2024
Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarcinoma
Patiño-García A, Guruceaga E, Andueza M, Ocón M, Sokoudjou J, de Villalonga Zornoza N, Alkorta-Aranburu G, Uria I, Gurpide A, Camps C, Jantus-Lewintre E, Navamuel-Andueza M, Sanmamed M, Melero I, Elgendy M, Fusco J, Zulueta J, de-Torres J, Bastarrika G, Seijo L, Pio R, Montuenga L, Hernáez M, Ochoa I, Perez-Gracia J. Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarcinoma. EBioMedicine 2024, 102: 105048. PMID: 38484556, PMCID: PMC10955643, DOI: 10.1016/j.ebiom.2024.105048.Peer-Reviewed Original ResearchHeavy smokersWhole-exome sequencingGermline profilingLung cancerLow riskLung adenocarcinomaCoding genetic variantsIdentification of high-risk subjectsIndividual variantsHigh-risk subjectsSequencing germline DNATobacco consumptionDiscovery cohortAdvanced agePack-yearsExome sequencingProfile of subjectsRisk factorsGenetic variantsYounger ageSmokersFunding bodiesTobaccoCohortAnalysis of individualsPhenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank
Wong J, Blechter B, Hubbard A, Machiela M, Shi J, Gadalla S, Hu W, Rahman M, Rothman N, Lan Q. Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank. Thorax 2024, 79: 274-278. PMID: 38238005, PMCID: PMC10923134, DOI: 10.1136/thorax-2023-220076.Peer-Reviewed Original ResearchConceptsLung cancer riskLeucocyte telomere lengthCancer riskUK BiobankMendelian randomization analysisGenetic instrumentsIncident casesRandomization analysisNever smokersPolygenic scoresDose-response relationshipTelomere lengthCox regressionBiobankMultivariate Cox regressionRiskAssociationLung cancerNeverSmokersLungParticipants
2023
Chest Wall Anomaly Presenting as Pulmonary Nodule
Ely S, Van Udelsman B, Bader A, Woodard G. Chest Wall Anomaly Presenting as Pulmonary Nodule. Annals Of Thoracic Surgery Short Reports 2023, 2: 88-90. PMID: 39790260, PMCID: PMC11708574, DOI: 10.1016/j.atssr.2023.11.021.Peer-Reviewed Original ResearchIs hospitalization a missed opportunity to intervene on tobacco cessation?
Nielsen E, Zhang J, Marsden J, Bays C, Moran W, Mauldin P, Lenert L, Toll B, Schreiner A, Heincelman M. Is hospitalization a missed opportunity to intervene on tobacco cessation? The American Journal Of The Medical Sciences 2023, 367: 89-94. PMID: 38043793, DOI: 10.1016/j.amjms.2023.11.024.Peer-Reviewed Original ResearchTobacco cessationNRT prescriptionCurrent smokersTobacco usePatient-centered medical homeStudy periodNicotine replacement therapy productsRetrospective cohort studyPrimary care physiciansLogistic regression modelsProportion of adultsHealth-related changesAdult patientsCohort studyHospital dischargeMost patientsCare physiciansElevated morbidityMedical homeHospitalizationSmokersPatientsCessationPrescriptionTeachable momentAssociations between Health-Related Use of Social Media and Positive Lifestyle Behaviors: Findings from a Representative Sample of US Adult Smokers
Onyeaka H, Chido-Amajuoyi O, Daskalakis E, Deary E, Boardman A, Basiru T, Muoghalu C, Uwandu Q, Baiden P, Nkemjika S, Aneni K, Amonoo H. Associations between Health-Related Use of Social Media and Positive Lifestyle Behaviors: Findings from a Representative Sample of US Adult Smokers. Substance Use & Misuse 2023, 59: 527-535. PMID: 38037958, PMCID: PMC10922700, DOI: 10.1080/10826084.2023.2287199.Peer-Reviewed Original ResearchHealth-related social media useHealth-related purposesSmoking cessationCigarette smokersHealth promotionWeekly strength trainingCardiovascular risk factorsHealth Information National Trends SurveyPositive lifestyle behaviorsMultivariable logistic regressionUS adult smokersDaily vegetable intakeWeekly physical activityNational Trends SurveyPositive health behaviorsCurrent smokersGuideline recommendationsLifestyle behaviorsSmoking interventionsVegetable intakeRisk factorsAdult smokersPhysical activitySmokersHealth behaviorsThe smoking and vaping model, A user-friendly model for examining the country-specific impact of nicotine VAPING product use: application to Germany
Sánchez-Romero L, Liber A, Li Y, Yuan Z, Tam J, Travis N, Jeon J, Issabakhsh M, Meza R, Levy D. The smoking and vaping model, A user-friendly model for examining the country-specific impact of nicotine VAPING product use: application to Germany. BMC Public Health 2023, 23: 2299. PMID: 37990171, PMCID: PMC10662637, DOI: 10.1186/s12889-023-17152-y.Peer-Reviewed Original ResearchConceptsNicotine vaping productsMortality riskNVP usePopulation health effectsPublic health interventionsPublic health impactAdults ages 18Smoking prevalenceSmokingHealth interventionsAge 18Tobacco controlDeath rateHealth effectsVaping productsLife expectancyProduct useHealth impactsSVaDPrevalenceLYLSame periodRiskSmokersPopulationLung Cancer Risk Prediction Models for Asian Ever-Smokers
Yang J, Wen W, Zahed H, Zheng W, Lan Q, Abe S, Rahman M, Islam M, Saito E, Gupta P, Tamakoshi A, Koh W, Gao Y, Sakata R, Tsuji I, Malekzadeh R, Sugawara Y, Kim J, Ito H, Nagata C, You S, Park S, Yuan J, Shin M, Kweon S, Yi S, Pednekar M, Kimura T, Cai H, Lu Y, Etemadi A, Kanemura S, Wada K, Chen C, Shin A, Wang R, Ahn Y, Shin M, Ohrr H, Sheikh M, Blechter B, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Inoue M, Kang D, Robbins H, Shu X. Lung Cancer Risk Prediction Models for Asian Ever-Smokers. Journal Of Thoracic Oncology 2023, 19: 451-464. PMID: 37944700, PMCID: PMC11126207, DOI: 10.1016/j.jtho.2023.11.002.Peer-Reviewed Original ResearchLow-intensity smokersLong-term quittersLung cancer riskRisk prediction modelProspective cohortCancer riskPopulation-based prospective cohortLung cancer risk prediction modelsLung cancer prediction modelsCancer risk prediction modelsRisk-based screeningRisk assessment toolEver smokersPooled analysisCancer prediction modelAsian cohortSmokersHighest AUCWestern populationsAsian populationsCohortGood calibrationQuittersAssessment toolRiskRandomized Trial of Mindfulness- and Reappraisal-Based Regulation of Craving Training Among Daily Cigarette Smokers
Roos C, Harp N, Vafaie N, Gueorguieva R, Frankforter T, Carroll K, Kober H. Randomized Trial of Mindfulness- and Reappraisal-Based Regulation of Craving Training Among Daily Cigarette Smokers. Psychology Of Addictive Behaviors 2023, 37: 829-840. PMID: 37535555, PMCID: PMC10834831, DOI: 10.1037/adb0000940.Peer-Reviewed Original ResearchCue-induced cravingDaily cigarette smokersGreater reductionSmoking-related imagesRandomized trialsCigarette smokersDaily smokersQuit ratesSmokingLarge effect sizesIntervention phaseIntervention controlCravingSmokersComputerized interventionSignificant increaseCBTEffect sizeEntire studyInterventionControlPostinterventionROCRegulationTrialsA Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study.
Vageli D, Doukas P, Shah R, Boyi T, Liu C, Judson B. A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study. Cancer Prevention Research 2023, 16: 653-659. PMID: 37683274, DOI: 10.1158/1940-6207.capr-23-0219.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaSerum miR-21Oral cancerMiR-136MiR-21Smoking historyPilot studySerum miRNAsEarly-stage oral squamous cell carcinomaMiR-29bSquamous cell carcinomaEarly malignant lesionsEarly-stage tumorsSerum miRNA panelFurther validationUseful indexSmoking statusCell carcinomaHealthy controlsPoor survivalTobacco useHealthy volunteersLarge cohortMalignant lesionsSmokersCannabis use among cancer survivors before and during the COVID-19 pandemic, 2019-2021
Sarkar S, Braun I, Nayak M, Bryan A, Poghosyan H. Cannabis use among cancer survivors before and during the COVID-19 pandemic, 2019-2021. JNCI Cancer Spectrum 2023, 7: pkad031. PMID: 37079754, PMCID: PMC10166585, DOI: 10.1093/jncics/pkad031.Peer-Reviewed Original ResearchConceptsCancer survivorsSubpopulation of cancer survivorsBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemCannabis usePoor mental healthEvidence-informed discussionsFactors associated with cannabis useCOVID-19 pandemicMental healthAlcohol consumersTobacco smokersSurveillance systemSurvivorsMedical reasonsCOVID-19PrevalenceCannabisCancerUseHealthPandemicSmokersTobacco
2022
Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial
Lang A, de Havenon A, Mac Grory B, Henninger N, Shu L, Furie K, Easton J, Kim A, Johnston S, Yaghi S. Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial. European Stroke Journal 2022, 8: 328-333. PMID: 37021190, PMCID: PMC10069178, DOI: 10.1177/23969873221148224.Peer-Reviewed Original ResearchConceptsSubsequent ischemic strokeEffect of clopidogrelSubsequent stroke riskIschemic strokeMajor hemorrhagePoint trialStroke riskSmoking statusMinor Ischemic Stroke (POINT) trialSubgroup interaction analysesMultivariable Cox regressionMinor ischemic strokeIschemic stroke trialsEffect of smokingNon-significant trendNew TIACurrent smokersStroke trialsTobacco smokingCox regressionIndex eventSmokersSecondary analysisClopidogrelStrokeDissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort
Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.Peer-Reviewed Original ResearchConceptsSmoking statusNicotine dependenceVeteran cohortNon-current smokersSerious public health issueNovel treatment strategiesPublic health issueUS military veteransEpigenome-wide association studiesCurrent smokersTreatment strategiesFagerström TestNicotine addictionSmokingHealth issuesRole of epigeneticsMilitary veteransMethylationEPIC BeadChip arraySmokersContinuous variablesF2RL3 geneCohortBiomarkersBeadChip arrayPrevious findingsSystemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers
Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.Peer-Reviewed Original ResearchConceptsEffects of LPSDopamine elevationTobacco smokersHealthy controlsSystemic inflammationDopamine systemImmune-brain interactionReward-related brain regionsAdministration of placeboAdministration of LPSSmoking statusRepeated-measures ANOVAPathophysiology of addictionDrug dosingPlaceboIndependent cohortSmokersDrug reinforcementEffect size determinationImmune systemRandomized orderBrain regionsLPSMethylphenidatePBO conditionFurther Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis
Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022, 158: 488-493. PMID: 35899981, DOI: 10.1093/ajcp/aqac074.Peer-Reviewed Original ResearchConceptsCystic neutrophilic granulomatous mastitisGranulomatous mastitisClinicopathologic characteristicsClinicopathologic featuresHigher Breast Imaging ReportingUnique infectious diseaseHospital-based cohortDistinct clinicopathologic featuresMass-like lesionCase-control studyData System scoreBreast Imaging ReportingPainful lesionsRadiologic studiesClinicopathologic profileSystem scoreImaging ReportingDemographic featuresInfectious diseasesPatientsLesionsDiseaseMastitisFurther characterizationSmokersChange in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation
Xu J, Guertin K, Gaddis N, Agler A, Parker R, Feldman J, Kristal A, Arnold K, Goodman P, Tangen C, Hancock D, Cassano P. Change in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation. American Journal Of Clinical Nutrition 2022, 115: 1205-1216. PMID: 35040869, PMCID: PMC8970985, DOI: 10.1093/ajcn/nqac013.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Genotyping ArrayFunctional declineMixed-effects linear regressionAttenuate age-related declinePulmonary function declineFEV1 declineNever smokersFormer smokersAdherent participantsEuropean ancestryDietary intakeHigh dietary intakeEffect sizeCytochrome P450 family 4 subfamily F member 2SmokersGenotyping arraysAge-related declineLinear regressionAssociationC alleleMissense variantsT alleleMissense variationsPulmonary functionBaselinePlasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans. Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.Peer-Reviewed Original ResearchSubjective drug effectsPlasma Mg concentrationHeart rateDrug effectsIntravenous deliveryNon-menthol cigarette smokersPlacebo-controlled studyTest sessionsCigarette smokersMenthol smokersAcute effectsIntravenous nicotineGlucuronide concentrationsMAIN OUTCOMENicotine infusionMenthol glucuronideSecondary analysisPlasma MgE-cigarettesBehavioral effectsMenthol exposureNicotineSmokersPhysiological effectsE-liquidsTargeted Next-Generation Sequencing Reveals Exceptionally High Rates of Molecular Driver Mutations in Never-Smokers With Lung Adenocarcinoma
Mack P, Klein M, Ayers K, Zhou X, Guin S, Fink M, Rossi M, AI-Kateb H, O’Connell T, Hantash F, Oh W, Newman S, Schadt E, Chen R, Hirsch F. Targeted Next-Generation Sequencing Reveals Exceptionally High Rates of Molecular Driver Mutations in Never-Smokers With Lung Adenocarcinoma. The Oncologist 2022, 27: 476-486. PMID: 35298662, PMCID: PMC9177106, DOI: 10.1093/oncolo/oyac035.Peer-Reviewed Original ResearchConceptsStage IV patientsActionable driver mutationsLung adenocarcinomaDriver mutationsIV patientsDiagnosis of adenocarcinomaMetastatic lung adenocarcinomaNext-generation sequencing panelEGFR-mutant tumorsTargeted Next-Generation SequencingHigh rateAssociated therapyNTRK1-3Never smokersMost patientsMultivariable analysisSmoking statusFemale sexSmokersKRAS G12CPatientsAdenocarcinomaDriver alterationsSequencing panelMutation groupCigarette Smoking and Risk of Different Pathologic Types of Stroke: A Systematic Review and Dose-Response Meta-Analysis
Luo J, Tang X, Li F, Wen H, Wang L, Ge S, Tang C, Xu N, Lu L. Cigarette Smoking and Risk of Different Pathologic Types of Stroke: A Systematic Review and Dose-Response Meta-Analysis. Frontiers In Neurology 2022, 12: 772373. PMID: 35145466, PMCID: PMC8821532, DOI: 10.3389/fneur.2021.772373.Peer-Reviewed Original ResearchDifferent pathologic typesNon-linear dose-response associationDose-response associationRisk of strokePathologic typeOdds ratioCigarette smokingDose-response relationshipCurrent smokersStroke incidenceStroke morbidityDifferent smoking characteristicsDose-Response MetaMortality of strokeProspective cohort studyPooled odds ratioSimilar dose-response relationshipDose-response relationInverse variance weightingSmoking control strategiesStroke preventionCohort studySmoking characteristicsGeneral populationSmokers
2021
Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking
Chen Y, Chaudhary S, Wang W, Li C. Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking. Addiction Neuroscience 2021, 1: 100003. PMID: 37220533, PMCID: PMC10201991, DOI: 10.1016/j.addicn.2021.100003.Peer-Reviewed Original ResearchGray matter volumeAnterior cingulate cortexYears of smokingHeavy smokersMatter volumeCingulate cortexSalience networkSmaller gray matter volumeSupplementary motor areaNicotine dependence scoresDorsal anterior cingulate cortexVoxel-based morphometryStructural imaging studiesMedial prefrontal cortexInternalizing scoresChronic smokingCigarette smokingFagerstrom TestInsula gray matter volumeMotor areaNicotine addictionSmokersSmokingImaging studiesDependence scoresExamining Menthol Preference as a Correlate of Change in Cigarette Smoking Behavior over a One-Year Period
Davis D, Parker M, Delnevo C, Villanti A. Examining Menthol Preference as a Correlate of Change in Cigarette Smoking Behavior over a One-Year Period. International Journal Of Environmental Research And Public Health 2021, 18: 10878. PMID: 34682624, PMCID: PMC8535481, DOI: 10.3390/ijerph182010878.Peer-Reviewed Original ResearchConceptsMenthol cigarette useRace/ethnicitySmoking behaviorCigarette useCigarette smokingCigarette smoking behaviorTobacco Use SupplementCurrent study's aimMenthol preferenceCigarette smokersHispanic smokersMenthol statusAdult smokersProspective survey dataMultinomial logistic regressionRepresentative cohortSmokingYounger ageOne-year periodStudy aimCorrelates of changeLogistic regressionSmokersOne-yearYoung adults
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