2025
Editorial: Where are the Trials on Adolescent Self-Harm and Suicide?
Kumpf K, Bloch M. Editorial: Where are the Trials on Adolescent Self-Harm and Suicide? Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40088968, DOI: 10.1016/j.jaac.2025.03.002.Peer-Reviewed Original ResearchNonsuicidal self-injurySelf-harmModerators of treatment effectsRandomized controlled trialsPublic health problemEvidence-based treatmentsAdolescent self-harmPrevent self-harmSelf-injuryHealth problemsRandom-effects meta-analysisRandom-effects meta-analysis of studiesTherapeutic interventionsSuicideMeta-analysis of studiesSource of morbidityAdolescentsIndividual patient dataSecondary analysisTreatment effectsNo significant differenceControlled trialsAggregate dataMeta-analysisEffective treatmentEpigenomic pathways from racism to preterm birth: secondary analysis of the Nulliparous Pregnancy Outcomes Study: monitoring Mothers-to-be (nuMoM2b) cohort study in the USA to examine how DNA methylation mediates the relationship between multilevel racism and preterm birth in black women: a study protocol
Barcelona V, Ray M, Zhao Y, Samari G, Wu H, Reho P, McNeil R, Reddy U. Epigenomic pathways from racism to preterm birth: secondary analysis of the Nulliparous Pregnancy Outcomes Study: monitoring Mothers-to-be (nuMoM2b) cohort study in the USA to examine how DNA methylation mediates the relationship between multilevel racism and preterm birth in black women: a study protocol. BMJ Open 2025, 15: e091801. PMID: 40037666, PMCID: PMC11881185, DOI: 10.1136/bmjopen-2024-091801.Peer-Reviewed Original ResearchConceptsNulliparous Pregnancy Outcomes StudyMonitoring Mothers-to-BeMothers-to-beBlack womenPregnancy Outcomes StudyParticipants' electronic health recordsPreterm birthSecondary analysisCohort studyGeocoded participant addressesSecondary analysis of dataStudy protocolElectronic health recordsStructural racism measuresUniversity Institutional Review BoardEffects of individual-Black pregnant womenOutcome studiesRacial residential segregationProspective cohort studyPregnancy-related morbidityParticipant's addressHealth recordsAdverse pregnancy outcomesWhite womenGLP-1RA Use and Thyroid Cancer Risk
Brito J, Herrin J, Swarna K, Ospina N, Montori V, Toro-Tobon D, Umpierrez G, Galindo R, Deng Y, Mickelson M, Shao H, Polley E, McCoy R. GLP-1RA Use and Thyroid Cancer Risk. JAMA Otolaryngology - Head & Neck Surgery 2025, 151: 243-252. PMID: 39847346, PMCID: PMC11907303, DOI: 10.1001/jamaoto.2024.4852.Peer-Reviewed Original ResearchConceptsDipeptidyl peptidase-4 inhibitorsModified intention-to-treatSodium-glucose cotransporter 2 inhibitorsTarget trial emulationGLP-1RA initiationComparative effectiveness studiesGLP-1RAThyroid cancerType 2 diabetesSecondary analysisMedicare fee-for-service planTrial emulationHazard ratioAssociated with increased overall riskIncident thyroid cancerDipeptidyl peptidase-4 inhibitor groupTreated with GLP-1RAGlucagon-like peptide-1 receptor agonistsHistory of thyroid cancerFee-for-service plansModified intention-to-treat analysisPeptide-1 receptor agonistsEnhanced early detectionGLP-1RA therapyPeptidase-4 inhibitorsAssociation between induction start time and labor duration in nulliparous women undergoing elective induction of labor
Facco F, MacPherson C, Reddy U, Tita A, Silver R, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Heyborne K, Srinivas S, Swamy G, Grobman W. Association between induction start time and labor duration in nulliparous women undergoing elective induction of labor. American Journal Of Perinatology 2025 PMID: 40015324, DOI: 10.1055/a-2547-4196.Peer-Reviewed Original ResearchInduction of laborCesarean delivery rateLabor durationShorter labor durationElective inductionBishop scoreNulliparous womenLow-risk nulliparous womenElective induction of laborModified Bishop scoreMean labour durationMulti-center randomized controlled trialDelivery rateBaseline maternal characteristicsBody mass indexFrequency of deliveryARRIVE trialInsurance statusCervical statusMaternal characteristicsSecondary analysisRupture of membranesSpontaneous laborWeeks 0 daysWomen MethodsPrenatal Cannabis Use and Depressive Symptoms
Pitt T, Allshouse A, Kim P, McMillin G, Silver R, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Metz T. Prenatal Cannabis Use and Depressive Symptoms. Obstetrics And Gynecology 2025, 145: 417-425. PMID: 40014863, PMCID: PMC11925678, DOI: 10.1097/aog.0000000000005860.Peer-Reviewed Original ResearchConceptsAssociated with later depressive symptomsCannabis exposureDepressive symptomsCannabis useTHC-COOHAssociated with increased depressive symptomsAssociated with greater oddsAssociated with depressive symptomsFirst-trimesterExposed to cannabisPregnancy outcome dataWeeks of gestationFirst-trimester exposureGreater oddsCannabis metabolitesSecondary analysisCannabisAssociated with increased oddsExploratory analysisUrine immunoassayTrimesterHigher levelsPrimary outcomePregnancyAcademic centersA systematic review on the assessment of pregnancy-specific psychological trauma during pregnancy: A call to action
Givrad S, Wall K, Goldman L, Shin J, Novak E, Lowell A, Penner F, Day M, Papa L, Wright D, Rutherford H. A systematic review on the assessment of pregnancy-specific psychological trauma during pregnancy: A call to action. AJOG Global Reports 2025, 5: 100451. PMID: 40093874, PMCID: PMC11909425, DOI: 10.1016/j.xagr.2025.100451.Peer-Reviewed Original ResearchSystematic reviewPerinatal periodPsychological traumaPreferred Reporting ItemsCare deliveryWeb of ScienceReporting ItemsHealthcare systemIndependent reviewersInfant healthSecondary analysisScreening measuresOvid MEDLINEFull-textOvid EmbaseHistory of traumatic experiencesResearch teamPsychological disordersPerinatal individualsOvidPregnancyTraumatic experiencesTeamTraumaPsycINFORadiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations.
Zaree O, Nguyen J, de Oliveira Santo I, Kertam A, Rahmani S, Johnson J, Tu L. Radiologist, trainee, and logistical factors impacting the timeliness of CTA head and neck reporting in stroke code activations. American Journal Of Neuroradiology 2025, ajnr.a8660. PMID: 39832953, DOI: 10.3174/ajnr.a8660.Peer-Reviewed Original ResearchStroke code activationAttending radiologistsTimeliness of reportingEmergency department settingRadiologist characteristicsCare settingsMultivariate regression modelImprove workflow efficiencyDepartment settingStroke codeModifiable factorsDescriptive statisticsSecondary analysisCoding activitiesReport factorsPatient ageObservational studyWorkflow efficiencyShift typeMedian TATMultivariate regressionInterquartile rangeRegression modelsCTA reportsLogistical factorsVascular Quality Initiative Assessment of Compliance with Society for Vascular Surgery Practice Guidelines for the Endovascular Management of Claudication
Iannuzzi J, Animilli S, Simons J, Tonnessen B, Koleilat I, Indes J, Conte M, Eldrup-Jorgensen J. Vascular Quality Initiative Assessment of Compliance with Society for Vascular Surgery Practice Guidelines for the Endovascular Management of Claudication. Journal Of Vascular Surgery 2025 PMID: 39824263, DOI: 10.1016/j.jvs.2025.01.007.Peer-Reviewed Original ResearchManagement of claudicationHospital-level variationGuideline releaseIncreased odds of smokingArea Deprivation IndexUptake of guidelinesChanges to clinical practiceOdds of smokingMedical managementSociety for Vascular SurgeryCases of claudicationHigh-grade recommendationsAlign careDeprivation indexImprove carePreoperative smoking cessationSmoking cessationMedical therapySocial deprivationDecreased oddsIncreased oddsSecondary analysisStent usePost-procedural recommendationsPractice guidelinesThe effect of inpatient brief cognitive-behavioral therapy for suicide prevention on post-discharge emergency department utilization: Secondary analysis of a randomized clinical trial
Diefenbach G, Collett S, Black S, Rudd M, Gueorguieva R, Tolin D. The effect of inpatient brief cognitive-behavioral therapy for suicide prevention on post-discharge emergency department utilization: Secondary analysis of a randomized clinical trial. General Hospital Psychiatry 2025, 93: 73-79. PMID: 39837259, DOI: 10.1016/j.genhosppsych.2025.01.007.Peer-Reviewed Original ResearchConceptsSubstance use disordersBrief cognitive-behavioral therapyCognitive-behavioral therapyED visitsSuicide preventionSecondary analysisEmergency departmentSuicide-related ED visitsHistory of suicide attemptsEmergency department utilizationElectronic medical record reviewPost-discharge emergency departmentMedical record reviewED utilizationPsychiatric readmissionTreatment effectsSuicide attemptsUse disorderRecord reviewSelf-reportRandomized clinical trialsGeneralized linear modelVisitsSuicidePost-discharge ED visitsGlobal variation in the assessment of psychological trauma in pregnancy
Wall K, Penner F, Goldman L, Shin J, Novak E, Lowell A, Day M, Papa L, Wright D, Givrad S, Rutherford H. Global variation in the assessment of psychological trauma in pregnancy. Cambridge Prisms Global Mental Health 2025, 12: e10. PMID: 39935728, PMCID: PMC11810758, DOI: 10.1017/gmh.2024.152.Peer-Reviewed Original ResearchSub-Saharan AfricaPregnant peopleSystematic reviewPsychological traumaImpact health outcomesMiddle EastIn-house assessmentPrevalence of traumatic experiencesCulturally appropriate measuresPreferred Reporting ItemsTraumatic experiencesObstetric careWeb of ScienceHealth outcomesCentral AmericaReporting ItemsSecondary analysisOvid MEDLINESub-SaharanOvid EmbaseSystematic literature reviewGeopolitical regionsAssessment of psychological traumaAfricaInterpersonal traumaThe impact of race, ethnicity, and socioeconomic status on early adolescent sleep disturbances for youth exposed to adverse childhood experiences
Senger-Carpenter T, Voepel-Lewis T, Stoddard S, Zhang A, Ordway M. The impact of race, ethnicity, and socioeconomic status on early adolescent sleep disturbances for youth exposed to adverse childhood experiences. Child Abuse & Neglect 2025, 160: 107236. PMID: 39754988, PMCID: PMC11792094, DOI: 10.1016/j.chiabu.2024.107236.Peer-Reviewed Original ResearchConceptsClinically significant sleep disturbanceCommunity socioeconomic statusAdverse childhood experiencesSocioeconomic statusSignificant sleep disturbanceImpact of raceFamily socioeconomic statusSleep disturbanceAdverse childhood experience exposureChildhood experiencesAdjusted odds ratiosMixed effects logistic regression modelsEffects logistic regression modelsMultilevel mixed effects logistic regression modelsSleep Disturbance ScaleInteractive effects of raceAdolescent sleep disturbancesLogistic regression modelsAffecting sleep disturbanceEffects of raceSecondary analysisOdds ratioDisturbance ScaleConfidence intervalsAged 9
2024
BCG-Induced DNA Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing the Risk for Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Longlax S, Koster K, Kamat A, Lozano M, Lerner S, Hannigan R, Nishiguchi T, Abhimanyu, Sheikh D, Ladki M, Portillo A, Koirala A, Patel T, Spieler Z, Benjamin A, Lebedev M, Ofili T, Hutchison R, Udeani G, Opperman L, Neal G, Mandalakas A, Netea M, Arditi M, Avalos P, Grimm S, Coarfa C, Cirillo J, DiNardo A. BCG-Induced DNA Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing the Risk for Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Open Forum Infectious Diseases 2024, 12: ofaf007. PMID: 39872813, PMCID: PMC11770274, DOI: 10.1093/ofid/ofaf007.Peer-Reviewed Original ResearchVaccine immunityDNA methylation changesBCG-induced trained immunityClinical trialsBCG vaccinationPlacebo-controlled clinical trialStudy enrollmentAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 infectionCovid-19 specific vaccineMethylation changesCoronavirus 2 infectionCOVID-19 vaccine immunitySymptomatic COVID-19Secondary analysisSARS-CoV-2 antigensInnate immune responseDouble-blindPlacebo armBCG TiceTrained immunitySevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Coronavirus immunityRespiratory syndrome coronavirus 2Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes: a secondary analysis of the TODAY randomised clinical trial
Nadeau K, Arslanian S, Bacha F, Caprio S, Chao L, Farrell R, Hughan K, Rayas M, Tung M, Cross K, El ghormli L. Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes: a secondary analysis of the TODAY randomised clinical trial. Diabetologia 2024, 68: 676-687. PMID: 39706874, DOI: 10.1007/s00125-024-06327-w.Peer-Reviewed Original ResearchConceptsYouth-onset type 2 diabetesType 2 diabetesBeta cell functionRandomised clinical trialsVisceral adipose tissueMarkers of adiposityInsulin sensitivityInsulin clearanceSubcutaneous adipose tissueCell functionClinical trialsResponse to rosiglitazone treatmentDual-energy X-ray absorptiometryPersistently elevated blood glucose levelsMarkers of insulin sensitivityFasting blood testsX-ray absorptiometryFasting C-peptideNon-Hispanic black raceAdipose tissueResponse to treatmentCompensatory response to changesElevated blood glucose levelsNational Institute of DiabetesSecondary analysisVoice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure
Lofthouse K, Beeson E, Dalgleish T, Danese A, Hodgekins J, Mahoney-Davies G, Smith P, Stallard P, Wilson J, Meiser-Stedman R. Voice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure. European Journal Of Psychotraumatology 2024, 15: 2435790. PMID: 39691055, PMCID: PMC11656750, DOI: 10.1080/20008066.2024.2435790.Peer-Reviewed Original ResearchConceptsNegative post-traumatic cognitionsPosttraumatic stress disorderPost-traumatic cognitionsPosttraumatic stress disorder symptom severityHearing groupPrevalence of sexual traumaVoice hearingPanic symptomsSymptom severitySexual traumaSecondary analysisExposure to multiple traumatic eventsCognitive phenotype of childrenHearing voicesExposure to multiple traumasPosttraumatic stress disorder diagnosisTrauma memory qualityMental health difficultiesMethods:</b> ParticipantsMultiple traumatic eventsMultiple trauma exposuresExploratory secondary analysisCognitive-behavioral factorsPhenotype of childrenHealth difficultiesArousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea. European Respiratory Journal 2024, 65: 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionCost-effectiveness of a simplified acute malnutrition program: a secondary analysis of the OptiMA randomized clinical trial in the Democratic Republic of the Congo
Resch S, Sato R, Phelan K, Cazes C, Ombotimbe A, Hubert V, Boubacar H, Bozama L, Sakubu G, Tshiala B, Tusuku T, Alitanou R, Kouamé A, Yao C, Gabillard D, Kinda M, Becquet R, Shepherd S, Hecht R. Cost-effectiveness of a simplified acute malnutrition program: a secondary analysis of the OptiMA randomized clinical trial in the Democratic Republic of the Congo. Health Policy And Planning 2024, 40: 273-286. PMID: 39513752, PMCID: PMC11886841, DOI: 10.1093/heapol/czae106.Peer-Reviewed Original ResearchMid-upper arm circumferenceIncremental cost-effectiveness ratioAcute malnutritionTreatment successReady-to-use supplementary foodFixed dose regimenRandomized clinical trialsCost-effectiveness ratioSecondary analysisChildren aged 6Tapering doseNo significant differenceArm circumferenceClinical trialsModerate casesMalnutrition programsCost-effectiveness analysisTherapeutic foodMean costStandard careAged 6Significant differenceStatistical differenceStandard groupRUTFWin Ratio Analyses Using a Modified Hierarchical Composite Outcome: Insights From PARAGLIDE-HF
Shoji S, Cyr D, Hernandez A, Velazquez E, Ward J, Williamson K, Sarwat S, Starling R, Desai A, Zieroth S, Solomon S, Mentz R. Win Ratio Analyses Using a Modified Hierarchical Composite Outcome: Insights From PARAGLIDE-HF. American Heart Journal 2024, 280: 70-78. PMID: 39505123, DOI: 10.1016/j.ahj.2024.10.020.Peer-Reviewed Original ResearchNT-proBNPComposite outcomeRenal outcomesEjection fractionHeart failureN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideNT-proBNP thresholdsNT-proBNP changesClinically significant eventsNatriuretic peptideAssessment of treatment effectsHF hospitalizationCardiovascular deathTreatment effectsTreatment benefitComprehensive assessment of treatment effectsPrimary analysisValsartanHF visitsSecondary analysisPatientsHierarchical outcomesOutcomesFood Insecurity among Women Involved in the Criminal Legal System and Members of their Risk Network.
Robles J, Kershaw T, Meyer J. Food Insecurity among Women Involved in the Criminal Legal System and Members of their Risk Network. Journal Of Health Care For The Poor And Underserved 2024, 35: 134-146. PMID: 39584269, DOI: 10.1353/hpu.2024.a942873.Peer-Reviewed Original ResearchConceptsCriminal legal systemFood insecurityDisadvantaged zip codesLegal systemZip codesFood assistancePrevalence of food insecurityHealth disparitiesSocial determinantsSecondary analysisMonthly incomeSubsistence needsSevere psychiatric disordersInsecurityMultivariate modelPsychiatric disordersWomenRisk networkRiskPeopleRace/ethnicityAssistanceCriminalsHealthDisparitiesPhenotypes of sleep health among adults with chronic heart failure in a randomized controlled trial of cognitive behavioral therapy for insomnia
Jeon S, Conley S, O'Connell M, Wang Z, Redeker N. Phenotypes of sleep health among adults with chronic heart failure in a randomized controlled trial of cognitive behavioral therapy for insomnia. Sleep Health 2024, 10: 705-712. PMID: 39482227, PMCID: PMC11624990, DOI: 10.1016/j.sleh.2024.09.006.Peer-Reviewed Original ResearchEmergency department visitsRandomized controlled trial of cognitive behavioral therapyCognitive behavioral therapyTrial of cognitive behavioral therapyDepartment visitsHealth phenotypesRandomized controlled trialsBehavioral therapyProportion of participantsGeneralized estimating equationsCox proportional hazards modelsProportional hazards modelCircadian quotientLinear mixed modelsLower fatigueGeneralized linear mixed modelsSecondary analysisWalking distanceSleep healthCollected hospitalFunctional performanceSleep phenotypesPoor sleepAdverse healthHeart failure outcomesAdherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death
Cersonsky T, Ayala N, Tucker N, Saade G, Dudley D, Pinar H, Silver R, Reddy U, Lewkowitz A. Adherence to recommended prenatal visit schedules and risk for stillbirth, according to probable cause of death. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2024, 303: 159-164. PMID: 39488137, PMCID: PMC11602338, DOI: 10.1016/j.ejogrb.2024.10.037.Peer-Reviewed Original ResearchRisk of stillbirthCause of deathIncreased risk of stillbirthHypertensive disordersPrenatal visit scheduleStillbirth Collaborative Research NetworkHigher risk of stillbirthSuboptimal prenatal careHypertensive disorders of pregnancyAssociated with higher riskDisorders of pregnancyVisit adherenceVisitation guidelinesPrenatal careSecondary analysisNon-adherenceVisit scheduleStillbirthIncreased riskMultivariate regressionStudy objectiveVisit frequencyPregnancyAdherenceGuidelines
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply