2025
Sacral tumors: a comprehensive review of imaging, diagnostic challenges, and tumor mimics
Adin M, Woolf G, Hegde R, Elsamadicy A, Mendel E, Zucconi W, Pucar D, Aygün N. Sacral tumors: a comprehensive review of imaging, diagnostic challenges, and tumor mimics. Skeletal Radiology 2025, 1-26. PMID: 39821683, DOI: 10.1007/s00256-024-04862-6.Peer-Reviewed Original ResearchPrimary tumorTumor mimicsImaging findingsAssessment of response to treatmentGerm cell tumorsEvaluation of systemic diseasesResponse to treatmentInsufficiency fracturesSacral massSecondary tumorsCell tumorsPretreatment evaluationDiagnostic challengeLymphoproliferative diseaseClinical detailsMalignant tumorsPrimary modalitySystemic diseaseEwing sarcomaTumorNotochordal remnantsDevelopmental entityEpidemiological factorsDiagnosisMetastasisThe Art of Dermatology: Lessons Learned from Master Morphologist, Dr. Irwin Braverman
Eisenstein A, Johnston M, Laird M, Perkins S, Siegel J, Watsky K. The Art of Dermatology: Lessons Learned from Master Morphologist, Dr. Irwin Braverman. Clinics In Dermatology 2025 PMID: 39778634, DOI: 10.1016/j.clindermatol.2024.12.012.Peer-Reviewed Original Research
2024
Lupus erythematosus and dermatomyositis
Ramachandran S, Little A, Gehlhausen J. Lupus erythematosus and dermatomyositis. Clinics In Dermatology 2024 PMID: 39694200, DOI: 10.1016/j.clindermatol.2024.12.009.Peer-Reviewed Original ResearchLupus erythematosusSystemic diseaseTraining of dermatologistsManifestation of systemic diseaseSymptoms of systemic lupus erythematosusCutaneous manifestations of systemic diseaseAutoimmune connective tissue diseaseSystemic lupus erythematosusConnective tissue diseaseSigns of systemic diseasePatient carePhysical examination findingsInternal medicineCutaneous manifestationsYoung dermatologistsTissue diseaseClinicopathologic correlationPathological findingsExamination findingsSkin signsSystem pathologyField of dermatologyClinical signsObservation skillsNail Disorders as clues to systemic disease
Rowe E, Zubek A. Nail Disorders as clues to systemic disease. Clinics In Dermatology 2024 PMID: 39694199, DOI: 10.1016/j.clindermatol.2024.12.013.Peer-Reviewed Original ResearchMixed and undifferentiated autoimmune connective tissue diseases
Vesely M. Mixed and undifferentiated autoimmune connective tissue diseases. Clinics In Dermatology 2024 PMID: 39681290, DOI: 10.1016/j.clindermatol.2024.12.011.Peer-Reviewed Original ResearchConnective tissue diseaseTissue diseaseCutaneous manifestationsUndifferentiated connective tissue diseaseAutoimmune connective tissue diseaseEra of molecular diagnosticsSigns of systemic diseaseUrticarial vasculitisSystemic complicationsSjogren's syndromeClinical entityDescription of patientsSystemic diseaseClinical observationsDisease characterizationMolecular diagnosticsDiseasePatientsVasculitisStandardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop
Chew E, Burns S, Abraham A, Bakhoum M, Beckman J, Chui T, Finger R, Frangi A, Gottesman R, Grant M, Hanssen H, Lee C, Meyer M, Rizzoni D, Rudnicka A, Schuman J, Seidelmann S, Tang W, Adhikari B, Danthi N, Hong Y, Reid D, Shen G, Oh Y. Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop. Nature Reviews Cardiology 2024, 22: 47-63. PMID: 39039178, DOI: 10.1038/s41569-024-01060-8.Peer-Reviewed Original ResearchPrimary care dataMicrovascular diseaseDiverse at-risk populationsCardiovascular diseaseRetinal biomarkersOphthalmic imaging techniqueRisk of cardiovascular diseaseRetinal microvascular diseaseIndividual-level riskAt-risk populationsMacrovascular risk factorsSystemic vascular bedsDevelopment of microvascular diseaseCoronary artery diseaseHealth workersCare dataLifestyle factorsMonitoring of systemic diseasesRetinal imaging biomarkersNational HeartVascular dementiaBlood InstituteHeart failureMultidisciplinary networkSystemic diseaseSpiny Keratoderma: Clinical and Histopathological Findings in a Series of 3 Cases
Hanly A, Turner N, Ko C, Panse G. Spiny Keratoderma: Clinical and Histopathological Findings in a Series of 3 Cases. American Journal Of Dermatopathology 2024, 46: 439-442. PMID: 38574081, DOI: 10.1097/dad.0000000000002705.Peer-Reviewed Original ResearchEmbracing cancer complexity: Hallmarks of systemic disease
Swanton C, Bernard E, Abbosh C, André F, Auwerx J, Balmain A, Bar-Sagi D, Bernards R, Bullman S, DeGregori J, Elliott C, Erez A, Evan G, Febbraio M, Hidalgo A, Jamal-Hanjani M, Joyce J, Kaiser M, Lamia K, Locasale J, Loi S, Malanchi I, Merad M, Musgrave K, Patel K, Quezada S, Wargo J, Weeraratna A, White E, Winkler F, Wood J, Vousden K, Hanahan D. Embracing cancer complexity: Hallmarks of systemic disease. Cell 2024, 187: 1589-1616. PMID: 38552609, DOI: 10.1016/j.cell.2024.02.009.Peer-Reviewed Original ResearchConceptsHuman genetic variationSystemic diseaseHallmarks of cancerTumor-related thrombosisGenetic variationGene-environment interactionsCancer-related deathsComplexity of cancerMolecular basisTreat human cancersNervous system interactionsMechanisms of carcinogenesisHuman cancersImprove patient qualityCancer cachexiaSystemic manifestationsTumor micro-Cancer outcomesDistant organsTumor initiationMolecular oncologyTumorPatients' qualityPrevent cancerCancer
2023
Report from the 2023 workshop on endothelial permeability, edema and inflammation
Vestweber D, Claesson-Welsh L, McDonald D, Williams T, Schwartz M, Scallan J, Gavins F, van Buul J, Gamble J, Vadas M, Annex B, Messe S, Perretti M, André H, Ferrara N, Hla T, Nourshargh S, Simons M. Report from the 2023 workshop on endothelial permeability, edema and inflammation. Nature Cardiovascular Research 2023, 2: 1120-1124. PMID: 39196154, DOI: 10.1038/s44161-023-00385-w.Peer-Reviewed Original ResearchSelected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases
Singh C, Theriault B, An Y, Yu J, Knisely J, Shepard M, Wegner R, Warnick R, Peker S, Samanci Y, Trifiletti D, Lee C, Yang H, Bernstein K, Kondziolka D, Tripathi M, Mathieu D, Mantziaris G, Pikis S, Sheehan J, Chiang V. Selected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e150-e151. DOI: 10.1016/j.ijrobp.2023.06.971.Peer-Reviewed Original ResearchWhole-brain radiation therapyTreatment of patientsSystemic diseaseBrain metastasesLesion locationIntracranial lesionsPrior whole-brain radiation therapyMultiple brain metastasesBrain radiation therapyUntreated brain metastasesBrain metastasis treatmentCurrent practice patternsSigns/symptomsPresence of symptomsMATERIAL/METHODSImmunotherapy optionsSystemic therapyUntreated lesionsMedical oncologyPerilesional edemaDrug optionsClinical trialsPractice patternsClinical indicationsMetastasis treatmentSelected-Lesion Stereotactic Radiosurgery (SL-SRS) as a Novel Strategy in the Treatment of Patients With Multiple Brain Metastases
Theriault B, Singh C, Yu J, Knisely J, Shepard M, Wegner R, Warnick R, Peker S, Samanci Y, Trifiletti D, Lee C, Yang H, Bernstein K, Kondziolka D, Tripathi M, Mathieu D, Mantziaris G, Pikis S, Sheehan J, Chiang V. Selected-Lesion Stereotactic Radiosurgery (SL-SRS) as a Novel Strategy in the Treatment of Patients With Multiple Brain Metastases. Cureus 2023, 15: e45457. PMID: 37859877, PMCID: PMC10583225, DOI: 10.7759/cureus.45457.Peer-Reviewed Original ResearchWhole brain radiotherapyInternational Radiosurgery Research FoundationPrior whole brain radiotherapyBrain metastasesStereotactic radiosurgeryCommon reasonAsymptomatic brain metastasesNon-eloquent locationsSystemic treatment optionsMultiple brain metastasesPoor functional statusTreatment of patientsCentral nervous systemAttributable symptomsExtracranial diseaseSystemic therapyUntreated lesionsMedical oncologySystemic diseaseFunctional statusTreatment optionsClinical trialsSingle lesionLesion locationIntracranial lesionsHIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent studyPathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review
Zhu Y, Sharma L, Chang D. Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review. Frontiers In Immunology 2023, 14: 1116131. PMID: 37646038, PMCID: PMC10461092, DOI: 10.3389/fimmu.2023.1116131.Peer-Reviewed Original ResearchConceptsClinical managementAppropriate host immune responseSevere acute pneumoniaMultiple organ failureCOVID-19 pathogenesisSecondary bacterial infectionLower respiratory systemSpecific pathogenic mechanismsHost immune responseLife-threatening consequencesCOVID-19SARS-CoV-2Spread of infectionOrgan failureAcute pneumoniaExcessive inflammationInfected subjectsSystemic diseaseProtease TMPRSS2Mild infectionImmune responseHealthcare threatPathogenic mechanismsTherapeutic paradigmBacterial infections
2022
Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program
Murphy M, Leasure A, Damsky W, Cohen J. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Archives Of Dermatological Research 2022, 315: 1439-1441. PMID: 36436011, DOI: 10.1007/s00403-022-02488-z.Peer-Reviewed Original ResearchConceptsCross-sectional studyMatched cross-sectional studyAssociation of sarcoidosisCoexistence of sarcoidosisCommon genetic susceptibilitySimilar immunopathogenesisCardiopulmonary symptomsPsoriasis patientsInflammatory skinMultivariable analysisSystemic diseasePsoriasis casesProgram databaseImmune responseSarcoidosisPsoriasisUs Research ProgramPotential associationGenetic susceptibilityDiseaseImmunopathogenesisAssociationSame individualFurther researchTh1Endometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina G, Taylor H. Endometriosis-associated infertility: From pathophysiology to tailored treatment. Frontiers In Endocrinology 2022, 13: 1020827. PMID: 36387918, PMCID: PMC9643365, DOI: 10.3389/fendo.2022.1020827.Peer-Reviewed Original ResearchConceptsEndometriosis-associated infertilityRole of surgeryCurrent treatment optionsNon-invasive diagnostic toolLevel of impairmentInfertile womenRelated infertilityEndometrial receptivitySystemic diseaseTreatment optionsClinical managementDysfunctional alterationsEndometriosisSystemic effectsClinical situationsInfertilityPelvic anatomyClinical settingEndometriosis subtypesPrecise diagnosisPatient phenotypesReproductive technologiesDiagnostic toolTreatmentPhenotypeIncobotulinimtoxinA (Xeomin) for the treatment of adductor laryngeal dystonia: A prospective, open-label clinical trial
Kohli N, Lerner M, Rashty J, Kirke D, Stewart T, Blitzer A. IncobotulinimtoxinA (Xeomin) for the treatment of adductor laryngeal dystonia: A prospective, open-label clinical trial. American Journal Of Otolaryngology 2022, 43: 103613. PMID: 36055061, DOI: 10.1016/j.amjoto.2022.103613.Peer-Reviewed Original ResearchConceptsAdductor spasmodic dysphoniaSpasmodic dysphoniaOpen-label clinical trialProspective open-label trialAdductor laryngeal dystoniaOpen-label trialFirst-line treatmentVoice Handicap Index-10Side effect profileTransient side effectsNormal functionVHI-10 scoresIncobotulinumtoxinA injectionsEffect profileLine treatmentSystemic diseaseTA muscleBotulinum toxinClinical trialsLaryngeal dystoniaNursing womenThyroarytenoid muscleInjection sessionsExclusion criteriaSide effectsO-163 Pathophysiology – what’s new
Taylor H. O-163 Pathophysiology – what’s new. Human Reproduction 2022, 37: deac105.073. DOI: 10.1093/humrep/deac105.073.Peer-Reviewed Original ResearchSystemic diseaseGynecological diseasesOral gonadotropin-releasing hormone antagonistClinical diagnosisLow-dose oral contraceptivesGonadotropin-releasing hormone antagonistEndometrial-like tissueFirst-line medicationAccurate clinical diagnosisFemale reproductive tractOral contraceptivesPrompt treatmentSystemic inflammationGnRH antagonistPain sensitizationProgesterone resistanceSymptomatic womenClinical presentationRetrograde menstruationEndometriosis careHormone antagonistReproductive ageEffective therapyTherapeutic alternativeMood disordersThe Disease Burden of Generalized Pustular Psoriasis: Real-World Evidence From CorEvitas’ Psoriasis Registry
Lebwohl M, Medeiros R, Mackey R, Harrold L, Valdecantos W, Flack M, Golembesky A, Kotowsky N, Strober B. The Disease Burden of Generalized Pustular Psoriasis: Real-World Evidence From CorEvitas’ Psoriasis Registry. Journal Of Psoriasis And Psoriatic Arthritis 2022, 7: 71-78. PMID: 39296823, PMCID: PMC11361522, DOI: 10.1177/24755303221079814.Peer-Reviewed Original ResearchPlaque psoriasisReal-world evidenceMore treatment experiencePsoriasis RegistryPustular psoriasisTreatment experiencePatient-reported outcome measuresGeneralized pustular psoriasisCurrent treatment optionsFuture treatment decisionsQuality of lifeGPP treatmentNeutrophilic pustulesPatient sociodemographicsMedian painMedication useNorth American adultsSystemic diseaseDisease characteristicsTreatment optionsRecurrent flaresDisease burdenPatient outcomesTreatment decisionsOutcome measuresSystemic Manifestations of Gastrointestinal Tract Diseases and Systemic Diseases Involving the Gastrointestinal Tract
Patel N, Das P, Jain D. Systemic Manifestations of Gastrointestinal Tract Diseases and Systemic Diseases Involving the Gastrointestinal Tract. 2022, 521-572. DOI: 10.1007/978-981-16-6395-6_14.Peer-Reviewed Original ResearchExtraintestinal manifestationsGastrointestinal disordersSystemic diseaseGastrointestinal tractPrimary gastrointestinal disordersCommon gastrointestinal disorderInflammatory bowel diseaseCommon systemic diseasesGastrointestinal tract diseaseGastrointestinal symptomsBowel diseaseRenal diseaseSystemic manifestationsVasculitic disordersWhipple's diseaseSystemic disordersVascular diseaseCeliac diseaseGastrointestinal infectionsTract diseasePathogenetic mechanismsPolyposis syndromeGastrointestinal diseasesPancreatic diseaseDiseaseUveitis associated with tattoo granulomas
Abdel-Aty A, Apostolopoulos N, Kombo N. Uveitis associated with tattoo granulomas. BMJ Case Reports 2022, 15: e244196. PMID: 35131770, PMCID: PMC8823039, DOI: 10.1136/bcr-2021-244196.Peer-Reviewed Original ResearchConceptsOcular symptomsEmergency departmentSystemic diseaseDays of feverNon-caseating granulomasPrimary care physiciansDesquamative rashSore throatCare physiciansBlurry visionPhysical examinationCommon reasonEarly manifestationFurther evaluationGranulomasPatientsSymptomsUveitisRashDiseaseDepartmentCorticosteroidsLymphadenopathyPhotophobiaTonsillar
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