2025
Extended Treatment Duration of Artemether‐Lumefantrine in Ugandan Children with HIV on Efavirenz‐Based Antiretroviral Therapy: A Randomized Controlled Pharmacokinetic and Pharmacodynamic Trial
Whalen M, Kajubi R, Goodwin J, Orukan F, Colt M, Huang L, Richards K, Hoffmann T, Aweeka F, Parikh S, Mwebaza N. Extended Treatment Duration of Artemether‐Lumefantrine in Ugandan Children with HIV on Efavirenz‐Based Antiretroviral Therapy: A Randomized Controlled Pharmacokinetic and Pharmacodynamic Trial. The Journal Of Clinical Pharmacology 2025, 65: 909-922. PMID: 39853752, DOI: 10.1002/jcph.6193.Peer-Reviewed Original ResearchDesbutyl-lumefantrineAntiretroviral therapyEfavirenz-based antiretroviral therapyEfavirenz-based HIV therapyEFV-based antiretroviral therapyEpisodes of malariaHIV co-infectionSignificant reductionExtended treatment durationStatistically significant reductionClinically significant reductionArtemether-lumefantrinePharmacodynamic trialsMalaria episodesPharmacokinetic samplingHIV therapyRandomized studyRecurrence riskDrug interactionsPrimary outcomeRegimensMalariaReinfection riskHIVCo-infection
2024
Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial
Ranade M, Foster M, Brady P, Sokol S, Butty S, Klein A, Maholic R, Safar A, Patel T, Zlotnick D, Gans D, Pollak J, Ferrera D, Stegman B, Basra S, Moriarty J, Keeling B, Investigators A. Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 4: 102463. PMID: 40061412, PMCID: PMC11887559, DOI: 10.1016/j.jscai.2024.102463.Peer-Reviewed Original ResearchAcute intermediate-risk PEMechanical aspiration thrombectomyIntermediate-risk PEPulmonary embolismAspiration thrombectomyRV/LV ratioClot burdenAdverse eventsMm HgLow rate of adverse eventsMean pulmonary artery pressureEnd pointsRate of adverse eventsAcute pulmonary embolismPulmonary artery pressureSafety end pointDevice-related deathsTreat pulmonary embolismSingle-arm studyEffectiveness end pointAccess site bleedingStatistically significant reductionCardiac injuryClinical deteriorationArterial pressureClinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study
Xu L, Chen X, Yang X, Chen S, Yang M, Yuan Z, Chen R, Wang J, Jiang H, Xu J, Wang Y. Clinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study. Frontiers In Cellular And Infection Microbiology 2024, 14: 1392491. PMID: 39211792, PMCID: PMC11358093, DOI: 10.3389/fcimb.2024.1392491.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsCOVID-19 pneumoniaViral shedding timeRetrospective cohort studyShort-term prognosisTransplant recipientsClinical featuresAntiviral drugsAntiviral medicationsCohort studyShort-term renal functionAdministration of antiviral drugsAssociated with better therapeutic outcomesSevere COVID-19 pneumoniaConcurrent coronavirus disease 2019Diagnosis of COVID-19 pneumoniaTransplanted kidney functionStatistically significant reductionShedding timeRenal functionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Clinical symptomsKidney functionInitial symptomsLinzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3)
Donnez J, Becker C, Taylor H, Herrera F, Donnez O, Horne A, Paszkowski M, Petraglia F, Renner S, Patel A, Boolell M, Bestel E, Dolmans M. Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3). Human Reproduction 2024, 39: 1208-1221. PMID: 38648863, PMCID: PMC11144970, DOI: 10.1093/humrep/deae076.Peer-Reviewed Original ResearchNon-menstrual pelvic painAdd-back therapyEndometriosis-associated painPelvic painMonths of therapyPhase 3 studyGedeon RichterData monitoring boardDaily doseStatistically significant reductionPlacebo groupDouble-blindRoche DiagnosticsTreatment of endometriosis-associated painHormonal add-back therapyRates of hot flushesReduce dysmenorrheaGonadotropin-releasing hormone antagonistRisk of bone lossDATE OF FIRST PATIENT’S ENROLMENT:Overall pelvic painPublished phase 2Hypoestrogenic side effectsMonitoring boardCompared to placeboEffect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial
Kandzari D, Weber M, Pathak A, Zidar J, Saxena M, David S, Schmieder R, Janas A, Langer C, Persu A, Mendelsohn F, Ameloot K, Foster M, Fischell T, Parise H, Mahfoud F. Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial. Circulation 2024, 149: 1875-1884. PMID: 38587557, DOI: 10.1161/circulationaha.124.069291.Peer-Reviewed Original ResearchSystolic blood pressureOffice systolic blood pressureRenal denervationOffice diastolic BPAmbulatory systolic BPBlood pressureSham controlsPrimary endpointBetween-group differencesNo significant differenceAntihypertensive medicationsDiastolic BPSystolic BPPresence of antihypertensive medicationBaseline-adjusted changeRenal artery dissectionMonths post-procedureSignificant differenceRenal denervation groupAmbulatory systolic blood pressureNo significant between-group differencesStatistically significant reductionSignificant between-group differencesSecondary endpointsOffice BPAlirocumab in Pediatric Patients With Heterozygous Familial Hypercholesterolemia
Santos R, Wiegman A, Caprio S, Cariou B, Averna M, Poulouin Y, Scemama M, Manvelian G, Garon G, Daniels S. Alirocumab in Pediatric Patients With Heterozygous Familial Hypercholesterolemia. JAMA Pediatrics 2024, 178: 283-293. PMID: 38315470, PMCID: PMC10845038, DOI: 10.1001/jamapediatrics.2023.6477.Peer-Reviewed Original ResearchDouble-blind periodLipid-lowering therapyHeterozygous familial hypercholesterolemiaPediatric patientsLDL-CLipid parametersFamilial hypercholesterolemiaRecommended low-density lipoprotein cholesterolAdjunctive lipid-lowering therapiesSecondary efficacy end pointsEnd pointsPediatric patients aged 8Least-squares mean differenceEfficacy of alirocumabOpen-label periodEfficacy end pointLow-density lipoprotein cholesterolReduced LDL-CBaseline to weekPrimary end pointAdverse event incidencePatients aged 8Randomized clinical trialsSquare mean differencesStatistically significant reductionIntegrating mental health into primary care in Nigeria: Implementation outcomes and clinical impact of the HAPPINESS intervention
Iheanacho T, Chu C, Aguocha C, Nwefoh E, Dike C. Integrating mental health into primary care in Nigeria: Implementation outcomes and clinical impact of the HAPPINESS intervention. Cambridge Prisms Global Mental Health 2024, 11: e9. PMID: 38390244, PMCID: PMC10882178, DOI: 10.1017/gmh.2024.4.Peer-Reviewed Original ResearchPost-interventionMental healthScale-up mental health servicesPatient Health Questionnaire scoresPrimary health care centersEffect sizeMental health servicesHealth care centersTechnology-supported interventionsStatistically significant reductionQuasi-experimental designPrimary careIntervention implementationImplementation outcomesHealth servicesHealth actionsCommunity-basedBrief Psychiatric Rating Scale scoresQuestionnaire scoresSignificant reductionPsychiatric Rating Scale scoresCare centerPsychiatric problemsHappiness interventionsHealthEffect of Dancing Interventions on Depression and Anxiety Symptoms in Older Adults: A Systematic Review and Meta-Analysis
Prudente T, Mezaiko E, Silveira E, Nogueira T. Effect of Dancing Interventions on Depression and Anxiety Symptoms in Older Adults: A Systematic Review and Meta-Analysis. Behavioral Sciences 2024, 14: 43. PMID: 38247695, PMCID: PMC10813489, DOI: 10.3390/bs14010043.Peer-Reviewed Original ResearchOlder adultsDance interventionAnxiety symptomsMeta-analysisEffects of dance interventionsSystematic reviewMental health interventionsEffects of danceMental well-beingRisk of biasRandomized trialsMild cognitive impairmentHealth interventionsAnxiety outcomesDepression scoresDepressive symptomsGrey literatureCochrane toolCognitive impairmentAnxietyDepressionDance classesInterventionWell-beingStatistically significant reduction
2022
Appropriate guideline directed HPV testing during routine pap smears via electronic medical record change: A quality improvement initiative (454)
Kailasam A, Harvey C, Jenusaitis L, White K, Wakefield D, Shepherd J, Hansen K. Appropriate guideline directed HPV testing during routine pap smears via electronic medical record change: A quality improvement initiative (454). Gynecologic Oncology 2022, 166: s227. DOI: 10.1016/s0090-8258(22)01676-6.Peer-Reviewed Original ResearchHuman papillomavirus testingPatients aged <Human papillomavirusPap smearElectronic medical recordsCervical cancerSmoking statusMedical recordsHard stopDetecting cervical dysplasiaVaginal Pap smearHuman papillomavirus statusChi-square analysisRoutine Pap smearsHPV-based testingPatients aged >Electronic medical record changesInstitutional electronic medical recordsRetrospective cohort studyPrevent cervical cancerQuality improvement initiativesQuality improvement studyStatistically significant reductionLogistic regression analysisCervical dysplasia
2018
Transgenic Expression of hCD47 Minimizes the Development of Proteinuria Following Pig-to-Baboon Kidney Transplantation and Reduces Phagocytosis of Porcine Endothelial Cells and Podocytes
Nomura S, Watanabe H, Ariyoshi Y, Pomposelli T, Garcia G, Sekijima M, Boyd L, Ekanayake-Alper D, Glor H, Tanabe T, Arn S, Hawley R, Sykes M, Sachs D, Richard J, Yamada K. Transgenic Expression of hCD47 Minimizes the Development of Proteinuria Following Pig-to-Baboon Kidney Transplantation and Reduces Phagocytosis of Porcine Endothelial Cells and Podocytes. Transplantation 2018, 102: s314-s315. DOI: 10.1097/01.tp.0000543036.39314.a6.Peer-Reviewed Original ResearchDevelopment of proteinuriaPorcine endothelial cellsEndothelial cellsGroup 2Development of massive proteinuriaGroup 1Glomerular cellsGlomerular endothelial damageExpression of hCD55Statistically significant reductionCo-culture assayIn vitro studiesCTLA-4IgImmunosuppressive regimensMinimal proteinuriaCTLA4-IgKidney transplantationMassive proteinuriaReduction of phagocytosisEndothelial damageInflammatory cascadeMediated cytotoxicityProteinuriaPromoting proteinuriaGroup 3
2017
The Perceval Sutureless Aortic Valve
Powell R, Pelletier M, Chu M, Bouchard D, Melvin K, Adams C. The Perceval Sutureless Aortic Valve. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2017, 12: 155-173. DOI: 10.1177/155698451701200301.Peer-Reviewed Original ResearchStatistically significant reductionStented prosthesesAortic valvePooled analysisLowest postoperative platelet countSutureless aortic valve bioprosthesisRate of permanent pacemaker implantationSurgical aortic valve replacementConcomitant valvular proceduresMinimally invasive casesPerceval aortic valveCardiopulmonary bypass timePostoperative platelet countBicuspid aortic valveSignificant reductionThirty-day mortalityAortic valve replacementAortic cross-clampingOff-label procedurePermanent pacemaker implantationTranscatheter aortic valve implantationAortic valve bioprosthesisCochrane Library databasesValve-in-valveAortic valve implantationThe Perceval Sutureless Aortic Valve
Powell R, Pelletier M, Chu M, Bouchard D, Melvin K, Adams C. The Perceval Sutureless Aortic Valve. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2017, 12: 155-173. PMID: 28570342, DOI: 10.1097/imi.0000000000000372.Peer-Reviewed Original ResearchConceptsStatistically significant reductionStented prosthesesAortic valvePooled analysisLowest postoperative platelet countSutureless aortic valve bioprosthesisRate of permanent pacemaker implantationSurgical aortic valve replacementConcomitant valvular proceduresMinimally invasive casesPerceval aortic valveCardiopulmonary bypass timePostoperative platelet countBicuspid aortic valveSignificant reductionThirty-day mortalityAortic valve replacementAortic cross-clampingOff-label procedurePermanent pacemaker implantationTranscatheter aortic valve implantationAortic valve bioprosthesisCochrane Library databasesValve-in-valveAortic valve implantation
2012
Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy
Tebben P, Milliner D, Horst R, Harris P, Singh R, Wu Y, Foreman J, Chelminski P, Kumar R. Hypercalcemia, Hypercalciuria, and Elevated Calcitriol Concentrations with Autosomal Dominant Transmission Due to CYP24A1 Mutations: Effects of Ketoconazole Therapy. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: e423-e427. PMID: 22337913, PMCID: PMC3319216, DOI: 10.1210/jc.2011-1935.Peer-Reviewed Original ResearchConceptsSplice junction mutationElevated serum 1,25-dihydroxyvitamin DSerum 1,25-dihydroxyvitamin DAutosomal dominant transmissionCYP24A1 geneIntermittent hypercalcemiaUrinary calciumAnalysis of family membersDominant transmissionNormal rangeD concentrationsElevated 1,25-dihydroxyvitamin DReduced bone mineral densitySerum 24,25-dihydroxyvitamin DCYP24A1 gene mutationsElevated urinary calciumReduced urinary calciumBone mineral densityGenetic analysisGenetic basisElevated 1,25-dihydroxyvitamin D concentrationsStatistically significant reductionDecreased PTH concentrationsFamily membersGenes
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