2025
Reporting of Fairness Metrics in Clinical Risk Prediction Models Used for Precision Health: Scoping Review
Rountree L, Lin Y, Liu C, Salvatore M, Admon A, Nallamothu B, Singh K, Basu A, Bu F, Mukherjee B. Reporting of Fairness Metrics in Clinical Risk Prediction Models Used for Precision Health: Scoping Review. Online Journal Of Public Health Informatics 2025, 17: e66598. PMID: 39962044, DOI: 10.2196/66598.Peer-Reviewed Original ResearchClinical risk prediction modelsRisk prediction modelFairness metricsSex-stratified modelsEthnicity dataPrecision healthClinical risk predictionSensitive featuresStudy populationCardiovascular diseaseRisk predictionEvaluate potential disparitiesTraining dataPotential disparitiesEmpirical evaluationPrediction modelPrimary preventionInformatics systemsHigh-impact publicationsCOVID-19Metrics usageStudy cohortGoogle ScholarImplementation frameworkCOVID-19 modelEvaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems
Aminorroaya A, Dhingra L, Oikonomou E, Khera R. Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems. Circulation Genomic And Precision Medicine 2025, 18: e004632. PMID: 39846171, PMCID: PMC11835527, DOI: 10.1161/circgen.124.004632.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemHealth systemVanderbilt University Medical CenterHealth system electronic health recordUniversity Medical CenterCoronary Artery Risk DevelopmentMulti-Ethnic Study of AtherosclerosisElectronic health recordsMedical CenterUS health systemHealth system patientsAssociated with significantly higher oddsMulti-Ethnic StudyUS-based cohortStudy of AtherosclerosisSignificantly higher oddsHealth recordsUK BiobankAtherosclerosis RiskRisk DevelopmentHigher oddsElevated Lp(aUniversal screeningSystem patientsStudy cohortComprehensive Molecular Profiling of Metastatic Pancreatic Adenocarcinomas
Antony V, Sun T, Dolezal D, Cai G. Comprehensive Molecular Profiling of Metastatic Pancreatic Adenocarcinomas. Cancers 2025, 17: 335. PMID: 39941707, PMCID: PMC11815932, DOI: 10.3390/cancers17030335.Peer-Reviewed Original ResearchMetastatic pancreatic ductal adenocarcinomaPancreatic ductal adenocarcinomaPrimary pancreatic ductal adenocarcinomaMolecular profilingGene mutationsGene copy number alterationsAdvanced-stage pancreatic cancerInsufficient tumor cellsOncomine Comprehensive AssayRate of TP53Copy number alterationsMetastatic diseasePDAC casesPIK3CA mutationsPancreatic cancerPoor prognosisTreatment optionsDuctal adenocarcinomaTumor cellsTumor progressionMolecular alterationsStudy cohortMolecular testingComprehensive assayTherapeutic targetIdentifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort.
John B, Bastaich D, Mezzacappa C, Ferreira R, Hentschel A, Samos A, Mahmud N, Taddei T, Kaplan D, Serper M, Dahman B. Identifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort. The American Journal Of Gastroenterology 2025 PMID: 39950372, DOI: 10.14309/ajg.0000000000003321.Peer-Reviewed Original ResearchElectronic health recordsCardiometabolic risk factorsAlcohol useChart reviewRetrospective study of participantsStudy of participantsLiver diseaseSteatotic liver diseaseIncreased alcohol intakeEligible veteransICD-9/10 codesHealth recordsNational cohortAlcohol intakeEvidence of hepatic steatosisEpidemiological studiesNatural language processing algorithmsRisk factorsStudy cohortOutcome studiesVeteransCohortClinical entityRetrospective studyMetabolic dysfunction
2024
Reproducibility of Semi-automated Quantitative Analyses of Tc-99m Pyrophosphate Uptake from Myocardial Perfusion Planar and SPECT Images
Goyal D, Sandoval V, Weyman C, Miller E, Liu Y. Reproducibility of Semi-automated Quantitative Analyses of Tc-99m Pyrophosphate Uptake from Myocardial Perfusion Planar and SPECT Images. Journal Of Medical And Biological Engineering 2024, 45: 84-91. DOI: 10.1007/s40846-024-00924-1.Peer-Reviewed Original ResearchStandardized uptake valueTc-99SPECT imagesStandard uptake value quantificationTransthyretin cardiac amyloidosisH/CL ratioTc-99m PYP uptakeMethodsOur study cohortInter-observer reproducibilityPlanar imagingTechnetium-99mCardiac amyloidosisClinical suspicionSPECT/CT imagingTc-99m PYP imagingTc-99m PYPConsecutive subjectsUptake valueObserver reproducibilityStudy cohortInter-observerPurposeThe aimResultsIntra-observerMyocardial uptakeSPECTMood lability and depression limit oral contraceptive therapy in endometriosis
Cevik E, Taylor H. Mood lability and depression limit oral contraceptive therapy in endometriosis. Fertility And Sterility 2024 PMID: 39672361, DOI: 10.1016/j.fertnstert.2024.12.011.Peer-Reviewed Original ResearchProgestin-only oral contraceptivesOral contraceptivesOC discontinuationOC useDiagnosis of depressionMood labilityEffects of oral contraceptivesOral contraceptive (OCDocumented diagnosis of depressionDiscontinued OC useEffect of OC useInternational Classification of Diseases-10 codesSide effects of OC useElectronic medical record reviewTreated with OCCourse of treatmentMedical record reviewIncreased incidence of depressionUniversity affiliated hospitalTreatment discontinuationIncidence of depressionEndometriosisStudy cohortPrimary outcomeIncreased incidenceCohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA
Vanegas S, Curado S, Gujral A, Valverde G, Parraga S, Aleman J, Reid M, Elbel B, Schmidt A, Heffron S, Segal E, Li H, Abrams C, Sevick M, Popp C, Armijos E, Merriwether E, Ivezaj V, Ren-Fielding C, Parikh M, Jay M. Cohort profile: study design and baseline characteristics of an observational longitudinal weight loss cohort and biorepository of patients undergoing sleeve gastrectomy in the USA. BMJ Open 2024, 14: e081201. PMID: 39181563, PMCID: PMC11344502, DOI: 10.1136/bmjopen-2023-081201.Peer-Reviewed Original ResearchConceptsObesity-related comorbiditiesMonths post-surgerySleeve gastrectomyPost-surgeryWeight maintenanceAmelioration of obesity-related comorbiditiesPredictive factors of weight lossRemission of obesity-related comorbiditiesLong-term follow-up dataLong-term weight maintenanceFactors of weight lossWeight loss cohortBariatric surgery clinicYears post-surgeryWeight loss outcomesFollow-up dataWeight loss successSocial determinants of healthDeterminants of healthBaseline characteristicsPredictive factorsSurgery clinicNon-Hispanic blacksClinical dataStudy cohortAre They Prepared? Comparing Intern Milestone Performance of Accelerated 3-Year and 4-Year Medical Graduates
Santen S, Yingling S, Hogan S, Vitto C, Traba C, Strano-Paul L, Robinson A, Reboli A, Leong S, Jones B, Gonzalez-Flores A, Grinnell M, Dodson L, Coe C, Cangiarella J, Bruce E, Richardson J, Hunsaker M, Holmboe E, Park Y. Are They Prepared? Comparing Intern Milestone Performance of Accelerated 3-Year and 4-Year Medical Graduates. Academic Medicine 2024, 99: 1267-1277. PMID: 39178363, DOI: 10.1097/acm.0000000000005855.Peer-Reviewed Original ResearchMedical schoolsFamily medicineAccreditation Council for Graduate Medical Education MilestonesMS ratesU.S. medical schoolsNo significant differenceEstimate group differencesSignificant differenceMedical graduatesEmergency medicineInternal medicineRandom effects regressionEducational milestonesMedical studentsStudy designResident performanceProgram effectivenessNoninferiority study designMilestone performanceStatistically significant differenceStudy cohortControl cohortGroup differencesGeneral surgerySpecialtyExposures to drinking water contaminants below regulatory limits and incident ovarian cancer in the California Teachers Study cohort
Spaur M, Hurwitz L, Madrigal J, Beane Freeman L, Keil A, Medgyesi D, Fisher J, Spielfogel E, Albert P, Lacey Jr. J, Jones R, Ward M. Exposures to drinking water contaminants below regulatory limits and incident ovarian cancer in the California Teachers Study cohort. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1684.Peer-Reviewed Original ResearchDifferential interactions between gene expressions and stressors across the lifespan in major depressive disorder
Wang R, Su Y, O'Donnell K, Caron J, Meaney M, Meng X, Li Y. Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder. Journal Of Affective Disorders 2024, 362: 688-697. PMID: 39029669, DOI: 10.1016/j.jad.2024.07.069.Peer-Reviewed Original ResearchMDD riskDepressive disorderPatterns of stressorsVulnerability-stress theoriesSusceptibility to MDDTranscriptome-wide association studyDimensions of stressorsLatent profile modelsLongitudinal community-based cohortPrefrontal cortexLifetime stressorsMDDGene expressionBrain amygdalaBasal gangliaStress researchNominal p-values <Southwest MontrealStressorsBrainFine-mapping analysisBrain cortexStudy cohortGenetic predispositionCortexOutcomes Following Implementation of an Electronic Model for Perioperative Hematologic Consultation
Su D, Rehman S, Wang K, Deng Y, Rose M, Dosani T, Kunstman J. Outcomes Following Implementation of an Electronic Model for Perioperative Hematologic Consultation. Journal Of Surgical Research 2024, 301: 10-17. PMID: 38905768, DOI: 10.1016/j.jss.2024.04.033.Peer-Reviewed Original ResearchHematology consultationSingle-center retrospective studyClavien-Dindo classificationVA Connecticut Healthcare SystemAssess operative outcomesTime to resolutionPrimary outcome measureE-consultationOperative morbidityPostoperative transfusionHematologic complicationsSurgical outcomesNo significant differenceRetrospective studyProcedural dataOperative outcomesProcedural outcomesStudy cohortPatient characteristicsConsult volumeSecondary outcomesHematologic issuesAssociated with changesReferral patternsSurgeryGeographic and psychosocial correlates of homelessness or unstable housing among US veterans in the Midwest
Umucu E, Lee B, Chang C, Szymkowiak D, Tsai J. Geographic and psychosocial correlates of homelessness or unstable housing among US veterans in the Midwest. American Journal Of Community Psychology 2024, 74: 142-151. PMID: 38747475, DOI: 10.1002/ajcp.12751.Peer-Reviewed Original ResearchVeterans Integrated Service NetworkUnstable housingMental health conditionsStably housed veteransAssociated with increased riskMultivariate logistic regression analysisLogistic regression analysisIntegrated services networksPsychosocial correlatesUS veteransHealth conditionsCorrelates of homelessnessRural locationsVeteransLocation scoreStudy cohortIncarceration experienceMidwestern stateRegression analysisRisky behaviorsHomelessnessService networkGeographical characteristicsCareHousingContemporary Decongestion Strategies in Patients Hospitalized for Heart Failure A National Community-Based Cohort Study
Zheng J, Ambrosy A, Bhatt A, Collins S, Flint K, Fonarow G, Fudim M, Greene S, Lala A, Testani J, Varshney A, Wi R, Sandhu A. Contemporary Decongestion Strategies in Patients Hospitalized for Heart Failure A National Community-Based Cohort Study. JACC Heart Failure 2024, 12: 1381-1392. PMID: 38678466, DOI: 10.1016/j.jchf.2024.04.002.Peer-Reviewed Original ResearchPredictors of weight lossHeart failureWeight lossHF hospitalizationPatient-level electronic health record dataCommunity-based health systemAssociated with less weight lossContinuous diuretic infusionsElectronic health record dataCommunity-based cohort studyAssociated with greater weight lossHealth record dataGreater weight lossBackground Heart failureEstimated weight lossLess weight lossAdjunctive diureticsDiuretic infusionAcute HFSerum creatinineClinical predictorsDecongestion strategiesAdmission weightStudy cohortDischarge weightA 10-year perspective on the question of whether surgeries for adolescent idiopathic scoliosis are “one and done”?
Gouzoulis M, Joo P, Jeong S, Jabbouri S, Moran J, Zhu J, Grauer J. A 10-year perspective on the question of whether surgeries for adolescent idiopathic scoliosis are “one and done”? Spine Deformity 2024, 12: 903-908. PMID: 38555557, DOI: 10.1007/s43390-024-00858-3.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisIdiopathic scoliosisRisk factorsAssociated with male sexTime of surgeryLong-term outcomesYear follow-upMultivariate regressionMonths to 2Reoperation incidenceReoperation ratePSF patientsExcellent outcomesPediatric surgeonsReoperationMale sexFollow-upStudy cohortPatient characteristicsPatient counselingSurgeryConclusionsThe current studyInterquartile rangeScoliosis fusionResultsIn totalDerivation of an Annualized Claims-Based Major Adverse Cardiovascular Event Estimator in Type 2 Diabetes
McCoy R, Swarna K, Deng Y, Herrin J, Ross J, Kent D, Borah B, Crown W, Montori V, Umpierrez G, Galindo R, Brito J, Mickelson M, Polley E. Derivation of an Annualized Claims-Based Major Adverse Cardiovascular Event Estimator in Type 2 Diabetes. JACC Advances 2024, 3: 100852. PMID: 38939660, PMCID: PMC11198625, DOI: 10.1016/j.jacadv.2024.100852.Peer-Reviewed Original ResearchType 2 diabetesMedicare fee-for-service planClaims-based prediction modelPopulation risk stratificationRisk of Major Adverse Cardiovascular EventsMajor adverse cardiovascular eventsNon-Hispanic whitesFee-for-service plansStudy cohortClinical trials of cardiovascular diseaseCox proportional hazards modelsProportional hazards modelCare populationHealth systemPrimary preventionMedicare AdvantageParticipant identificationPayer levelPharmacy claimsDecentralized clinical trialsHazards modelCardiovascular diseaseRisk predictionMedicarePatient populationSex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals
Laaksonen S, Saraste M, Nylund M, Hinz R, Snellman A, Rinne J, Matilainen M, Airas L. Sex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals. Frontiers In Neurology 2024, 15: 1352116. PMID: 38445263, PMCID: PMC10913932, DOI: 10.3389/fneur.2024.1352116.Peer-Reviewed Original ResearchDistribution volume ratioNormal-appearing white matterMale MS patientsCortical gray matterMS patientsPositron emission tomographyTSPO bindingMultiple sclerosisDisease progressionHealthy individualsClinical disease progressionWhole-brainBrain positron emission tomographySex differencesMales compared to femalesFemale patientsHealthy womenDisability progressionGreater likelihoodGray matterHealthy controlsStudy cohortFemale controlsEmission tomographyBrainAssociation of the clinical components in the distal interphalangeal joint synovio-entheseal complex and subsequent response to ixekizumab or adalimumab in psoriatic arthritis
McGonagle D, Kavanaugh A, McInnes I, Kristensen L, Merola J, Strober B, Bolce R, Lisse J, Pustizzi J, Sapin C, Ritchlin C. Association of the clinical components in the distal interphalangeal joint synovio-entheseal complex and subsequent response to ixekizumab or adalimumab in psoriatic arthritis. Rheumatology 2024, 63: 3115-3123. PMID: 38341669, PMCID: PMC11534097, DOI: 10.1093/rheumatology/keae060.Peer-Reviewed Original ResearchNail psoriasisJoint involvementPsoriatic arthritisJoint tendernessTargeting IL-17ADistal interphalangeal joint involvementPost hoc analysisPost-baseline assessmentSPIRIT-H2HInhibitor adalimumabIL-17AAdalimumabStudy cohortTNF-aDrug classesMusculoskeletal outcomesPsoriasisPatientsHoc analysisDistal interphalangealIxekizumabSynovio-entheseal complexWeeksAdjacent nailPSAImpaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies
Sharma R, de Havenon A, Rivier C, Payabvash S, Forman R, Krumholz H, Falcone G, Sheth K, Kernan W. Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies. BMJ Neurology Open 2024, 6: e000501. PMID: 38288313, PMCID: PMC10823923, DOI: 10.1136/bmjno-2023-000501.Peer-Reviewed Original ResearchVascular brain injurySlow walkingAtherosclerosis RiskMobility impairmentsAssociated with mobility impairmentImpaired mobilityUK Biobank (UKBStroke-free cohortMarkers of vascular brain injuryAdjusted multivariate logistic regression analysisGait dataMultivariate logistic regression analysisCommunity-dwellingLogistic regression analysisBrain injuryARICUKBInclusion criteriaStudy cohortWalkingClinical strokeRegression analysisImpaired outcomeMRI markersStudy background
2023
Mechanical thrombectomy for the treatment of primary and secondary anterior cerebral artery occlusions: insights from STAR
Dabhi N, Kumar J, Ironside N, Kellogg R, Sowlat M, Uchida K, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Howard B, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Matouk C, Levitt M, Brinjikji W, Moss M, Dumont T, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A, Park M. Mechanical thrombectomy for the treatment of primary and secondary anterior cerebral artery occlusions: insights from STAR. Journal Of NeuroInterventional Surgery 2023, 16: 1282-1287. PMID: 37968114, DOI: 10.1136/jnis-2023-020997.Peer-Reviewed Original ResearchConceptsMechanical thrombectomyProcedural outcomesCerebral arteryAnterior cerebral artery occlusionEfficacy of mechanical thrombectomyAnterior cerebral arteryMann-Whitney U testMT-treatedCerebral artery occlusionRetrospective reviewBaseline characteristicsClinical outcomesOcclusion groupStudy cohortArtery occlusionFunctional outcomesBaseline variablesIdeal patientStroke thrombectomyMann-WhitneyPatientsU testCategorical variablesThrombectomyOcclusionEffects of novel Coronavirus (COVID-19) on presentation, management, and outcomes of acute cholecystitis at an academic tertiary care center cholecystitis management during COVID-19
Peters N, O'Connor R, Bhattacharya B, Kunstman J. Effects of novel Coronavirus (COVID-19) on presentation, management, and outcomes of acute cholecystitis at an academic tertiary care center cholecystitis management during COVID-19. Heliyon 2023, 9: e22043. PMID: 38027854, PMCID: PMC10658381, DOI: 10.1016/j.heliyon.2023.e22043.Peer-Reviewed Original ResearchTertiary care centerAcute cholecystitisCare centerPersonal protective equipment (PPE) guidelinesAcademic tertiary care centerAcute surgical problemsNon-operative managementPre-operative testingCOVID-19 pandemicNon-significant trendCholecystitis patientsComplication rateStudy cohortOperative managementControl cohortCOVID cohortSurgical problemsRetrospective analysisSurgical carePatientsControl groupEquipment guidelinesCholecystitisAspects of healthcareCohort
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