ICPTertiary referral centerNeurointensive care unitRetrospective observational studyBolus of ketamineSingle-institution studyBrain injury populationIntracranial pressure monitorSystemic hypotensionReferral centerSedative medicationsAdequate sedationComa ScaleTracheostomy Is Associated With a Decrease in Delirium and Sedation for Intubated COVID-19 Patients
Morton C, Pisani M, Doyle M, Puchalski J. Tracheostomy Is Associated With a Decrease in Delirium and Sedation for Intubated COVID-19 Patients. Journal Of Bronchology & Interventional Pulmonology 2022, 30: 32-36. PMID: 35288526, DOI: 10.1097/lbr.0000000000000841.Peer-Reviewed Original ResearchConceptsProportion of daysCoronavirus disease 2019 acute respiratory distress syndromeIntubated COVID-19 patientsRichmond Agitation-Sedation Scale scoreUrban tertiary referral centerAcute respiratory distress syndromeAmount of opioidsConfusion Assessment MethodTertiary referral centerRespiratory distress syndromeSedation Scale scoreCOVID-19 patientsSignificant decreaseIntensive care unit dataBenzodiazepine dosingLorazepam equivalentsMorphine equivalentsOpioid dosingVentilator liberationRespiratory failureReferral centerDistress syndromeSedation needsSedation requirementsLower incidenceSurvival in total preoperative verus perioperative chemotherapy for patients with metastatic high-grade appendiceal adenocarcinoma undergoing CRS/HIPEC.
Morgan R, Yan A, Dhiman A, Sood D, Ong C, Wu X, Shergill A, Polite B, Turaga K, Eng O. Survival in total preoperative verus perioperative chemotherapy for patients with metastatic high-grade appendiceal adenocarcinoma undergoing CRS/HIPEC. Journal Of Clinical Oncology 2022, 40: 90-90. DOI: 10.1200/jco.2022.40.4_suppl.090.Peer-Reviewed Original ResearchPeri-operative groupPre-operative groupChemotherapy-related toxicityAppendiceal cancerAppendiceal adenocarcinomaPeritoneal metastasisHigh-grade appendiceal adenocarcinomaHigh-grade appendiceal cancerMonths of systemic chemotherapyOptimal timing of chemotherapyRetrospective review of patientsSignet ring cell histologyAssociated with similar survivalPlanned 6 monthsMedian overall survivalHyperthermic intraperitoneal chemotherapyPre-operative chemotherapyPoorly differentiated tumorsTiming of chemotherapyPeri-operative treatmentReview of patientsTertiary referral centerColon cancer patientsCytoreductive surgeryCell histologyDouble pigtail stent placement as an adjunct to lumen-apposing metal stents for drainage of pancreatic fluid collections may not affect outcomes: A multicenter experience
Shamah SP, Sahakian AB, Chapman CG, Buxbaum JL, Muniraj T, Aslanian HA, Villa E, Cho J, Haider HI, Waxman I, Siddiqui UD. Double pigtail stent placement as an adjunct to lumen-apposing metal stents for drainage of pancreatic fluid collections may not affect outcomes: A multicenter experience. Endoscopic Ultrasound 2022, 11: 53-58. PMID: 35102901, PMCID: PMC8887040, DOI: 10.4103/eus-d-21-00030.Peer-Reviewed Original ResearchDouble-pigtail plastic stentsLumen-apposing metal stentsEUS-guided drainagePancreatic fluid collectionsAdverse eventsFluid collectionMetal stentsUS tertiary referral centersHigher adverse event ratesMulticenter retrospective studyTertiary referral centerAdverse event ratesOverall technical successTypes of PFCsPigtail plastic stentsPostsurgical fluid collectionReintervention rateMulticenter experienceReferral centerClinical outcomesRetrospective studyMulticenter studyStent placementTechnical successSubgroup analysis
2021
Treatment of Persistent Erythema Multiforme With Janus Kinase Inhibition and the Role of Interferon Gamma and Interleukin 15 in Its Pathogenesis
Murphy MJ, Gruenstein D, Wang A, Peterson D, Levitt J, King B, Damsky W. Treatment of Persistent Erythema Multiforme With Janus Kinase Inhibition and the Role of Interferon Gamma and Interleukin 15 in Its Pathogenesis. JAMA Dermatology 2021, 157: 1477-1482. PMID: 34757416, PMCID: PMC8581795, DOI: 10.1001/jamadermatol.2021.4084.Peer-Reviewed Original ResearchConceptsPersistent erythema multiformeErythema multiformeJanus kinase (JAK) inhibitionBiopsy specimensInterleukin-15Interferon gammaMajor tertiary referral centreImportant cytokine mediatorMean disease durationMarked clinical improvementTertiary referral centerRetrospective case seriesCase series studySkin biopsy specimensMultiple treatment approachesKinase inhibitionClinical improvementDisease durationReferral centerConsecutive patientsTofacitinib treatmentCase seriesCytokine mediatorsFemale patientsRNA sequencingEvaluation of the association of health care system access with kidney cancer surgical outcomes for hispanic and non-hispanic white patients
Javier-DesLoges JF, Meagher MF, Walia A, Nguyen MV, Perry JM, Narasimhan RS, Hakimi K, Soliman S, Yuan J, Chakoumakos MA, Ghali F, Patel DN, Wan F, Murphy JD, Derweesh IH. Evaluation of the association of health care system access with kidney cancer surgical outcomes for hispanic and non-hispanic white patients. Urologic Oncology Seminars And Original Investigations 2021, 39: 837.e1-837.e7. PMID: 34580026, DOI: 10.1016/j.urolonc.2021.08.021.Peer-Reviewed Original ResearchConceptsNon-Hispanic white patientsCancer-specific survivalRenal cell carcinomaMedically Underserved AreasCause mortalityWhite patientsHealth care system accessSpecific survivalNon-Hispanic whitesLocalized Renal Cell CarcinomaTertiary referral centerCause mortality riskKaplan-Meier analysisLog-rank testCancer surgical outcomesOverall survivalReferral centerSecondary outcomesPrimary outcomeHispanic patientsMeier analysisCox regressionSurgical outcomesCell carcinomaRisk factorsIncremental biomarker and clinical outcomes after switch from enzyme therapy to eliglustat substrate reduction therapy in Gaucher disease
Kleytman N, Ruan J, Ruan A, Zhang B, Murugesan V, Lin H, Guo L, Klinger K, Mistry PK. Incremental biomarker and clinical outcomes after switch from enzyme therapy to eliglustat substrate reduction therapy in Gaucher disease. Molecular Genetics And Metabolism Reports 2021, 29: 100798. PMID: 34485083, PMCID: PMC8408524, DOI: 10.1016/j.ymgmr.2021.100798.Peer-Reviewed Original ResearchLong-term enzyme replacement therapyEnzyme replacement therapySubstrate reduction therapyGaucher diseaseStable patientsReduction therapySingle tertiary referral centerPhase 3 clinical trialsChronic metabolic inflammationFirst-line therapyTertiary referral centerGD type 1Primary metabolic defectLipid-laden cellsType 1 patientsGD type 1 patientsSubstrate glucosylceramideDisease activityOral therapyReferral centerAvascular necrosisMetabolic inflammationWeek infusionClinical outcomesInflammatory cascadeTrochlear Dysplasia as Shown by Increased Sulcus Angle Is Associated With Osteochondral Damage in Patients With Patellar Instability
Fones L, Jimenez AE, Cheng C, Chevalier N, Brimacombe MB, Cohen A, Pace JL. Trochlear Dysplasia as Shown by Increased Sulcus Angle Is Associated With Osteochondral Damage in Patients With Patellar Instability. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2021, 37: 3469-3476. PMID: 33964393, DOI: 10.1016/j.arthro.2021.04.054.Peer-Reviewed Original ResearchConceptsCohort of patientsBody mass indexPatellar instabilityTrochlear dysplasiaTrochlear groove distanceSulcus angleOsteochondral damageSymptom durationMass indexTibial tubercleRisk factorsOsteochondral injurySignificant associationGroove distanceAcute osteochondral fracturesHigher sulcus angleTertiary referral centerPatient demographic characteristicsRetrospective chart reviewAnatomic risk factorsDemographic characteristicsCaton-Deschamps ratioImportant risk factorFrequency of dislocationRetrospective prognostic studyMultifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks
Schwartz N, Brown KD, Sasaki-Adams D, Morgan SA, Zanation AM, Thorp BD, O’Connell B. Multifocal Skull Base Defects With Associated Spontaneous Cerebrospinal Fluid Leaks. Otology & Neurotology 2021, 42: e624-e628. PMID: 33416298, DOI: 10.1097/mao.0000000000003048.Peer-Reviewed Original ResearchConceptsSpontaneous CSF leaksSpontaneous cerebrospinal fluid leaksElevated intracranial pressureCerebrospinal fluid leakCSF leakSurgical repairSurgical outcomesIntracranial pressureFluid leakSkull basePatients 18 yearsPercent of patientsTertiary referral centerRetrospective case seriesBody mass indexCSF leak repairOverall success rateCSF leak patientsAfrican AmericansSkull base defectsLeak patientsReferral centerCase seriesClinical presentationMass index
2020
Early Skin-to-Skin Care with a Polyethylene Bag for Neonatal Hypothermia: A Randomized Clinical Trial
Travers C, Ramani M, Gentle S, Schuyler A, Brown C, Dills M, Davis C, Mwenechanya M, Chomba E, Aban I, Manasyan A, Ambalavanan N, Carlo W. Early Skin-to-Skin Care with a Polyethylene Bag for Neonatal Hypothermia: A Randomized Clinical Trial. The Journal Of Pediatrics 2020, 231: 55-60.e1. PMID: 33373672, DOI: 10.1016/j.jpeds.2020.12.064.Peer-Reviewed Original ResearchConceptsSkin-to-skin careResource-limited settingsEarly skin-to-skin careSequentially numbered sealed opaque envelopesSevere hypothermiaTertiary referral centerPhase 2 treatmentReferral centerNeonatal hypothermiaMaternal temperatureAdverse eventsAlone groupReduce hypothermiaBag groupInfantsHypothermiaClinical trial objectivesOpaque envelopesBirthSkin careTrial objectivesPhase 2CareHoursGroupAudiologic Outcomes of Cochlear Implantation in Cochlear Malformations: A Comparative Analysis of Lateral Wall and Perimodiolar Electrode Arrays.
Schwartz N, Brown KD, Park LR. Audiologic Outcomes of Cochlear Implantation in Cochlear Malformations: A Comparative Analysis of Lateral Wall and Perimodiolar Electrode Arrays. Otology & Neurotology 2020, 41: e1201-e1206. PMID: 33433084, DOI: 10.1097/mao.0000000000002833.Peer-Reviewed Original ResearchConceptsCochlear malformationsCochlear implantationLateral wallCochlear implantsTertiary referral centerRetrospective case seriesCochlear nerve deficiencyInner ear malformationsPediatric cochlear implant recipientsType of malformationCochlear implant recipientsConsonant word scoresSpeech perception outcomesReferral centerAudiologic outcomesCase seriesOutcome advantageEar malformationsRecognition outcomesMAIN OUTCOMESpeech perception scoresImplant recipientsMalformationsPerimodiolar electrode arrayPerception outcomes
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