2024
Performance Status and End-of-Life Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer Treated With Androgen Receptor Targeted Therapy
Mellgard G, Saffran N, Chakrani Z, McCroskery S, Taylor N, Patel M, Liaw B, Galsky M, Oh W, Tsao C, Patel V. Performance Status and End-of-Life Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer Treated With Androgen Receptor Targeted Therapy. American Journal Of Clinical Oncology 2024, 47: 459-464. PMID: 39087466, DOI: 10.1097/coc.0000000000001115.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerPerformance statusProstate cancerOverall survivalAndrogen receptor-targeted therapiesCompare overall survivalReceptor-targeted therapyReduced performance statusSingle-institution studyCompare baseline characteristicsAssessment of PSFisher's exact testWilcoxon signed-rank testTaxane chemotherapyShorter OSCompare OSSigned-rank testTargeted therapyTreatment courseAndrogen receptorBaseline characteristicsExact testCox regressionART treatmentCINDERELLA clinical trial: Using artificial intelligence–driven healthcare to enhance breast cancer locoregional treatment decisions.
Bonci E, Kaidar-Person O, Antunes M, Ciani O, Cruz H, Di Micco R, Gentilini O, Heil J, Kabata P, Romariz M, Gonçalves T, Martins H, Borsoi L, Mika M, Pfob A, Romem N, Schinkoethe T, Silva G, Bobowicz M, Cardoso M. CINDERELLA clinical trial: Using artificial intelligence–driven healthcare to enhance breast cancer locoregional treatment decisions. Journal Of Clinical Oncology 2024, 42: tps621-tps621. DOI: 10.1200/jco.2024.42.16_suppl.tps621.Peer-Reviewed Original ResearchPatient expectationsQuality of lifeResults post-interventionPatient-centred careCancer patients' expectationsBreast cancer expertsOverall quality of lifeImprove patient satisfactionWeighted Cohen's kappaPsychological well-beingBreast cancer treatmentPost-interventionNon-metastatic breast cancer patientsWilcoxon signed-rank testApp contentClinical study sitesLocoregional treatment decisionsCancer expertsBreast cancer patientsPatient satisfactionSigned-rank testPatient informationAesthetic outcomesEligibility criteriaOutcome levelReal-World Multicenter Study of PD-1 Blockade in HIV-Associated Classical Hodgkin Lymphoma Across the United States
Lurain K, Zarif T, Ramaswami R, Nassar A, Adib E, Abdel-Wahab N, Chintapally N, Drolen C, Feldman T, Haykal T, Nebhan C, Thiruvengadam S, Li M, Mittra A, Lorentsen M, Kim C, Drakaki A, Morse M, Johnson D, Mangla A, Dittus C, Ravi P, Baiocchi R, Chiao E, Rubinstein P, Yellapragada S, LaCasce A, Sonpavde G, Naqash A, Herrera A. Real-World Multicenter Study of PD-1 Blockade in HIV-Associated Classical Hodgkin Lymphoma Across the United States. Clinical Lymphoma Myeloma & Leukemia 2024, 24: 523-530. PMID: 38714474, PMCID: PMC11283942, DOI: 10.1016/j.clml.2024.03.011.Peer-Reviewed Original ResearchConceptsPD-1 blockadeCD4<sup>+</sup> T-cell countImmune-mediated adverse eventsOverall response rateT-cell countsHodgkin lymphomaBaseline CD4<sup>+</sup> T-cell countEfficacy of PD-1 blockadeMedian duration of responseCancer therapyClassical Hodgkin lymphomaProgression-free survivalDuration of responseProportion of patientsEnd-of-treatmentWilcoxon signed-rank testLugano classificationCheckpoint inhibitorsComplete responsePD-1Brentuximab vedotinTreatment discontinuationMedian durationSigned-rank testAdverse eventsQuantitative Evaluation of Large Language Models to Streamline Radiology Report Impressions: A Multimodal Retrospective Analysis.
Doshi R, Amin K, Khosla P, Bajaj S, Chheang S, Forman H. Quantitative Evaluation of Large Language Models to Streamline Radiology Report Impressions: A Multimodal Retrospective Analysis. Radiology 2024, 310: e231593. PMID: 38530171, DOI: 10.1148/radiol.231593.Peer-Reviewed Original ResearchConceptsLanguage modelReport impressionsRadiology reportsRetrospective comparative analysisWilcoxon signed-rank testReading grade levelMedical Information Mart for Intensive Care (MIMIC)-IV databaseElectronic health recordsNonparametric Wilcoxon signed-rank testSigned-rank testRetrospective analysisPrimary outcomeComplex medical terminologyImaging modalitiesHealth recordsPatientsRadiologyAnatomical regionsReadabilityIncrease accessModalitiesQuantitative evaluationReadability indicesReadability scoresReportsThe role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas
Najem E, Marin T, Zhuo Y, Lahoud R, Tian F, Beddok A, Rozenblum L, Xing F, Moteabbed M, Lim R, Liu X, Woo J, Lostetter S, Lamane A, Chen Y, Ma C, El Fakhri G. The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas. Radiotherapy And Oncology 2024, 194: 110186. PMID: 38412906, PMCID: PMC11042980, DOI: 10.1016/j.radonc.2024.110186.Peer-Reviewed Original ResearchGross tumor volume delineationGross tumor volumeDice similarity coefficientF-FDG PET imagingSoft tissue sarcomasInter-reader variabilityGTV delineationRadiation therapy treatment planningF-FDGF-FDG PETTherapy treatment planningPerformance level estimationTumor volume delineationTissue sarcomasPET imagingVolume delineationSimultaneous truthHausdorff distanceDice similarity coefficient scoreAccurate gross tumor volumeImaging modality groupsWilcoxon signed-rank testStatistically significant decreaseSigned-rank testTumor volume
2023
Longitudinal Assessment of Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination
NV B, McCollum S, Faherty E, Steele J, Karnik R. Longitudinal Assessment of Left Ventricular Function in Patients with Myopericarditis After mRNA COVID-19 Vaccination. Pediatric Cardiology 2023, 45: 1524-1532. PMID: 37294336, PMCID: PMC10251331, DOI: 10.1007/s00246-023-03200-2.Peer-Reviewed Original ResearchLeft ventricular longitudinal strainMRNA COVID-19 vaccinationCOVID-19 vaccinationSubclinical myocardial injuryEjection fractionFractional shorteningInitial presentationMyocardial injurySingle-center reviewMedian ejection fractionLeft ventricular functionVentricular longitudinal strainTime 0Area-length methodWilcoxon signed-rank testAcute illnessDiastolic functionVentricular functionDiastolic parametersLV functionRisk stratificationMyocardial recoveryTissue DopplerSigned-rank testMyopericarditisPercutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical data
2022
Obstetrician/Gynecologists' Knowledge, Attitudes, and Practice Regarding Suicide Screening Among Women
Stacy M, Dwyer E, Kremer M, Schulkin J. Obstetrician/Gynecologists' Knowledge, Attitudes, and Practice Regarding Suicide Screening Among Women. Journal Of Women's Health 2022, 31: 1481-1489. PMID: 35984865, DOI: 10.1089/jwh.2021.0646.Peer-Reviewed Original ResearchConceptsSuicide risk assessmentSuicide riskEdinburgh Postnatal Depression ScaleInadequate mental health servicesFrequency of screeningMental health referralsPostnatal Depression ScaleObstetrician/gynecologistsMental health servicesOB/GYNsPublic health issueSuicide ideation/behaviorWilcoxon signed-rank testPregnant patientsPostpartum patientsRisk patientsGynecologists' knowledgeHealth referralsSigned-rank testCommon interventionDepression ScaleSuicide screeningResponse rateHealth servicesPatientsDifferences in Performance on Quality Measures for Thrombectomy‐Capable Stroke Centers Compared With Comprehensive Stroke Centers in 2019 to 2020
Baker D, Schmaltz S, Kolbusz K, Messé S, Jauch E, Schwamm L. Differences in Performance on Quality Measures for Thrombectomy‐Capable Stroke Centers Compared With Comprehensive Stroke Centers in 2019 to 2020. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000302.Peer-Reviewed Original ResearchComprehensive stroke centerLarge vessel occlusionMechanical thrombectomyStroke centersSkin punctureCerebral infarctionMedian timeStroke center certificationSymptomatic hemorrhagic complicationsSymptomatic hemorrhagic transformationPercentage of patientsProportion of patientsSuccessful mechanical thrombectomyThrombectomy-capable stroke centersProlonged transport timesWilcoxon rank sum testRank sum testHemorrhagic transformationHemorrhagic complicationsStroke careCenter certificationSigned-rank testCurrent recommendationsPatientsMedian proportionInternational Multicenter Registry for Hyperbaric Oxygen Therapy: Results through June 2021.
Harlan NP, Ptak JA, Rees JR, Cowan DR, Fellows AM, Moses RA, Kertis JA, Hannigan PM, Juggan SA, Peacock J, Bennett M, Buckey JC. International Multicenter Registry for Hyperbaric Oxygen Therapy: Results through June 2021. Undersea And Hyperbaric Medicine 2022, 49: 275-287. PMID: 36001560, DOI: 10.22462/05.06.2022.1.Peer-Reviewed Original ResearchConceptsInternational multicenter registryHyperbaric oxygen therapyQuality of lifeMulticenter registryOxygen therapyIdiopathic sudden sensorineural hearing lossSudden sensorineural hearing lossMultiple centersProspective data collectionSensorineural hearing lossHyperbaric Medical SocietyNon-healing woundsWilcoxon signed-rank testCarbon monoxide poisoningComplication rateComplication dataProspective dataTherapy indicationsSigned-rank testWound scoreRadiation injuryHearing lossPost-treatment dataOutcome dataControl groupThe Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients
Trant A, Chagpar A, Wei W, Neumeister V, Rimm D, Stavris K, Lurie B, Frederick C, Andrejeva L, Raghu M, Killelea B, Horowitz N, Lannin D, Knill-Selby E, Sturrock T, Hofstatter E. The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients. Integrative Cancer Therapies 2022, 21: 15347354221137290. PMID: 36444764, PMCID: PMC9716631, DOI: 10.1177/15347354221137290.Peer-Reviewed Original ResearchConceptsTumor volumeBlack cohoshSitu patientsDuctal carcinomaAnti-inflammatory effectsTumor cellular proliferationBreast cancer treatmentCellular proliferationWilcoxon signed-rank testDCIS patientsAdverse eventsEligible subjectsWindow trialsCore biopsyInvasive diseaseKi67 expressionSigned-rank testBreast cancerGrade 3Hormone changesPatientsQuantitative immunofluorescenceBC extractSignificant toxicityCancer treatment
2021
Safety and Glycemic Outcomes During the MiniMed™ Advanced Hybrid Closed-Loop System Pivotal Trial in Adolescents and Adults with Type 1 Diabetes
Carlson AL, Sherr JL, Shulman DI, Garg SK, Pop-Busui R, Bode BW, Lilenquist DR, Brazg RL, Kaiserman KB, Kipnes MS, Thrasher JR, Reed JHC, Slover RH, Philis-Tsimikas A, Christiansen M, Grosman B, Roy A, Vella M, Jonkers RAM, Chen X, Shin J, Cordero TL, Lee SW, Rhinehart AS, Vigersky RA. Safety and Glycemic Outcomes During the MiniMed™ Advanced Hybrid Closed-Loop System Pivotal Trial in Adolescents and Adults with Type 1 Diabetes. Diabetes Technology & Therapeutics 2021, 24: 178-189. PMID: 34694909, PMCID: PMC8971997, DOI: 10.1089/dia.2021.0319.Peer-Reviewed Original ResearchConceptsAdvanced hybrid closed-loop systemMulticenter single-arm studyPredictive low glucose managementDiabetic ketoacidosis eventsSingle-arm studySensor-augmented pumpType 1 diabetesWilcoxon signed-rank testStudy phaseKetoacidosis eventsTreat populationHybrid closed-loop systemMean A1CGlycemic targetsGlucose targetsPivotal trialsStudy endpointGlucose managementGlycemic outcomesSigned-rank testAge groupsStudy participantsType 1Safety eventsA1CConventional Hepatic Volumetry May Lead to Inaccurate Segmental Yttrium-90 Radiation Dosimetry
Stein SI, Soliman MM, Sparapani J, Doustaly R, Cobb BW, Malhotra A, Charalel R, May BJ, Lee KS, Madoff DC, Talenfeld AD. Conventional Hepatic Volumetry May Lead to Inaccurate Segmental Yttrium-90 Radiation Dosimetry. CardioVascular And Interventional Radiology 2021, 44: 1973-1985. PMID: 34414494, DOI: 10.1007/s00270-021-02898-y.Peer-Reviewed Original ResearchConceptsMedical Internal Radiation DosimetryCone-beam CTCT/MRI scansSegmental volumesVariant arterial anatomyCT/MRIWilcoxon signed-rank testY90 radioembolizationZone volumeArterial anatomyVenous anatomyTumor locationSigned-rank testInternal radiation dosimetryHepatic volumetryMRI scansLobar volumesVolumetric differencesCouinaudDose targetsPersonalized dosimetryBeam CTAngiogramsDosesVolumetry
2020
Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD
Copetti M, Lopes A, Requena G, Johnson I, Greenberg B, Noren G, McLaughlin N, Shavitt R, Miguel E, Batistuzzo M, Hoexter M. Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD. Frontiers In Psychiatry 2020, 10: 936. PMID: 31998155, PMCID: PMC6962231, DOI: 10.3389/fpsyt.2019.00936.Peer-Reviewed Original ResearchGamma ventral capsulotomyPersonality disorder symptomsIntractable obsessive-compulsive disorderObsessive-compulsive disorderDisorder symptomsOCD patientsTreatment responseDisorder symptom changeSymptom changeStructured Clinical InterviewWorse treatment responseDSM-IV personality disordersWilcoxon signed-rank testPoorer ResponseClinical responseTreatment optionsInternal capsuleSigned-rank testTreatment attemptsAnterior limbClinical InterviewRadiosurgical proceduresPatientsSymptomsVentral part
2019
The feasibility of contrast echocardiography in the assessment of right ventricular size and function
Pereira JB, Essa M, Ugonabo I, Hur DJ, Crandall I, Vaccarelli M, Sugeng L. The feasibility of contrast echocardiography in the assessment of right ventricular size and function. Echocardiography 2019, 36: 1979-1988. PMID: 31633241, DOI: 10.1111/echo.14504.Peer-Reviewed Original ResearchConceptsRight ventricular evaluationRight ventricular sizeSegmental wall motionRight ventricular imagingRV-focused viewWall motionRight ventricle evaluationContrast enhancementWilcoxon signed-rank testInter-observer agreementRV dimensionsEchocardiography studyIntra-observer reproducibilityVentricular sizeSigned-rank testContrast echocardiographyRV imagingAnatomical assessmentVentricular imagingPatientsPercent agreementIrregular rhythmTotal segmentsIndependent observersSample t-test
2015
Mindfulness and Modification Therapy for Behavioral Dysregulation: A Comparison Trial Focused on Substance Use and Aggression
Wupperman P, Cohen MG, Haller DL, Flom P, Litt LC, Rounsaville BJ. Mindfulness and Modification Therapy for Behavioral Dysregulation: A Comparison Trial Focused on Substance Use and Aggression. Journal Of Clinical Psychology 2015, 71: 964-978. PMID: 26287444, DOI: 10.1002/jclp.22213.Peer-Reviewed Original ResearchConceptsVerbal aggressionPhysical aggressionAlcohol/drug useBehavioral dysregulationDrug useCurrent pilot studyTransdiagnostic TreatmentTransdiagnostic therapyMultilevel modelingAggressionAlcohol problemsSubstance useMindfulnessSelf-referred womenSpecific behaviorsPreliminary findingsWilcoxon signed-rank testModification therapySigned-rank testGreater improvementComparison trialPilot studySignificant decreaseGreater decreaseSignificant differences
2014
Findings from a community-based asthma education fair for Latino caregivers
Riera A, Ocasio A, Goncalves P, Krumeich L, Katz KH, Trevino S, Vaca FE. Findings from a community-based asthma education fair for Latino caregivers. Journal Of Asthma 2014, 52: 71-80. PMID: 25019349, DOI: 10.3109/02770903.2014.944982.Peer-Reviewed Original ResearchMeSH KeywordsAbsenteeismAdolescentAdrenal Cortex HormonesAdrenergic beta-AgonistsAdultAmbulatory Care FacilitiesAnti-Asthmatic AgentsAsthmaCaregiversChildChild, PreschoolCommunity-Based Participatory ResearchEmergency Service, HospitalHealth EducationHealth Knowledge, Attitudes, PracticeHispanic or LatinoHospitalizationHumansInfantLanguageMetered Dose InhalersMiddle AgedQuality of LifeResidence CharacteristicsYoung AdultConceptsLEP caregiversCaregiver qualityMedication recognitionPediatric Asthma Caregiver's QualityEmergency department visitsPeak flow meterIndividualized action plansWilcoxon signed-rank testPACQLQ scoresClinic visitsAsthma diagnosisDepartment visitsHealthcare utilizationQOL improvementChildren 1Life QuestionnaireCaregiver QOLSigned-rank testActivity limitationsCaregivers' abilityMcNemar testSchool absenteeismLatino caregiversCaregiversBaseline dataAnalysis of plethysmographic waveform changes induced by beach chair positioning under general anesthesia
Zhu R, Atteya G, Shelley KH, Silverman DG, Alian AA. Analysis of plethysmographic waveform changes induced by beach chair positioning under general anesthesia. Journal Of Clinical Monitoring And Computing 2014, 28: 591-596. PMID: 24420341, DOI: 10.1007/s10877-014-9555-9.Peer-Reviewed Original ResearchConceptsBeach chair positioningVasoactive drugsBlood pressureShoulder surgeryNoninvasive hemodynamic parametersPostoperative cerebral ischemiaMean arterial pressureTidal carbon dioxideBeach chair positionIntermittent blood pressureChair positionWilcoxon signed-rank testPosition surgeryArterial pressureCerebral ischemiaGeneral anesthesiaSigned-rank testHemodynamic parametersRare caseDevastating outcomesHeart rateRespiratory frequencyPatientsSurgeryAmplitude densityImproving Door-to-Needle Times
Ruff I, Ali S, Goldstein J, Lev M, Copen W, McIntyre J, Rost N, Schwamm L. Improving Door-to-Needle Times. Stroke 2014, 45: 504-508. PMID: 24399372, DOI: 10.1161/strokeaha.113.004073.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overClinical ProtocolsComorbidityData Interpretation, StatisticalEarly DiagnosisEmergency Medical ServicesFemaleFibrinolytic AgentsHumansInternational Classification of DiseasesMaleMiddle AgedProspective StudiesQuality ImprovementRetrospective StudiesSocioeconomic FactorsStrokeThrombolytic TherapyTissue Plasminogen ActivatorTomography, X-Ray ComputedTreatment OutcomeConceptsIntravenous tissue-type plasminogen activatorEmergency department arrivalTissue-type plasminogen activatorAcute strokeDTN timeNeedle timeHealth Stroke Scale scorePlasminogen activatorAcute ischemic strokePercentage of patientsStroke Scale scoreAmerican Heart AssociationStroke care modelWilcoxon signed-rank testImproving DoorIschemic strokeStroke guidelinesHeart AssociationPostintervention periodSigned-rank testPre interventionCare modelNational guidelinesPost interventionPatients
2013
Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations
Hoang D, Broer N, Roman SA, Yao X, Abitbol N, Li F, Sosa JA, Sue GR, DeWan AT, Wong ML, Licinio J, Simpson C, Li AY, Pizzoferrato N, Narayan D. Leptin Signaling and Hyperparathyroidism: Clinical and Genetic Associations. Journal Of The American College Of Surgeons 2013, 218: 1239-1250.e4. PMID: 24468228, DOI: 10.1016/j.jamcollsurg.2013.11.013.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsLeptin levelsParathyroid glandsHormone levelsBaseline leptin levelsLarge parathyroid glandsBody mass indexRole of leptinWilcoxon signed-rank testHyperplasia subgroupsParathyroid sizeObese patientsPostoperative changesMass indexParathyroid adenomaProspective studyParathyroid tissueBland-Altman methodLeptin productionSigned-rank testSurgical conditionsClinical studiesLeptin signalingLEPR polymorphismsLeptin
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