2025
Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke
Sun S, Lomachinsky V, Smith L, Newhouse J, Westover M, Blacker D, Schwamm L, Haneuse S, Moura L. Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke. Neurology Clinical Practice 2025, 15: e200452. PMID: 40144887, DOI: 10.1212/cpj.0000000000200452.Peer-Reviewed Original ResearchFall-related injuriesRisk of fallsOlder adultsAcute ischemic strokeRisk differenceAcute ischemic stroke admissionsElectronic health recordsHypothetical randomized trialInverse probability weightingIschemic strokeRecovery periodHealth recordsBenzodiazepine initiationPoststroke periodConfounding biasImmortal timeMild strokeBenzodiazepine prescriptionsBZD useDay of admissionProbability weightingSubgroup analysisAnalyzed dataStrokeAdultsSignificance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging
Kokkinidis D, Kyriakoulis I, Chui P, Agarwal R, Liu Y, Khera R, Sinusas A, Velazquez E, Miller E, Feher A. Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. JACC Advances 2025, 4: 101618. PMID: 39983619, PMCID: PMC11891677, DOI: 10.1016/j.jacadv.2025.101618.Peer-Reviewed Original ResearchCoronary artery calcificationMyocardial perfusion imagingIschemic ECG changesLow event ratesECG changesNormal perfusionArtery calcificationPerfusion imagingSingle-photon emission computed tomography/computed tomographyStress ECGCAC evaluationPresence of coronary artery calcificationSuspected coronary artery diseaseMedian follow-upEvent ratesIschemic electrocardiographic changesAnalysis to patientsComposite endpoint rateCoronary artery diseaseTomography/computed tomographyPrognostic informationMACE rateFollow-upSubgroup analysisAdverse outcomesEfficacy of cannabinoids for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis
Chow R, Basu A, Kaur J, Hui D, Im J, Prsic E, Boldt G, Lock M, Eng L, Ng T, Zimmermann C, Scotte F. Efficacy of cannabinoids for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis. Supportive Care In Cancer 2025, 33: 193. PMID: 39953210, PMCID: PMC11828838, DOI: 10.1007/s00520-025-09251-w.Peer-Reviewed Original ResearchConceptsChemotherapy-induced nausea and vomitingEfficacy of cannabinoidsTHC:CBDMeta-analysisPrevention of chemotherapy-induced nausea and vomitingProphylaxis of chemotherapy-induced nausea and vomitingChemotherapy-induced nausea and vomiting controlControlled trialsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsNausea and vomitingChemotherapy-induced nauseaMethodsA literature searchCochrane Central RegisterComplete responseRandomized controlled trialsNo vomitingAdjunctive therapyRescue medicationAntiemetic regimensComposite endpointSubgroup analysisCannabinoidSecondary preventionProfile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study
Wei X, Li C, Liu D, Chen J, Ju Y, Liu J, Liu B, Zhang Y. Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study. BMC Public Health 2025, 25: 420. PMID: 39894807, PMCID: PMC11789399, DOI: 10.1186/s12889-025-21479-z.Peer-Reviewed Original ResearchConceptsPhysical health indicatorsHealth indicatorsMild cognitive impairmentOlder adultsChina HealthCognitive performanceRight grip strengthChinese older adultsScreening of cognitive declineCognitive domainsLongitudinal cohort designCognitive performance domainsSubgroup analysisDomains of cognitive performancePhysical functionBackgroundExisting studiesGrip strengthCohort designLinear regression modelsMultiple linear regression modelStandardised interviewMethodsThe present studyResultsPulmonary functionSex-specific factorsGeneral cognitionEnteral and parenteral nutrition in patients with cancer: complication rates compared—updated systematic review and meta-analysis
Chow R, Im J, Arends J, Del Fabbro E, Mortensen-Truscott L, Qeska D, Balaji S, Walsh C, Watson G, Lock M, Prsic E, Eng L, Zimmermann C, Bruera E. Enteral and parenteral nutrition in patients with cancer: complication rates compared—updated systematic review and meta-analysis. BMJ Supportive & Palliative Care 2025, spcare-2024-005244. PMID: 39890439, DOI: 10.1136/spcare-2024-005244.Peer-Reviewed Original ResearchCumulative meta-analysisNutrition support complicationsSystematic reviewProtein-energy malnutritionEnteral nutritionParenteral nutritionMeta-analysisRandomised controlled trialsSubgroup analysisLeave-one-out analysisStandard careEffect estimatesControlled trialsType I errorComplication rateComplicationsAdultsNutritionPatientsInfectionInfection rateCancerMortalityEndpointChildrenSafety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), for the Prevention of Recurrent Clostridioides difficile Infection in Participants With Inflammatory Bowel Disease in PUNCH CD3-OLS
Allegretti J, Feuerstadt P, Knapple W, Orenstein R, Pinton P, Sheh A, Khanna S. Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), for the Prevention of Recurrent Clostridioides difficile Infection in Participants With Inflammatory Bowel Disease in PUNCH CD3-OLS. Inflammatory Bowel Diseases 2025, izae291. PMID: 39862395, DOI: 10.1093/ibd/izae291.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsRecurrent Clostridioides difficile infectionInflammatory bowel diseaseClostridioides difficile infectionWeeks of administrationPrevention of recurrent CDISerious treatment-emergent adverse eventsSubgroup analysisSustained clinical response ratesBowel diseaseSustained clinical responseClinical response rateModerate gastrointestinal symptomsUS Food and Drug AdministrationTreatment success rateFood and Drug AdministrationClinical responseSingle-doseProspective trialsFecal microbiotaEfficacy outcomesDifficile infectionAdverse eventsGastrointestinal symptomsTreatment successEffects Of Angiotensin-Neprilysin Inhibition In Women Versus Men With Mildly Reduced Or Preserved Ejection Fraction And Worsening Heart Failure: Insights From PARAGLIDE-HF
Rambarat P, Erickson T, Cyr D, Ward J, Hernandez A, Morrow D, Starling R, Velazquez E, Zieroth S, Williamson K, Solomon S, Braunwald E, Mentz R. Effects Of Angiotensin-Neprilysin Inhibition In Women Versus Men With Mildly Reduced Or Preserved Ejection Fraction And Worsening Heart Failure: Insights From PARAGLIDE-HF. Journal Of Cardiac Failure 2025, 31: 330-331. DOI: 10.1016/j.cardfail.2024.10.383.Peer-Reviewed Original ResearchNT-proBNPHeart failureAmino-terminal pro-B type natriuretic peptideTime-averaged proportional changePro B-type natriuretic peptideTime-averaged reductionIncidence of adverse eventsWorsening heart failureAngiotensin-neprilysin inhibitionCoronary artery diseaseHigh-risk populationDifferential treatment effectsDrug dosage levelsTreatment effectsHFpEF therapyEjection fractionPrimary endpointNatriuretic peptideNo significant differenceRenal functionAdverse eventsSac/ValSubgroup analysisArtery diseaseWeek 4
2024
Impact of Fatigue on Work Productivity, Activity Impairment, and Healthcare Resource Utilization in Inflammatory Bowel Disease
Feagins L, Moore P, Crabtree M, Eliot M, Lemay C, Loughlin A, Gaidos J. Impact of Fatigue on Work Productivity, Activity Impairment, and Healthcare Resource Utilization in Inflammatory Bowel Disease. Crohn's & Colitis 360 2024, 7: otae073. PMID: 39742035, PMCID: PMC11684069, DOI: 10.1093/crocol/otae073.Peer-Reviewed Original ResearchRates of healthcare utilizationImpact of fatigueHealthcare utilizationHigher fatigueLower fatigueActivity impairmentRate of fatigueWork productivity lossEmergency room visitsHealthcare resource utilizationIBD registryLogistic regression analysisFatigue scoresDisease-related hospitalizationsRoom visitsCrohn's diseaseUlcerative colitisWPAIInactive diseaseWork productivitySubgroup analysisSubgroup analysis of patientsAbsenteeismHealthcarePresenteeismComparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment
Singh K, Abdou H, Panth N, Chiang V, Buono F, Schwartz N, Mahajan A. Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment. Otology & Neurotology 2024, 46: 196-200. PMID: 39792983, DOI: 10.1097/mao.0000000000004392.Peer-Reviewed Original ResearchConceptsTumor volume assessmentABC/2 methodVestibular schwannomaVolume assessmentPlanimetry methodTumor volumeTumor volume changesFollow-up scansOverestimate tumor volumePatients' quality of lifeTumor sizeRetrospective reviewIntracranial tumorsImprove clinical decision makingSubgroup analysisVolumetric assessmentTumorClinical decision makingQuality of lifePatients' qualityPatientsClinical settingPlanimetryImaging techniquesPositive correlationComplete revascularization versus culprit‐only revascularization in older adults with ST‐elevation myocardial infarction: Systematic review and meta‐analysis of randomized controlled trials
Park D, Hu J, Frampton J, Rymer J, Al Damluji A, Nanna M. Complete revascularization versus culprit‐only revascularization in older adults with ST‐elevation myocardial infarction: Systematic review and meta‐analysis of randomized controlled trials. Journal Of The American Geriatrics Society 2024, 73: 874-880. PMID: 39639558, PMCID: PMC11908960, DOI: 10.1111/jgs.19295.Peer-Reviewed Original ResearchContrast-associated acute kidney injuryST-elevation myocardial infarctionCulprit-only revascularizationRandomized controlled trialsComplete revascularizationHazard of MACEMeta-analysisOlder adultsHazard ratioClass III to class IMeta-analysis of randomized controlled trialsAssociated with reduced MACEMyocardial infarctionControlled trialsAcute kidney injuryRandomized controlled trials of CRAdverse cardiovascular eventsBenefits of CRComplexity of lesionsRandom-effects modelBleeding riskKidney injuryMeta-analysis to dateCardiovascular eventsSubgroup analysisHow Much More Time Neurologic Examination Adds to Outpatient Visits
Ney J, Wilson A, Raphaelson M, de Havenon A. How Much More Time Neurologic Examination Adds to Outpatient Visits. Neurology Clinical Practice 2024, 15: e200404. PMID: 39649023, PMCID: PMC11620545, DOI: 10.1212/cpj.0000000000200404.Peer-Reviewed Original ResearchSurvey design variablesPatient visitsNational Ambulatory Medical Care SurveyStrong doctor-patient relationshipCost of careDoctor-patient relationshipSubgroup analysisNeurological examinationMedical decision makingNeurologist visitCare SurveyAmbulatory careInsurance statusOutpatient visitsPatient accessAnnual visitsLonger visitsVisit informationGeographic regionsVisit timeNeurological diagnosisVisitsOVERTURE Phase 2 Clinical Trial MRI Outcomes Demonstrate Consistent Treatment Benefits in Subgroup Analysis
Kern R, Kuang C, Seshagiri C, Konisky A, Galley A, Boasso A, Hempel E, Malchano Z, Vaughan B, Cimenser A, Da X, Shpokayte M, Hajos M. OVERTURE Phase 2 Clinical Trial MRI Outcomes Demonstrate Consistent Treatment Benefits in Subgroup Analysis. Alzheimer's & Dementia 2024, 20: e085091. PMCID: PMC11714597, DOI: 10.1002/alz.085091.Peer-Reviewed Original ResearchRandomized controlled trialsAPOE4 carrier statusBaseline subgroupsMild-moderate Alzheimer's diseasePhase 2 clinical trialIndicators of neurodegenerationBrain atrophyBrain volume outcomesBaseline ageBrain volume lossWhole brain volume lossCarrier statusWBVMagnetic resonance imagingAlzheimer's diseaseBaseline covariatesMonth 6Subgroup analysisAt-homeParticipantsClinical trialsTreatment outcomesActive treatmentOne-hourSham treatmentThe Incidence and Significance of Iliac Vein Stenosis in Patients with Deep Vein Thrombosis
Ali S, Chan S, Brahmandam A, Xu Y, Deng Y, Elbadawy A, Lee A, Ochoa Chaar C. The Incidence and Significance of Iliac Vein Stenosis in Patients with Deep Vein Thrombosis. Annals Of Vascular Surgery 2024, 111: 310-318. PMID: 39617297, DOI: 10.1016/j.avsg.2024.11.016.Peer-Reviewed Original ResearchIliac vein stenosisIpsilateral DVT recurrenceCross-sectional imagingDVT recurrenceVein stenosisMedical records of consecutive adult patientsRecords of consecutive adult patientsSubgroup analysisPrevention of pulmonary embolismDevelopment of DVTConsecutive adult patientsIncidence of PEDeep vein thrombosisGroup of patientsLower extremity DVTRecurrent DVTPulmonary embolismVein thrombosisBaseline characteristicsRetrospective studyAdult patientsDVTPatientsElectronic medical recordsStatistical significanceInfluence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial
Chey W, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden C. Influence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial. JGH Open 2024, 8: e70044. PMID: 39554983, PMCID: PMC11567116, DOI: 10.1002/jgh3.70044.Peer-Reviewed Original ResearchRandomized phase II trial of weekly ixabepilone with or without biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer: Updated survival and subgroup analyses
Roque D, Siegel E, Buza N, Bellone S, Huang G, Andikyan V, Clark M, Azodi M, Schwartz P, Rao G, Xu F, Hui P, Altwerger G, Ratner E, Santin A. Randomized phase II trial of weekly ixabepilone with or without biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer: Updated survival and subgroup analyses. Gynecologic Oncology 2024, 190: s299-s301. DOI: 10.1016/j.ygyno.2024.07.449.Peer-Reviewed Original ResearchAvutometinib plus defactinib in recurrent low-grade serous ovarian cancer: A subgroup analysis of ENGOT-OV60/GOG-3052/RAMP 201 Part A
Banerjee S, Van Nieuwenhuysen E, Santin A, Ring K, Colombo N, Thaker P, Prendergast E, Clamp A, Ray-Coquard I, Chon H, Moore K, Salinas E, Rose P, O'Malley D, Oaknin A, Monk B, Holloway R, Newman G, Moroney J, Van Gorp T, Kalbacher E, Gennigens C, Wojtynek N, Lustgarten S, Grisham R. Avutometinib plus defactinib in recurrent low-grade serous ovarian cancer: A subgroup analysis of ENGOT-OV60/GOG-3052/RAMP 201 Part A. Gynecologic Oncology 2024, 190: s55-s56. DOI: 10.1016/j.ygyno.2024.07.084.Peer-Reviewed Original ResearchMortality effects of beta-blockers on myocardial infarction in patients without reduced ejection fraction or heart failure in the contemporary reperfusion era : a systematic review and meta-analysis
Y K, Lee P, Chowdhury I, Schwartz R, Kang Y, Mangalesh S, Babapour G, Akman Z, Chang Y, Song J, Lessa Y, Damluji A, Nanna M, Nanna M. Mortality effects of beta-blockers on myocardial infarction in patients without reduced ejection fraction or heart failure in the contemporary reperfusion era : a systematic review and meta-analysis. European Heart Journal 2024, 45: ehae666.1640. DOI: 10.1093/eurheartj/ehae666.1640.Peer-Reviewed Original ResearchRandomized controlled trialsReduced ejection fractionBeta-blockersEjection fractionHeart failureMortality benefitReduced EFMeta-regressionEF patientsPreserved EFBB usersReperfusion eraMeta-analysisSubgroup analysisSystematic reviewPost-MIPost-MI careEffect of beta-blockersIncreased all-cause mortalityHistory of HFEvent-free periodAll-cause mortalityTemporal trendsStudy inclusion periodModern randomized controlled trialsLong-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database
Satam K, Brahmandam A, Zheng X, Mao J, Goodney P, Ochoa Chaar C. Long-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database. Journal Of Vascular Surgery 2024, 81: 672-681.e2. PMID: 39454844, DOI: 10.1016/j.jvs.2024.10.026.Peer-Reviewed Original ResearchPopliteal artery aneurysm repairGreat saphenous veinLong-term outcomesVascular Quality InitiativeAneurysm repairAssociated with increased survivalShort hospital length of stayGreat saphenous vein bypassHospital length of stayRandomized multicenter studyCox proportional hazards regressionKaplan-Meier curvesAssociated with lower mortalityPopliteal aneurysm repairPopliteal artery aneurysmPeripheral vascular interventionsProportional hazards regressionLength of stayP2Y12 inhibitorsBaseline characteristicsMulticenter studyEndovascular therapyArtery aneurysmPropensity-matchedSubgroup analysisCan ChatGPT-4 Diagnose and Treat Like an Orthopaedic Surgeon? Testing Clinical Decision Making and Diagnostic Ability in Soft-Tissue Pathologies of the Foot and Ankle.
Hartman H, Essis M, Tung W, Oh I, Peden S, Gianakos A. Can ChatGPT-4 Diagnose and Treat Like an Orthopaedic Surgeon? Testing Clinical Decision Making and Diagnostic Ability in Soft-Tissue Pathologies of the Foot and Ankle. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39442011, DOI: 10.5435/jaaos-d-24-00595.Peer-Reviewed Original ResearchAverage sum scoreOrthopaedic surgeonsProfessional licensure examinationPatient education materialsDecision-making capacityClinical decision makingAnkle pathologyAnkle casesTreatment optionsAnkleEducational materialsSum scoreLicensure ExaminationLikert scaleLower scoresCriterion 5Higher scoresSubgroup analysisFootAlternative treatment optionCriterion 1Criterion 2ScoresSoft tissue pathologySurgeon evaluationApplying Language Models to Radiology Text for Identifying Oligometastatic Non-Small Cell Lung Cancer
Moore N, Laird J, Verma N, Hager T, Sritharan D, Lee V, Maresca R, Chadha S, Park H, Aneja S. Applying Language Models to Radiology Text for Identifying Oligometastatic Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e644. DOI: 10.1016/j.ijrobp.2024.07.1417.Peer-Reviewed Original ResearchNon-small cell lung cancerOligometastatic diseaseCell lung cancerRadiologic impressionTumor RegistryTest cohortOligometastatic non-small cell lung cancerIV non-small cell lung cancerStage IV non-small cell lung cancerLung cancerConvolutional neural networkMetastasis-directed therapyOligometastatic NSCLC patientsMonths of diagnosisLanguage modelClinician reviewNSCLC patientsPatient cohortClinical dataScreening patientsSubgroup analysisBrain MRIClinical textBurden of diseaseClinical relevance
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