2024
Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis.
Wallis R, Sabi I, Lalashowi J, Bakuli A, Mapamba D, Olomi W, Siyame E, Ngaraguza B, Chimbe O, Charalambous S, Rachow A, Ivanova O, Zurba L, Myombe B, Kunambi R, Hoelscher M, Ntinginya N, Churchyard G. Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis. NEJM Evidence 2024, 3: evidoa2300332. PMID: 39189858, DOI: 10.1056/evidoa2300332.Peer-Reviewed Original ResearchConceptsWhole blood glutathione levelsLung functionN-acetylcysteinePulmonary tuberculosisCulture conversionSecondary outcomesGlutathione levelsEffect of N-acetylcysteineTuberculosis treatment outcomesOutcome of lung functionOral N-acetylcysteineRecovery of lung functionAdjunctive N-acetylcysteineAssociated with improved recoveryN-acetylcysteine treatmentPermanent lung injuryFar-advanced tuberculosisSputum cultureStandard therapyNAC administrationAdverse eventsLung injuryGlobal health concernCohort studyClinical evaluation
2023
Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease
Siegel S, Griffith D, Philley J, Brown-Elliott B, Brunton A, Sullivan P, Fuss C, Strnad L, Wallace R, Winthrop K. Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease. CHEST Journal 2023, 164: 846-859. PMID: 37419144, PMCID: PMC10645596, DOI: 10.1016/j.chest.2023.05.036.Peer-Reviewed Original ResearchConceptsAmikacin liposome inhalation suspensionAmikacin resistanceCulture conversionInhalation suspensionMycobacterium abscessus lung diseasePresence of macrolide resistanceEnd pointsMicrobiological end pointsMonthly sputum culturesSputum culture conversionTreatment-refractory diseaseOpen-label protocolSecondary end pointsOpen-label trialCohort of patientsCavitary diseaseSputum culturePretreatment isolatesM abscessusOpen-labelOral antimicrobialsParenteral antibioticsCompanion therapyMacrolide resistanceMultidrug therapy
2021
Blood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study
Moreira F, Verma R, dos Santos P, Leite A, da Silva Santos A, de Araujo R, da Silva B, de Sá Queiroz J, Persing D, Södersten E, Gnanashanmugam D, Khatri P, Croda J, Andrews J. Blood-based host biomarker diagnostics in active case finding for pulmonary tuberculosis: A diagnostic case-control study. EClinicalMedicine 2021, 33: 100776. PMID: 33842866, PMCID: PMC8020164, DOI: 10.1016/j.eclinm.2021.100776.Peer-Reviewed Original ResearchCare C-reactive proteinXpert MTB/RIFMTB/RIFDiagnostic case-control studyXpert MTBCase-control studyTuberculosis casesTriage testSputum Xpert MTB/RIFHigh tuberculosis burden settingsActive casesSputum bacillary burdenC-reactive proteinHigh-burden populationsCulture-confirmed casesMass screening programCulture-negative controlsBacillary burdenTuberculosis symptomsPulmonary tuberculosisSputum cultureScreening program
2020
Oral swab testing by Xpert® MTB/RIF Ultra for mass tuberculosis screening in prisons
Lima F, Santos A, Oliveira R, Silva C, Gonçalves C, Andrews J, Croda J. Oral swab testing by Xpert® MTB/RIF Ultra for mass tuberculosis screening in prisons. Journal Of Clinical Tuberculosis And Other Mycobacterial Diseases 2020, 19: 100148. PMID: 32099908, PMCID: PMC7031315, DOI: 10.1016/j.jctube.2020.100148.Peer-Reviewed Original ResearchNucleic acid amplification testsOral swabsPulmonary tuberculosisSwab testingAmplification testsMTB/RIF UltraMass screening studyOral swab samplingCourse of illnessScreening studySputum cultureXpert testingBacillary loadMycobacterial loadCase findingSputumXpertSwabsTuberculosisFurther studiesSwab samplingParticipantsComparable sensitivityPrison inmatesIndividuals
2017
Diagnostic Outcomes After Chest Radiograph Interpretation in Patients With Suspected Tuberculosis and Negative Sputum Smears in a High-Burden Human Immunodeficiency Virus and Tuberculosis Setting
Cudahy PGT, Dawson R, Allwood BW, Maartens G, Wilson D. Diagnostic Outcomes After Chest Radiograph Interpretation in Patients With Suspected Tuberculosis and Negative Sputum Smears in a High-Burden Human Immunodeficiency Virus and Tuberculosis Setting. Open Forum Infectious Diseases 2017, 4: ofx123. PMID: 28721354, PMCID: PMC5508775, DOI: 10.1093/ofid/ofx123.Peer-Reviewed Original ResearchAcid-fast bacilliNegative sputum smearsSputum smearPulmonary tuberculosisChest radiographsSputum smear-negative patientsSmear-negative pulmonary tuberculosisSmear-negative patientsEvaluation of patientsPrimary care clinicsChest X-ray readingsPoor diagnostic utilityX-ray readingsChest radiograph interpretationSputum cultureCare clinicsExperienced pulmonologistsDiagnostic utilityClinical diagnosisPatientsTuberculosisDiagnostic outcomesRadiograph interpretationLow specificitySmears
2016
The role for neutrophil extracellular traps in cystic fibrosis autoimmunity
Skopelja S, Hamilton BJ, Jones JD, Yang ML, Mamula M, Ashare A, Gifford AH, Rigby WF. The role for neutrophil extracellular traps in cystic fibrosis autoimmunity. JCI Insight 2016, 1: e88912. PMID: 27777975, PMCID: PMC5070963, DOI: 10.1172/jci.insight.88912.Peer-Reviewed Original ResearchConceptsAnti-citrullinated protein autoantibodiesNeutrophil extracellular trapsAnti-BPI autoantibodiesDevelopment of autoimmunityCystic fibrosisBactericidal permeability-increasing proteinProtein autoantibodiesExtracellular trapsACPA-positive RA patientsDiminished lung functionRheumatoid arthritis patientsAirway inflammationAutoantibody levelsCF disease severityRA patientsRespiratory failureArthritis patientsLung functionSputum cultureAutoantibody profileLung damagePermeability-increasing proteinAutoantibody specificitiesChronic infectionCF patients
2015
High Prevalence of Antimicrobial Resistance Among Common Bacterial Isolates in a Tertiary Healthcare Facility in Rwanda
Ntirenganya C, Manzi O, Muvunyi CM, Ogbuagu O. High Prevalence of Antimicrobial Resistance Among Common Bacterial Isolates in a Tertiary Healthcare Facility in Rwanda. American Journal Of Tropical Medicine And Hygiene 2015, 92: 865-870. PMID: 25646259, PMCID: PMC4385787, DOI: 10.4269/ajtmh.14-0607.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Infective AgentsDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedPrevalenceProspective StudiesRwandaStaphylococcal InfectionsStaphylococcus aureusTertiary HealthcareYoung AdultConceptsKigali University Teaching HospitalCommon bacterial isolatesPrevalence of AMRAntimicrobial resistanceProspective observational studyAntibiotic sensitivity patternTertiary healthcare facilityUniversity Teaching HospitalSerious therapeutic challengeSerious public health threatAdequate surveillance systemsThird-generation cephalosporinsAntimicrobial resistance ratesPublic health threatE. coli isolatesStaphylococcus aureus strainMedical wardsSputum cultureTherapeutic challengeCommon infectionsUnique patientsWound swabsSwab specimensTeaching hospitalHigh prevalenceActive and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study
Carbone Ada S, Paião DS, Sgarbi RV, Lemos EF, Cazanti RF, Ota MM, Junior AL, Bampi JV, Elias VP, Simionatto S, Motta-Castro AR, Pompílio MA, de Oliveira SM, Ko AI, Andrews JR, Croda J. Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study. BMC Infectious Diseases 2015, 15: 24. PMID: 25608746, PMCID: PMC4307675, DOI: 10.1186/s12879-015-0764-8.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionPrevalence of LTBITuberculin skin testActive TBLTBI prevalenceWeeks of symptomsHigh transmission settingsCross-sectional studyPopulation-based samplePoisson regression modelsDuration of incarcerationHierarchical Poisson regression modelActive diseaseTB infectionLatent tuberculosisTB casesHIV testingSputum cultureTuberculosis infectionPoint prevalenceSkin testTuberculosis incidenceRisk factorsMultivariable modelSputum samples
2014
A 33-year-old Haitian immigrant with 7 months of abdominal pain and progressive distension
Farhadian S, Shenoi SV, Villanueva MS. A 33-year-old Haitian immigrant with 7 months of abdominal pain and progressive distension. BMJ Case Reports 2014, 2014: bcr2014205371. PMID: 25008341, PMCID: PMC4091201, DOI: 10.1136/bcr-2014-205371.Peer-Reviewed Case Reports and Technical NotesConceptsTB peritonitisAbdominal painPositive tuberculin skin testNon-necrotising granulomasAnti-TB treatmentLatent tuberculosis infectionSmall bowel mesenteryTuberculin skin testAbdominal CT scanAbnormal soft tissuePeritoneal thickeningAbdominal distensionDilated loopsMild ascitesPulmonary TBHIV testingSputum cultureTuberculosis infectionBowel mesenterySmall bowelOmental massSkin testProgressive distensionBiopsy culturesGreater omentum
2011
Spread of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa
Moodley P, Shah NS, Tayob N, Connolly C, Zetola N, Gandhi N, Friedland G, Sturm AW. Spread of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa. PLOS ONE 2011, 6: e17513. PMID: 21655324, PMCID: PMC3104985, DOI: 10.1371/journal.pone.0017513.Peer-Reviewed Original ResearchConceptsMDR-TB casesDrug-resistant tuberculosisXDR-TB casesXDR-TBDrug susceptibility test resultsExtensively Drug-Resistant TuberculosisMDR tuberculosis casesMDR-TB patientsXDR-TB patientsCulture-confirmed casesProvincial referral hospitalCross-sectional studyKwaZulu-Natal ProvinceSource of infectionTB casesNumber of hospitalsReferral hospitalSputum cultureTuberculosis casesScotland hospitalsPatientsHealthcare districtsHospitalClinical diagnosisLaboratory databaseCulture Conversion Among HIV Co-Infected Multidrug-Resistant Tuberculosis Patients in Tugela Ferry, South Africa
Brust JC, Lygizos M, Chaiyachati K, Scott M, van der Merwe TL, Moll AP, Li X, Loveday M, Bamber SA, Lalloo UG, Friedland GH, Shah NS, Gandhi NR. Culture Conversion Among HIV Co-Infected Multidrug-Resistant Tuberculosis Patients in Tugela Ferry, South Africa. PLOS ONE 2011, 6: e15841. PMID: 21253585, PMCID: PMC3017058, DOI: 10.1371/journal.pone.0015841.Peer-Reviewed Original ResearchConceptsMDR-TB patientsCulture conversion rateMDR-TB treatmentMonths of therapyAntiretroviral therapyHIV-coCulture conversionHIV co-infected patientsMultidrug-resistant tuberculosis patientsTiming of ARTMDR-TB therapyCo-infected patientsHIV-negative patientsSecond-line regimenSimilar cure ratesDays of initiationResource-limited settingsHIV prevalentART medicationsCD4 countMDR-TBTuberculosis patientsSputum cultureSuch patientsHIV status
2010
Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study
Heysell SK, Thomas TA, Gandhi NR, Moll AP, Eksteen FJ, Coovadia Y, Roux L, Babaria P, Lalloo U, Friedland G, Shah S. Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional study. BMC Infectious Diseases 2010, 10: 344. PMID: 21134279, PMCID: PMC3016377, DOI: 10.1186/1471-2334-10-344.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsChildChild, PreschoolCross-Sectional StudiesExtensively Drug-Resistant TuberculosisFemaleHIV InfectionsHumansInfantInfant, NewbornMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesRisk FactorsRural PopulationSouth AfricaSputumYoung AdultConceptsDrug-resistant TBMycobacterial blood culturesDrug-resistant tuberculosisBlood culturesXDR-TBRural South AfricaMDR-TBM. tuberculosisMycobacterium tuberculosis bacteremiaCross-sectional studyPositive blood culturesDiagnosis of MDRCross-sectional analysisAntiretroviral therapySecondary outcomesSputum cultureTB suspectsRisk factorsPatientsHIVTuberculosisDiagnosisTBSimilar settingsBacteremia
2008
Salmonella typhimurium pulmonary infection in an immunocompetent patient.
Genzen JR, Towle DM, Kravetz JD, Campbell SM. Salmonella typhimurium pulmonary infection in an immunocompetent patient. Connecticut Medicine 2008, 72: 139-42. PMID: 18426179.Peer-Reviewed Case Reports and Technical NotesConceptsImmunocompetent patientsRight upper lobePrimary care providersAbnormal chest radiographTwo-week historyProgression of symptomsSalmonella typhimurium infectionRadiologic improvementEsophageal dysmotilityPulmonary infectionSevere immunosuppressionAntibiotic therapySputum cultureUpper lobeChronic alcoholismSputum specimenChest radiographsTyphimurium infectionCare providersPatientsSalmonella infectionAreas of cavitationInfectionLarge consolidationDysmotility
2006
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. The Lancet 2006, 368: 1575-1580. PMID: 17084757, DOI: 10.1016/s0140-6736(06)69573-1.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisCo-infected patientsXDR tuberculosisMDR tuberculosisHIV co-infected patientsCulture-confirmed tuberculosisRecent hospital admissionTime of diagnosisSecond-line drugsDrug susceptibility testingCause of deathDate of deathHigh mortality rateAntiretroviral therapyMedian survivalHospital admissionSputum cultureHIV-1PatientsMortality rateHigh mortalityUrgent interventionTreatment programTuberculosisSusceptibility testing
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