2025
TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis
Krishna M, Joseph M, Ezenna C, Pereira V, Rossi R, Akman Z, Rubens M, Mahadevan V, Nanna M, Goldsweig A. TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis. Cardiovascular Revascularization Medicine 2025 PMID: 40425422, DOI: 10.1016/j.carrev.2025.05.021.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementPatient-prosthesis mismatchIntermediate surgical riskSevere patient-prosthesis mismatchAcute kidney injuryAortic valve replacementPermanent pacemaker implantationRandomized controlled trialsSurgical riskParavalvular leakFollow-upValve replacementPacemaker implantationAtrial fibrillationClinical outcomes of transcatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementRate of permanent pacemaker implantationSafety of transcatheter aortic valve replacementBenefits of transcatheter aortic valve replacementNew-onset atrial fibrillationRates of all-cause deathAortic valve reinterventionNew-onset AFSevere aortic stenosisOutcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-cause mortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsTranscatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis
Ahmed A, Kaddoura R, Aggarwal A, Zinyandu T, Webber F, Davila C, Zarich S. Transcatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis. Catheterization And Cardiovascular Interventions 2025, 105: 754-760. PMID: 39748537, DOI: 10.1002/ccd.31367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementAortic valve replacementHypertrophic cardiomyopathyAortic stenosisRenal impairmentValve replacementAortic dissectionVascular complicationsCardiogenic shockOdds ratioTranscatheter aortic valve replacement outcomesSevere aortic stenosisPermanent pacemaker implantationComplete heart blockAssociated with higher ratesObservational cohort studyGold standard managementConfidence intervalsRandom-effects modelSignificantly higher occurrenceSurgical riskPacemaker implantationHeart blockSurgical intervention
2024
Acute Decompensated Valvular Disease in the Intensive Care Unit
Miller P, Senman B, Gage A, Carnicelli A, Jacobs M, Rali A, Senussi M, Bhatt A, Hollenberg S, Kini A, Menon V, Grubb K, Morrow D, Section A. Acute Decompensated Valvular Disease in the Intensive Care Unit. JACC Advances 2024, 3: 101402. PMID: 39735779, PMCID: PMC11681797, DOI: 10.1016/j.jacadv.2024.101402.Peer-Reviewed Original ResearchIntensive care unitCardiac intensive care unitValvular diseaseCritically ill patientsCare unitIll patientsPrimary cardiac disorderMultidisciplinary heart teamModern cardiac intensive care unitPercutaneous interventional therapyDefinitive treatmentSurgical riskClinical presentationSocietal guidelinesHeart teamValvular disordersTreatment optionsInterventional therapyCardiac disordersDiseasePatientsTreatmentDisordersSurgeryTherapyProceedings from an international consensus meeting on ablation in urogenital diseases
Iezzi R, Contegiacomo A, De Filippis A, Gunn A, Atwell T, Mcclure T, Jing Z, Posa A, Scrofani A, Maresca A, Madoff D, Goldberg S, Kelekis A, Filippiadis D, Sala E, Ahmed M. Proceedings from an international consensus meeting on ablation in urogenital diseases. Insights Into Imaging 2024, 15: 267. PMID: 39514046, PMCID: PMC11549275, DOI: 10.1186/s13244-024-01841-2.Peer-Reviewed Original ResearchInternational Consensus MeetingAblation techniqueIntermediate-risk prostate cancerImage-guided ablation techniquesPreoperative surgical riskManagement of oncological diseasesRenal cell carcinomaConsensus meetingTraditional surgical treatmentGenitourinary tract diseaseFibroid SymptomCell carcinomaProstate cancerSurgical riskAblation therapyImprove patient outcomesTumor managementSurgical treatmentMechanism of actionEffective alternativeTherapeutic alternativeSite of applicationEffective treatmentUrogenital diseasesOncological diseasesSurgical Risk Does Not Predict Ischemic Stroke or Acute Infarction After TAVR: Results of a Patient-Level Pooled Analysis
Grubman D, Lansky A, Dwyer M, Zivadinov R, Pietras C, Nazif T, Moses J, Shah T, Gambone L, Leon M, Forrest J, Vora A, Parise H, Messé S. Surgical Risk Does Not Predict Ischemic Stroke or Acute Infarction After TAVR: Results of a Patient-Level Pooled Analysis. Cardiovascular Revascularization Medicine 2024, 65: 80. DOI: 10.1016/j.carrev.2024.04.179.Peer-Reviewed Original ResearchTranscatheter or Surgical Aortic Valve Replacement in Women With Small Annuli at Low or Intermediate Surgical Risk
Modine T, Forrest J, Van Mieghem N, Deeb G, Yakubov S, Ali W, Tchétché D, Lam K, Oh J, Huang J, Mehran R, Reardon M. Transcatheter or Surgical Aortic Valve Replacement in Women With Small Annuli at Low or Intermediate Surgical Risk. The American Journal Of Cardiology 2024, 223: 147-155. PMID: 38641189, DOI: 10.1016/j.amjcard.2024.04.013.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementAortic valve replacementIntermediate surgical riskValve replacementSurgical riskAortic stenosisTranscatheter aortic valve replacement groupImpact of transcatheter aortic valve replacementSurgical aortic valve replacementMid-term clinical outcomesPatient-prothesis mismatchSmall aortic annulusMidterm clinical outcomesSevere aortic stenosisSelf-expandingEffective orifice areaAll-cause mortalityEvaluated 2 yearsPost hoc analysisRandomized controlled trialsAortic annulusSurgical groupPrimary endpointHemodynamic outcomesClinical outcomesMitral Transcatheter Edge-to-Edge Repair Advancing Treatment Options for Degenerative Mitral Regurgitation
Zahid S, Anjali Garg J, Altibi A, Golwala H. Mitral Transcatheter Edge-to-Edge Repair Advancing Treatment Options for Degenerative Mitral Regurgitation. Interventional Cardiology Clinics 2024, 13: 155-165. PMID: 38432759, DOI: 10.1016/j.iccl.2024.01.001.Peer-Reviewed Original ResearchConceptsDegenerative mitral regurgitationMitral regurgitationMitral transcatheter edge-to-edge repairTranscatheter edge-to-edge repairEdge-to-edge repairEdge-to-edge repair devicesSevere MR patientsTranscatheter edge-to-edge repair deviceLeft ventricular dysfunctionHeart failure syndromeStandard of careAdverse heart remodelingPulmonary hypertensionVentricular dysfunctionTranscatheter therapyFailure syndromeMR patientsSurgical riskTreatment optionsSurgical patientsHeart remodelingClinical needRegurgitationPatientsRepair devices
2023
What determines outcomes in multivalve reoperations? Effect of patient and surgical complexity
Insler J, Tipton A, Bakaeen F, Bakhos J, Houghtaling P, Blackstone E, Roselli E, Soltesz E, Tong M, Unai S, McCurry K, Vargo P, Hodges K, Smedira N, Pettersson G, Weiss A, Koprivanac M, Elgharably H, Gillinov A, Svensson L. What determines outcomes in multivalve reoperations? Effect of patient and surgical complexity. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 1632-1642.e2. PMID: 38081538, DOI: 10.1016/j.jtcvs.2023.12.005.Peer-Reviewed Original ResearchOperative mortalitySurgical complexitySurgical componentCardiac surgeryNew York Heart Association functional classPredictors of operative mortalityFirst-time reoperationsCoronary artery bypass graftingEffect of patient variablesArtery bypass graftingPeripheral arterial diseaseMultivalve surgeryEffect of patientsRenal dysfunctionSurgical riskSurgical urgencyReoperationBypass graftingPatient characteristicsArtery diseaseCardiac valvesSurgeryRisk factorsPatient variablesFunctional classChronological comparison of TAVI and SAVR stratified to surgical risk: a systematic review, meta-analysis, and meta-regression
Park D, An S, Kassab K, Jolly N, Attanasio S, Sawaqed R, Malhotra S, Doukky R, Vij A. Chronological comparison of TAVI and SAVR stratified to surgical risk: a systematic review, meta-analysis, and meta-regression. Acta Cardiologica 2023, 78: 778-789. PMID: 37294002, DOI: 10.1080/00015385.2023.2218025.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationAll-cause mortalitySevere aortic regurgitationSevere paravalvular regurgitationSurgical riskAortic regurgitationPacemaker placementParavalvular regurgitationFollow-upAlternative to surgical aortic valve replacementAssociated with higher all-cause mortalityLong-term follow-upNewer-generation valvesRisk of all-cause mortalityPeriod of follow-upHigh surgical riskIntermediate surgical riskLow surgical riskMeta-regressionAortic valve replacementSevere aortic stenosisMeta-analysisLong-term outcomesScore-matched studyCerebral Embolic Protection in Transcatheter Aortic Valve Replacement
Iskander M, Jamil Y, Forrest J, Madhavan M, Makkar R, Leon M, Lansky A, Ahmad Y. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Structural Heart 2023, 7: 100169. PMID: 37520138, PMCID: PMC10382985, DOI: 10.1016/j.shj.2023.100169.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementCerebral embolic protection devicesCerebral embolic protectionAortic valve replacementEmbolic protection devicesValve replacementEmbolic protectionSymptomatic severe aortic stenosisSevere aortic stenosisLow-risk patientsPredictors of strokeOccurrence of complicationsRisk of strokeRecent trial dataRelevant clinical studiesOverall evidence baseExpansion of TAVRFeared complicationAortic stenosisSurgical riskTreatment optionsWorse outcomesClinical studiesPatientsTrial data
2022
Propensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis
Deeb G, Yakubov S, Reardon M, Ramlawi B, Chetcuti S, Kleiman N, Zahr F, Song H, Gada H, Mumtaz M, Ito S, Huang J, Forrest J. Propensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 2: 100525. PMID: 39132531, PMCID: PMC11307701, DOI: 10.1016/j.jscai.2022.100525.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementSurgical aortic valve replacementAortic valve stenosisTricuspid aortic valve stenosisBicuspid aortic valve stenosisAortic valve replacementSAVR patientsValve replacementValve stenosisEvolut Low Risk trialIndependent clinical events committeeLow-risk trialsSerious adverse eventsSevere aortic regurgitationClinical events committeeLow surgical riskLow-risk patientsIndependent core laboratoryEffective orifice areaTAVR groupValve gradientAdverse eventsAortic regurgitationSurgical riskEvents committeeImaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease
Ahmad Y, Agarwal V, Williams M, Wang D, Reardon M, Cavalcante J, Makkar R, Forrest J. Imaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100506. PMID: 39132366, PMCID: PMC11307905, DOI: 10.1016/j.jscai.2022.100506.Peer-Reviewed Original ResearchAortic valve replacementTranscatheter aortic valve replacementBicuspid aortic valve diseaseAortic valve diseaseValve replacementValve diseaseBAV diseaseSevere symptomatic aortic stenosisSurgical aortic valve replacementPivotal randomized trialsAortic valve surgerySymptomatic aortic stenosisRandomized clinical trialsValve surgeryHeart teamAortic stenosisSurgical riskPatient selectionRandomized trialsBicuspid valveSurgical approachTreatment optionsClinical trialsPatientsDiseaseTranscatheter Aortic Valve Replacement Optimization Strategies: Cusp Overlap, Commissural Alignment, Sizing, and Positioning
Siddique S, Khanal R, Vora A, Gada H. Transcatheter Aortic Valve Replacement Optimization Strategies: Cusp Overlap, Commissural Alignment, Sizing, and Positioning. US Cardiology Review 2022, 16: e10. PMID: 39600846, PMCID: PMC11588177, DOI: 10.15420/usc.2021.24.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementYounger patientsIncreased risk of post-procedural complicationsRisk of post-procedural complicationsCommissural alignmentLow surgical riskProsthesis-patient mismatchAortic valve replacementPost-procedural complicationsCusp-overlap techniqueTranscatheter heart valveSurgical riskValve replacementConduction abnormalitiesParavalvular leakProcedural complicationsCoronary accessCoronary cannulationIncreased riskRisk factorsDelivery techniquesPatientsConduction systemTranscatheterComplications
2021
Comparison of Transcatheter and Open Mitral Valve Repair Among Patients With Mitral Regurgitation
Kay B, Chouairi F, Clark KAA, Reinhardt SW, Fuery M, Guha A, Ahmad T, Kaple RK, Desai NR. Comparison of Transcatheter and Open Mitral Valve Repair Among Patients With Mitral Regurgitation. Mayo Clinic Proceedings 2021, 96: 1522-1529. PMID: 34088415, DOI: 10.1016/j.mayocp.2021.01.029.Peer-Reviewed Original ResearchConceptsMitral valve repairMitral regurgitationValve repairInternational ClassificationPatient underwent mitral valve repairOpen mitral valve repairUnderwent mitral valve repairTranscatheter mitral valve repairStudy periodComparison of transcatheterProhibitive surgical riskTenth Revision codesTotal hospital chargesDegenerative mitral regurgitationNational Inpatient SampleLength of stayTranscatheter mitral valve repair deviceDischarge homeHospital mortalityDischarge dispositionPatient comorbiditiesSurgical riskHospital chargesMedian lengthNinth RevisionEarly outcomes from the CLASP IID trial roll‐in cohort for prohibitive risk patients with degenerative mitral regurgitation
Lim D, Smith R, Zahr F, Dhoble A, Laham R, Lazkani M, Kodali S, Kliger C, Hermiller J, Vora A, Sarembock I, Gray W, Kapadia S, Greenbaum A, Rassi A, Lee D, Chhatriwalla A, Shah P, Rodés‐Cabau J, Ibrahim H, Satler L, Herrmann H, Mahoney P, Davidson C, Petrossian G, Guerrero M, Koulogiannis K, Marcoff L, Gillam L, Investigators T. Early outcomes from the CLASP IID trial roll‐in cohort for prohibitive risk patients with degenerative mitral regurgitation. Catheterization And Cardiovascular Interventions 2021, 98: e637-e646. PMID: 34004077, DOI: 10.1002/ccd.29749.Peer-Reviewed Original ResearchConceptsRoll-in cohortRoll-in patientsRe-interventionMyocardial infarctionSurgical riskSevere bleedingPASCAL transcatheter valve repair systemMitral valve re-interventionCentral screening committeeClinically significant MREchocardiographic core laboratoryNYHA class I/IIPASCAL repair systemValve re-interventionDegenerative mitral regurgitationNYHA class III/IVClinical events committeeLocal heart teamRenal replacement therapyClass III/IVMitral regurgitationPivotal trialsRisk patientsSignificant MRTranscatheter repairLiving Donor Nephrectomy: Approaches, Innovations, and Outcomes
Merola J, Cooper M, Kulkarni S. Living Donor Nephrectomy: Approaches, Innovations, and Outcomes. 2021, 291-302. DOI: 10.1007/978-3-030-53618-3_13.Peer-Reviewed Original ResearchDonor nephrectomySuperior long-term outcomesLong-term outcomesCareful preoperative planningSingle-port surgeryKidney transplantationSurgical riskDeceased donorsOrgan recipientsSurgical approachSurgical considerationsSurgical techniqueKidney donationNephrectomyPreoperative planningInformed consentOutcomesAdequate trainingRiskDonorsAllograftsDonationSurgeryTransplantationSurgeons
2020
Three-Year Outcomes With a Contemporary Self-Expanding Transcatheter Valve From the Evolut PRO US Clinical Study
Wyler von Ballmoos MC, Reardon MJ, Williams MR, Mangi AA, Kleiman NS, Yakubov SJ, Watson D, Kodali S, George I, Tadros P, Zorn GL, Brown J, Kipperman R, Oh JK, Qiao H, Forrest JK. Three-Year Outcomes With a Contemporary Self-Expanding Transcatheter Valve From the Evolut PRO US Clinical Study. Cardiovascular Revascularization Medicine 2020, 26: 12-16. PMID: 33199247, DOI: 10.1016/j.carrev.2020.11.007.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEvolut PRO valveParavalvular regurgitationUS clinical studiesCause mortalityClinical studiesNew York Heart Association class ISelf-expanding transcatheter valveValve Academic Research ConsortiumExtreme surgical riskMild paravalvular regurgitationAcademic Research ConsortiumAortic valve replacementIndependent core laboratoryThree-Year OutcomesSelf-expanding prosthesisLong-term resultsEffective orifice areaValve thrombosisCardiovascular mortalityExcellent hemodynamicsValve replacementEchocardiographic measuresSurgical riskTranscatheter valveCochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk
Kolkailah A, Doukky R, Pelletier M, Volgman A, Kaneko T, Nabhan A. Cochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Heart 2020, 106: 1043-1045. PMID: 32482670, DOI: 10.1136/heartjnl-2020-316661.Peer-Reviewed Original ResearchThe Sky Is Not Falling: Surgical Perspectives on a New Transcatheter Paradigm
Percy E, Hirji S, Yazdchi F, Pelletier M. The Sky Is Not Falling: Surgical Perspectives on a New Transcatheter Paradigm. Canadian Journal Of Cardiology 2020, 37: 22-26. PMID: 32649869, DOI: 10.1016/j.cjca.2020.03.016.Peer-Reviewed Original ResearchConceptsCardiac surgeonsTranscatheter aortic valve replacement trialsTreatment of aortic valve diseaseTranscatheter aortic valve replacementCardiac surgery communityLow surgical riskAortic valve replacementCardiac surgical communityAortic valve diseaseExpansion of transcatheter aortic valve replacementSurgical riskValve replacementHeart teamValve diseaseSurgical perspectiveReplacement trialsSurgery communitySurgical communityOperative volumeSurgeonsHeart medicineTrialsSurgicallyPatients
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