2025
Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis
Fisch S, Tudor A, Benchekroun E, Landsberg W, Feldstein N, Lamb M, Carpenter T, Rundle A, Jacobson J, Neugut A, Freedberg D. Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis. Bone 2025, 196: 117488. PMID: 40220947, DOI: 10.1016/j.bone.2025.117488.Peer-Reviewed Original ResearchX-linked hypophosphatemiaPrevalence of craniosynostosisPooled prevalenceSystematic reviewMeta-analysisRandom-effects modelWeb of SciencePediatric populationSkull abnormalitiesCohort studyImpaired phosphate reabsorptionElevated FGF23 levelsPrevalenceFemale predominanceCase seriesFGF23 levelsPhosphate reabsorptionGene variantsChildrenIncreased vigilanceCraniosynostosisAbnormal bone growthGenetic disordersHypophosphatemiaAbnormalitiesExperiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis
Shahar G. Experiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis. Psychoanalytic Psychology 2025, 42: 123-127. DOI: 10.1037/pap0000533.Peer-Reviewed Original ResearchAGA Living Clinical Practice Guideline on Computer-Aided Detection–Assisted Colonoscopy
Sultan S, Shung D, Kolb J, Foroutan F, Hassan C, Kahi C, Liang P, Levin T, Siddique S, Lebwohl B. AGA Living Clinical Practice Guideline on Computer-Aided Detection–Assisted Colonoscopy. Gastroenterology 2025, 168: 691-700. PMID: 40121061, DOI: 10.1053/j.gastro.2025.01.002.Peer-Reviewed Original ResearchConceptsSessile serrated lesion detection rateSerrated lesion detection rateDetection of colorectal polypsSystematic reviewAdenoma detection rateIntensive surveillance colonoscopyPreferences of patientsClinical practice guidelinesSystematic review of studiesPatient-important outcomesCertainty of evidenceAmerican Gastroenterological Association (AGAAdvanced adenomasSurveillance colonoscopyComputer-aided detectionEffect of computer-aided detectionColorectal polypsProvider trustGuideline methodologistsRecommendations AssessmentReview of studiesMultidisciplinary panelColonoscopyIncreasing burdenContent expertsAmerican Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary
Siegal D, Tseng E, Schünemann H, Angchaisuksiri P, Cuker A, Dane K, DeSancho M, Diuguid D, Griffin D, Klok F, Lee A, Neumann I, Pai A, Righini M, Sanfilippo K, Terrell D, Akl E, Al Jabiri R, Al Jabiri Y, Barbara A, Bognanni A, Akl I, Boulos M, Brignardello-Petersen R, Chan M, Charide R, Colunga-Lozano L, Dearness K, Darzi A, Hussein H, Karam S, Kolb P, Mansour R, Morgano G, Morsi R, Muti-Schünemann G, Nadim M, Noori A, Philip B, Piggott T, Qiu Y, Benitez Y, Schünemann F, Stevens A, Solo K, Wiercioch W, Mustafa R, Nieuwlaat R. American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary. Blood Advances 2025, 9: 1247-1260. PMID: 39437797, DOI: 10.1182/bloodadvances.2024014219.Peer-Reviewed Original ResearchConceptsCOVID-19-related critical illnessConditional recommendationAcute illnessHealth care professionalsAmerican Society of HematologyProphylactic-intensity anticoagulationCritical illnessEvidence-based recommendationsVenous thromboembolismRandomized controlled trialsCare professionalsPatient representativesRisk of venous thromboembolismGuideline developmentRecommendations AssessmentTherapeutic-intensity anticoagulationExecutive summaryLiving guidelinesMultidisciplinary panelIncreased risk of venous thromboembolismSystematic reviewAssessed certaintyCOVID-19-relatedControlled trialsMcMaster UniversityThe association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-regressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individualsThe therapeutic effects of psychedelics for opioid use disorder: A systematic review of clinical studies
Weleff J, Pulido-Saavedra A, Aghaei A, Ing K, Arakelian M, Fontenele R, Nero N, Barnett B, Anand A, Bassir Nia A, Angarita G. The therapeutic effects of psychedelics for opioid use disorder: A systematic review of clinical studies. Psychiatry Research 2025, 348: 116446. PMID: 40147088, DOI: 10.1016/j.psychres.2025.116446.Peer-Reviewed Original ResearchOpioid use disorderStudies of psychedelicsSystematic review of clinical studiesUse disorderReview of clinical studiesTherapeutic effects of psychedelicsEffects of psychedelicsOpioid receptor systemApplications of psychedelicsClinical studiesMu-opioid receptorsNaturalistic studySerotonergic psychedelicsOpioid withdrawalPlacebo-controlled trialPsychedelicsSubstance useUnited States Food and Drug AdministrationStates Food and Drug AdministrationMu-opioidFood and Drug AdministrationSystematic reviewReceptor systemClinical study designDouble-blindTranscriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review
Valizadeh A, Veenhuis R, Bradley B, Xu K. Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review. International Journal Of Molecular Sciences 2025, 26: 2598. PMID: 40141240, PMCID: PMC11942185, DOI: 10.3390/ijms26062598.Peer-Reviewed Original ResearchConceptsSimian immunodeficiency virus (SIV)-infected macaquesPrevalence of cannabis useSIV-infected macaquesChronic immune activationHIV-infected human cellsEpithelial cell proliferationModulate immune responsesSystematic reviewSIV/HIV infectionHIV infectionPreclinical evidencePathways related to inflammationImmune activationCannabis useMicro-RNA expressionImmunomodulatory roleImmunomodulatory effectsReduce inflammationImmune responseTetrahydrocannabinolComprehensive searchCell proliferationTranscriptomic alterationsMethodological qualityPWHUnderstanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review
Yilmaz S, Aryal K, King J, Bischof J, Hong A, Wood N, Gould Rothberg B, Hudson M, Heinert S, Wattana M, Coyne C, Reyes-Gibby C, Todd K, Lyman G, Klotz A, Abar B, Grudzen C, Bastani A, Baugh C, Henning D, Bernstein S, Rico J, Ryan R, Yeung S, Qdaisat A, Padela A, Madsen T, Liu R, Adler D. Understanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review. BMC Emergency Medicine 2025, 25: 40. PMID: 40045233, PMCID: PMC11883922, DOI: 10.1186/s12873-025-01183-2.Peer-Reviewed Original ResearchConceptsEmergency departmentEmergency visitsPredictors of ED usePeer-reviewed original research studiesSystematic reviewOncologic emergencyCancer incidence ratesCare delivery pathwaysGeriatric oncology researchManagement of oncologic emergenciesEmergency department visitsResultsThe search strategyTreatment side effectsOriginal research studiesCancer patientsVulnerable patient populationAcute careSingle-site studyWeb of ScienceCare venuesED useDepartment visitsHealth systemED visitsED presentationsExperiencing Housing Instability in Rural North America and Access to Health Care and Supportive Services: A Scoping Review.
Roncarati J, Cusack M, True G, Browne J, Harris T, deRussy A, Tsai J, Elwy A, Byrne T, Montgomery A. Experiencing Housing Instability in Rural North America and Access to Health Care and Supportive Services: A Scoping Review. Journal Of Health Care For The Poor And Underserved 2025, 36: 21-55. PMID: 39957636, DOI: 10.1353/hpu.2025.a951583.Peer-Reviewed Original ResearchConceptsHousing instabilityPromote better health outcomesRural North AmericaMeta-Analyses ExtensionBetter health outcomesFull-text reviewPreferred Reporting ItemsExperience housing instabilityPeer-reviewed articlesHealth disparitiesHealth outcomesScoping reviewBehavioral healthHealth careRural settingsOlder personsReporting ItemsSupport servicesSystematic reviewInclusion criteriaMeta-analysesHealthService provisionRural areasRural contextThe experience and role of dissociation in psychosis following developmental trauma: A systematic review
Melegkovits E, Tang R, Pounds O, Ashcroft K, Jung P, Kennerley H, Fonagy P, Bloomfield M. The experience and role of dissociation in psychosis following developmental trauma: A systematic review. Clinical Psychology Review 2025, 117: 102564. PMID: 40058297, DOI: 10.1016/j.cpr.2025.102564.Peer-Reviewed Original ResearchDevelopmental traumaPositive psychotic symptomsAssociated with dissociationElevated dissociationDelusional ideationDissociative symptomsPsychotic featuresPsychotic symptomsPsychotic manifestationsPsychosisEmotional abuseModerate associationPre-registeredDose-response effectClinical considerationsAbuseGeneral populationElevated riskSymptomsSystematic reviewIdeationParanoiaHallucinationsRisk of biasIndividualsEffect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025 PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalEpidemiological Profile and Mortality of Infective Endocarditis Over the Past Decade: A Systematic Review and Meta-Analysis of 133 Studies
Tzoumas A, Sagris M, Xenos D, Ntoumaziou A, Kyriakoulis I, Kakargias F, Liaqat W, Nagraj S, Patel R, Korosoglou G, Tousoulis D, Tsioufis K, Kokkinidis D, Palaiodimos L. Epidemiological Profile and Mortality of Infective Endocarditis Over the Past Decade: A Systematic Review and Meta-Analysis of 133 Studies. The American Journal Of Cardiology 2025, 244: 67-88. PMID: 40015544, DOI: 10.1016/j.amjcard.2025.02.023.Peer-Reviewed Original ResearchInfective endocarditisCausative microorganismsMortality of infective endocarditisEpidemiological profileTricuspid valve IEViridans group streptococciMortality rateRandom-effects model meta-analysisMeta-analysisProfile of IEShort-term mortality rateIncidence of health-careSystematic reviewIncreasingly prevalent conditionGroup streptococciAffected valvePubMed/MEDLINE databaseMitral valveStaphylococcus speciesAortic valveCardiac valvesIncreased incidenceStreptococci speciesEnterococci speciesS. aureusExamining the Impact of the Syndemic on Black Birthing Individuals in the USA: a Systematic Review
Wisniewski K, Henry N, Flanagan A, Popoola A, Weaver N, Iglio L, Alexandre C, Myers D, Tieu T, Waller R, Kornfield S, Gur R, Momplaisir F, Njoroge W. Examining the Impact of the Syndemic on Black Birthing Individuals in the USA: a Systematic Review. Journal Of Racial And Ethnic Health Disparities 2025, 1-15. PMID: 39994154, DOI: 10.1007/s40615-025-02311-1.Peer-Reviewed Original ResearchBirthing individualsSystematic reviewMaternal health disparitiesWork-related challengesHealthcare discriminationPeer-reviewed articlesHealth disparitiesPostpartum experiencesSystemic racismWeb of ScienceInclusion criteriaAbstracted dataPRISMA guidelinesWell-beingMinoritized populationsScreening studiesPeer reviewFamily relationshipsCOVID-19COVID-19 pandemicSyndemicsThemesPublished literatureIndividual experienceCoronavirus disease 2019Effect of empiric antibiotics against Pseudomonas aeruginosa on mortality in hospitalized patients: a systematic review and meta-analysis—authors’ response
Hunter C, Marhoffer E, Holleck J, Alshaeba S, Grimshaw A, Chou A, Carey G, Gunderson C. Effect of empiric antibiotics against Pseudomonas aeruginosa on mortality in hospitalized patients: a systematic review and meta-analysis—authors’ response. Journal Of Antimicrobial Chemotherapy 2025, dkaf047. PMID: 39976564, DOI: 10.1093/jac/dkaf047.Peer-Reviewed Original ResearchPatients with Seizure Disorders Undergoing Surgery for Recurrent Anterior Shoulder Instability Demonstrate Variable Rates of Recurrence with Seizures as the Most Common Cause of Failure: A Systematic Review
Fong S, Darby F, Patel S, Fox J, Lee M, Moran J, Gillinov S, Norman M, Zhu J, Mahatme R, Apostolakos J, Jimenez A. Patients with Seizure Disorders Undergoing Surgery for Recurrent Anterior Shoulder Instability Demonstrate Variable Rates of Recurrence with Seizures as the Most Common Cause of Failure: A Systematic Review. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2025 PMID: 39983798, DOI: 10.1016/j.arthro.2025.02.009.Peer-Reviewed Original ResearchAnterior shoulder instabilityRecurrent anterior shoulder instabilityShoulder instabilitySeizure disorderStabilization surgerySurgical stabilizationEvaluate postoperative outcomes of patientsTreatment of recurrent anterior shoulder instabilityPostoperative outcomes of patientsRecurrence of anterior shoulder instabilitySystematic reviewEvaluate postoperative outcomesOutcomes of patientsRegister of Controlled TrialsHistory of seizuresMeta-analyses criteriaAugmentation surgeryPostoperative outcomesSubluxation rateInstability recurrenceAugmentation proceduresLevel IVRecurrent instabilitySeizure groupNonseizure groupEvidence-Based Practices and Treatments in Autism Spectrum Disorder: Concluding Thoughts
Volkmar F, Doehring P, Reichow B. Evidence-Based Practices and Treatments in Autism Spectrum Disorder: Concluding Thoughts. 2025, 525-534. DOI: 10.1007/978-3-031-78143-8_22.Peer-Reviewed Original ResearchEvidence-based practiceSignificant levels of disabilitySystematic reviewCommunity-based settingsLevel of disabilityCommunity-based professionalsReview of practicesStudy selectionPopulation impactOutcomes researchSystematic review of practicesOutcome studiesMeta-analytic studiesPersistent gapPotential biasResearch designPolicy changesQuestions of research designSignificance levelRacial factorsPracticeEarly 1990sOutcomesAutism spectrum disorderConcluding thoughtsFunctional Outcomes for Patients With Congenital Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence Based Practice Committee
Rialon K, Smith C, Rentea R, Acker S, Baird R, Beres A, Chang H, Christison-Lagay E, Diesen D, Englum B, Gonzalez K, Gulack B, Ham P, Huerta C, Kulaylat A, Levene T, Lucas D, Mansfield S, Pennell C, Ricca R, Sulkowski J, Tashiro J, Wakeman D, Yousef Y, Kelley-Quon L, Kawaguchi A, Committee A. Functional Outcomes for Patients With Congenital Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence Based Practice Committee. Journal Of Pediatric Surgery 2025, 60: 162243. PMID: 40023107, DOI: 10.1016/j.jpedsurg.2025.162243.Peer-Reviewed Original ResearchQuality of lifeSystematic reviewStructured care planFunctional outcomesAnorectal malformationsOptimal patient counselingComplex patient populationTransitional careLevel of evidenceCare planningImprove carePatient transitionsPsychosocial issuesAdult careAmerican Pediatric Surgical Association OutcomesPsychosocial functioningCareConstipation ratePractice CommitteeAnorectal malformation patientsAssociated outcomesCongenital anorectal malformationsMulti-institutional registryPatient counselingLong-term outcomesX-Linked Hypophosphatemia Management in Children: An International Working Group Clinical Practice Guideline
Ali D, Carpenter T, Imel E, Ward L, Appelman-Dijkstra N, Chaussain C, de Beur S, Florenzano P, Abu Alrob H, Aldabagh R, Alexander R, Alsarraf F, Beck-Nielsen S, Biosse-Duplan M, Crowley R, Dandurand K, Filler G, Friedlander L, Fukumoto S, Gagnon C, Goodyer P, Grasemann C, Grimbly C, Hussein S, Javaid M, Khan S, Khan A, Lehman A, Lems W, Lewiecki E, McDonnell C, Mirza R, Morgante E, Morrison A, Portale A, Rao C, Rhee Y, Rush E, Siggelkow H, Tetradis S, Tosi L, Guyatt G, Brandi M, Khan A. X-Linked Hypophosphatemia Management in Children: An International Working Group Clinical Practice Guideline. The Journal Of Clinical Endocrinology & Metabolism 2025, dgaf093. PMID: 39960858, DOI: 10.1210/clinem/dgaf093.Peer-Reviewed Original ResearchClinical practice guidelinesInternational Working GroupX-linked hypophosphatemiaClinical practice surveyPractice guidelinesMultidisciplinary healthcare professionalsPractice surveyManagement of "X-linked hypophosphatemiaPatient-important outcomesCertainty of evidenceCare of childrenNo therapyConventional therapyHealthcare professionalsDiagnosis of XLHPatient partnersMonitoring recommendationsTreatment of X-linked hypophosphatemiaMethodological expertsGRADE recommendationsSystematic reviewGenetic testingGRADE methodologyNarrative reviewDental complicationsCauses of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential
Bulletti F, Sciorio R, Conforti A, De Luca R, Bulletti C, Palagiano A, Berrettini M, Scaravelli G, Pierson R. Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential. Frontiers In Endocrinology 2025, 15: 1429193. PMID: 40028443, PMCID: PMC11867936, DOI: 10.3389/fendo.2024.1429193.Peer-Reviewed Original ResearchConceptsAssisted reproductive technologyPGT-AImplantation rateImplant successEmbryo transferEndometrial receptivityMeta-analysisMeta-analysis of subgroupsTime of endometrial receptivityGestational carrierMonths of unprotected sexual intercourseReduced embryo implantationPreimplantation genetic testingOlder womenImprove implantation ratesEmbryo implantation potentialUnprotected sexual intercourseOdds of implantationSystematic reviewComprehensive literature searchEmbryo euploidyEuploid embryosDiagnostic hysteroscopyRisk of biasIVF-ETAdvanced imaging in the evaluation of lupus arthritis: A systematic literature review and meta-analysis
Tang W, Khalili L, Gong R, Souvignier M, Wang X, Murray S, Chavez G, Nordmann-Gomes A, Geraldino-Pardilla L, Gartshteyn Y, Clancy R, Nikpour M, Askanase A. Advanced imaging in the evaluation of lupus arthritis: A systematic literature review and meta-analysis. Seminars In Arthritis And Rheumatism 2025, 71: 152661. PMID: 39985848, DOI: 10.1016/j.semarthrit.2025.152661.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingMSK-USIdentified articlesMeasurement propertiesSystematic literature reviewWork-related disabilityUS synovitisLiterature reviewAdvanced imagingEvaluation of handMSK manifestationsOutcome measuresAdvanced imaging modalitiesSystematic reviewCochrane LibraryMeta-analysisLiterature searchLupus arthritisLupus patientsMSKPooled analysisJoint symptomsImaging abnormalitiesClinical trialsJoint manifestations
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply