2025
The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDiseaseMake It Happen NOW: Barriers and Inequities in Eat, Sleep, Console Implementation for Neonatal Opioid Withdrawal Syndrome.
Chaudhury N, Zhao S, Ostfeld-Johns S. Make It Happen NOW: Barriers and Inequities in Eat, Sleep, Console Implementation for Neonatal Opioid Withdrawal Syndrome. Hospital Pediatrics 2025, 15: e99-e101. PMID: 39894048, DOI: 10.1542/hpeds.2025-008332.Peer-Reviewed Original ResearchInsights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab
Foss F, Kim Y, Scarisbrick J, Akilov O, Ristuccia R, Dwyer K, Wu W, Bagot M. Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab. Journal Of Dermatological Treatment 2025, 36: 2438794. PMID: 39894454, DOI: 10.1080/09546634.2024.2438794.Peer-Reviewed Original ResearchConceptsMogamulizumab-associated rashConcomitant steroid useSezary syndromeAdvanced diseaseMycosis fungoidesSteroid useResponse to mogamulizumabProportion of patientsPercentage of patientsTreatment of patientsConcomitant steroidsRelapsed/refractory patientsLong-term responseMogamulizumabNext treatmentPatient characteristicsPatientsLymphopeniaVorinostatPatient responseFungoidesPFSMycosisSyndromeTreatmentSalivary gland stem/progenitor cells: advancing from basic science to clinical applications
Langthasa J, Guan L, Jinagal S, Le Q. Salivary gland stem/progenitor cells: advancing from basic science to clinical applications. Cell Regeneration 2025, 14: 4. PMID: 39856475, PMCID: PMC11759724, DOI: 10.1186/s13619-025-00221-5.Peer-Reviewed Original ResearchSalivary gland stem/progenitor cellsBioengineered organ replacementTissue-based therapiesEffective clinical therapiesRadiation therapySjogren's syndromeStem/progenitor cellsClinical therapyTherapyDifferentiation pathwayClinical applicationRegenerative medicineSyndromeTissue regenerationOrgan replacementCulture techniquesSjogrenTransplantationPatients16 Metabolic Syndrome and Obesity
Alonso W, Canapari C. 16 Metabolic Syndrome and Obesity. 2025, 175-184. DOI: 10.1016/b978-0-323-75566-5.00016-2.Peer-Reviewed Original ResearchMetabolic syndromeComponents of metabolic syndromeInvolvement of adipocytokinesSleep-disordered breathingIncreased sympathetic activityElevated blood pressureCardiovascular risk factorsRates of obesityIntermittent hypoxemiaTruncal obesityDysregulation of glucose metabolismSleep fragmentationSympathetic activityBlood pressureSleep curtailmentRisk factorsSyndromeObesityShort sleepGlucose metabolismCircadian factorsSleepHypoxemiaDyslipidemiaAdipocytokines
2024
Untargeted metabolomics analysis as a potential screening tool for 3-methylglutaconic aciduria syndromes
DiFalco C, Gijavanekar C, Wang Y, Grace A, Machol K, Emrick L, Liu N, Mizerik E, Mackay L, Dai H, Vossaert L, Xia F, Elsea S, Scaglia F. Untargeted metabolomics analysis as a potential screening tool for 3-methylglutaconic aciduria syndromes. Molecular Genetics And Metabolism 2024, 144: 109009. PMID: 39787888, DOI: 10.1016/j.ymgme.2024.109009.Peer-Reviewed Original ResearchConceptsUrine organic acid analysisUntargeted metabolomic profilingInborn errors of metabolismErrors of metabolismMetabolomic profilesMetabolomic analysisHeterogeneous group of inborn errors of metabolismGroup of inborn errors of metabolismUntargeted metabolomics analysisDegree of clinical sensitivityBiochemical screening toolScreening toolOrganic acid analysisClinical sensitivityBiochemical abnormalitiesDistal defectsInborn errorsSyndromeHeterogeneous groupPlasma samplesDetectable elevationImpaired functionClinical modalityBiochemical phenotypeUrineComparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach
Johnson K, Berkwitt A, Yankova L, Osborn R. Comparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach. Seminars In Perinatology 2024, 49: 152021. PMID: 39736490, DOI: 10.1016/j.semperi.2024.152021.Peer-Reviewed Original ResearchA Yale Dermatology Perspective on Cutaneous T-Cell Lymphoma: Historical Reflection to Emerging Therapies
Swallow M, Edelson R, Girardi M. A Yale Dermatology Perspective on Cutaneous T-Cell Lymphoma: Historical Reflection to Emerging Therapies. Clinics In Dermatology 2024 PMID: 39694197, DOI: 10.1016/j.clindermatol.2024.12.006.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaT-cell lymphomaMycosis fungoidesSubtype of cutaneous T-cell lymphomaPathogenesis of cutaneous T-cell lymphomaNon-Hodgkin's lymphomaEvolving treatment landscapeSezary syndromeHistological variantsTreatment landscapeLymph nodesSchool of MedicineLymphomaYale School of MedicineFungoidesClinical careMalignancyLymphMycosisSyndromeSubtypesPathogenesisPelvic Floor Physical Therapy Prehabilitation (PrePFPT) for the prevention of low anterior resection syndrome
Coppersmith N, Schultz K, Esposito A, Reinhart K, Ray E, Leeds I, Pantel H, Reddy V, Longo W, Mongiu A. Pelvic Floor Physical Therapy Prehabilitation (PrePFPT) for the prevention of low anterior resection syndrome. Surgical Oncology Insight 2024, 1: 100097. DOI: 10.1016/j.soi.2024.100097.Peer-Reviewed Original ResearchLow anterior resection syndromeAnterior resection syndromePelvic floor physical therapyQuality of life outcomesSymptoms of low anterior resection syndromeImprove patient qualityPhysical therapyRectal cancerPrehabilitationDevelopment of low anterior resection syndromeStudy designTreatment of low anterior resection syndromeTreatment of rectal cancerIncidence of low anterior resection syndromeLife outcomesEvaluated pre-Patients' qualityRectal cancer patientsCancer patientsDevelopment of symptomsNeoadjuvant chemoradiotherapyDefecatory dysfunctionImproved recoveryInternational trialsSyndromeHospital sequelae, discharge, and early interventions in infants with Neonatal Opioid Withdrawal Syndrome
Cheng F. Hospital sequelae, discharge, and early interventions in infants with Neonatal Opioid Withdrawal Syndrome. Seminars In Perinatology 2024, 49: 152008. PMID: 39581774, DOI: 10.1016/j.semperi.2024.152008.Peer-Reviewed Original ResearchInfluenza B Triggering Atypical Hemolytic Uremic Syndrome (aHUS) in a Patient with Cobalamin C (CblC) Disease Carrier State and a Complement Factor H (CFH) Mutation
Becerra L, Moeckel G, Gunasekaran D. Influenza B Triggering Atypical Hemolytic Uremic Syndrome (aHUS) in a Patient with Cobalamin C (CblC) Disease Carrier State and a Complement Factor H (CFH) Mutation. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024vajywpws. DOI: 10.1681/asn.2024vajywpws.Peer-Reviewed Original ResearchTubulointerstitial Nephritis and Uveitis Syndrome Presenting with Scleritis
Desai S, Gaudio P. Tubulointerstitial Nephritis and Uveitis Syndrome Presenting with Scleritis. Ocular Immunology And Inflammation 2024, 33: 310-312. PMID: 39259815, DOI: 10.1080/09273948.2024.2401139.Peer-Reviewed Original ResearchUveitis syndromeTubulointerstitial nephritisBilateral anterior uveitisBilateral episcleritisBilateral scleritisPatient's scleritisUnilateral panuveitisFellow eyesAnterior uveitisOcular manifestationsSystemic immunosuppressionLocal corticosteroidsScleritisUveitisTINUSyndromeNephritisPatientsMalePanuveitisEpiscleritisCorticosteroidsImmunosuppressionEyesAnalysis of drug–drug interactions in patients with HIV and metabolic syndrome
Tuan J, Igiraneza G, Ogbuagu O. Analysis of drug–drug interactions in patients with HIV and metabolic syndrome. Expert Opinion On Drug Metabolism & Toxicology 2024, 20: 953-965. PMID: 39230187, DOI: 10.1080/17425255.2024.2401044.Peer-Reviewed Original ResearchDrug-drug interactionsAntiretroviral therapyMetabolic disordersMetabolic syndromeNanotechnology-based drug delivery platformsPrevalence of metabolic comorbiditiesSelection of antiretroviral therapyLong-acting antiretroviral therapyContemporary antiretroviral therapyEffective antiretroviral therapyPrevalence of metabolic disordersRepertoire of treatment optionsDrug-drug interaction dataTreat metabolic syndromeMetabolic comorbiditiesTreatment optionsDrug delivery platformPrescribing informationAnalysis of drug-drug interactionsHIVInjectable medicationsDrug prescribing informationWeight lossPWHSyndromeLong-term natural history of ellipsoid zone width in USH2A-retinopathy
Heyang M, Warren J, Ocieczek P, Duncan J, Moosajee M, Del Priore L, Shen L. Long-term natural history of ellipsoid zone width in USH2A-retinopathy. British Journal Of Ophthalmology 2024, 109: 383-390. PMID: 39103200, PMCID: PMC11866300, DOI: 10.1136/bjo-2024-325323.Peer-Reviewed Original Research565 Cutaneous delivery of LEKTI via an engineered strain of staphylococcus epidermidis for the treatment of netherton syndrome
Mootien S, Leger R, Martins D, Whitfill T. 565 Cutaneous delivery of LEKTI via an engineered strain of staphylococcus epidermidis for the treatment of netherton syndrome. Journal Of Investigative Dermatology 2024, 144: s99. DOI: 10.1016/j.jid.2024.06.581.Peer-Reviewed Original Research288 Clinical study of Netherton syndrome treated topically with a Staphylococcus epidermidis strain expressing recombinant human LEKTI-D6 (ATR12-351)
Spellman M, Salva F, Mootien S, Leger R, Whitfill T. 288 Clinical study of Netherton syndrome treated topically with a Staphylococcus epidermidis strain expressing recombinant human LEKTI-D6 (ATR12-351). Journal Of Investigative Dermatology 2024, 144: s50. DOI: 10.1016/j.jid.2024.06.304.Peer-Reviewed Original ResearchPlacental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations
Dave E, Bahtiyar M, Campbell W, Morotti R, Kohari K. Placental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations. Twin Research And Human Genetics 2024, 27: 251-255. PMID: 39508257, DOI: 10.1017/thg.2024.35.Peer-Reviewed Original ResearchTwin-to-twin transfusion syndromeTwin anemia-polycythemia sequenceDichorionic twin gestationsVascular anastamosesTwin gestationsDichorionic twin pregnanciesTwin transfusion syndromePlacental vascular anastomosesDichorionic gestationsMonochorionic pregnanciesPrenatal surveillanceTransfusion syndromeTwin pregnanciesGestationMitigate morbidityVascular anastomosisAssociated pathologyPregnancyAnastamosesPathologyDichorionicityMorbidityPathophysiologySyndromeTherapeutic plasma exchange for hyperviscosity syndrome in IgA multiple myeloma
Yurtsever N, Binns T, Hendrickson J, Tormey C, Lee E. Therapeutic plasma exchange for hyperviscosity syndrome in IgA multiple myeloma. Lab Medicine 2024, 56: 85-88. PMID: 39038224, DOI: 10.1093/labmed/lmae054.Peer-Reviewed Original ResearchDisorders with Ophthalmic and Thoracic Involvement.
Gosangi B, Lang P, Johnson M, Zukerman R, Tu L, Traube L, Bader A, Rubinowitz A. Disorders with Ophthalmic and Thoracic Involvement. RadioGraphics 2024, 44: e230132. PMID: 38870047, DOI: 10.1148/rg.230132.Peer-Reviewed Original ResearchConceptsClinical manifestationsExamination of family membersEhlers-Danlos syndromeAffecting patient outcomesAcute sarcoidosisOphthalmologic examinationThoracic symptomsDry eyeThoracic involvementOphthalmological symptomsOphthalmologic manifestationsEye symptomsMarfan syndromeSjogren's syndromeImaging findingsRadiological studiesLung diseasePatient outcomesEhlers-DanlosFamily membersMultimodal imagingSystem conditionsSyndromeThoracicSarcoidosisNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original Research
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