2024
Total spine MRI for the preoperative evaluation of adolescent idiopathic scoliosis: Part 2 – spinal cord tumors, dysraphisms, diastematomyelia, and vertebral anomalies
Lee H, Janjua F, Ragab A, Moran J, Haims A, Rubio D, Tuason D, Porrino J. Total spine MRI for the preoperative evaluation of adolescent idiopathic scoliosis: Part 2 – spinal cord tumors, dysraphisms, diastematomyelia, and vertebral anomalies. Current Problems In Diagnostic Radiology 2024, 53: 415-421. PMID: 38262798, DOI: 10.1067/j.cpradiol.2024.01.017.Peer-Reviewed Original ResearchTotal spine MRISpinal cord tumorsAdolescent idiopathic scoliosisCord tumorsSpine MRIIdiopathic scoliosisEvaluation of adolescent idiopathic scoliosisVertebral anomaliesNeural axis abnormalitiesArnold-Chiari malformationTime of diagnosisTethered cordAxis abnormalitiesChiari malformationPreoperative evaluationScreening examinationDiastematomyeliaDysraphismTumorScoliosisAbnormalitiesMRIMalformationsSyringomyeliaCordTotal spine MRI for the preoperative evaluation of adolescent idiopathic scoliosis: part 1
Lee H, Janjua F, Ragab A, Moran J, Haims A, Rubio D, Tuason D, Porrino J. Total spine MRI for the preoperative evaluation of adolescent idiopathic scoliosis: part 1. Current Problems In Diagnostic Radiology 2024, 53: 405-414. PMID: 38246795, DOI: 10.1067/j.cpradiol.2024.01.016.Peer-Reviewed Original ResearchTotal spine MRIAdolescent idiopathic scoliosisSpine MRIIdiopathic scoliosisEvaluation of adolescent idiopathic scoliosisNeural axis abnormalitiesSpinal cord tumorsTime of diagnosisArnold-Chiari malformationCord tumorsTethered cordAxis abnormalitiesChiari malformationPreoperative evaluationScreening examinationVertebral anomaliesScoliosisAbnormalitiesMRIDiastematomyeliaDysraphismSyringomyeliaMalformationsTumor
2023
Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology.
Hersh A, Pennington Z, Lubelski D, Elsamadicy A, Dea N, Desai A, Gokaslan Z, Goodwin C, Hsu W, Jallo G, Krishnaney A, Laufer I, Lo S, Macki M, Mehta A, Ozturk A, Shin J, Soliman H, Sciubba D. Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology. Journal Of Neurosurgery Spine 2023, 40: 1-10. PMID: 37856379, DOI: 10.3171/2023.8.spine23190.Peer-Reviewed Original ResearchConceptsIntramedullary spinal cord tumorsSpinal cord tumorsTumor-specific characteristicsOperative candidacyCord tumorsResection strategyNew neurological deficitsGross total resectionT2 signal changeSet of patientsAreas of controversyIMSCT resectionFrail patientsChronic myelopathyChronic paraplegiaNeurological deficitsPreoperative symptomsTranscranial motorDelphi techniqueSurgical managementMild numbnessOperative managementSurgical interventionFurther resectionRare tumorNCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.
Horbinski C, Nabors L, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon D, Chao S, Chheda M, Fabiano A, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala M, Nagpal S, Nedzi L, Nevel K, Nghiemphu P, Parney I, Patel T, Peters K, Puduvalli V, Rockhill J, Rusthoven C, Shonka N, Swinnen L, Weiss S, Wen P, Willmarth N, Bergman M, Darlow S. NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022. Journal Of The National Comprehensive Cancer Network 2023, 21: 12-20. PMID: 36634606, DOI: 10.6004/jnccn.2023.0002.Peer-Reviewed Original ResearchConceptsCentral nervous system cancerNervous system cancersNCCN guidelinesCNS cancersSystem cancersPrimary spinal cord tumorsExtensive brain metastasesNCCN Guidelines InsightsMetastatic spine tumorsPrimary CNS lymphomaSpinal cord tumorsBrain metastasesCNS lymphomaSystemic therapyCord tumorsSpine tumorsLeptomeningeal metastasesSurgical managementCNS tumorsRelevant new dataSpinal ependymomasBrain tumorsCancer panelTumorsCancer
2022
A novel online calculator to predict nonroutine discharge, length of stay, readmission, and reoperation in patients undergoing surgery for intramedullary spinal cord tumors
Hersh AM, Patel J, Pennington Z, Antar A, Goldsborough E, Porras JL, Feghali J, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo GI, Gokaslan ZL, Lo SL, Sciubba DM. A novel online calculator to predict nonroutine discharge, length of stay, readmission, and reoperation in patients undergoing surgery for intramedullary spinal cord tumors. The Spine Journal 2022, 22: 1345-1355. PMID: 35342014, DOI: 10.1016/j.spinee.2022.03.005.Peer-Reviewed Original ResearchConceptsIntramedullary spinal cord tumorsModified McCormick ScaleSpinal cord tumorsNonroutine dischargeDay readmissionIndependent predictorsWeb-based calculatorBowel dysfunctionNonhome dischargePatient demographicsCord tumorsIncision lengthHigher preoperative white blood cell countResection of ISCTsPreoperative white blood cell countStepwise multivariable logistic regression modelSingle comprehensive cancer centerWhite blood cell countMultivariable logistic regression modelRetrospective cohort study PATIENT SAMPLEBaseline neurological statusDays unplanned readmissionLonger incision lengthNovel online calculatorPreoperative neurological symptomsPerioperative outcomes and survival after surgery for intramedullary spinal cord tumors: a single-institution series of 302 patients.
Hersh AM, Patel J, Pennington Z, Porras JL, Goldsborough E, Antar A, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo G, Gokaslan ZL, Lo SL, Sciubba DM. Perioperative outcomes and survival after surgery for intramedullary spinal cord tumors: a single-institution series of 302 patients. Journal Of Neurosurgery Spine 2022, 37: 252-262. PMID: 35213831, DOI: 10.3171/2022.1.spine211235.Peer-Reviewed Original ResearchIntramedullary spinal cord tumorsLong-term survivalPerioperative outcomesSpinal cord tumorsSingle-institution seriesFisher's exact testChi-square testCervical cordCord tumorsClinical presentationTumor histologyAmerican Spinal Injury Association gradeExact testPrimary intramedullary spinal cord tumorsTumor pathologyShort-term clinical coursePoor long-term survivalLarge single-institution seriesBaseline neurological statusHigh-grade ependymomasCohort of patientsGross total resectionExtent of resectionLog-rank testLength of stay
2021
Impact of Racial Disparities on All-Cause Mortality in Patients With Tumors of the Spinal Cord or Spinal Meninges: A Propensity-Score Analysis
Elsamadicy AA, Freedman I, Koo AB, David WB, Reeves BC, Hengartner A, Pennington Z, Laurans M, Kolb L, Shin JH, Sciubba D. Impact of Racial Disparities on All-Cause Mortality in Patients With Tumors of the Spinal Cord or Spinal Meninges: A Propensity-Score Analysis. Global Spine Journal 2021, 13: 1365-1373. PMID: 34318727, PMCID: PMC10416582, DOI: 10.1177/21925682211033827.Peer-Reviewed Original ResearchSpinal cordCause mortalitySpinal meningesNonmalignant tumorsCox proportional hazards regression analysisProportional hazards regression analysisIntradural spine tumorsReceipt of RTOutcomes of patientsRetrospective cohort studyEnd Results registryKaplan-Meier methodOverall survival estimatesSpinal cord tumorsAssociation of survivalLog-rank testAfrican American patientsPopulation-based estimatesPropensity score analysisPropensity-score matchingCohort studyCord tumorsSpine tumorsWhite patientsAnalysis age
2020
A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma
Gilbert MR, Yuan Y, Wu J, Mendoza T, Vera E, Omuro A, Lieberman F, Robins HI, Gerstner ER, Wu J, Wen PY, Mikkelsen T, Aldape K, Armstrong TS. A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. Neuro-Oncology 2020, 23: 468-477. PMID: 33085768, PMCID: PMC7992893, DOI: 10.1093/neuonc/noaa240.Peer-Reviewed Original ResearchConceptsProgression-free survivalDose-dense temozolomideMedian progression-free survivalAdult patientsObjective responseSymptom burdenClinical trialsRecurrent ependymomaMD Anderson Symptom Inventory-Brain TumorProspective phase II clinical trialMedian Karnofsky performance statusPhase II clinical trialDemonstrated clinical activityModerate-severe painPatients age 18Phase II studyKarnofsky performance statusProspective clinical trialsSpinal cord tumorsStandard medical treatmentPrimary outcome measureSpinal cord ependymomasDisease-related symptomsExpression of ErbB2Daily lapatinibClinical experience of ONC201 in patients with recurrent H3 K27M-mutant spinal cord glioma.
Kurz S, Tarapore R, Odia Y, Butowski N, Koschmann C, Aguilera D, MacDonald T, Lu G, Allen J, Oster W, Mehta M, Chi A, Wen P. Clinical experience of ONC201 in patients with recurrent H3 K27M-mutant spinal cord glioma. Journal Of Clinical Oncology 2020, 38: 2563-2563. DOI: 10.1200/jco.2020.38.15_suppl.2563.Peer-Reviewed Original ResearchSingle agent groupSpinal cord tumorsCombination groupCord tumorsPediatric patientsSpinal cordH3 K27M mutationMedian survival time rangesMedian follow-up timePhase I clinical trialPhase II clinical trialK27M mutationSurvival time rangesClinical experienceSpinal cord gliomasFollow-up timeHigh-grade gliomasII clinical trialsDose reductionDRD2 antagonistsMedian ageProlonged survivalAgent groupDiffuse gliomasUnfavorable prognosis
2018
Thirty-day complication and readmission rates associated with resection of metastatic spinal tumors: a single institutional experience
Elsamadicy AA, Adogwa O, Lubkin DT, Sergesketter AR, Vatsia S, Sankey EW, Cheng J, Bagley CA, Karikari IO. Thirty-day complication and readmission rates associated with resection of metastatic spinal tumors: a single institutional experience. Journal Of Spine Surgery 2018, 4: 304-310. PMID: 30069522, PMCID: PMC6046345, DOI: 10.21037/jss.2018.05.14.Peer-Reviewed Original ResearchReadmission ratesMetastatic spinal tumorsPost-operative complicationsIntensive care unitUncontrolled painSpinal metastasesSpinal tumorsSensory deficitsTumor pathologyCommon post-operative complicationCommon tumor pathologyNew sensory deficitsNerve root injurySingle institutional experienceThirty-day complicationsUnplanned readmission rateMajority of patientsSpinal cord tumorsSensory-motor deficitsSpinal tumor resectionElective resectionCommon complicationMost patientsPatient demographicsCord tumors
2014
Thoracic Epidural Teratoma: Case Report and Review of the Literature
Quon JL, Grant RA, Huttner AJ, Duncan CC. Thoracic Epidural Teratoma: Case Report and Review of the Literature. Clinical Pathology 2014, 7: cpath.s14723. PMID: 24940089, PMCID: PMC4055415, DOI: 10.4137/cpath.s14723.Peer-Reviewed Original ResearchSpinal teratomaClinical presentationSevere spinal cord compressionDiagnosis of teratomaSpinal cord compressionGross total resectionSpinal cord tumorsHeterogeneous contrast enhancementSignificant neurologic compromiseClinician's differentialMarked spasticityAmbulatory functionCord compressionCord tumorsTotal resectionNeurologic compromiseEpidural tumorCystic massRare entityCase reportRare subsetMotor milestonesTumorsTeratomaPathophysiology
2006
Ovarian cryopreservation with transposition of a contralateral ovary: a combined approach for fertility preservation in women receiving pelvic radiation
Martin JR, Kodaman P, Oktay K, Taylor HS. Ovarian cryopreservation with transposition of a contralateral ovary: a combined approach for fertility preservation in women receiving pelvic radiation. Fertility And Sterility 2006, 87: 189.e5-189.e7. PMID: 17084399, DOI: 10.1016/j.fertnstert.2006.04.051.Peer-Reviewed Original ResearchConceptsReproductive-age womenPelvic radiationFertility preservationOvarian transpositionOvarian cryopreservationContralateral ovaryAge womenFuture fertility optionsLaparoscopic ovarian transpositionTertiary care hospitalSpinal cord tumorsNulligravid womenPelvic irradiationCare hospitalCord tumorsCase reportIVF centerLaparoscopic surgeryFertility optionsMAIN OUTCOMESingle ovaryWomenOvariesCryopreservationTransposition
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